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Items: 1 to 50 of 90

1.

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.

Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM.

Structure. 2019 Aug 6. pii: S0969-2126(19)30244-8. doi: 10.1016/j.str.2019.07.012. [Epub ahead of print]

PMID:
31402222
2.

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.

Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA.

Elife. 2019 Aug 9;8. pii: e49110. doi: 10.7554/eLife.49110. [Epub ahead of print]

3.

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling.

Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X.

Structure. 2019 Aug 6;27(8):1296-1307.e5. doi: 10.1016/j.str.2019.05.011. Epub 2019 Jun 27.

PMID:
31257107
4.

Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles.

Flockton TR, Schnorbus L, Araujo A, Adams J, Hammel M, Perez LJ.

Pathogens. 2019 Apr 24;8(2). pii: E55. doi: 10.3390/pathogens8020055.

5.

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein.

Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X, Zhang L.

Cell Rep. 2018 Jul 10;24(2):441-452. doi: 10.1016/j.celrep.2018.06.041.

6.

Conformational Plasticity of the Immunoglobulin Fc Domain in Solution.

Remesh SG, Armstrong AA, Mahan AD, Luo J, Hammel M.

Structure. 2018 Jul 3;26(7):1007-1014.e2. doi: 10.1016/j.str.2018.03.017. Epub 2018 May 3.

7.

Hydrogen bonds are a primary driving force for de novo protein folding. Corrigendum.

Lee S, Wang C, Liu H, Xiong J, Jiji R, Hong X, Yan X, Chen Z, Hammel M, Wang Y, Dai S, Wang J, Jiang C, Zhang G.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):380. doi: 10.1107/S2059798318004047. Epub 2018 Apr 6.

8.

Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles.

Schneidman-Duhovny D, Hammel M.

Methods Mol Biol. 2018;1764:449-473. doi: 10.1007/978-1-4939-7759-8_29.

9.

Hydrogen bonds are a primary driving force for de novo protein folding.

Lee S, Wang C, Liu H, Xiong J, Jiji R, Hong X, Yan X, Chen Z, Hammel M, Wang Y, Dai S, Wang J, Jiang C, Zhang G.

Acta Crystallogr D Struct Biol. 2017 Dec 1;73(Pt 12):955-969. doi: 10.1107/S2059798317015303. Epub 2017 Nov 10. Retraction in: Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):380.

10.

Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.

Aceytuno RD, Piett CG, Havali-Shahriari Z, Edwards RA, Rey M, Ye R, Javed F, Fang S, Mani R, Weinfeld M, Hammel M, Tainer JA, Schriemer DC, Lees-Miller SP, Glover JNM.

Nucleic Acids Res. 2017 Jun 2;45(10):6238-6251. doi: 10.1093/nar/gkx275.

11.

The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.

Leksa NC, Chiu PL, Bou-Assaf GM, Quan C, Liu Z, Goodman AB, Chambers MG, Tsutakawa SE, Hammel M, Peters RT, Walz T, Kulman JD.

J Thromb Haemost. 2017 Jun;15(6):1167-1179. doi: 10.1111/jth.13700. Epub 2017 May 3.

12.

Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome.

Wallen JR, Zhang H, Weis C, Cui W, Foster BM, Ho CMW, Hammel M, Tainer JA, Gross ML, Ellenberger T.

Structure. 2017 Jan 3;25(1):157-166. doi: 10.1016/j.str.2016.11.019.

13.

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.

Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA.

J Biol Chem. 2016 Dec 30;291(53):26987-27006. doi: 10.1074/jbc.M116.751867. Epub 2016 Nov 14.

14.

Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.

Nikolaienko RM, Hammel M, Dubreuil V, Zalmai R, Hall DR, Mehzabeen N, Karuppan SJ, Harroch S, Stella SL, Bouyain S.

J Biol Chem. 2016 Oct 7;291(41):21335-21349. Epub 2016 Aug 18.

15.

HU multimerization shift controls nucleoid compaction.

Hammel M, Amlanjyoti D, Reyes FE, Chen JH, Parpana R, Tang HY, Larabell CA, Tainer JA, Adhya S.

Sci Adv. 2016 Jul 29;2(7):e1600650. doi: 10.1126/sciadv.1600650. eCollection 2016 Jul.

16.

FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles.

Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A.

Nucleic Acids Res. 2016 Jul 8;44(W1):W424-9. doi: 10.1093/nar/gkw389. Epub 2016 May 5.

17.

