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Items: 1 to 50 of 119

1.

Conditioned medium from rat dental pulp reduces the number of osteoclasts via attenuation of adhesiveness in osteoclast precursors.

Mori H, Hamamura K, Yo S, Hamajima K, Ootani K, Honda M, Ishizuka K, Kondo H, Tanaka K, Kodama D, Hirai T, Miyazawa K, Goto S, Togari A.

J Oral Sci. 2018 Jul 9. doi: 10.2334/josnusd.17-0342. [Epub ahead of print]

2.

Suppression of osteoclastogenesis via α2-adrenergic receptors.

Hamajima K, Hamamura K, Chen A, Yokota H, Mori H, Yo S, Kondo H, Tanaka K, Ishizuka K, Kodama D, Hirai T, Miyazawa K, Goto S, Togari A.

Biomed Rep. 2018 May;8(5):407-416. doi: 10.3892/br.2018.1075. Epub 2018 Mar 9.

3.

Coexistence of Cervical Leiomyosarcoma and Gastric-Type Adenocarcinoma In Situ with Extensive Extension to the Endometrium and Fallopian Tube.

Ura A, Ogura K, Sakaguchi A, Onagi H, Ogishima D, Sugimori Y, Hamamura K, Fukunaga M, Matsumoto T.

Case Rep Pathol. 2018 Feb 18;2018:5848629. doi: 10.1155/2018/5848629. eCollection 2018.

4.

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice.

Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S.

Biochem Biophys Res Commun. 2018 Mar 25;498(1):86-91. doi: 10.1016/j.bbrc.2017.11.162. Epub 2018 Feb 19.

PMID:
29470987
5.

Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects.

Okazaki F, Matsunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, Kutsukake M, Fukumori S, Tsuji Y, To H.

Cancer Res. 2017 Dec 1;77(23):6603-6613. doi: 10.1158/0008-5472.CAN-17-0720. Epub 2017 Oct 16.

PMID:
29038345
6.

Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multidimensional peptide analysis in females with pregnancy-induced hypertension.

Hamamura K, Yanagida M, Ishikawa H, Banzai M, Yoshitake H, Nonaka D, Tanaka K, Sakuraba M, Miyakuni Y, Takamori K, Nojima M, Yoshida K, Fujiwara H, Takeda S, Araki Y.

Ann Clin Biochem. 2018 Mar;55(2):287-295. doi: 10.1177/0004563217717748. Epub 2017 Jul 17.

PMID:
28656816
7.

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.

Chen A, Wang L, Li BY, Sherman J, Ryu JE, Hamamura K, Liu Y, Nakshatri H, Yokota H.

Sci Rep. 2017 Jun 14;7(1):3459. doi: 10.1038/s41598-017-03811-9.

8.

The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine.

Mizoguchi H, Watanabe C, Hayashi T, Iwata Y, Watanabe H, Katsuyama S, Hamamura K, Sakurada T, Ohtsu H, Yanai K, Sakurada S.

Eur J Pharmacol. 2017 Apr 5;800:9-15. doi: 10.1016/j.ejphar.2017.01.031. Epub 2017 Jan 26.

PMID:
28131781
9.

Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system.

Kodama D, Hirai T, Kondo H, Hamamura K, Togari A.

FEBS Lett. 2017 Feb;591(3):527-539. doi: 10.1002/1873-3468.12561. Epub 2017 Feb 3.

10.

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.

EBioMedicine. 2016 Nov;13:262-273. doi: 10.1016/j.ebiom.2016.10.008. Epub 2016 Oct 6.

11.

Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice.

Takigawa S, Frondorf B, Liu S, Liu Y, Li B, Sudo A, Wallace JM, Yokota H, Hamamura K.

J Pharmacol Sci. 2016 Oct;132(2):154-161. doi: 10.1016/j.jphs.2016.09.006. Epub 2016 Oct 1.

12.

Guanabenz Downregulates Inflammatory Responses via eIF2α Dependent and Independent Signaling.

Takigawa S, Chen A, Nishimura A, Liu S, Li BY, Sudo A, Yokota H, Hamamura K.

Int J Mol Sci. 2016 May 5;17(5). pii: E674. doi: 10.3390/ijms17050674.

13.

A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.

Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K.

Biochim Biophys Acta. 2016 Aug;1860(8):1753-63. doi: 10.1016/j.bbagen.2016.04.005. Epub 2016 Apr 9.

PMID:
27068854
14.

Role of miR-222-3p in c-Src-Mediated Regulation of Osteoclastogenesis.

Takigawa S, Chen A, Wan Q, Na S, Sudo A, Yokota H, Hamamura K.

Int J Mol Sci. 2016 Feb 16;17(2):240. doi: 10.3390/ijms17020240.

15.

Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.

Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 25;291(13):7017-28. doi: 10.1074/jbc.M115.713412. Epub 2016 Jan 21.

16.

α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts.

Tanaka K, Hirai T, Kodama D, Kondo H, Hamamura K, Togari A.

