Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 58

1.

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.

Zheng H, Yu WM, Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK.

Sci Adv. 2018 Oct 10;4(10):eaat2681. doi: 10.1126/sciadv.aat2681. eCollection 2018 Oct.

PMID:
30338292
2.

Immune Microenvironment in Glioblastoma Subtypes.

Chen Z, Hambardzumyan D.

Front Immunol. 2018 May 8;9:1004. doi: 10.3389/fimmu.2018.01004. eCollection 2018. Review.

3.

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma.

Sadahiro H, Kang KD, Gibson JT, Minata M, Yu H, Shi J, Chhipa R, Chen Z, Lu S, Simoni Y, Furuta T, Sabit H, Zhang S, Bastola S, Yamaguchi S, Alsheikh H, Komarova S, Wang J, Kim SH, Hambardzumyan D, Lu X, Newell EW, DasGupta B, Nakada M, Lee LJ, Nabors B, Norian LA, Nakano I.

Cancer Res. 2018 Jun 1;78(11):3002-3013. doi: 10.1158/0008-5472.CAN-17-2433. Epub 2018 Mar 12.

PMID:
29531161
4.

Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance.

Tran AN, Walker K, Harrison DG, Chen W, Mobley J, Hocevar L, Hackney JR, Sedaka RS, Pollock JS, Goldberg MS, Hambardzumyan D, Cooper SJ, Gillespie Y, Hjelmeland AB.

Neuro Oncol. 2018 Jul 5;20(8):1055-1067. doi: 10.1093/neuonc/noy012.

PMID:
29409010
5.

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.

Szulzewsky F, Schwendinger N, Güneykaya D, Cimino PJ, Hambardzumyan D, Synowitz M, Holland EC, Kettenmann H.

Neuro Oncol. 2018 Feb 19;20(3):355-366. doi: 10.1093/neuonc/nox165.

PMID:
29016864
6.

Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival.

Müller-Greven G, Carlin CR, Burgett ME, Ahluwalia MS, Lauko A, Nowacki AS, Herting CJ, Qadan MA, Bredel M, Toms SA, Lathia JD, Hambardzumyan D, Sarkaria JN, Hamerlik P, Gladson CL.

Clin Cancer Res. 2017 Nov 15;23(22):7059-7071. doi: 10.1158/1078-0432.CCR-17-0249. Epub 2017 Sep 14.

PMID:
28912141
7.

Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.

Herting CJ, Chen Z, Pitter KL, Szulzewsky F, Kaffes I, Kaluzova M, Park JC, Cimino PJ, Brennan C, Wang B, Hambardzumyan D.

Glia. 2017 Dec;65(12):1914-1926. doi: 10.1002/glia.23203. Epub 2017 Aug 24.

PMID:
28836293
8.

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.

Wang C, Zhang CJ, Martin BN, Bulek K, Kang Z, Zhao J, Bian G, Carman JA, Gao J, Dongre A, Xue H, Miller SD, Qian Y, Hambardzumyan D, Hamilton T, Ransohoff RM, Li X.

Nat Commun. 2017 May 31;8:15508. doi: 10.1038/ncomms15508.

9.

Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.

Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH.

Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516.

10.

Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma.

Chen Z, Feng X, Herting CJ, Garcia VA, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D.

Cancer Res. 2017 May 1;77(9):2266-2278. doi: 10.1158/0008-5472.CAN-16-2310. Epub 2017 Feb 24.

11.

Reply: Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels.

Weller M, Holland EC, Hambardzumyan D.

Brain. 2017 Mar 1;140(3):e17. doi: 10.1093/brain/aww325. No abstract available.

PMID:
28007996
12.

Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.

Möhle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, French T, Hambardzumyan D, Matzinger P, Dunay IR, Wolf SA.

Cell Rep. 2016 May 31;15(9):1945-56. doi: 10.1016/j.celrep.2016.04.074. Epub 2016 May 19.

13.

Glioblastoma: Defining Tumor Niches.

Hambardzumyan D, Bergers G.

Trends Cancer. 2015 Dec;1(4):252-265.

14.

Corticosteroids compromise survival in glioblastoma.

Pitter KL, Tamagno I, Alikhanyan K, Hosni-Ahmed A, Pattwell SS, Donnola S, Dai C, Ozawa T, Chang M, Chan TA, Beal K, Bishop AJ, Barker CA, Jones TS, Hentschel B, Gorlia T, Schlegel U, Stupp R, Weller M, Holland EC, Hambardzumyan D.

Brain. 2016 May;139(Pt 5):1458-71. doi: 10.1093/brain/aww046. Epub 2016 Mar 28.

15.

The role of microglia and macrophages in glioma maintenance and progression.