Structural basis for Marburg virus neutralization by a cross-reactive human antibody.

Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE Jr, Saphire EO.

Cell. 2015 Feb 26;160(5):904-912. doi: 10.1016/j.cell.2015.01.041.

18.

Chemoenzymatic synthesis of vitamin B5-intermediate (R)-pantolactone via combined asymmetric organo- and biocatalysis.

Heidlindemann M, Hammel M, Scheffler U, Mahrwald R, Hummel W, Berkessel A, Gröger H.

J Org Chem. 2015 Apr 3;80(7):3387-96. doi: 10.1021/jo502667x. Epub 2015 Mar 23.

PMID:
25710713
19.

Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.

Römmler F, Hammel M, Waldhuber A, Müller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T.

PLoS One. 2015 Feb 19;10(2):e0116703. doi: 10.1371/journal.pone.0116703. eCollection 2015.

20.

Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.

Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA.

DNA Repair (Amst). 2014 May;17:110-20. doi: 10.1016/j.dnarep.2014.02.009. Epub 2014 Mar 20. Review.

21.

Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding.

Barta ML, Hickey JM, Anbanandam A, Dyer K, Hammel M, Hefty PS.

PLoS One. 2014 Mar 19;9(3):e91760. doi: 10.1371/journal.pone.0091760. eCollection 2014.

22.

Distinct structural features of the peroxide response regulator from group A Streptococcus drive DNA binding.

Lin CS, Chao SY, Hammel M, Nix JC, Tseng HL, Tsou CC, Fei CH, Chiou HS, Jeng US, Lin YS, Chuang WJ, Wu JJ, Wang S.

PLoS One. 2014 Feb 21;9(2):e89027. doi: 10.1371/journal.pone.0089027. eCollection 2014.

23.

ModBase, a database of annotated comparative protein structure models and associated resources.

Pieper U, Webb BM, Dong GQ, Schneidman-Duhovny D, Fan H, Kim SJ, Khuri N, Spill YG, Weinkam P, Hammel M, Tainer JA, Nilges M, Sali A.

Nucleic Acids Res. 2014 Jan;42(Database issue):D336-46. doi: 10.1093/nar/gkt1144. Epub 2013 Nov 23.

24.

High-throughput SAXS for the characterization of biomolecules in solution: a practical approach.

Dyer KN, Hammel M, Rambo RP, Tsutakawa SE, Rodic I, Classen S, Tainer JA, Hura GL.

Methods Mol Biol. 2014;1091:245-58. doi: 10.1007/978-1-62703-691-7_18.

25.

Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing.

Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P.

Nucleic Acids Res. 2014 Jan;42(2):906-17. doi: 10.1093/nar/gkt924. Epub 2013 Oct 22.

26.

Structural insights into the interaction of IL-33 with its receptors.

Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14918-23. doi: 10.1073/pnas.1308651110. Epub 2013 Aug 26.

27.

Accurate SAXS profile computation and its assessment by contrast variation experiments.

Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A.

Biophys J. 2013 Aug 20;105(4):962-74. doi: 10.1016/j.bpj.2013.07.020.

28.

Guanine modification of inhibitory oligonucleotides potentiates their suppressive function.

Römmler F, Jurk M, Uhlmann E, Hammel M, Waldhuber A, Pfeiffer L, Wagner H, Vollmer J, Miethke T.

J Immunol. 2013 Sep 15;191(6):3240-53. doi: 10.4049/jimmunol.1300706. Epub 2013 Aug 21.

29.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.

30.

Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model.

Herber-Jonat S, Mittal R, Huppmann M, Hammel M, Liebisch G, Yildirim AÖ, Eickelberg O, Schmitz G, Hrabé de Angelis M, Flemmer AW, Holzinger A.

Pediatr Res. 2013 Oct;74(4):384-92. doi: 10.1038/pr.2013.127. Epub 2013 Jul 23.

PMID:
23881110
31.

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.

32.

Comprehensive macromolecular conformations mapped by quantitative SAXS analyses.

Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA.

Nat Methods. 2013 Jun;10(6):453-4. doi: 10.1038/nmeth.2453. No abstract available.

33.

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.

Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.

Biochem Cell Biol. 2013 Feb;91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review.

34.

Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.

Classen S, Hura GL, Holton JM, Rambo RP, Rodic I, McGuire PJ, Dyer K, Hammel M, Meigs G, Frankel KA, Tainer JA.

J Appl Crystallogr. 2013 Feb 1;46(Pt 1):1-13. Epub 2013 Jan 17.

