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Items: 27

1.

The gut microbiota in type 1 diabetes: friend or foe?

Gavin PG, Hamilton-Williams EE.

Curr Opin Endocrinol Diabetes Obes. 2019 May 27. doi: 10.1097/MED.0000000000000483. [Epub ahead of print]

PMID:
31145129
2.

Early-life exposure to gut microbiota from disease-protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice.

Mullaney JA, Stephens JE, Geeling BE, Hamilton-Williams EE.

Immunol Cell Biol. 2019 Jan;97(1):97-103. doi: 10.1111/imcb.12201. Epub 2018 Oct 9.

PMID:
30191611
3.

Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes.

Gavin PG, Mullaney JA, Loo D, Cao KL, Gottlieb PA, Hill MM, Zipris D, Hamilton-Williams EE.

Diabetes Care. 2018 Oct;41(10):2178-2186. doi: 10.2337/dc18-0777. Epub 2018 Aug 12.

PMID:
30100563
4.

Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.

Mullaney JA, Stephens JE, Costello ME, Fong C, Geeling BE, Gavin PG, Wright CM, Spector TD, Brown MA, Hamilton-Williams EE.

Microbiome. 2018 Mar 20;6(1):51. doi: 10.1186/s40168-018-0438-z.

5.

A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.

Mehdi AM, Hamilton-Williams EE, Cristino A, Ziegler A, Bonifacio E, Le Cao KA, Harris M, Thomas R.

JCI Insight. 2018 Mar 8;3(5). pii: 98212. doi: 10.1172/jci.insight.98212.

6.

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota.

Mullaney JA, Stephens JE, Costello ME, Fong C, Geeling BE, Gavin PG, Wright CM, Spector TD, Brown MA, Hamilton-Williams EE.

Microbiome. 2018 Feb 17;6(1):35. doi: 10.1186/s40168-018-0417-4. Erratum in: Microbiome. 2018 Mar 20;6(1):51.

7.

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice.

Reeves PLS, Rudraraju R, Wong FS, Hamilton-Williams EE, Steptoe RJ.

Eur J Immunol. 2017 Sep;47(9):1550-1561. doi: 10.1002/eji.201747089. Epub 2017 Jul 18.

8.

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

Reeves PL, Rudraraju R, Liu X, Wong FS, Hamilton-Williams EE, Steptoe RJ.

Immunol Cell Biol. 2017 Oct;95(9):765-774. doi: 10.1038/icb.2017.48. Epub 2017 Jun 14.

PMID:
28611473
9.

CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes.

Brenu EW, Bartley TJ, Wright CM, Hamilton-Williams EE.

Immunol Cell Biol. 2017 Oct;95(9):803-813. doi: 10.1038/icb.2017.49. Epub 2017 Jun 14.

PMID:
28611472
10.

Maintenance of peripheral tolerance to islet antigens.

Hamilton-Williams EE, Bergot AS, Reeves PL, Steptoe RJ.

J Autoimmun. 2016 Aug;72:118-25. doi: 10.1016/j.jaut.2016.05.009. Epub 2016 May 30. Review.

PMID:
27255733
11.

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice.

James CR, Buckle I, Muscate F, Otsuka M, Nakao M, Oon JSh, Steptoe RJ, Thomas R, Hamilton-Williams EE.

Immunol Cell Biol. 2016 May;94(5):509-19. doi: 10.1038/icb.2016.7. Epub 2016 Jan 14.

PMID:
26763864
12.

Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes.

Pang D, Irvine KM, Mehdi AM, Thomas HE, Harris M, Hamilton-Williams EE, Thomas R.

Clin Transl Immunology. 2015 Aug 28;4(8):e41. doi: 10.1038/cti.2015.17. eCollection 2015 Aug.

13.

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.

Hamilton-Williams EE, Rainbow DB, Cheung J, Christensen M, Lyons PA, Peterson LB, Steward CA, Sherman LA, Wicker LS.

Mamm Genome. 2013 Oct;24(9-10):358-75. doi: 10.1007/s00335-013-9466-y. Epub 2013 Aug 11.

14.

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.

Lin X, Hamilton-Williams EE, Rainbow DB, Hunter KM, Dai YD, Cheung J, Peterson LB, Wicker LS, Sherman LA.

J Immunol. 2013 Apr 1;190(7):3109-20. doi: 10.4049/jimmunol.1203422. Epub 2013 Feb 20.

15.

PTPN22 alters the development of regulatory T cells in the thymus.

Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA.

J Immunol. 2012 Jun 1;188(11):5267-75. doi: 10.4049/jimmunol.1200150. Epub 2012 Apr 25.

16.

Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5.

Hamilton-Williams EE, Cheung J, Rainbow DB, Hunter KM, Wicker LS, Sherman LA.

Diabetes. 2012 Jan;61(1):166-74. doi: 10.2337/db11-0790. Epub 2011 Nov 21.

17.

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.

Hamilton-Williams EE, Wong SB, Martinez X, Rainbow DB, Hunter KM, Wicker LS, Sherman LA.

Diabetes. 2010 Jun;59(6):1478-86. doi: 10.2337/db09-1801. Epub 2010 Mar 18.

18.

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.

Hamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA.

J Immunol. 2009 Aug 1;183(3):1533-41. doi: 10.4049/jimmunol.0900428. Epub 2009 Jul 10.

19.

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.

Heymann F, Meyer-Schwesinger C, Hamilton-Williams EE, Hammerich L, Panzer U, Kaden S, Quaggin SE, Floege J, Gröne HJ, Kurts C.

J Clin Invest. 2009 May;119(5):1286-97. doi: 10.1172/JCI38399. Epub 2009 Apr 20. Erratum in: J Clin Invest. 2009 Jul;119(7):2114.

20.

CD25+ T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens.

Ludwig-Portugall I, Hamilton-Williams EE, Gotot J, Kurts C.

Eur J Immunol. 2009 Jan;39(1):225-33. doi: 10.1002/eji.200838699.

21.

Cutting edge: CD25+ regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens.

Ludwig-Portugall I, Hamilton-Williams EE, Gottschalk C, Kurts C.

J Immunol. 2008 Oct 1;181(7):4447-51.

22.

The use of idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen.

Hamilton-Williams EE, Martinez X, Lyman M, Hunter K, Wicker LS, Sherman LA.

Ann N Y Acad Sci. 2007 Apr;1103:118-27. Epub 2007 Mar 21.

PMID:
17376833
23.

Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens.

Benke D, Krüger T, Lang A, Hamilton-Williams EE, Kurts C.

J Immunol Methods. 2006 Mar 20;310(1-2):12-9. Epub 2006 Jan 19.

PMID:
16510151
24.

Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens.

Hamilton-Williams EE, Lang A, Benke D, Davey GM, Wiesmüller KH, Kurts C.

J Immunol. 2005 Feb 1;174(3):1159-63.

25.

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

Krüger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Müller-Newen G, Floege J, Kurts C.

J Am Soc Nephrol. 2004 Mar;15(3):613-21.

26.

Beta cell MHC class I is a late requirement for diabetes.

Hamilton-Williams EE, Palmer SE, Charlton B, Slattery RM.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6688-93. Epub 2003 May 15.

27.

Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.

Hamilton-Williams EE, Serreze DV, Charlton B, Johnson EA, Marron MP, Mullbacher A, Slattery RM.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11533-8. Erratum in: Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13472.

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