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Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge Verongula rigida.

Kochanowska-Karamyan AJ, Araujo HC, Zhang X, El-Alfy A, Carvalho P, Avery MA, Holmbo SD, Magolan J, Hamann MT.

J Nat Prod. 2020 Mar 31. doi: 10.1021/acs.jnatprod.9b01107. [Epub ahead of print]


The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein.

Karan D, Dubey S, Pirisi L, Nagel A, Pina I, Choo YM, Hamann MT.

J Nat Prod. 2020 Feb 28;83(2):286-295. doi: 10.1021/acs.jnatprod.9b00577. Epub 2020 Feb 5.


The anti-MRSA compound 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) inhibits protein synthesis in Staphylococcus aureus.

Carruthers NJ, Stemmer PM, Media J, Swartz K, Wang X, Aube N, Hamann MT, Valeriote F, Shaw J.

J Proteomics. 2020 Jan 6;210:103539. doi: 10.1016/j.jprot.2019.103539. Epub 2019 Oct 17.


Hepatoprotective Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata.

Liu J, Pandey P, Wang X, Adams K, Qi X, Chen J, Sun H, Hou Q, Ferreira D, Doerksen RJ, Hamann MT, Li S.

J Nat Prod. 2019 Oct 25;82(10):2842-2851. doi: 10.1021/acs.jnatprod.9b00576. Epub 2019 Sep 26.


Marine natural products in the discovery and development of potential pancreatic cancer therapeutics.

Wang X, Hamann MT.

Adv Cancer Res. 2019;144:299-314. doi: 10.1016/bs.acr.2019.05.003. Epub 2019 Jun 6.


Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean.

Zou Y, Wang X, Sims J, Wang B, Pandey P, Welsh CL, Stone RP, Avery MA, Doerksen RJ, Ferreira D, Anklin C, Valeriote FA, Kelly M, Hamann MT.

J Am Chem Soc. 2019 Mar 13;141(10):4338-4344. doi: 10.1021/jacs.8b11403. Epub 2019 Mar 5.


Computationally Assisted Assignment of the Kadsuraols, a Class of Chemopreventive Agents for the Control of Liver Cancer.

Wang X, Liu J, Pandey P, Fronczek FR, Doerksen RJ, Chen J, Qi X, Zhang P, Ferreira D, Valeriote FA, Sun H, Li S, Hamann MT.

Org Lett. 2018 Sep 21;20(18):5559-5563. doi: 10.1021/acs.orglett.8b02207. Epub 2018 Sep 7.


Lemon yellow #15 a new highly stable, water soluble food colorant from the peel of Citrus limon.

Chen X, Ding Y, Forrest B, Oh J, Boussert SM, Hamann MT.

Food Chem. 2019 Jan 1;270:251-256. doi: 10.1016/j.foodchem.2018.07.055. Epub 2018 Jul 9.


Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells.

Park HB, Tuan NQ, Oh J, Son Y, Hamann MT, Stone R, Kelly M, Oh S, Na M.

Mar Drugs. 2018 Aug 27;16(9). pii: E297. doi: 10.3390/md16090297.


Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids.

Simithy J, Fuanta NR, Alturki M, Hobrath JV, Wahba AE, Pina I, Rath J, Hamann MT, DeRuiter J, Goodwin DC, Calderón AI.

Biochemistry. 2018 Aug 14;57(32):4923-4933. doi: 10.1021/acs.biochem.8b00231. Epub 2018 Jul 31.


Raistrickiones A-E from a Highly Productive Strain of Penicillium raistrickii Generated through Thermo Change.

Liu DS, Rong XG, Kang HH, Ma LY, Hamann MT, Liu WZ.

Mar Drugs. 2018 Jun 18;16(6). pii: E213. doi: 10.3390/md16060213.


A Chemical Investigation of the Leaves of Morus alba L.

Chen XY, Zhang T, Wang X, Hamann MT, Kang J, Yu DQ, Chen RY.

