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Items: 1 to 50 of 276

1.

Modulation of mutant KrasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function.

Zhou X, Padanad MS, Evers BM, Smith B, Novaresi N, Suresh S, Richardson JA, Stein E, Zhu J, Hammer RE, O'Donnell KA.

Mol Cancer Res. 2018 Nov 8. pii: molcanres.0739.2018. doi: 10.1158/1541-7786.MCR-18-0739. [Epub ahead of print]

PMID:
30409919
2.

Loss of Dis3l2 partially phenocopies Perlman syndrome in mice and results in up-regulation of Igf2 in nephron progenitor cells.

Hunter RW, Liu Y, Manjunath H, Acharya A, Jones BT, Zhang H, Chen B, Ramalingam H, Hammer RE, Xie Y, Richardson JA, Rakheja D, Carroll TJ, Mendell JT.

Genes Dev. 2018 Jul 1;32(13-14):903-908. doi: 10.1101/gad.315804.118. Epub 2018 Jun 27.

PMID:
29950491
3.

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice.

Linden AG, Li S, Choi HY, Fang F, Fukasawa M, Uyeda K, Hammer RE, Horton JD, Engelking LJ, Liang G.

J Lipid Res. 2018 Mar;59(3):475-487. doi: 10.1194/jlr.M081836. Epub 2018 Jan 15.

4.

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.

Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J.

Elife. 2017 Nov 16;6. pii: e29292. doi: 10.7554/eLife.29292.

5.

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.

Gu YF, Cohn S, Christie A, McKenzie T, Wolff N, Do QN, Madhuranthakam AJ, Pedrosa I, Wang T, Dey A, Busslinger M, Xie XJ, Hammer RE, McKay RM, Kapur P, Brugarolas J.

Cancer Discov. 2017 Aug;7(8):900-917. doi: 10.1158/2159-8290.CD-17-0292. Epub 2017 May 4.

6.
7.

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

Rong S, Cortés VA, Rashid S, Anderson NN, McDonald JG, Liang G, Moon YA, Hammer RE, Horton JD.

Elife. 2017 Feb 28;6. pii: e25015. doi: 10.7554/eLife.25015.

8.

The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.

Barnea E, Melamed Kadosh D, Haimovich Y, Satumtira N, Dorris ML, Nguyen MT, Hammer RE, Tran TM, Colbert RA, Taurog JD, Admon A.

Mol Cell Proteomics. 2017 Apr;16(4):642-662. doi: 10.1074/mcp.M116.066241. Epub 2017 Feb 10.

9.

Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin.

Comerford SA, Hinnant EA, Chen Y, Bansal H, Klapproth S, Rakheja D, Finegold MJ, Lopez-Terrada D, O'Donnell KA, Tomlinson GE, Hammer RE.

JCI Insight. 2016 Oct 6;1(16):e88549.

10.

Mesolimbic neuropeptide W coordinates stress responses under novel environments.

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6023-8. doi: 10.1073/pnas.1518658113. Epub 2016 May 2.

11.

p53 genes function to restrain mobile elements.

Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM.

Genes Dev. 2016 Jan 1;30(1):64-77. doi: 10.1101/gad.266098.115. Epub 2015 Dec 23.

12.

Reelin protects against amyloid β toxicity in vivo.

Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J.

Sci Signal. 2015 Jul 7;8(384):ra67. doi: 10.1126/scisignal.aaa6674.

13.

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.

Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J.

PLoS One. 2015 Feb 17;10(2):e0116701. doi: 10.1371/journal.pone.0116701. eCollection 2015.

14.

Acetate dependence of tumors.

Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP.

Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020.

15.

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.

Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J.

Sci Signal. 2014 Nov 25;7(353):ra113. doi: 10.1126/scisignal.2005438.

16.

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.

Wang SS, Gu YF, Wolff N, Stefanius K, Christie A, Dey A, Hammer RE, Xie XJ, Rakheja D, Pedrosa I, Carroll T, McKay RM, Kapur P, Brugarolas J.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16538-43. doi: 10.1073/pnas.1414789111. Epub 2014 Oct 30.

17.

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.

Moon YA, Ochoa CR, Mitsche MA, Hammer RE, Horton JD.

J Lipid Res. 2014 Dec;55(12):2597-605. doi: 10.1194/jlr.M054353. Epub 2014 Oct 3.

18.

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.

Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H.

Cancer Cell. 2014 Aug 11;26(2):248-61. doi: 10.1016/j.ccr.2014.06.018.

19.

An acetate switch regulates stress erythropoiesis.

Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA.

Nat Med. 2014 Sep;20(9):1018-26. doi: 10.1038/nm.3587. Epub 2014 Aug 10.

20.

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.

Li H, Guo Q, Inoue T, Polito VA, Tabuchi K, Hammer RE, Pautler RG, Taffet GE, Zheng H.

Mol Neurodegener. 2014 Aug 9;9:28. doi: 10.1186/1750-1326-9-28.

21.

Pathogenesis of autosomal dominant hereditary spastic paraplegia (SPG6) revealed by a rat model.

Watanabe F, Arnold WD, Hammer RE, Ghodsizadeh O, Moti H, Schumer M, Hashmi A, Hernandez A, Sneh A, Sahenk Z, Kisanuki YY.

J Neuropathol Exp Neurol. 2013 Nov;72(11):1016-28. doi: 10.1097/NEN.0000000000000000. Erratum in: J Neuropathol Exp Neurol. 2014 Feb;73(2):190.

22.

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kröger S, Johnson EB, Hammer RE, Lin W, Herz J.

Elife. 2013 Aug 20;2:e00220. doi: 10.7554/eLife.00220.

23.

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.

Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184-9. doi: 10.1073/pnas.1213343109. Epub 2012 Aug 27.

