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Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa.

Lokits AD, Indrischek H, Meiler J, Hamm HE, Stadler PF.

BMC Evol Biol. 2018 Apr 11;18(1):51. doi: 10.1186/s12862-018-1147-8.


GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4501-4506. doi: 10.1073/pnas.1712725115. Epub 2018 Apr 9.


G Protein Preassembly Rescues Efficacy of W6.48 Toggle Mutations in Neuropeptide Y2 Receptor.

Kaiser A, Hempel C, Wanka L, Schubert M, Hamm HE, Beck-Sickinger AG.

Mol Pharmacol. 2018 Apr;93(4):387-401. doi: 10.1124/mol.117.110544. Epub 2018 Feb 7.


Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles.

Schmidt P, Bender BJ, Kaiser A, Gulati K, Scheidt HA, Hamm HE, Meiler J, Beck-Sickinger AG, Huster D.

Front Mol Biosci. 2018 Jan 17;4:100. doi: 10.3389/fmolb.2017.00100. eCollection 2017.


Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Brain Synaptosomes.

Yim YY, McDonald WH, Hyde K, Cruz-Rodríguez O, Tesmer JJG, Hamm HE.

Biochemistry. 2017 Oct 10;56(40):5405-5416. doi: 10.1021/acs.biochem.7b00433. Epub 2017 Sep 21.


Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.

Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE.

J Biol Chem. 2017 Jul 21;292(29):12165-12177. doi: 10.1074/jbc.M116.773523. Epub 2017 May 17.


A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.

Van Hook MJ, Babai N, Zurawski Z, Yim YY, Hamm HE, Thoreson WB.

J Neurosci. 2017 Apr 26;37(17):4618-4634. doi: 10.1523/JNEUROSCI.2948-16.2017. Epub 2017 Mar 31.


Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.

Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE.

Mol Pharmacol. 2017 Jan;91(1):39-47. Epub 2016 Oct 26.


Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.

Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5481-5486. doi: 10.1016/j.bmcl.2016.10.020. Epub 2016 Oct 11.


Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.

Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW.

J Med Chem. 2016 Aug 25;59(16):7690-5. doi: 10.1021/acs.jmedchem.6b00928. Epub 2016 Aug 8.


A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2016 Sep 9;291(37):19674-86. doi: 10.1074/jbc.M116.745513. Epub 2016 Jul 26.


Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through Dysregulation of the 5-HT2A Receptor.

Oliver KH, Duvernay MT, Hamm HE, Carneiro AM.

J Biol Chem. 2016 Sep 16;291(38):20210-9. doi: 10.1074/jbc.M116.736983. Epub 2016 Jul 15.


Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6041-6. doi: 10.1073/pnas.1521825113. Epub 2016 May 9.


Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coupled Receptors.

Zurawski Z, Rodriguez S, Hyde K, Alford S, Hamm HE.

Mol Pharmacol. 2016 Jan;89(1):75-83. doi: 10.1124/mol.115.101600. Epub 2015 Oct 30.


Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention.

Friedman EA, Texeira L, Delaney J, Weeke PE, Lynch DR Jr, Kasasbeh E, Song Y, Harrell FE Jr, Denny JC, Hamm HE, Roden DM, Cleator JH.

J Thromb Thrombolysis. 2016 May;41(4):656-62. doi: 10.1007/s11239-015-1285-4.


Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation.

Duvernay MT, Matafonov A, Lindsley CW, Hamm HE.

Biochemistry. 2015 Sep 15;54(36):5578-88. doi: 10.1021/acs.biochem.5b00549. Epub 2015 Sep 1.


A Novel and Selective PAR4 Antagonist: ML354.

Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Wood MR, Hamm HE, Lindsley CW.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 15 [updated 2015 Feb 11].


Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles.

Kaya AI, Iverson TM, Hamm HE.

Methods Mol Biol. 2015;1271:67-76. doi: 10.1007/978-1-4939-2330-4_5.


The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.

Jacobson R, Mignemi N, Rose K, O'Rear L, Sarilla S, Hamm HE, Barnett JV, Verhamme IM, Schoenecker J.

Thromb Res. 2014 Dec;134(6):1350-7. doi: 10.1016/j.thromres.2014.09.038. Epub 2014 Oct 5.


Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.

Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW 2nd, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713. doi: 10.1016/j.bmcl.2014.08.021. Epub 2014 Aug 15.


Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects.

Cleator JH, Duvernay MT, Holinstat M, Colowick NE, Hudson WJ, Song Y, Harrell FE, Hamm HE.

J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. doi: 10.1124/jpet.114.215616. Epub 2014 Jul 22.


A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2014 Aug 29;289(35):24475-87. doi: 10.1074/jbc.M114.572875. Epub 2014 Jul 18.


A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM.

J Biol Chem. 2014 Apr 18;289(16):11331-41. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4.


Differential localization of G protein βγ subunits.

Betke KM, Rose KL, Friedman DB, Baucum AJ 2nd, Hyde K, Schey KL, Hamm HE.

Biochemistry. 2014 Apr 15;53(14):2329-43. doi: 10.1021/bi500091p. Epub 2014 Apr 1.


Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.

Hamid E, Church E, Wells CA, Zurawski Z, Hamm HE, Alford S.

J Neurosci. 2014 Jan 1;34(1):260-74. doi: 10.1523/JNEUROSCI.3633-12.2014.


Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release.

Alexander NS, Preininger AM, Kaya AI, Stein RA, Hamm HE, Meiler J.

Nat Struct Mol Biol. 2014 Jan;21(1):56-63. doi: 10.1038/nsmb.2705. Epub 2013 Dec 1.


