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Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research.

Hamad ARA, Sadasivam M, Rabb H.

J Clin Invest. 2019 Aug 5;130:3527-3529. doi: 10.1172/JCI130313. eCollection 2019 Aug 5.


A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen.

Ahmed R, Omidian Z, Giwa A, Cornwell B, Majety N, Bell DR, Lee S, Zhang H, Michels A, Desiderio S, Sadegh-Nasseri S, Rabb H, Gritsch S, Suva ML, Cahan P, Zhou R, Jie C, Donner T, Hamad ARA.

Cell. 2019 May 30;177(6):1583-1599.e16. doi: 10.1016/j.cell.2019.05.007.


IL-17 and limits of success.

Omidian Z, Ahmed R, Giwa A, Donner T, Hamad ARA.

Cell Immunol. 2019 May;339:33-40. doi: 10.1016/j.cellimm.2018.09.001. Epub 2018 Sep 17.


Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2.

Sadasivam M, Noel S, Lee SA, Gong J, Allaf ME, Pierorazio P, Rabb H, Hamad ARA.

J Am Soc Nephrol. 2019 Feb;30(2):277-292. doi: 10.1681/ASN.2018080815. Epub 2019 Jan 8.


Gut Microbiota-Kidney Cross-Talk in Acute Kidney Injury.

Gong J, Noel S, Pluznick JL, Hamad ARA, Rabb H.

Semin Nephrol. 2019 Jan;39(1):107-116. doi: 10.1016/j.semnephrol.2018.10.009. Review.


Unexpected alliance between syndecan-1 and innate-like T cells to protect host from autoimmune effects of interleukin-17.

Jaiswal AK, Sadasivam M, Hamad ARA.

World J Diabetes. 2018 Dec 15;9(12):220-225. doi: 10.4239/wjd.v9.i12.220. Review.


Hiding in plain sight: time to unlock autoimmune clues in human CD5+ B cells by using nextgen technology.

Ahmed R, Omidian Z, Donner T, Hamad ARA.

Discov Med. 2018 Sep;26(142):79-83.


Syndecan-1 Regulates Psoriasiform Dermatitis by Controlling Homeostasis of IL-17-Producing γδ T Cells.

Jaiswal AK, Sadasivam M, Archer NK, Miller RJ, Dillen CA, Ravipati A, Park PW, Chakravarti S, Miller LS, Hamad ARA.

J Immunol. 2018 Sep 15;201(6):1651-1661. doi: 10.4049/jimmunol.1800104. Epub 2018 Jul 25.


Characterization of kidney CD45intCD11bintF4/80+MHCII+CX3CR1+Ly6C- "intermediate mononuclear phagocytic cells".

Lee SA, Noel S, Sadasivam M, Allaf ME, Pierorazio PM, Hamad ARA, Rabb H.

PLoS One. 2018 Jun 1;13(6):e0198608. doi: 10.1371/journal.pone.0198608. eCollection 2018. Erratum in: PLoS One. 2018 Jun 27;13(6):e0200056.


KEAP1 Editing Using CRISPR/Cas9 for Therapeutic NRF2 Activation in Primary Human T Lymphocytes.

Noel S, Lee SA, Sadasivam M, Hamad ARA, Rabb H.

J Immunol. 2018 Mar 1;200(5):1929-1936. doi: 10.4049/jimmunol.1700812. Epub 2018 Jan 19.


Editorial: Ying and Yang Members of the Tumor Necrosis Factor Superfamily: Friends or Foes in Immune-Mediated Diseases and Cancer.

Giwa A, Ahmed R, Donner T, Yagita H, Hamad ARA.

Front Immunol. 2017 Nov 23;8:1584. doi: 10.3389/fimmu.2017.01584. eCollection 2017. No abstract available.


Role of Immune Cells in Acute Kidney Injury and Repair.

Lee SA, Noel S, Sadasivam M, Hamad ARA, Rabb H.

Nephron. 2017;137(4):282-286. doi: 10.1159/000477181. Epub 2017 Jun 10. Review.


Syndecan-1-coating of interleukin-17-producing natural killer T cells provides a specific method for their visualization and analysis.

