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Items: 36


Phase 1 Open-Label, Multicenter Study of First-in-Class RORγ Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity.

Mahalingam D, Wang JS, Hamilton EP, Sarantopoulos J, Nemunaitis J, Weems G, Carter L, Hu X, Schreeder M, Wilkins HJ.

Clin Cancer Res. 2019 Jun 15;25(12):3508-3516. doi: 10.1158/1078-0432.CCR-18-3185. Epub 2019 Feb 28.


Efficacy and Safety of Avelumab for Patients With Recurrent or Refractory Ovarian Cancer: Phase 1b Results From the JAVELIN Solid Tumor Trial.

Disis ML, Taylor MH, Kelly K, Beck JT, Gordon M, Moore KM, Patel MR, Chaves J, Park H, Mita AC, Hamilton EP, Annunziata CM, Grote HJ, von Heydebreck A, Grewal J, Chand V, Gulley JL.

JAMA Oncol. 2019 Mar 1;5(3):393-401. doi: 10.1001/jamaoncol.2018.6258.


A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER+/HER2- Advanced Breast Cancer.

Hamilton EP, Patel MR, Armstrong AC, Baird RD, Jhaveri K, Hoch M, Klinowska T, Lindemann JPO, Morgan SR, Schiavon G, Weir HM, Im SA.

Clin Cancer Res. 2018 Aug 1;24(15):3510-3518. doi: 10.1158/1078-0432.CCR-17-3102. Epub 2018 Feb 13.


Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study.

Banerjee S, Oza AM, Birrer MJ, Hamilton EP, Hasan J, Leary A, Moore KN, Mackowiak-Matejczyk B, Pikiel J, Ray-Coquard I, Trask P, Lin K, Schuth E, Vaze A, Choi Y, Marsters JC, Maslyar DJ, Lemahieu V, Wang Y, Humke EW, Liu JF.

Ann Oncol. 2018 Apr 1;29(4):917-923. doi: 10.1093/annonc/mdy023.


Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study.

Dirix LY, Takacs I, Jerusalem G, Nikolinakos P, Arkenau HT, Forero-Torres A, Boccia R, Lippman ME, Somer R, Smakal M, Emens LA, Hrinczenko B, Edenfield W, Gurtler J, von Heydebreck A, Grote HJ, Chin K, Hamilton EP.

Breast Cancer Res Treat. 2018 Feb;167(3):671-686. doi: 10.1007/s10549-017-4537-5. Epub 2017 Oct 23.


A germline-limited piggyBac transposase gene is required for precise excision in Tetrahymena genome rearrangement.

Feng L, Wang G, Hamilton EP, Xiong J, Yan G, Chen K, Chen X, Dui W, Plemens A, Khadr L, Dhanekula A, Juma M, Dang HQ, Kapler GM, Orias E, Miao W, Liu Y.

Nucleic Acids Res. 2017 Sep 19;45(16):9481-9502. doi: 10.1093/nar/gkx652.


Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome.

Hamilton EP, Kapusta A, Huvos PE, Bidwell SL, Zafar N, Tang H, Hadjithomas M, Krishnakumar V, Badger JH, Caler EV, Russ C, Zeng Q, Fan L, Levin JZ, Shea T, Young SK, Hegarty R, Daza R, Gujja S, Wortman JR, Birren BW, Nusbaum C, Thomas J, Carey CM, Pritham EJ, Feschotte C, Noto T, Mochizuki K, Papazyan R, Taverna SD, Dear PH, Cassidy-Hanley DM, Xiong J, Miao W, Orias E, Coyne RS.

Elife. 2016 Nov 28;5. pii: e19090. doi: 10.7554/eLife.19090.


Propofol for Treatment of Refractory Alcohol Withdrawal Syndrome: A Review of the Literature.

Brotherton AL, Hamilton EP, Kloss HG, Hammond DA.

Pharmacotherapy. 2016 Apr;36(4):433-42. doi: 10.1002/phar.1726. Epub 2016 Apr 1. Review.


Correction: Selecting One of Several Mating Types through Gene Segment Joining and Deletion in Tetrahymena thermophila.

Cervantes MD, Hamilton EP, Xiong J, Lawson MJ, Yuan D, Hadjithomas M, Miao W, Orias E.

PLoS Biol. 2015 Oct 21;13(10):e1002284. doi: 10.1371/journal.pbio.1002284. eCollection 2015 Oct. No abstract available.


CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.

Sutton LM, Geradts J, Hamilton EP, Havlin KA, Kimmick GG, Marcom PK, Spector NL, Watson M, Rabin DU, Bruno TO, Noe A, Miller S, Subramaniam C, Layton S, Grichnik K.

J Natl Compr Canc Netw. 2015 Aug;13(8):1005-11.


Prevalence and impact of correlative science in breast cancer phase II trials.

Zhang T, Schneider A, Hamilton EP, Patel K, Kamal AH, Lyman GH, Peppercorn JM.

Breast Cancer Res Treat. 2013 Jun;139(3):845-50. doi: 10.1007/s10549-013-2590-2. Epub 2013 Jun 15.


How can we optimize treatment of HER2-positive metastatic breast cancer?

Hamilton EP, Blackwell KL.

Oncology (Williston Park). 2013 Mar;27(3):180, 182. No abstract available.


Selecting one of several mating types through gene segment joining and deletion in Tetrahymena thermophila.

