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Items: 1 to 50 of 216

1.

111In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis.

Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T.

Ann Nucl Med. 2019 Oct 12. doi: 10.1007/s12149-019-01408-y. [Epub ahead of print]

PMID:
31605356
2.

Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome.

Tachibana K, Ishimoto K, Takahashi R, Kadono H, Awaji T, Yuzuriha T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Aoki S, Doi T.

Chem Pharm Bull (Tokyo). 2019;67(3):199-202. doi: 10.1248/cpb.c18-00627.

3.

Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface.

Yamashita T, Mizohata E, Nagatoishi S, Watanabe T, Nakakido M, Iwanari H, Mochizuki Y, Nakayama T, Kado Y, Yokota Y, Matsumura H, Kawamura T, Kodama T, Hamakubo T, Inoue T, Fujitani H, Tsumoto K.

Structure. 2019 Mar 5;27(3):519-527.e5. doi: 10.1016/j.str.2018.11.002. Epub 2018 Dec 27.

PMID:
30595454
4.

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin.

Tashima T, Nagatoishi S, Caaveiro JMM, Nakakido M, Sagara H, Kusano-Arai O, Iwanari H, Mimuro H, Hamakubo T, Ohnuma SI, Tsumoto K.

Commun Biol. 2018 Apr 19;1:33. doi: 10.1038/s42003-018-0038-2. eCollection 2018.

5.

Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody.

Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K.

J Struct Biol. 2018 Nov;204(2):207-214. doi: 10.1016/j.jsb.2018.08.011. Epub 2018 Aug 18.

PMID:
30125694
6.

Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.

Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S.

Nat Struct Mol Biol. 2018 Jul;25(7):570-576. doi: 10.1038/s41594-018-0079-8. Epub 2018 Jul 2.

PMID:
29967536
7.

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody.

Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K.

Biochemistry. 2018 Jul 17;57(28):4177-4185. doi: 10.1021/acs.biochem.8b00592. Epub 2018 Jul 5.

PMID:
29936828
8.

Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody.

Miyanabe K, Akiba H, Kuroda D, Nakakido M, Kusano-Arai O, Iwanari H, Hamakubo T, Caaveiro JMM, Tsumoto K.

J Biochem. 2018 Jul 1;164(1):65-76. doi: 10.1093/jb/mvy032.

PMID:
29924367
9.

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.

Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00116-18. doi: 10.1128/MCB.00116-18. Print 2018 Aug 15.

10.

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T.

J Biol Chem. 2018 Jun 29;293(26):10333-10343. doi: 10.1074/jbc.RA118.002077. Epub 2018 May 15.

11.

Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17.

Kusano-Arai O, Iwanari H, Kudo S, Kikuchi C, Yui A, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T.

Monoclon Antib Immunodiagn Immunother. 2018 Feb;37(1):1-11. doi: 10.1089/mab.2017.0043.

PMID:
29474162
12.

Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.

Shimazu T, Furuse T, Balan S, Yamada I, Okuno S, Iwanari H, Suzuki T, Hamakubo T, Dohmae N, Yoshikawa T, Wakana S, Shinkai Y.

Sci Rep. 2018 Jan 19;8(1):1179. doi: 10.1038/s41598-018-19615-4.

13.

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells.

Miura T, Kume M, Kawamura T, Yamamoto K, Hamakubo T, Nishihara S.

Stem Cell Reports. 2018 Jan 9;10(1):272-286. doi: 10.1016/j.stemcr.2017.11.007. Epub 2017 Dec 14.

14.

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

Chowdhury AMMA, Katoh H, Hatanaka A, Iwanari H, Nakamura N, Hamakubo T, Natsume T, Waku T, Kobayashi A.

Sci Rep. 2017 Oct 2;7(1):12494. doi: 10.1038/s41598-017-12675-y.

15.

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen.

Yumura K, Akiba H, Nagatoishi S, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K.

J Biochem. 2017 Sep 1;162(3):203-210. doi: 10.1093/jb/mvx023.

PMID:
28637250
16.

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

Ishimoto K, Hayase A, Kumagai F, Kawai M, Okuno H, Hino N, Okada Y, Kawamura T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Tachibana K, Doi T.

Biochem Biophys Res Commun. 2017 Jun 17;488(1):159-164. doi: 10.1016/j.bbrc.2017.04.159. Epub 2017 May 5.

PMID:
28483528
17.

Correction: Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.

Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata KI, Mizutani KI.

Development. 2017 May 1;144(9):1735. doi: 10.1242/dev.153130. No abstract available.

18.

Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.

Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y.