Br J Pharmacol. 2016 Mar;173(6):1058-69. doi: 10.1111/bph.13418. Epub 2016 Feb 22.

17.

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.

Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.

J Biol Chem. 2016 Mar 4;291(10):4913-27. doi: 10.1074/jbc.M115.696930. Epub 2016 Jan 4.

18.

Emergency cases in internal medicine.

Fukuzawa Y, Yoshitomi A, Nakamori S, Murakami D, Mikamo M, Ibuki E, Ushikoshi H, Hamamura K.

Nihon Naika Gakkai Zasshi. 2015 Nov 10;104(11):2436-44. Japanese. No abstract available.

PMID:
28530360
19.

Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.

Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.

Biochem Biophys Res Commun. 2015 Nov 6;467(1):157-63. doi: 10.1016/j.bbrc.2015.09.086. Epub 2015 Sep 25.

PMID:
26403971
20.

MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.

Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, Liu Y, Jin Y, Shi S.

Cell Metab. 2015 Oct 6;22(4):606-18. doi: 10.1016/j.cmet.2015.08.018. Epub 2015 Sep 10.

21.

Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.

Xu W, Wan Q, Na S, Yokota H, Yan JL, Hamamura K.

Cell Signal. 2015 Dec;27(12):2332-42. doi: 10.1016/j.cellsig.2015.08.014. Epub 2015 Aug 21.

PMID:
26303573
23.

Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis.

Hamamura K, Nishimura A, Iino T, Takigawa S, Sudo A, Yokota H.

Bone Joint Res. 2015 May;4(5):84-92. doi: 10.1302/2046-3758.45.2000378.

24.

Multiple-herbicide resistance in Echinochloa crus-galli var. formosensis, an allohexaploid weed species, in dry-seeded rice.

Iwakami S, Hashimoto M, Matsushima K, Watanabe H, Hamamura K, Uchino A.

Pestic Biochem Physiol. 2015 Mar;119:1-8. doi: 10.1016/j.pestbp.2015.02.007. Epub 2015 Feb 25.

PMID:
25868810
25.

Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy.

Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y.

Ann Clin Biochem. 2016 Jan;53(Pt 1):85-96. doi: 10.1177/0004563215583697. Epub 2015 Apr 2.

PMID:
25838414
26.

Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis.

Hamamura K, Nishimura A, Chen A, Takigawa S, Sudo A, Yokota H.

Cell Signal. 2015 Apr;27(4):828-35. doi: 10.1016/j.cellsig.2015.01.010. Epub 2015 Jan 22.

27.

In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz.

Hamamura K, Chen A, Tanjung N, Takigawa S, Sudo A, Yokota H.

Cell Signal. 2015 Feb;27(2):353-62. doi: 10.1016/j.cellsig.2014.11.020. Epub 2014 Nov 27.

PMID:
25435425
28.

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis.

Hamamura K, Chen A, Nishimura A, Tanjung N, Sudo A, Yokota H.

Cell Signal. 2014 Nov;26(11):2358-69. doi: 10.1016/j.cellsig.2014.07.018. Epub 2014 Jul 16.

29.

Attenuation of malignant phenotypes of breast cancer cells through eIF2α-mediated downregulation of Rac1 signaling.

Hamamura K, Minami K, Tanjung N, Wan Q, Koizumi M, Matsuura N, Na S, Yokota H.

Int J Oncol. 2014 Jun;44(6):1980-8. doi: 10.3892/ijo.2014.2366. Epub 2014 Apr 2.

PMID:
24691491
30.

24-hour rhythm of aquaporin-3 function in the epidermis is regulated by molecular clocks.

Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.

J Invest Dermatol. 2014 Jun;134(6):1636-1644. doi: 10.1038/jid.2014.13. Epub 2014 Jan 13.

31.

Knee loading reduces MMP13 activity in the mouse cartilage.

Hamamura K, Zhang P, Zhao L, Shim JW, Chen A, Dodge TR, Wan Q, Shih H, Na S, Lin CC, Sun HB, Yokota H.

BMC Musculoskelet Disord. 2013 Nov 1;14:312. doi: 10.1186/1471-2474-14-312.

32.

Clinical peptidomic analysis by a one-step direct transfer technology: its potential utility for monitoring of pathophysiological status in female reproductive system disorders.

Araki Y, Nonaka D, Hamamura K, Yanagida M, Ishikawa H, Banzai M, Maruyama M, Endo S, Tajima A, Lee LJ, Nojima M, Takamori K, Yoshida K, Takeda S, Tanaka K.

J Obstet Gynaecol Res. 2013 Oct;39(10):1440-8. doi: 10.1111/jog.12140. Epub 2013 Sep 5. Review.

PMID:
24033768
33.

Rac1 mediates load-driven attenuation of mRNA expression of nerve growth factor beta in cartilage and chondrocytes.

Shim JW, Hamamura K, Chen A, Wan Q, Na S, Yokota H.

J Musculoskelet Neuronal Interact. 2013 Sep;13(3):372-9.

34.

Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells.

