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Items: 50


Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases.

Holmgren G, Ulfenborg B, Asplund A, Toet K, Andersson CX, Hammarstedt A, Hanemaaijer R, Küppers-Munther B, Synnergren J.

Int J Mol Sci. 2020 Jan 11;21(2). pii: E469. doi: 10.3390/ijms21020469.


The Novel Adipokine Gremlin 1 Antagonizes Insulin Action and is Increased in Type 2 Diabetes and NAFLD/NASH.

Hedjazifar S, Shahidi RK, Hammarstedt A, Bonnet L, Church C, Boucher J, Blüher M, Smith U.

Diabetes. 2019 Dec 27. pii: db190701. doi: 10.2337/db19-0701. [Epub ahead of print]


Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.

Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U.

Sci Rep. 2018 Oct 25;8(1):15757. doi: 10.1038/s41598-018-34113-3.


Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity.

Hammarstedt A, Gogg S, Hedjazifar S, Nerstedt A, Smith U.

Physiol Rev. 2018 Oct 1;98(4):1911-1941. doi: 10.1152/physrev.00034.2017. Review.


TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.

Romero M, Sabaté-Pérez A, Francis VA, Castrillón-Rodriguez I, Díaz-Ramos Á, Sánchez-Feutrie M, Durán X, Palacín M, Moreno-Navarrete JM, Gustafson B, Hammarstedt A, Fernández-Real JM, Vendrell J, Smith U, Zorzano A.

Nat Cell Biol. 2018 Apr;20(4):443-454. doi: 10.1038/s41556-018-0072-9. Epub 2018 Mar 28.


CCN5/WISP2 and metabolic diseases.

Grünberg JR, Elvin J, Paul A, Hedjazifar S, Hammarstedt A, Smith U.

J Cell Commun Signal. 2018 Mar;12(1):309-318. doi: 10.1007/s12079-017-0437-z. Epub 2017 Dec 15. Review.


Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.

Longo M, Raciti GA, Zatterale F, Parrillo L, Desiderio A, Spinelli R, Hammarstedt A, Hedjazifar S, Hoffmann JM, Nigro C, Mirra P, Fiory F, Formisano P, Miele C, Smith U, Beguinot F.

Diabetologia. 2018 Feb;61(2):369-380. doi: 10.1007/s00125-017-4471-4. Epub 2017 Oct 24.


BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue.

Hoffmann JM, Grünberg JR, Church C, Elias I, Palsdottir V, Jansson JO, Bosch F, Hammarstedt A, Hedjazifar S, Smith U.

Cell Rep. 2017 Aug 1;20(5):1038-1049. doi: 10.1016/j.celrep.2017.07.020.


Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.

Henninger J, Rawshani A, Hammarstedt A, Eliasson B.

BMC Endocr Disord. 2017 Jul 14;17(1):40. doi: 10.1186/s12902-017-0191-5.


Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice.

Ohlsson C, Hammarstedt A, Vandenput L, Saarinen N, Ryberg H, Windahl SH, Farman HH, Jansson JO, Movérare-Skrtic S, Smith U, Zhang FP, Poutanen M, Hedjazifar S, Sjögren K.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E450-E462. doi: 10.1152/ajpendo.00093.2017. Epub 2017 Jun 27.


Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes.

Eliasson B, Rawshani A, Axelsen M, Hammarstedt A, Smith U.

PLoS One. 2017 Mar 13;12(3):e0173654. doi: 10.1371/journal.pone.0173654. eCollection 2017.


Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U.

Sci Rep. 2017 Feb 27;7:43515. doi: 10.1038/srep43515.


Metabolic predictors of impaired glucose tolerance and type 2 diabetes in a predisposed population--A prospective cohort study.

Henninger J, Hammarstedt A, Rawshani A, Eliasson B.

BMC Endocr Disord. 2015 Sep 25;15:51. doi: 10.1186/s12902-015-0048-8.


Insulin resistance and impaired adipogenesis.

Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U.

Trends Endocrinol Metab. 2015 Apr;26(4):193-200. doi: 10.1016/j.tem.2015.01.006. Epub 2015 Feb 18. Review.


BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis.

Gustafson B, Hammarstedt A, Hedjazifar S, Hoffmann JM, Svensson PA, Grimsby J, Rondinone C, Smith U.