Gpr125 modulates Dishevelled distribution and planar cell polarity signaling.

Li X, Roszko I, Sepich DS, Ni M, Hamm HE, Marlow FL, Solnica-Krezel L.

Development. 2013 Jul;140(14):3028-39. doi: 10.1242/dev.094839.


Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets.

Young SE, Duvernay MT, Schulte ML, Lindsley CW, Hamm HE.

PLoS One. 2013 Jun 11;8(6):e65528. doi: 10.1371/journal.pone.0065528. Print 2013.


Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective.

Preininger AM, Meiler J, Hamm HE.

J Mol Biol. 2013 Jul 10;425(13):2288-98. doi: 10.1016/j.jmb.2013.04.011. Epub 2013 Apr 16. Review.


Linking receptor activation to changes in Sw I and II of Gα proteins.

Hamm HE, Kaya AI, Gilbert JA 3rd, Preininger AM.

J Struct Biol. 2013 Oct;184(1):63-74. doi: 10.1016/j.jsb.2013.02.016. Epub 2013 Mar 4.


Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.

Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE.

Mol Pharmacol. 2013 Apr;83(4):781-92. doi: 10.1124/mol.112.083477. Epub 2013 Jan 10. Erratum in: Mol Pharmacol. 2013 Sep;84(3):487. Hamm, Heidi [corrected to Hamm, Heidi E].


Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor.

Natarajan C, Hata AN, Hamm HE, Zent R, Breyer RM.

Mol Pharmacol. 2013 Jan;83(1):206-16. doi: 10.1124/mol.112.080473. Epub 2012 Oct 18.


Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation.

Holinstat M, Colowick NE, Hudson WJ, Blakemore D, Chen Q, Hamm HE, Cleator JH.

J Thromb Thrombolysis. 2013 Feb;35(2):209-22. doi: 10.1007/s11239-012-0812-9.


Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.

Wells CA, Zurawski Z, Betke KM, Yim YY, Hyde K, Rodriguez S, Alford S, Hamm HE.

Mol Pharmacol. 2012 Dec;82(6):1136-49. doi: 10.1124/mol.112.080507. Epub 2012 Sep 7.


Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics.

Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G.

PLoS One. 2012;7(5):e37832. doi: 10.1371/journal.pone.0037832. Epub 2012 May 25.


Label-free detection of G protein-SNARE interactions and screening for small molecule modulators.

Wells CA, Betke KM, Lindsley CW, Hamm HE.

ACS Chem Neurosci. 2012 Jan 18;3(1):69-78.


Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.

Preininger AM, Kaya AI, Gilbert JA 3rd, Busenlehner LS, Armstrong RN, Hamm HE.

Biochemistry. 2012 Mar 6;51(9):1911-24. doi: 10.1021/bi201472c. Epub 2012 Feb 22.


GPCR mediated regulation of synaptic transmission.

Betke KM, Wells CA, Hamm HE.

Prog Neurobiol. 2012 Mar;96(3):304-21. doi: 10.1016/j.pneurobio.2012.01.009. Epub 2012 Jan 28. Review.


Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective.

Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM.

Methods Mol Biol. 2012;796:133-74. doi: 10.1007/978-1-61779-334-9_8.


Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo: procoagulant nature of osteosarcoma.

Ichikawa J, Cole HA, Magnussen RA, Mignemi NA, Butler M, Holt GE, O'Rear L, Yuasa M, Pabla B, Haro H, Cates JM, Hamm HE, Schwartz HS, Schoenecker JG.

Cancer. 2012 May 1;118(9):2494-506. doi: 10.1002/cncr.26518. Epub 2011 Sep 27.


Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.

Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9420-4. doi: 10.1073/pnas.1105810108. Epub 2011 May 23.


Identification of key factors that reduce the variability of the single photon response.

Caruso G, Bisegna P, Andreucci D, Lenoci L, Gurevich VV, Hamm HE, DiBenedetto E.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7804-7. doi: 10.1073/pnas.1018960108. Epub 2011 Apr 25.


Coupling efficiency of rhodopsin and transducin in bicelles.

Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE.

Biochemistry. 2011 Apr 19;50(15):3193-203. doi: 10.1021/bi200037j. Epub 2011 Mar 25.


Mathematical model of PAR1-mediated activation of human platelets.

Lenoci L, Duvernay M, Satchell S, DiBenedetto E, Hamm HE.

Mol Biosyst. 2011 Apr;7(4):1129-37. doi: 10.1039/c0mb00250j. Epub 2011 Jan 12.


Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod photoresponse.

Caruso G, Bisegna P, Lenoci L, Andreucci D, Gurevich VV, Hamm HE, DiBenedetto E.

PLoS Comput Biol. 2010 Dec 16;6(12):e1001031. doi: 10.1371/journal.pcbi.1001031.


Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.

Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):435-42. doi: 10.1161/ATVBAHA.110.219527. Epub 2010 Dec 2.


Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E.

Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647.


Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters.

Shen L, Caruso G, Bisegna P, Andreucci D, Gurevich VV, Hamm HE, DiBenedetto E.

IET Syst Biol. 2010 Jan;4(1):12-32. doi: 10.1049/iet-syb.2008.0154.


Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.

Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA.

J Biol Chem. 2009 Dec 11;284(50):34640-7. doi: 10.1074/jbc.M109.020990. Epub 2009 Oct 8.


Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.

Hamm HE, Meier SM, Liao G, Preininger AM.

Protein Sci. 2009 Nov;18(11):2326-35. doi: 10.1002/pro.243.

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