Molecules. 2018 Apr 26;23(5). pii: E1018. doi: 10.3390/molecules23051018.


Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone.

Simithy J, Fuanta NR, Hobrath JV, Kochanowska-Karamyan A, Hamann MT, Goodwin DC, Calderón AI.

Biochim Biophys Acta Proteins Proteom. 2018 May - Jun;1866(5-6):731-739. doi: 10.1016/j.bbapap.2018.04.007. Epub 2018 Apr 12.


Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata.

Liu J, Pandey P, Wang X, Qi X, Chen J, Sun H, Zhang P, Ding Y, Ferreira D, Doerksen RJ, Hamann MT, Li S.

J Nat Prod. 2018 Apr 27;81(4):846-857. doi: 10.1021/acs.jnatprod.7b00934. Epub 2018 Mar 29.


Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J-based configurational analysis and HSQC overlay experiments.

Wang X, Liu J, Pandey P, Chen J, Fronczek FR, Parnham S, Qi X, Doerksen RJ, Ferreira D, Sun H, Li S, Hamann MT.

Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3089-3095. doi: 10.1016/j.bbagen.2017.09.001. Epub 2017 Sep 15.


Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

Gogineni V, Hamann MT.

Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):81-196. doi: 10.1016/j.bbagen.2017.08.014. Epub 2017 Aug 24. Review.


Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space.

Ibrahim MA, El-Alfy AT, Ezel K, Radwan MO, Shilabin AG, Kochanowska-Karamyan AJ, Abd-Alla HI, Otsuka M, Hamann MT.

Mar Drugs. 2017 Aug 9;15(8). pii: E248. doi: 10.3390/md15080248.


Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction.

Wang X, Fronczek FR, Chen J, Liu J, Ferreira D, Li S, Hamann MT.

Molecules. 2017 Jan 2;22(1). pii: E65. doi: 10.3390/molecules22010065.


Antibacterial Activities of Metabolites from Platanus occidentalis (American sycamore) against Fish Pathogenic Bacteria.

Schrader KK, Hamann MT, McChesney JD, Rodenburg DL, Ibrahim MA.

J Aquac Res Dev. 2015 Oct;6(10). pii: 364. Epub 2015 Oct 15.


In silico investigation of lavandulyl flavonoids for the development of potent fatty acid synthase-inhibitory prototypes.

Oh J, Liu H, Park HB, Ferreira D, Jeong GS, Hamann MT, Doerksen RJ, Na M.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3180-3188. doi: 10.1016/j.bbagen.2016.08.001. Epub 2016 Aug 13.


SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.

Cassilly CD, Maddox MM, Cherian PT, Bowling JJ, Hamann MT, Lee RE, Reynolds TB.

PLoS One. 2016 May 16;11(5):e0154932. doi: 10.1371/journal.pone.0154932. eCollection 2016.


New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge.

Hoye TR, Alarif WM, Basaif SS, Abo-Elkarm M, Hamann MT, Wahba AE, Ayyad SN.

ARKIVOC. 2015;2015(5):164-175. Epub 2015 Apr 5.


Stereochemical Studies of the Karlotoxin Class Using NMR Spectroscopy and DP4 Chemical-Shift Analysis: Insights into their Mechanism of Action.

Waters AL, Oh J, Place AR, Hamann MT.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15705-10. doi: 10.1002/anie.201507418. Epub 2015 Nov 16.


HPLC Plasma Assay of a Novel Anti-MRSA Compound, Kaempferol-3-O-Alpha-L-(2",3"-di-p-coumaroyl)rhamnoside, from Sycamore Leaves.

Zhang Y, Valeriote F, Swartz K, Chen B, Hamann MT, Rodenburg DL, McChesney JD, Shaw J.

Nat Prod Commun. 2015 Aug;10(8):1383-6.


Role of Marine Natural Products in the Genesis of Antiviral Agents.

Gogineni V, Schinazi RF, Hamann MT.