Diabetes. 2015 May;64(5):1670-81. doi: 10.2337/db14-1127. Epub 2015 Jan 20.


Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C.

Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12.


Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell. 2014 Oct 9;159(2):318-32. doi: 10.1016/j.cell.2014.09.035.


Comparison of predictive measures of speech recognition after noise reduction processing.

Smeds K, Leijon A, Wolters F, Hammarstedt A, Båsjö S, Hertzman S.

J Acoust Soc Am. 2014 Sep;136(3):1363. doi: 10.1121/1.4892766.


Adipocyte hypertrophy, inflammation and fibrosis characterize subcutaneous adipose tissue of healthy, non-obese subjects predisposed to type 2 diabetes.

Henninger AM, Eliasson B, Jenndahl LE, Hammarstedt A.

PLoS One. 2014 Aug 22;9(8):e105262. doi: 10.1371/journal.pone.0105262. eCollection 2014.


The Novel Secreted Adipokine WNT1-inducible Signaling Pathway Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT.

Grünberg JR, Hammarstedt A, Hedjazifar S, Smith U.

J Biol Chem. 2014 Mar 7;289(10):6899-907. doi: 10.1074/jbc.M113.511964. Epub 2014 Jan 22.


Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4.

Gustafson B, Hammarstedt A, Hedjazifar S, Smith U.

Diabetes. 2013 Sep;62(9):2997-3004. doi: 10.2337/db13-0473. No abstract available.


WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.

Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Grünberg J, Gustafson B, Klimcakova E, Stich V, Langin D, Laakso M, Smith U.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2563-8. doi: 10.1073/pnas.1211255110. Epub 2013 Jan 28.


Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.

Hammarstedt A, Graham TE, Kahn BB.

Diabetol Metab Syndr. 2012 Sep 19;4(1):42. doi: 10.1186/1758-5996-4-42.


Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro.

D'Esposito V, Passaretti F, Hammarstedt A, Liguoro D, Terracciano D, Molea G, Canta L, Miele C, Smith U, Beguinot F, Formisano P.

Diabetologia. 2012 Oct;55(10):2811-2822. doi: 10.1007/s00125-012-2629-7. Epub 2012 Jul 15.


Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.

Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB.

Mol Cell Biol. 2012 May;32(10):2010-9. doi: 10.1128/MCB.06193-11. Epub 2012 Mar 19.


Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis.

Arner P, Arner E, Hammarstedt A, Smith U.

PLoS One. 2011 Apr 12;6(4):e18284. doi: 10.1371/journal.pone.0018284.


Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G; EUGENE2 Consortium.

Diabetologia. 2011 Apr;54(4):795-802. doi: 10.1007/s00125-010-2038-8. Epub 2011 Jan 14.


Circulating fibroblast growth factor-23 is associated with fat mass and dyslipidemia in two independent cohorts of elderly individuals.

Mirza MA, Alsiö J, Hammarstedt A, Erben RG, Michaëlsson K, Tivesten A, Marsell R, Orwoll E, Karlsson MK, Ljunggren O, Mellström D, Lind L, Ohlsson C, Larsson TE.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):219-27. doi: 10.1161/ATVBAHA.110.214619. Epub 2010 Oct 21.


Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity.

Smith U, Hammarstedt A.

Biochim Biophys Acta. 2010 Mar;1801(3):377-80. doi: 10.1016/j.bbalip.2009.11.006. Epub 2009 Nov 24. Review.


Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals.

Murdolo G, Hammarstedt A, Schmelz M, Jansson PA, Smith U.

J Clin Endocrinol Metab. 2009 Nov;94(11):4508-16. doi: 10.1210/jc.2009-0431. Epub 2009 Oct 9.


Inflammation and impaired adipogenesis in hypertrophic obesity in man.

Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E999-E1003. doi: 10.1152/ajpendo.00377.2009. Epub 2009 Jul 21. Review.


Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation.

Isakson P, Hammarstedt A, Gustafson B, Smith U.

Diabetes. 2009 Jul;58(7):1550-7. doi: 10.2337/db08-1770. Epub 2009 Apr 7.


Inflamed adipose tissue, insulin resistance and vascular injury.

