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Items: 16

1.

Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1.

Ahlstedt J, Förnvik K, Zolfaghari S, Kwak D, Hammarström LGJ, Ernfors P, Salford LG, Redebrandt HN.

Oncotarget. 2018 Jan 3;9(9):8391-8399. doi: 10.18632/oncotarget.23842. eCollection 2018 Feb 2.

2.

Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Nilsson KF, Hammarström LGJ, Ernfors P.

Cell. 2017 Jul 13;170(2):407. doi: 10.1016/j.cell.2017.06.044. No abstract available.

3.

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KSA, Wallner OA, Hammarström LGJ, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Carreras Puigvert J, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jenmalm Jensen A, Artursson P, Nilsson JA, Stenmark P, Scobie M; Ulrika Warpman Berglund &Thomas Helleday.

Nature. 2017 Apr 26;544(7651):508. doi: 10.1038/nature22083. No abstract available.

PMID:
28447629
4.

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, Schmidt L, Fritz N, Dehnisch I, Kyriatzis G, Krafcikova M, Carson BB, Feenstra JM, Marinescu VD, Segerman A, Haraldsson M, Gustavsson AL, Hammarström LG, Jenmalm Jensen A, Uhrbom L, Altelaar AF, Linnarsson S, Uhlén P, Trantirek L, Vincent CT, Nelander S, Enger PØ, Andäng M.

Cancer Res. 2017 Apr 1;77(7):1741-1752. doi: 10.1158/0008-5472.CAN-16-2274. Epub 2017 Jan 13.

5.

The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.

Hammarström LG, Harmel RK, Granath M, Ringom R, Gravenfors Y, Färnegårdh K, Svensson PH, Wennman D, Lundin G, Roddis Y, Kitambi SS, Bernlind A, Lehmann F, Ernfors P.

J Med Chem. 2016 Sep 22;59(18):8577-92. doi: 10.1021/acs.jmedchem.6b01009. Epub 2016 Sep 8.

PMID:
27607569
6.

Crystal structures of the kinase domain of the sulfate-activating complex in Mycobacterium tuberculosis.

Poyraz Ö, Brunner K, Lohkamp B, Axelsson H, Hammarström LG, Schnell R, Schneider G.

PLoS One. 2015 Mar 25;10(3):e0121494. doi: 10.1371/journal.pone.0121494. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127016.

7.

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T.

Nature. 2014 Apr 10;508(7495):215-21. doi: 10.1038/nature13181. Epub 2014 Apr 2. Erratum in: Nature. 2017 Apr 26;544(7651):508.

PMID:
24695224
8.

RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Forsberg Nilsson K, Hammarström LGJ, Ernfors P.

Cell. 2014 Apr 10;157(2):313-328. doi: 10.1016/j.cell.2014.02.021. Epub 2014 Mar 20. Retraction in: Cell. 2017 Jul 13;170(2):407.

9.

Chemical Biology Consortium Sweden.

Hammarström LG, Jensen AJ.

ACS Chem Biol. 2013 Dec 20;8(12):2605-6. doi: 10.1021/cb400858v. No abstract available.

PMID:
24354290
10.

Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.

Vodnala SK, Lundbäck T, Yeheskieli E, Sjöberg B, Gustavsson AL, Svensson R, Olivera GC, Eze AA, de Koning HP, Hammarström LG, Rottenberg ME.

J Med Chem. 2013 Dec 27;56(24):9861-73. doi: 10.1021/jm401530a. Epub 2013 Dec 10.

PMID:
24283924
11.

In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.

Vodnala SK, Lundbäck T, Sjöberg B, Svensson R, Rottenberg ME, Hammarström LG.

Antimicrob Agents Chemother. 2013 Feb;57(2):1012-8. doi: 10.1128/AAC.01870-12. Epub 2012 Dec 17.

12.

Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design.

Ekström F, Hörnberg A, Artursson E, Hammarström LG, Schneider G, Pang YP.

PLoS One. 2009 Jun 18;4(6):e5957. doi: 10.1371/journal.pone.0005957.

13.

Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides.

Fu Y, Hammarström LG, Miller TJ, Fronczek FR, McLaughlin ML, Hammer RP.

J Org Chem. 2001 Oct 19;66(21):7118-24.

PMID:
11597239
14.

Amphipathic control of the 3(10)-/alpha-helix equilibrium in synthetic peptides.

Hammarström LG, Gauthier TJ, Hammer RP, McLaughlin ML.

J Pept Res. 2001 Aug;58(2):108-16.

PMID:
11532070
15.

Two N-ortho-nitrobenzenesulfonyl alpha,alpha-disubstituted amino acid adducts.

Hammarström LG, Zhang T, Giraldés J, McLaughlin ML, Billodeaux DR, Fronczek FR.

Acta Crystallogr C. 2000 Dec;56(Pt 12):1484-6.

PMID:
11118999
16.

Synthesis of an N-methyldehydroalanine-containing fragment of microcystin by combination of solid phase peptide synthesis and beta-elimination in solution.

Zetterström M, Trogen L, Hammarström LG, Juhlin L, Nilsson B, Damberg C, Bartfai T, Langel U.

Acta Chem Scand. 1995 Sep;49(9):696-700.

PMID:
7546982

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