Chem Rev. 2015 Sep 23;115(18):9655-706. doi: 10.1021/cr4006318. Epub 2015 Aug 28. Review. No abstract available.


Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine.

Chatwichien J, Basu S, Murphy ME, Hamann MT, Winkler JD.

Tetrahedron Lett. 2015 Jun 3;56(23):3515-3517.


An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata.

Wang B, Waters AL, Valeriote FA, Hamann MT.

Biochim Biophys Acta. 2015 Sep;1850(9):1849-54. doi: 10.1016/j.bbagen.2015.05.004. Epub 2015 May 9.


Cytotoxic activity of rearranged drimane meroterpenoids against colon cancer cells via down-regulation of β-catenin expression.

Hwang IH, Oh J, Zhou W, Park S, Kim JH, Chittiboyina AG, Ferreira D, Song GY, Oh S, Na M, Hamann MT.

J Nat Prod. 2015 Mar 27;78(3):453-61. doi: 10.1021/np500843m. Epub 2015 Jan 15.


Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms.

Falodun A, Imieje V, Erharuyi O, Ahomafor J, Jacob MR, Khan SI, Hamann MT.

Afr J Tradit Complement Altern Med. 2014 Jun 4;11(4):142-6. eCollection 2014.


An analysis of the sponge Acanthostrongylophora igens' microbiome yields an actinomycete that produces the natural product manzamine A.

Waters AL, Peraud O, Kasanah N, Sims JW, Kothalawala N, Anderson MA, Abbas SH, Rao KV, Jupally VR, Kelly M, Dass A, Hill RT, Hamann MT.

Front Mar Sci. 2014 Oct;1. pii: 54. Epub 2014 Oct 17.


The utility of metabolomics in natural product and biomarker characterization.

Cox DG, Oh J, Keasling A, Colson KL, Hamann MT.

Biochim Biophys Acta. 2014 Dec;1840(12):3460-3474. doi: 10.1016/j.bbagen.2014.08.007. Epub 2014 Aug 20. Review.


An iridoid glucoside and the related aglycones from Cornus florida.

He Y, Peng J, Hamann MT, West LM.

J Nat Prod. 2014 Sep 26;77(9):2138-43. doi: 10.1021/np5002362. Epub 2014 Aug 21.


Marine actinomycete Streptomyces sp. ISP2-49E, a new source of Rhamnolipid.

Yan X, Sims J, Wang B, Hamann MT.

Biochem Syst Ecol. 2014 Aug 1;55:292-295. No abstract available.


Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.

Yang F, Zou Y, Wang RP, Hamann MT, Zhang HJ, Jiao WH, Han BN, Song SJ, Lin HW.

Mar Drugs. 2014 Aug 8;12(8):4399-416. doi: 10.3390/md12084399.


The first cyclomegastigmane rhododendroside A from Rhododendron brachycarpum alleviates HMGB1-induced sepsis.

Zhou W, Oh J, Wonhwa L, Kwak S, Li W, Chittiboyina AG, Ferreira D, Hamann MT, Lee SH, Bae JS, Na M.

Biochim Biophys Acta. 2014 Jun;1840(6):2042-9. doi: 10.1016/j.bbagen.2014.02.016. Epub 2014 Feb 24.


Metabolism and resistance of Fusarium spp. to the manzamine alkaloids via a putative retro pictet-spengler reaction and utility of the rational design of antimalarial and antifungal agents.

Kasanah N, Farr LL, Gholipour A, Wedge DE, Hamann MT.

Mar Biotechnol (NY). 2014 Aug;16(4):412-22. doi: 10.1007/s10126-014-9557-0. Epub 2014 Feb 20.


Solution structure of a sponge-derived cystine knot peptide and its notable stability.

Li H, Su M, Hamann MT, Bowling JJ, Kim HS, Jung JH.

J Nat Prod. 2014 Feb 28;77(2):304-10. doi: 10.1021/np400899a. Epub 2014 Feb 5.