35.

SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia.

Mittal RA, Hammel M, Schwarz J, Heschl KM, Bretschneider N, Flemmer AW, Herber-Jonat S, Königshoff M, Eickelberg O, Holzinger A.

PLoS One. 2012;7(6):e40011. doi: 10.1371/journal.pone.0040011. Epub 2012 Jun 29.

36.

Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

Duda DM, Olszewski JL, Tron AE, Hammel M, Lambert LJ, Waddell MB, Mittag T, DeCaprio JA, Schulman BA.

Mol Cell. 2012 Aug 10;47(3):371-82. doi: 10.1016/j.molcel.2012.05.044. Epub 2012 Jun 28.

37.

Validation of macromolecular flexibility in solution by small-angle X-ray scattering (SAXS).

Hammel M.

Eur Biophys J. 2012 Oct;41(10):789-99. doi: 10.1007/s00249-012-0820-x. Epub 2012 May 26. Review.

38.

Binding to retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen.

Williams CK, Vaithiyalingam S, Hammel M, Pipas J, Chazin WJ.

Arch Biochem Biophys. 2012 Feb 15;518(2):111-8. doi: 10.1016/j.abb.2011.12.014. Epub 2011 Dec 29.

39.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA.

Mol Cell. 2011 Nov 4;44(3):451-61. doi: 10.1016/j.molcel.2011.08.034.

40.

XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.

Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA.

J Biol Chem. 2011 Sep 16;286(37):32638-50. doi: 10.1074/jbc.M111.272641. Epub 2011 Jul 20.

41.

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

Williams GJ, Williams RS, Williams JS, Moncalian G, Arvai AS, Limbo O, Guenther G, SilDas S, Hammel M, Russell P, Tainer JA.

Nat Struct Mol Biol. 2011 Apr;18(4):423-31. doi: 10.1038/nsmb.2038. Epub 2011 Mar 27. Erratum in: Nat Struct Mol Biol. 2011 Sep;18(9):1084. Nat Struct Mol Biol. 2012 Mar;19(3):364.

42.

The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.

Biersmith BH, Hammel M, Geisbrecht ER, Bouyain S.

J Mol Biol. 2011 May 13;408(4):616-27. doi: 10.1016/j.jmb.2011.03.013. Epub 2011 Mar 21.

43.

XLF regulates filament architecture of the XRCC4·ligase IV complex.

Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA.

Structure. 2010 Nov 10;18(11):1431-42. doi: 10.1016/j.str.2010.09.009.

44.

Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system.

Classen S, Rodic I, Holton J, Hura GL, Hammel M, Tainer JA.

J Synchrotron Radiat. 2010 Nov;17(6):774-81. doi: 10.1107/S0909049510028566. Epub 2010 Sep 3.

45.

Macromolecular docking restrained by a small angle X-ray scattering profile.

Schneidman-Duhovny D, Hammel M, Sali A.

J Struct Biol. 2011 Mar;173(3):461-71. doi: 10.1016/j.jsb.2010.09.023. Epub 2010 Oct 12.

46.

Allosteric inhibition of complement function by a staphylococcal immune evasion protein.

Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu YQ, Tzekou A, Li S, Geisbrecht BV, Woods VL Jr, Lambris JD.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17621-6. doi: 10.1073/pnas.1003750107. Epub 2010 Sep 27.

47.

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P.

Nat Struct Mol Biol. 2010 Oct;17(10):1255-9. doi: 10.1038/nsmb.1916. Epub 2010 Sep 26.

48.

Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.

Cotner-Gohara E, Kim IK, Hammel M, Tainer JA, Tomkinson AE, Ellenberger T.

Biochemistry. 2010 Jul 27;49(29):6165-76. doi: 10.1021/bi100503w.

49.

Heterozygous SOX9 mutations allowing for residual DNA-binding and transcriptional activation lead to the acampomelic variant of campomelic dysplasia.

Staffler A, Hammel M, Wahlbuhl M, Bidlingmaier C, Flemmer AW, Pagel P, Nicolai T, Wegner M, Holzinger A.

Hum Mutat. 2010 Jun;31(6):E1436-44. doi: 10.1002/humu.21238.

PMID:
20513132
50.

FoXS: a web server for rapid computation and fitting of SAXS profiles.

Schneidman-Duhovny D, Hammel M, Sali A.

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W540-4. doi: 10.1093/nar/gkq461. Epub 2010 May 27.

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