Andersson CX, Gustafson B, Hammarstedt A, Hedjazifar S, Smith U.

Diabetes Metab Res Rev. 2008 Nov-Dec;24(8):595-603. doi: 10.1002/dmrr.889. Review.


High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects.

Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U.

J Intern Med. 2008 Apr;263(4):440-9. doi: 10.1111/j.1365-2796.2007.01914.x.


The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.

Boesgaard TW, Zilinskaite J, Vänttinen M, Laakso M, Jansson PA, Hammarstedt A, Smith U, Stefan N, Fritsche A, Häring H, Hribal M, Sesti G, Zobel DP, Pedersen O, Hansen T; EUGENE 2 Consortium.

Diabetologia. 2008 May;51(5):816-20. doi: 10.1007/s00125-008-0955-6. Epub 2008 Mar 7.


Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

Stancáková A, Pihlajamäki J, Kuusisto J, Stefan N, Fritsche A, Häring H, Andreozzi F, Succurro E, Sesti G, Boesgaard TW, Hansen T, Pedersen O, Jansson PA, Hammarstedt A, Smith U, Laakso M; EUGENE2 Consortium.

J Clin Endocrinol Metab. 2008 May;93(5):1924-30. doi: 10.1210/jc.2007-2218. Epub 2008 Feb 19.


A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.

Staiger H, Stancáková A, Zilinskaite J, Vänttinen M, Hansen T, Marini MA, Hammarstedt A, Jansson PA, Sesti G, Smith U, Pedersen O, Laakso M, Stefan N, Fritsche A, Häring HU.

Diabetes. 2008 Feb;57(2):514-7. Epub 2007 Nov 26.


Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals.

Murdolo G, Kempf K, Hammarstedt A, Herder C, Smith U, Jansson PA.

J Endocrinol Invest. 2007 Sep;30(8):RC17-21.


Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis.

Gustafson B, Hammarstedt A, Andersson CX, Smith U.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2276-83. Epub 2007 Sep 6. Review.


Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin.

Murdolo G, Hammarstedt A, Sandqvist M, Schmelz M, Herder C, Smith U, Jansson PA.

J Clin Endocrinol Metab. 2007 Jul;92(7):2688-95. Epub 2007 Apr 24.


Wnt-signaling is maintained and adipogenesis inhibited by TNFalpha but not MCP-1 and resistin.

Hammarstedt A, Isakson P, Gustafson B, Smith U.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):700-6. Epub 2007 Apr 10.


Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB.

N Engl J Med. 2006 Jun 15;354(24):2552-63.


Visfatin is an adipokine, but it is not regulated by thiazolidinediones.

Hammarstedt A, Pihlajamäki J, Rotter Sopasakis V, Gogg S, Jansson PA, Laakso M, Smith U.

J Clin Endocrinol Metab. 2006 Mar;91(3):1181-4. Epub 2006 Jan 4.


The effect of PPARgamma ligands on the adipose tissue in insulin resistance.

Hammarstedt A, Andersson CX, Rotter Sopasakis V, Smith U.

Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):65-75. Review.


Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males.

Sandqvist M, Nyberg G, Hammarstedt A, Klintland N, Gogg S, Caidahl K, Ahrén B, Smith U, Jansson PA.

Atherosclerosis. 2005 May;180(1):119-25. Epub 2005 Jan 5.


Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects.

Hammarstedt A, Sopasakis VR, Gogg S, Jansson PA, Smith U.

Diabetologia. 2005 Jan;48(1):96-104. Epub 2004 Dec 29.


High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator.

Sopasakis VR, Sandqvist M, Gustafson B, Hammarstedt A, Schmelz M, Yang X, Jansson PA, Smith U.

Obes Res. 2004 Mar;12(3):454-60.


A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin.

Jansson PA, Pellmé F, Hammarstedt A, Sandqvist M, Brekke H, Caidahl K, Forsberg M, Volkmann R, Carvalho E, Funahashi T, Matsuzawa Y, Wiklund O, Yang X, Taskinen MR, Smith U.

FASEB J. 2003 Aug;17(11):1434-40.


Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.

Hammarstedt A, Jansson PA, Wesslau C, Yang X, Smith U.

Biochem Biophys Res Commun. 2003 Feb 7;301(2):578-82.


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