Karlotoxin synthetic studies: concise synthesis of a C(42-63) B-ring tetrahydropyran fragment.

Tomioka T, Takahashi Y, Maejima T, Yabe Y, Iwata H, Hamann MT.

Tetrahedron Lett. 2013 Nov 1;54(48). doi: 10.1016/j.tetlet.2013.09.104.


In vitro evaluation of aliphatic fatty alcohol metabolites of Perseaamericana seed as potential antimalarial and antimicrobial agents.

Falodun A, Erharuyi O, Imieje V, Ahomafor J, Akunyuli C, Jacobs M, Khan S, Hamann MT, Langer P.

Niger J Biotechnol. 2014;27:1-7.


Anti-cancerous triterpenoid saponins from Lecaniodiscus cupanioides.

Adesegun SA, Coker HA, Hamann MT.

J Nat Prod (Gorakhpur). 2014;7:155-161.


Asteropsins B-D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugs.

Li H, Bowling JJ, Su M, Hong J, Lee BJ, Hamann MT, Jung JH.

Biochim Biophys Acta. 2014 Mar;1840(3):977-84. doi: 10.1016/j.bbagen.2013.11.001. Epub 2013 Nov 10.


Significance of endangered and threatened plant natural products in the control of human disease.

Ibrahim MA, Na M, Oh J, Schinazi RF, McBrayer TR, Whitaker T, Doerksen RJ, Newman DJ, Zachos LG, Hamann MT.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16832-7. doi: 10.1073/pnas.1311528110. Epub 2013 Sep 30.


Characterization of the bacterial community of the chemically defended Hawaiian sacoglossan Elysia rufescens.

Davis J, Fricke WF, Hamann MT, Esquenazi E, Dorrestein PC, Hill RT.

Appl Environ Microbiol. 2013 Nov;79(22):7073-81. doi: 10.1128/AEM.01568-13. Epub 2013 Sep 6.


A novel natural phenyl alkene with cytotoxic activity.

Hwang IH, Oh J, Kochanowska-Karamyan A, Doerksen RJ, Na M, Hamann MT.

Tetrahedron Lett. 2013 Jul 17;54(29):3872-3876. Epub 2013 May 18.


Configurational assignments of conformationally restricted bis-monoterpene hydroquinones: utility in exploration of endangered plants.

Oh J, Bowling JJ, Zou Y, Chittiboyina AG, Doerksen RJ, Ferreira D, Leininger TD, Hamann MT.

Biochim Biophys Acta. 2013 Aug;1830(8):4229-34. doi: 10.1016/j.bbagen.2013.04.029. Epub 2013 Apr 26.


Complex marine natural products as potential epigenetic and production regulators of antibiotics from a marine Pseudomonas aeruginosa.

Wang B, Waters AL, Sims JW, Fullmer A, Ellison S, Hamann MT.

Microb Ecol. 2013 May;65(4):1068-75. doi: 10.1007/s00248-013-0213-4. Epub 2013 Apr 9.


Acantholactone, a new manzamine related alkaloid with an unprecedented δ-lactone and ε-lactam ring system.

Wahba AE, Fromentin Y, Zou Y, Hamann MT.

Tetrahedron Lett. 2012 Nov 1;53(47):6329-6331. Epub 2012 Sep 7.


Atkamine: a new pyrroloiminoquinone scaffold from the cold water Aleutian Islands Latrunculia sponge.

Zou Y, Hamann MT.

Org Lett. 2013 Apr 5;15(7):1516-9. doi: 10.1021/ol400294v. Epub 2013 Mar 8.


Computationally assisted assignment of kahalalide Y configuration using an NMR-constrained conformational search.

Albadry MA, Elokely KM, Wang B, Bowling JJ, Abdelwahab MF, Hossein MH, Doerksen RJ, Hamann MT.

J Nat Prod. 2013 Feb 22;76(2):178-85. doi: 10.1021/np3006088. Epub 2013 Jan 30.

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