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Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.

Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF.

Int J Mol Sci. 2018 Nov 9;19(11). pii: E3530. doi: 10.3390/ijms19113530.


A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome.

Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA.

J Control Release. 2018 Dec 28;292:183-195. doi: 10.1016/j.jconrel.2018.10.026. Epub 2018 Oct 23.


NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis.

Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF.

Exp Eye Res. 2018 Nov;176:243-251. doi: 10.1016/j.exer.2018.09.002. Epub 2018 Sep 8.


Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome.

Janga SR, Shah M, Ju Y, Meng Z, Edman MC, Hamm-Alvarez SF.

Biomarkers. 2018 Sep 12:1-12. doi: 10.1080/1354750X.2018.1514656. [Epub ahead of print]


Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients.

Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF.

Sci Rep. 2018 Jul 23;8(1):11044. doi: 10.1038/s41598-018-29411-9.


Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models.

Hawley D, Tang X, Zyrianova T, Shah M, Janga S, Letourneau A, Schicht M, Paulsen F, Hamm-Alvarez S, Makarenkova HP, Zoukhri D.

Sci Rep. 2018 Jul 2;8(1):9919. doi: 10.1038/s41598-018-28227-x.


Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome.

Meng Z, Klinngam W, Edman MC, Hamm-Alvarez SF.

PLoS One. 2017 Sep 13;12(9):e0184781. doi: 10.1371/journal.pone.0184781. eCollection 2017.


Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome.

Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D.

Stem Cells Int. 2017;2017:3134543. doi: 10.1155/2017/3134543. Epub 2017 Mar 2.


Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome.

Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):372-385. doi: 10.1167/iovs.16-19159.


Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome.

Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C942-54. doi: 10.1152/ajpcell.00275.2015. Epub 2016 Apr 13.


Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines.

Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA.

J Control Release. 2016 Oct 28;240:93-108. doi: 10.1016/j.jconrel.2015.11.010. Epub 2015 Nov 11. Review.


Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles.

Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA.

J Mater Chem B. 2014 Dec 14;2(46):8131-8141.


Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland.

Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA.

J Control Release. 2015 Jun 28;208:2-13. doi: 10.1016/j.jconrel.2014.12.017. Epub 2014 Dec 16.


A thermo-responsive protein treatment for dry eyes.

Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA.

J Control Release. 2015 Feb 10;199:156-67. doi: 10.1016/j.jconrel.2014.11.016. Epub 2014 Dec 3.


Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains.

Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA.

Adv Funct Mater. 2014 Sep 10;24(34):5340-5347.


Tear cathepsin S as a candidate biomarker for Sjögren's syndrome.

Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W.

Arthritis Rheumatol. 2014 Jul;66(7):1872-81. doi: 10.1002/art.38633.


A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome.

Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF.

J Control Release. 2013 Nov 10;171(3):269-79. doi: 10.1016/j.jconrel.2013.07.016. Epub 2013 Jul 25.


Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells.

Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF.

J Cell Sci. 2013 Jun 15;126(Pt 12):2704-17. doi: 10.1242/jcs.122242. Epub 2013 Apr 19.


Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms.

Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Nanomedicine. 2013 Aug;9(6):786-94. doi: 10.1016/j.nano.2013.01.007. Epub 2013 Feb 20.


Analyzing live cellularity in the human trabecular meshwork.

Gonzalez JM Jr, Hamm-Alvarez S, Tan JC.

Invest Ophthalmol Vis Sci. 2013 Feb 5;54(2):1039-47. doi: 10.1167/iovs.12-10479.


A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains.

Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA.

Biomacromolecules. 2012 Nov 12;13(11):3439-44. doi: 10.1021/bm301090x. Epub 2012 Oct 25.


Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances.

Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF.

Adv Drug Deliv Rev. 2013 Jan;65(1):121-38. doi: 10.1016/j.addr.2012.09.041. Epub 2012 Sep 29. Review.


In situ autofluorescence visualization of human trabecular meshwork structure.

Tan JC, Gonzalez JM Jr, Hamm-Alvarez S, Song J.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2080-8. doi: 10.1167/iovs.11-8141.


Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site.

Chiang L, Karvar S, Hamm-Alvarez SF.

PLoS One. 2012;7(2):e31789. doi: 10.1371/journal.pone.0031789. Epub 2012 Feb 20.


The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.

Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ.

PLoS One. 2012;7(2):e31616. doi: 10.1371/journal.pone.0031616. Epub 2012 Feb 20.


Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells.

Contreras J, Hsueh PY, Pei H, Hamm-Alvarez SF.

Cytotechnology. 2012 Mar;64(2):149-56. doi: 10.1007/s10616-011-9404-3. Epub 2011 Dec 3.


Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers.

Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Int J Nanomedicine. 2011;6:2849-57. doi: 10.2147/IJN.S26051. Epub 2011 Nov 10.


A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland.

Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S.

J Cell Sci. 2011 Oct 15;124(Pt 20):3503-14. doi: 10.1242/jcs.088906. Epub 2011 Oct 7.


Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

Contreras J, Elnagar AY, Hamm-Alvarez SF, Camarero JA.

J Control Release. 2011 Oct 30;155(2):134-43. doi: 10.1016/j.jconrel.2011.08.030. Epub 2011 Aug 30.


Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain.

Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA.

J Control Release. 2011 Oct 30;155(2):218-26. doi: 10.1016/j.jconrel.2011.06.010. Epub 2011 Jun 14.


Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C507-21. doi: 10.1152/ajpcell.00355.2010. Epub 2011 Apr 27. Erratum in: Am J Physiol Cell Physiol. 2011 Dec;301(6):C1480.


Polystyrene nanoparticle trafficking across MDCK-II.

Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Nanomedicine. 2011 Oct;7(5):588-94. doi: 10.1016/j.nano.2011.01.008. Epub 2011 Feb 26.


Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure.

Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Am J Respir Crit Care Med. 2010 Dec 1;182(11):1398-409. doi: 10.1164/rccm.201002-0185OC. Epub 2010 Jul 16.


Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse.

Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF.

Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5019-29. doi: 10.1167/iovs.09-4523. Epub 2010 May 12.


Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells.

Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez SF.

ACS Nano. 2010 May 25;4(5):2735-47. doi: 10.1021/nn901385y.


Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy.

Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF.

Exp Eye Res. 2010 Feb;90(2):223-37. doi: 10.1016/j.exer.2009.10.008. Epub 2009 Oct 21.


Mitochondrial medicine and therapeutics, Part II. Preface.

Hamm-Alvarez S, Cadenas E.

Adv Drug Deliv Rev. 2009 Nov 30;61(14):1233. doi: 10.1016/j.addr.2009.10.002. Epub 2009 Oct 14. No abstract available.


Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles.

Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Am J Respir Cell Mol Biol. 2010 May;42(5):604-14. doi: 10.1165/rcmb.2009-0138OC. Epub 2009 Jul 2.


Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland.

Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez SF.

Exp Eye Res. 2009 Sep;89(3):319-32. doi: 10.1016/j.exer.2009.03.020. Epub 2009 Apr 2.


Site-specific labeling of enveloped viruses with quantum dots for single virus tracking.

Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P.

ACS Nano. 2008 Aug;2(8):1553-62. doi: 10.1021/nn8002136.


Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol.

Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez SF, Trousdale MD.

Exp Eye Res. 2009 Mar;88(3):467-78. doi: 10.1016/j.exer.2008.10.023. Epub 2008 Nov 13.


Mitochondrial medicine and mitochondrion-based therapeutics.

Hamm-Alvarez S, Cadenas E.

Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1437-8. doi: 10.1016/j.addr.2008.07.001. Epub 2008 Jul 17. No abstract available.


The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini.

Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C13-28. doi: 10.1152/ajpcell.00330.2007. Epub 2008 Apr 23.


Quantitative second harmonic generation imaging of cartilage damage.

Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K.

Cell Tissue Bank. 2008 Dec;9(4):299-307. doi: 10.1007/s10561-008-9070-7. Epub 2008 Apr 23.


Polystyrene nanoparticle trafficking across alveolar epithelium.

Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Nanomedicine. 2008 Jun;4(2):139-45. doi: 10.1016/j.nano.2008.02.002. Epub 2008 Mar 28.


Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells.

Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT.

Am J Physiol Cell Physiol. 2008 Mar;294(3):C662-74. doi: 10.1152/ajpcell.00623.2006. Epub 2008 Jan 2.


Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.

Norouziyan F, Shen WC, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C7-21. Epub 2007 Oct 24.


Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells.

Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Mircheff AK, Schechter JE.

Exp Eye Res. 2007 Dec;85(6):749-61. Epub 2007 Aug 24.


Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome.

Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF.

Matrix Biol. 2008 Jan;27(1):53-66. Epub 2007 Jul 17.

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