Hambardzumyan D, Gutmann DH, Kettenmann H.

Nat Neurosci. 2016 Jan;19(1):20-7. doi: 10.1038/nn.4185. Review.

16.

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.

Bish R, Cuevas-Polo N, Cheng Z, Hambardzumyan D, Munschauer M, Landthaler M, Vogel C.

Biomolecules. 2015 Jul 15;5(3):1441-66. doi: 10.3390/biom5031441.

17.

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.

Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen RD, Alvarez-Garcia V, Kim Y, Wang B, Tamagno I, Zhou H, Li X, Kettenmann H, Ransohoff RM, Hambardzumyan D.

Oncotarget. 2015 Jun 20;6(17):15077-94.

18.

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman IR, Wang X, Eggen BJ, Boddeke HW, Hambardzumyan D, Wolf SA, Kettenmann H.

PLoS One. 2015 Feb 6;10(2):e0116644. doi: 10.1371/journal.pone.0116644. eCollection 2015.

19.

Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes.

Raychaudhuri B, Rayman P, Huang P, Grabowski M, Hambardzumyan D, Finke JH, Vogelbaum MA.

J Neurooncol. 2015 Apr;122(2):293-301. doi: 10.1007/s11060-015-1720-6. Epub 2015 Jan 13.

PMID:
25579983
20.

Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions.

Richter N, Wendt S, Georgieva PB, Hambardzumyan D, Nolte C, Kettenmann H.

Neurosci Lett. 2014 Nov 7;583:130-5. doi: 10.1016/j.neulet.2014.09.035. Epub 2014 Sep 27.

21.

The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions.

Pitter KL, Tamagno I, Feng X, Ghosal K, Amankulor N, Holland EC, Hambardzumyan D.

Glia. 2014 Oct;62(10):1595-607. doi: 10.1002/glia.22702. Epub 2014 Jun 4.

22.

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.

Fan Y, Potdar AA, Gong Y, Eswarappa SM, Donnola S, Lathia JD, Hambardzumyan D, Rich JN, Fox PL.

Nat Cell Biol. 2014 May;16(5):445-56. doi: 10.1038/ncb2954. Epub 2014 Apr 20.

23.

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

Miao H, Gale NW, Guo H, Qian J, Petty A, Kaspar J, Murphy AJ, Valenzuela DM, Yancopoulos G, Hambardzumyan D, Lathia JD, Rich JN, Lee J, Wang B.

Oncogene. 2015 Jan 29;34(5):558-67. doi: 10.1038/onc.2013.590. Epub 2014 Feb 3.

24.

Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules.

Leder K, Pitter K, LaPlant Q, Hambardzumyan D, Ross BD, Chan TA, Holland EC, Michor F.

Cell. 2014 Jan 30;156(3):603-616. doi: 10.1016/j.cell.2013.12.029.

25.

F11R is a novel monocyte prognostic biomarker for malignant glioma.

Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH.

PLoS One. 2013 Oct 11;8(10):e77571. doi: 10.1371/journal.pone.0077571. eCollection 2013.

26.

Prominin 1/CD133 endothelium sustains growth of proneural glioma.

Ding BS, James D, Iyer R, Falciatori I, Hambardzumyan D, Wang S, Butler JM, Rabbany SY, Hormigo A.

PLoS One. 2013 Apr 25;8(4):e62150. doi: 10.1371/journal.pone.0062150. Print 2013.

27.

Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.

Benezra M, Hambardzumyan D, Penate-Medina O, Veach DR, Pillarsetty N, Smith-Jones P, Phillips E, Ozawa T, Zanzonico PB, Longo V, Holland EC, Larson SM, Bradbury MS.

Neoplasia. 2012 Dec;14(12):1132-43.

28.

Therapeutic targeting of VEGF in the treatment of glioblastoma.

Robles Irizarry L, Hambardzumyan D, Nakano I, Gladson CL, Ahluwalia MS.

Expert Opin Ther Targets. 2012 Oct;16(10):973-84. doi: 10.1517/14728222.2012.711817. Epub 2012 Aug 9. Review.

PMID:
22876981
29.

Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma.

Barrett LE, Granot Z, Coker C, Iavarone A, Hambardzumyan D, Holland EC, Nam HS, Benezra R.

Cancer Cell. 2012 Jan 17;21(1):11-24. doi: 10.1016/j.ccr.2011.11.025.

30.

The probable cell of origin of NF1- and PDGF-driven glioblastomas.

Hambardzumyan D, Cheng YK, Haeno H, Holland EC, Michor F.

PLoS One. 2011;6(9):e24454. doi: 10.1371/journal.pone.0024454. Epub 2011 Sep 9.

31.

