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Items: 35

1.

Hepatitis C replication inhibitors that target the viral NS4B protein.

Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW 3rd, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ.

J Med Chem. 2014 Mar 13;57(5):2107-20. doi: 10.1021/jm400125h. Epub 2013 Apr 19.

PMID:
23544424
2.

Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition.

Mazzucco CE, Hamatake RK, Colonno RJ, Tenney DJ.

Antimicrob Agents Chemother. 2008 Feb;52(2):598-605. Epub 2007 Dec 3.

3.

Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.

Gunic E, Girardet JL, Ramasamy K, Stoisavljevic-Petkov V, Chow S, Yeh LT, Hamatake RK, Raney A, Hong Z.

Bioorg Med Chem Lett. 2007 May 1;17(9):2452-5. Epub 2007 Feb 14.

PMID:
17331721
4.

6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors.

Gunic E, Chow S, Rong F, Ramasamy K, Raney A, Li DY, Huang J, Hamatake RK, Hong Z, Girardet JL.

Bioorg Med Chem Lett. 2007 May 1;17(9):2456-8. Epub 2007 Feb 14.

PMID:
17331718
5.

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study.

Yan S, Appleby T, Larson G, Wu JZ, Hamatake RK, Hong Z, Yao N.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1991-5. Epub 2007 Jan 19.

PMID:
17276060
6.

A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.

Zhang Z, Xu W, Koh YH, Shim JH, Girardet JL, Yeh LT, Hamatake RK, Hong Z.

Antimicrob Agents Chemother. 2007 Feb;51(2):429-37. Epub 2006 Nov 20.

7.

Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.

Zhang Z, Walker M, Xu W, Shim JH, Girardet JL, Hamatake RK, Hong Z.

Antimicrob Agents Chemother. 2006 Aug;50(8):2772-81.

8.

HEP DART 2003: Frontiers in drug development for viral hepatitis.

Raney AK, Hamatake RK, Hong Z.

Expert Opin Investig Drugs. 2004 Mar;13(3):289-93.

PMID:
15013947
9.

The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication.

Stracker TH, Cassell GD, Ward P, Loo YM, van Breukelen B, Carrington-Lawrence SD, Hamatake RK, van der Vliet PC, Weller SK, Melendy T, Weitzman MD.

J Virol. 2004 Jan;78(1):441-53.

10.

Agents in clinical development for the treatment of chronic hepatitis B.

Raney AK, Hamatake RK, Hong Z.

Expert Opin Investig Drugs. 2003 Aug;12(8):1281-95. Review.

PMID:
12882617
11.

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus.

Luo G, Hamatake RK, Mathis DM, Racela J, Rigat KL, Lemm J, Colonno RJ.

J Virol. 2000 Jan;74(2):851-63.

12.

In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir.

Seifer M, Hamatake RK, Colonno RJ, Standring DN.

Antimicrob Agents Chemother. 1998 Dec;42(12):3200-8.

14.

Characterization of monoclonal antibodies recognizing amino- and carboxy-terminal epitopes of the herpes simplex virus UL42 protein.

Sheaffer AK, Hurlburt WW, Stevens JT, Bifano M, Hamatake RK, Colonno RJ, Tenney DJ.

Virus Res. 1995 Oct;38(2-3):305-14.

PMID:
8578868
15.

Sequence-dependent primer synthesis by the herpes simplex virus helicase-primase complex.

Tenney DJ, Sheaffer AK, Hurlburt WW, Bifano M, Hamatake RK.

J Biol Chem. 1995 Apr 21;270(16):9129-36.

16.
17.

The herpes simplex virus type 1 DNA polymerase accessory protein, UL42, contains a functional protease-resistant domain.

Hamatake RK, Bifano M, Tenney DJ, Hurlburt WW, Cordingley MG.

J Gen Virol. 1993 Oct;74 ( Pt 10):2181-9.

PMID:
8409941
18.

Deletions of the carboxy terminus of herpes simplex virus type 1 UL42 define a conserved amino-terminal functional domain.

Tenney DJ, Hurlburt WW, Bifano M, Stevens JT, Micheletti PA, Hamatake RK, Cordingley MG.

J Virol. 1993 Apr;67(4):1959-66.

19.

Mutations in the C terminus of herpes simplex virus type 1 DNA polymerase can affect binding and stimulation by its accessory protein UL42 without affecting basal polymerase activity.

Tenney DJ, Micheletti PA, Stevens JT, Hamatake RK, Matthews JT, Sanchez AR, Hurlburt WW, Bifano M, Cordingley MG.

J Virol. 1993 Jan;67(1):543-7.

20.

Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae.

Araki H, Hamatake RK, Morrison A, Johnson AL, Johnston LH, Sugino A.

Nucleic Acids Res. 1991 Sep 25;19(18):4867-72.

21.

DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.

Araki H, Hamatake RK, Johnston LH, Sugino A.

Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4601-5.

22.

Cloning and characterization of DST2, the gene for DNA strand transfer protein beta from Saccharomyces cerevisiae.

Dykstra CC, Kitada K, Clark AB, Hamatake RK, Sugino A.

Mol Cell Biol. 1991 May;11(5):2583-92.

23.

A third essential DNA polymerase in S. cerevisiae.

Morrison A, Araki H, Clark AB, Hamatake RK, Sugino A.

Cell. 1990 Sep 21;62(6):1143-51.

PMID:
2169349
24.
25.
26.

Effect of accessory proteins on the fidelity of DNA synthesis by eukaryotic replicative polymerases.

Roberts JD, Hamatake RK, Fitzgerald MS, Sugino A, Kunkel TA.

Prog Clin Biol Res. 1990;340A:91-100. No abstract available.

PMID:
2167484
27.

Fidelity of DNA polymerase I and the DNA polymerase I-DNA primase complex from Saccharomyces cerevisiae.

Kunkel TA, Hamatake RK, Motto-Fox J, Fitzgerald MP, Sugino A.

Mol Cell Biol. 1989 Oct;9(10):4447-58.

28.
29.

The J gene of phi X174: isolation and characterization of a J gene mutant.

Hamatake RK, Buckley KJ, Hayashi M.

Mol Gen Genet. 1988 Jan;211(1):72-7.

PMID:
2963945
30.

The J gene of bacteriophage phi X174: in vitro analysis of J protein function.

Hamatake RK, Aoyama A, Hayashi M.

J Virol. 1985 May;54(2):345-50.

31.

In vitro synthesis of bacteriophage phi X174 by purified components.

Aoyama A, Hamatake RK, Hayashi M.

Proc Natl Acad Sci U S A. 1983 Jul;80(14):4195-9.

32.

Purification of phi X174 gene C protein.

Aoyama A, Hamatake RK, Mukai R, Hayashi M.

J Biol Chem. 1983 May 10;258(9):5798-803.

33.

Morphogenesis of phi X174: in vitro synthesis of infectious phage from purified viral components.

Aoyama A, Hamatake RK, Hayashi M.

Proc Natl Acad Sci U S A. 1981 Dec;78(12):7285-9.

34.

Role of DNA gyrase subunits in synthesis of bacteriophage phi X174 viral DNA.

Hamatake RK, Mukai R, Hayashi M.

Proc Natl Acad Sci U S A. 1981 Mar;78(3):1532-6.

35.

Isolation and identification of bacteriophage phi X174 prohead.

Mukai R, Hamatake RK, Hayashi M.

Proc Natl Acad Sci U S A. 1979 Oct;76(10):4877-81.

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