PLoS One. 2017 Apr 10;12(4):e0175452. doi: 10.1371/journal.pone.0175452. eCollection 2017.

19.

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H, Osawa T.

Cell Rep. 2017 Feb 28;18(9):2228-2242. doi: 10.1016/j.celrep.2017.02.006.

20.

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.

Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata KI, Mizutani KI.

Development. 2017 Feb 1;144(3):385-399. doi: 10.1242/dev.136382. Epub 2016 Dec 19. Erratum in: Development. 2017 May 1;144(9):1735.

21.

Optical inactivation of synaptic AMPA receptors erases fear memory.

Takemoto K, Iwanari H, Tada H, Suyama K, Sano A, Nagai T, Hamakubo T, Takahashi T.

Nat Biotechnol. 2017 Jan;35(1):38-47. doi: 10.1038/nbt.3710. Epub 2016 Dec 5.

PMID:
27918547
22.

Visualization of ligand-induced Gi-protein activation in chemotaxing cells.

Masuda K, Kitakami JI, Kozasa T, Kodama T, Ihara S, Hamakubo T.

FASEB J. 2017 Mar;31(3):910-919. doi: 10.1096/fj.201601102R. Epub 2016 Nov 23.

PMID:
27881485
23.

Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.

Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T.

PLoS One. 2016 Oct 31;11(10):e0165766. doi: 10.1371/journal.pone.0165766. eCollection 2016.

24.

The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs.

Daigo K, Takamatsu Y, Hamakubo T.

Front Immunol. 2016 Sep 7;7:344. doi: 10.3389/fimmu.2016.00344. eCollection 2016. Review.

25.

Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer.

Matsusaka K, Ushiku T, Urabe M, Fukuyo M, Abe H, Ishikawa S, Seto Y, Aburatani H, Hamakubo T, Kaneda A, Fukayama M.

Oncotarget. 2016 Sep 27;7(39):64168-64181. doi: 10.18632/oncotarget.11638.

26.

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients.

Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, Kobayashi M, Mita Y, Shichiri M, Hisahara S, Hara Y, Fujimura H, Takamatsu H, Hagihara Y, Yoshida Y, Hamakubo T, Kusunoki S, Shimohama S, Noguchi N.

Sci Rep. 2016 Jul 29;6:30793. doi: 10.1038/srep30793.

27.

The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis.

Huang P, Takai Y, Kusano-Arai O, Ramadhanti J, Iwanari H, Miyauchi T, Sakihama T, Han JY, Aoki M, Hamakubo T, Fujihara K, Yasui M, Abe Y.

Biochem Biophys Rep. 2016 May 26;7:77-83. doi: 10.1016/j.bbrep.2016.05.017. eCollection 2016 Sep.

28.

Kinetic exclusion assay of monoclonal antibody affinity to the membrane protein Roundabout 1 displayed on baculovirus.

Kusano-Arai O, Fukuda R, Kamiya W, Iwanari H, Hamakubo T.

Anal Biochem. 2016 Jul 1;504:41-9. doi: 10.1016/j.ab.2016.04.004. Epub 2016 Apr 16.

PMID:
27095060
29.

Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.

Iba T, Hamakubo T, Nagaoka I, Sato K, Thachil J.

Microcirculation. 2016 Apr;23(3):240-7. doi: 10.1111/micc.12269.

PMID:
26806786
30.

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4.

Enomoto S, Mitsui K, Kawamura T, Iwanari H, Daigo K, Horiuchi K, Minami T, Kodama T, Hamakubo T.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):797-802. doi: 10.1016/j.bbrc.2015.12.075. Epub 2015 Dec 20.

PMID:
26713366
31.

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody.

Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M.

Acta Neuropathol Commun. 2015 Dec 4;3:82. doi: 10.1186/s40478-015-0259-2.

32.

Crystal structure of the anion exchanger domain of human erythrocyte band 3.

Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, Abe Y, Hino T, Ikeda-Suno C, Kuma H, Kang D, Murata T, Hamakubo T, Cameron AD, Kobayashi T, Hamasaki N, Iwata S.

Science. 2015 Nov 6;350(6261):680-4. doi: 10.1126/science.aaa4335.

33.

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.

Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T.

Sci Rep. 2015 Oct 6;5:14780. doi: 10.1038/srep14780.

34.

Structure and mechanism of the mammalian fructose transporter GLUT5.

Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D.

Nature. 2015 Oct 15;526(7573):397-401. doi: 10.1038/nature14909. Epub 2015 Sep 30.

35.

High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.

Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y.

Br J Pharmacol. 2016 Jan;173(1):103-14. doi: 10.1111/bph.13340. Epub 2015 Nov 4.

36.

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.

Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.

Biochem Biophys Res Commun. 2015 Oct 2;465(4):725-31. doi: 10.1016/j.bbrc.2015.08.065. Epub 2015 Aug 18.

PMID:
26296461
37.

MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.

Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T, Okano H.

Stem Cell Reports. 2015 Sep 8;5(3):365-77. doi: 10.1016/j.stemcr.2015.06.006. Epub 2015 Jul 23.

38.

90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts.

Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.

PLoS One. 2015 May 27;10(5):e0125468. doi: 10.1371/journal.pone.0125468. eCollection 2015.

39.

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.

Morita M, Sekine A, Urano Y, Nishimura T, Takabe W, Arai H, Hamakubo T, Kodama T, Noguchi N.

J Biochem. 2015 Oct;158(4):331-8. doi: 10.1093/jb/mvv044. Epub 2015 May 21.

PMID:
25998247
40.

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.

Csincsi ÁI, Kopp A, Zöldi M, Bánlaki Z, Uzonyi B, Hebecker M, Caesar JJ, Pickering MC, Daigo K, Hamakubo T, Lea SM, Goicoechea de Jorge E, Józsi M.

J Immunol. 2015 May 15;194(10):4963-73. doi: 10.4049/jimmunol.1403121. Epub 2015 Apr 8.

41.

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.

Nishimura T, Kawamura T, Sugihara Y, Bando Y, Sakamoto S, Nomura M, Ikeda N, Ohira T, Fujimoto J, Tojo H, Hamakubo T, Kodama T, Andersson R, Fehniger TE, Kato H, Marko-Varga G.

Clin Transl Med. 2014 Nov 22;3(1):61. doi: 10.1186/s40169-014-0038-x. eCollection 2014 Dec.

42.

Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor.

Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N.

Monoclon Antib Immunodiagn Immunother. 2014 Dec;33(6):378-85. doi: 10.1089/mab.2014.0041.

43.

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses.

Nakayama T, Mizohata E, Yamashita T, Nagatoishi S, Nakakido M, Iwanari H, Mochizuki Y, Kado Y, Yokota Y, Satoh R, Tsumoto K, Fujitani H, Kodama T, Hamakubo T, Inoue T.

Protein Sci. 2015 Mar;24(3):328-40. doi: 10.1002/pro.2619. Epub 2015 Jan 13.

44.

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.

Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M.

Nat Med. 2015 Jan;21(1):19-26. doi: 10.1038/nm.3759. Epub 2014 Dec 8.

PMID:
25485908
45.

Differential expression of pentraxin 3 in neutrophils.

Razvina O, Jiang S, Matsubara K, Ohashi R, Hasegawa G, Aoyama T, Daigo K, Kodama T, Hamakubo T, Naito M.

Exp Mol Pathol. 2015 Feb;98(1):33-40. doi: 10.1016/j.yexmp.2014.11.009. Epub 2014 Nov 20.

PMID:
25449330
46.

Laboratory-size three-dimensional x-ray microscope with Wolter type I mirror optics and an electron-impact water window x-ray source.

Ohsuka S, Ohba A, Onoda S, Nakamoto K, Nakano T, Miyoshi M, Soda K, Hamakubo T.

Rev Sci Instrum. 2014 Sep;85(9):093701. doi: 10.1063/1.4894468.

PMID:
25273730
47.

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.

Daigo K, Nakakido M, Ohashi R, Fukuda R, Matsubara K, Minami T, Yamaguchi N, Inoue K, Jiang S, Naito M, Tsumoto K, Hamakubo T.

Sci Signal. 2014 Sep 16;7(343):ra88. doi: 10.1126/scisignal.2005522.

PMID:
25227610
48.

Generation of antibodies against membrane proteins.

Hamakubo T, Kusano-Arai O, Iwanari H.

Biochim Biophys Acta. 2014 Nov;1844(11):1920-1924. doi: 10.1016/j.bbapap.2014.08.007. Epub 2014 Aug 15. Review.

PMID:
25135856
49.

A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy.

Fujiwara K, Koyama K, Suga K, Ikemura M, Saito Y, Hino A, Iwanari H, Kusano-Arai O, Mitsui K, Kasahara H, Fukayama M, Kodama T, Hamakubo T, Momose T.

EJNMMI Res. 2014 Jun 1;4:29. doi: 10.1186/s13550-014-0029-3. eCollection 2014.

50.

Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.

Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T.

Mol Pharmacol. 2014 Sep;86(3):252-62. doi: 10.1124/mol.114.093914. Epub 2014 Jun 23. Erratum in: Mol Pharmacol. 2015 Nov;88(5):880.

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