Cervantes MD, Hamilton EP, Xiong J, Lawson MJ, Yuan D, Hadjithomas M, Miao W, Orias E.

PLoS Biol. 2013;11(3):e1001518. doi: 10.1371/journal.pbio.1001518. Epub 2013 Mar 26. Erratum in: PLoS Biol. 2015 Oct;13(10):e1002284.


Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila.

Fass JN, Joshi NA, Couvillion MT, Bowen J, Gorovsky MA, Hamilton EP, Orias E, Hong K, Coyne RS, Eisen JA, Chalker DL, Lin D, Collins K.

G3 (Bethesda). 2011 Nov;1(6):515-22. doi: 10.1534/g3.111.000927. Epub 2011 Nov 1.


Safety of bevacizumab in patients with metastatic breast cancer.

Hamilton EP, Blackwell KL.

Oncology. 2011;80(5-6):314-25. doi: 10.1159/000328757. Epub 2011 Jul 19. Review.


Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes.

Orias E, Cervantes MD, Hamilton EP.

Res Microbiol. 2011 Jul-Aug;162(6):578-86. doi: 10.1016/j.resmic.2011.05.001. Epub 2011 May 18. Review.


Availability of experimental therapy outside oncology randomized clinical trials in the United States.

Hamilton EP, Lyman GH, Peppercorn J.

J Clin Oncol. 2010 Dec 1;28(34):5067-73. doi: 10.1200/JCO.2010.28.6567. Epub 2010 Oct 25.


Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure.

Coyne RS, Thiagarajan M, Jones KM, Wortman JR, Tallon LJ, Haas BJ, Cassidy-Hanley DM, Wiley EA, Smith JJ, Collins K, Lee SR, Couvillion MT, Liu Y, Garg J, Pearlman RE, Hamilton EP, Orias E, Eisen JA, Methé BA.

BMC Genomics. 2008 Nov 26;9:562. doi: 10.1186/1471-2164-9-562.


Tetrahymena metallothioneins fall into two discrete subfamilies.

Díaz S, Amaro F, Rico D, Campos V, Benítez L, Martín-González A, Hamilton EP, Orias E, Gutiérrez JC.

PLoS One. 2007 Mar 14;2(3):e291.


Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote.

Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK Jr, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E.

PLoS Biol. 2006 Sep;4(9):e286.


Use of HAPPY mapping for the higher order assembly of the Tetrahymena genome.

Hamilton EP, Dear PH, Rowland T, Saks K, Eisen JA, Orias E.

Genomics. 2006 Oct;88(4):443-51. Epub 2006 Jun 19.


The highly conserved family of Tetrahymena thermophila chromosome breakage elements contains an invariant 10-base-pair core.

Hamilton EP, Williamson S, Dunn S, Merriam V, Lin C, Vong L, Russell-Colantonio J, Orias E.

Eukaryot Cell. 2006 Apr;5(4):771-80.


Genome-wide characterization of Tetrahymena thermophila chromosome breakage sites. II. Physical and genetic mapping.

Cassidy-Hanley D, Bisharyan Y, Fridman V, Gerber J, Lin C, Orias E, Orias JD, Ryder H, Vong L, Hamilton EP.

Genetics. 2005 Aug;170(4):1623-31. Epub 2005 Jun 14.


Autonomously replicating macronuclear DNA pieces are the physical basis of genetic coassortment groups in Tetrahymena thermophila.

Wong L, Klionsky L, Wickert S, Merriam V, Orias E, Hamilton EP.

Genetics. 2000 Jul;155(3):1119-25.


Genetically mapping new mutants and cloned genes.

Hamilton EP, Orias E.

Methods Cell Biol. 2000;62:265-80. Review. No abstract available.


Genetically sorting a collection of Tetrahymena mutants.

Orias E, Hamilton EP.

Methods Cell Biol. 2000;62:253-63. Review. No abstract available.


Genetic crosses: setting up crosses, testing progeny, and isolating phenotypic assortants.

Hamilton EP, Orias E.

Methods Cell Biol. 2000;62:219-28. Review. No abstract available.


Tetrahymena as a laboratory organism: useful strains, cell culture, and cell line maintenance.

Orias E, Hamilton EP, Orias JD.

Methods Cell Biol. 2000;62:189-211. Review. No abstract available.


Arabinose-induced binding of AraC protein to araI2 activates the araBAD operon promoter.

Lee N, Francklyn C, Hamilton EP.

Proc Natl Acad Sci U S A. 1987 Dec;84(24):8814-8.


Repression and catabolite gene activation in the araBAD operon.

Lichenstein HS, Hamilton EP, Lee N.

J Bacteriol. 1987 Feb;169(2):811-22.


A microtubule meshwork associated with gametic pronucleus transfer across a cell-cell junction.

Orias JD, Hamilton EP, Orias E.

Science. 1983 Oct 14;222(4620):181-4.


Autoradiographic evidence for self-fertilization in Tetrahymena thermophila.

Hamilton EP, Suhr-Jessen PB.

Exp Cell Res. 1980 Apr;126(2):391-6. No abstract available.


Osmotic shock prevents nuclear exchange and produces whole-genome homozygotes in conjugating Tetrahymena.

Orias E, Hamilton EP, Flacks M.

Science. 1979 Feb 16;203(4381):660-3.


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