Glioma development: where did it all go wrong?

Sukhdeo K, Hambardzumyan D, Rich JN.

Cell. 2011 Jul 22;146(2):187-8. doi: 10.1016/j.cell.2011.06.047.

32.

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, MacSwords J, Eyler CE, McLendon RE, Heddleston JM, Shou W, Hambardzumyan D, Lee J, Hjelmeland AB, Sloan AE, Bredel M, Stark GR, Rich JN, Bao S.

Cancer Cell. 2011 Apr 12;19(4):498-511. doi: 10.1016/j.ccr.2011.03.004.

33.

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.

Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P.

J Clin Invest. 2011 Apr;121(4):1344-8. doi: 10.1172/JCI44656. Epub 2011 Mar 14.

34.

Genetic modeling of gliomas in mice: new tools to tackle old problems.

Hambardzumyan D, Parada LF, Holland EC, Charest A.

Glia. 2011 Aug;59(8):1155-68. doi: 10.1002/glia.21142. Epub 2011 Feb 8. Review.

35.

Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.

Pitter KL, Galbán CJ, Galbán S, Tehrani OS, Li F, Charles N, Bradbury MS, Becher OJ, Chenevert TL, Rehemtulla A, Ross BD, Holland EC, Hambardzumyan D.

PLoS One. 2011 Jan 18;6(1):e14545. doi: 10.1371/journal.pone.0014545. Erratum in: PLoS One. 2011;6(1). doi: 10.1371/annotation/66641ad6-afb9-4d3c-ade6-73fcd5aab061. Saeed-Tehrani, Omid [corrected to Tehrani, Omid Saeed].

36.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Sep 30;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

37.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Aug 19;5(8):e12310. doi: 10.1371/journal.pone.0012310. Corrected and republished in: PLoS One. 2010;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

38.

SCCRO promotes glioma formation and malignant progression in mice.

Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B.

Neoplasia. 2010 Jun;12(6):476-84.

39.

Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.

Castellino RC, Barwick BG, Schniederjan M, Buss MC, Becher O, Hambardzumyan D, Macdonald TJ, Brat DJ, Durden DL.

PLoS One. 2010 May 26;5(5):e10849. doi: 10.1371/journal.pone.0010849.

40.

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.

Becher OJ, Hambardzumyan D, Walker TR, Helmy K, Nazarian J, Albrecht S, Hiner RL, Gall S, Huse JT, Jabado N, MacDonald TJ, Holland EC.

Cancer Res. 2010 Mar 15;70(6):2548-57. doi: 10.1158/0008-5472.CAN-09-2503. Epub 2010 Mar 2.

41.

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.

Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC.

Cell Stem Cell. 2010 Feb 5;6(2):141-52. doi: 10.1016/j.stem.2010.01.001.

42.

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.

Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E.

PLoS One. 2009 Nov 13;4(11):e7752. doi: 10.1371/journal.pone.0007752.

43.

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.

Bhatia B, Northcott PA, Hambardzumyan D, Govindarajan B, Brat DJ, Arbiser JL, Holland EC, Taylor MD, Kenney AM.

Cancer Res. 2009 Sep 15;69(18):7224-34. doi: 10.1158/0008-5472.CAN-09-1299. Epub 2009 Sep 8.

44.

Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation.

Amankulor NM, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA, Holland EC.

J Neurosci. 2009 Aug 19;29(33):10299-308. doi: 10.1523/JNEUROSCI.2500-09.2009.

45.

Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.

Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y.

Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1580-91. doi: 10.1016/j.ijrobp.2009.03.047. Epub 2009 Jun 17.

PMID:
19540073
46.

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.

Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC.

Genes Dev. 2009 Jun 1;23(11):1327-37. doi: 10.1101/gad.1777409.

47.

Modeling Adult Gliomas Using RCAS/t-va Technology.

Hambardzumyan D, Amankulor NM, Helmy KY, Becher OJ, Holland EC.

Transl Oncol. 2009 May;2(2):89-95.

48.

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.

Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC.

Cell Stem Cell. 2009 Mar 6;4(3):226-35. doi: 10.1016/j.stem.2009.01.007.

49.

AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors.

Hambardzumyan D, Sergent-Tanguy S, Thinard R, Bonnamain V, Masip M, Fabre A, Boudin H, Neveu I, Naveilhan P.

J Neurosci Res. 2009 May 1;87(6):1296-309. doi: 10.1002/jnr.21957.

PMID:
19115409
50.

Seeding and propagation of untransformed mouse mammary cells in the lung.

Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H.

Science. 2008 Sep 26;321(5897):1841-4. doi: 10.1126/science.1161621. Epub 2008 Aug 28.

Supplemental Content

Loading ...
Support Center