Yokota H, Hamamura K, Chen A, Dodge TR, Tanjung N, Abedinpoor A, Zhang P.

BMC Musculoskelet Disord. 2013 Jul 1;14:197. doi: 10.1186/1471-2474-14-197.

35.

Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.

Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, Okajima T, Furukawa K, Urano T, Furukawa K.

J Biol Chem. 2013 Aug 16;288(33):24264-76. doi: 10.1074/jbc.M113.455006. Epub 2013 Jun 27.

36.

Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha.

Hamamura K, Tanjung N, Yokota H.

J Bone Miner Metab. 2013 Nov;31(6):618-28. doi: 10.1007/s00774-013-0450-0. Epub 2013 Mar 28.

PMID:
23536193
37.

Salubrinal reduces expression and activity of MMP13 in chondrocytes.

Hamamura K, Lin CC, Yokota H.

Osteoarthritis Cartilage. 2013 May;21(5):764-72. doi: 10.1016/j.joca.2013.02.657. Epub 2013 Mar 7.

38.

Molecular mechanism regulating 24-hour rhythm of dopamine D3 receptor expression in mouse ventral striatum.

Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.

Mol Pharmacol. 2013 May;83(5):959-67. doi: 10.1124/mol.112.083535. Epub 2013 Feb 21.

39.

Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.

Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.

Glycoconj J. 2013 Aug;30(6):585-97. doi: 10.1007/s10719-012-9458-2. Epub 2012 Dec 15.

PMID:
23242548
40.

Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering.

Hashimoto N, Hamamura K, Kotani N, Furukawa K, Kaneko K, Honke K, Furukawa K.

Proteomics. 2012 Nov;12(21):3154-63. doi: 10.1002/pmic.201200279. Epub 2012 Oct 1.

PMID:
22936677
41.

Disialyl gangliosides enhance tumor phenotypes with differential modalities.

Furukawa K, Hamamura K, Ohkawa Y, Ohmi Y, Furukawa K.

Glycoconj J. 2012 Dec;29(8-9):579-84. doi: 10.1007/s10719-012-9423-0. Epub 2012 Jul 5. Review.

PMID:
22763744
42.

Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.

Shibuya H, Hamamura K, Hotta H, Matsumoto Y, Nishida Y, Hattori H, Furukawa K, Ueda M, Furukawa K.

Cancer Sci. 2012 Sep;103(9):1656-64. doi: 10.1111/j.1349-7006.2012.02344.x. Epub 2012 Jul 16.

43.

Fine tuning of cell signals by glycosylation.

Furukawa K, Ohkawa Y, Yamauchi Y, Hamamura K, Ohmi Y, Furukawa K.

J Biochem. 2012 Jun;151(6):573-8. doi: 10.1093/jb/mvs043. Epub 2012 May 22. Review.

PMID:
22621974
44.

Salubrinal promotes healing of surgical wounds in rat femurs.

Zhang P, Hamamura K, Jiang C, Zhao L, Yokota H.

J Bone Miner Metab. 2012 Sep;30(5):568-79. doi: 10.1007/s00774-012-0359-z. Epub 2012 May 19.

PMID:
22610062
45.

RhoA-mediated signaling in mechanotransduction of osteoblasts.

Hamamura K, Swarnkar G, Tanjung N, Cho E, Li J, Na S, Yokota H.

Connect Tissue Res. 2012;53(5):398-406. doi: 10.3109/03008207.2012.671398. Epub 2012 Apr 10.

PMID:
22420753
46.

Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells.

Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshiyama Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.

Mol Pharmacol. 2012 May;81(5):739-47. doi: 10.1124/mol.111.076406. Epub 2012 Feb 21.

47.

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.

Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, Tsuchida A, Matsubara T, Hori T, Okajima T, Furukawa K, Urano T, Furukawa K.

Biochem Biophys Res Commun. 2012 Mar 2;419(1):7-13. doi: 10.1016/j.bbrc.2012.01.086. Epub 2012 Jan 28.

PMID:
22306014
48.

Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.

Yamamoto S, Matsunaga N, Hitaka T, Yamada M, Hara T, Miyazaki J, Santou T, Kusaka M, Yamaoka M, Kanzaki N, Furuya S, Tasaka A, Hamamura K, Ito M.

Bioorg Med Chem. 2012 Jan 1;20(1):422-34. doi: 10.1016/j.bmc.2011.10.067. Epub 2011 Oct 28.

PMID:
22094279
49.

Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor.

Miwa K, Hitaka T, Imada T, Sasaki S, Yoshimatsu M, Kusaka M, Tanaka A, Nakata D, Furuya S, Endo S, Hamamura K, Kitazaki T.

J Med Chem. 2011 Jul 28;54(14):4998-5012. doi: 10.1021/jm200216q. Epub 2011 Jun 23.

PMID:
21657270
50.

Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen.

Yamauchi Y, Furukawa K, Hamamura K, Furukawa K.

Cancer Res. 2011 Jul 15;71(14):4989-97. doi: 10.1158/0008-5472.CAN-10-4108. Epub 2011 Jun 1.

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