24.

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats.

Taurog JD, Rival C, van Duivenvoorde LM, Satumtira N, Dorris ML, Sun M, Shelton JM, Richardson JA, Hamra FK, Hammer RE, Tung KS.

Arthritis Rheum. 2012 Aug;64(8):2518-28. doi: 10.1002/art.34480.

25.
26.

The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells.

Gao Z, Ure K, Ding P, Nashaat M, Yuan L, Ma J, Hammer RE, Hsieh J.

J Neurosci. 2011 Jun 29;31(26):9772-86. doi: 10.1523/JNEUROSCI.1604-11.2011.

27.

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.

Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17362-7. doi: 10.1073/pnas.1012568107. Epub 2010 Sep 20. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13228.

28.

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H.

J Biol Chem. 2010 Oct 1;285(40):30598-605. doi: 10.1074/jbc.M110.137729. Epub 2010 Aug 6.

29.

CDK5RAP2 regulates centriole engagement and cohesion in mice.

Barrera JA, Kao LR, Hammer RE, Seemann J, Fuchs JL, Megraw TL.

Dev Cell. 2010 Jun 15;18(6):913-26. doi: 10.1016/j.devcel.2010.05.017.

30.

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.

Kisanuki YY, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, Kedzierski RM, Hammer RE, Yanagisawa H, Williams SC, Richardson JA, Suzuki T, Yanagisawa M.

Hypertension. 2010 Jul;56(1):121-8. doi: 10.1161/HYPERTENSIONAHA.109.138701. Epub 2010 Jun 1.

PMID:
20516397
31.

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.

Li Y, Hu J, Höfer K, Wong AM, Cooper JD, Birnbaum SG, Hammer RE, Hofmann SL.

J Biol Chem. 2010 Apr 23;285(17):13022-31. doi: 10.1074/jbc.M109.079426. Epub 2010 Feb 22.

32.

Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity.

Alexander MS, Shi X, Voelker KA, Grange RW, Garcia JA, Hammer RE, Garry DJ.

Dev Biol. 2010 Jan 15;337(2):396-404. doi: 10.1016/j.ydbio.2009.11.015. Epub 2009 Nov 13.

33.

Sterile testis complementation with spermatogonial lines restores fertility to DAZL-deficient rats and maximizes donor germline transmission.

Richardson TE, Chapman KM, Tenenhaus Dann C, Hammer RE, Hamra FK.

PLoS One. 2009 Jul 21;4(7):e6308. doi: 10.1371/journal.pone.0006308.

34.

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J.

Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.

35.

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy.

Cortés VA, Curtis DE, Sukumaran S, Shao X, Parameswara V, Rashid S, Smith AR, Ren J, Esser V, Hammer RE, Agarwal AK, Horton JD, Garg A.

Cell Metab. 2009 Feb;9(2):165-76. doi: 10.1016/j.cmet.2009.01.002.

36.

Characterization of a Dazl-GFP germ cell-specific reporter.

Nicholas CR, Xu EY, Banani SF, Hammer RE, Hamra FK, Reijo Pera RA.

Genesis. 2009 Feb;47(2):74-84. doi: 10.1002/dvg.20460.

37.

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.

Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN, Kyba M, Garry DJ.

Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):814-9. doi: 10.1073/pnas.0807583106. Epub 2009 Jan 7.

38.

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.

Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72. doi: 10.1073/pnas.0808567105. Epub 2008 Oct 17.

39.

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.

Moon YA, Hammer RE, Horton JD.

J Lipid Res. 2009 Mar;50(3):412-23. doi: 10.1194/jlr.M800383-JLR200. Epub 2008 Oct 6.

40.

White fat progenitor cells reside in the adipose vasculature.

Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM.

Science. 2008 Oct 24;322(5901):583-6. doi: 10.1126/science.1156232. Epub 2008 Sep 18.

41.

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.

Science. 2008 Sep 12;321(5895):1507-10. doi: 10.1126/science.1163174. Epub 2008 Aug 14.

42.

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.

Kotadia S, Kao LR, Comerford SA, Jones RT, Hammer RE, Megraw TL.

Oncogene. 2008 Oct 23;27(49):6334-46. doi: 10.1038/onc.2008.254. Epub 2008 Jul 28.

43.

Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type A spermatogonia.

Hao J, Yamamoto M, Richardson TE, Chapman KM, Denard BS, Hammer RE, Zhao GQ, Hamra FK.

Stem Cells. 2008 Jun;26(6):1587-97. doi: 10.1634/stemcells.2007-0502. Epub 2008 Mar 13.

44.

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA.

Mol Endocrinol. 2008 Jun;22(6):1345-56. doi: 10.1210/me.2007-0565. Epub 2008 Mar 6.

45.

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.

Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC.

Science. 2007 Oct 5;318(5847):71-6. Epub 2007 Sep 6.

46.

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2007 Jun;5(6):415-25.

47.

The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

Kroon E, MacDonald RJ, Hammer RE.

Genes Funct. 1997 Dec;1(5-6):309-19.

PMID:
17366701
48.

Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells.

Meeson AP, Shi X, Alexander MS, Williams RS, Allen RE, Jiang N, Adham IM, Goetsch SC, Hammer RE, Garry DJ.

EMBO J. 2007 Apr 4;26(7):1902-12. Epub 2007 Mar 15.

49.

ApoE receptor 2 controls neuronal survival in the adult brain.

Beffert U, Nematollah Farsian F, Masiulis I, Hammer RE, Yoon SO, Giehl KM, Herz J.

Curr Biol. 2006 Dec 19;16(24):2446-52.

50.

Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.

Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC.

J Neurosci. 2006 Dec 13;26(50):13089-101.

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