Jaiswal AK, Sadasivam M, Hamad ARA.

World J Diabetes. 2017 Apr 15;8(4):130-134. doi: 10.4239/wjd.v8.i4.130. Review.


Expansion of FasL-Expressing CD5+ B Cells in Type 1 Diabetes Patients.

Saxena A, Yagita H, Donner TW, Hamad ARA.

Front Immunol. 2017 Apr 7;8:402. doi: 10.3389/fimmu.2017.00402. eCollection 2017.


Beta-cell Specific Autoantibodies: Are they Just an Indicator of Type 1 Diabetes?

Fousteri G, Ippolito E, Ahmed R, Hamad ARA.

Curr Diabetes Rev. 2017;13(3):322-329. doi: 10.2174/1573399812666160427104157. Review.


B cell-targeted immunotherapy for type 1 diabetes: What can make it work?

Hamad AR, Ahmed R, Donner T, Fousteri G.

Discov Med. 2016 Mar;21(115):213-9. Review.


Sex and the single transplanted kidney.

Noel S, Desai NM, Hamad AR, Rabb H.

J Clin Invest. 2016 May 2;126(5):1643-5. doi: 10.1172/JCI87428. Epub 2016 Apr 18.


Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases.

Noel S, Hamad AR, Rabb H.

Kidney Int. 2015 Dec;88(6):1217-1218. doi: 10.1038/ki.2015.328.


From non-obese diabetic to Network for the Pancreatic Organ Donor with Diabetes: New heights in type 1 diabetes research.

Ramirez L, Hamad AR.

World J Diabetes. 2015 Nov 25;6(16):1309-11. doi: 10.4239/wjd.v6.i16.1309.


Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney.

Martina MN, Noel S, Saxena A, Bandapalle S, Majithia R, Jie C, Arend LJ, Allaf ME, Rabb H, Hamad AR.

J Am Soc Nephrol. 2016 Apr;27(4):1113-23. doi: 10.1681/ASN.2014121214. Epub 2015 Aug 27.


Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells in mice.

Dai H, Rahman A, Saxena A, Jaiswal AK, Mohamood A, Ramirez L, Noel S, Rabb H, Jie C, Hamad AR.

Eur J Immunol. 2015 Nov;45(11):3045-51. doi: 10.1002/eji.201545532. Epub 2015 Sep 10.


T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.

Noel S, Martina MN, Bandapalle S, Racusen LC, Potteti HR, Hamad AR, Reddy SP, Rabb H.

J Am Soc Nephrol. 2015 Dec;26(12):2989-3000. doi: 10.1681/ASN.2014100978. Epub 2015 Aug 20.


Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy.

Saxena A, Khosraviani S, Noel S, Mohan D, Donner T, Hamad AR.

Cytokine. 2015 Jul;74(1):27-34. doi: 10.1016/j.cyto.2014.10.031. Epub 2014 Dec 4. Review.


Double negative (DN) αβ T cells: misperception and overdue recognition.

Martina MN, Noel S, Saxena A, Rabb H, Hamad AR.

Immunol Cell Biol. 2015 Mar;93(3):305-10. doi: 10.1038/icb.2014.99. Epub 2014 Nov 25. Review.


Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease.

Noel S, Martina-Lingua MN, Bandapalle S, Pluznick J, Hamad AR, Peterson DA, Rabb H.

Nephron Clin Pract. 2014;127(1-4):139-43. doi: 10.1159/000363209. Epub 2014 Sep 24. Review.


T lymphocytes and acute kidney injury: update.

Martina MN, Noel S, Bandapalle S, Hamad AR, Rabb H.

Nephron Clin Pract. 2014;127(1-4):51-5. doi: 10.1159/000363719. Epub 2014 Sep 24. Review.


Isolation of double negative αβ T cells from the kidney.

Martina MN, Bandapalle S, Rabb H, Hamad AR.

J Vis Exp. 2014 May 16;(87). doi: 10.3791/51192.


Status of autoimmune diabetes 20-year after generation of BDC2.5-TCR transgenic non-obese diabetic mouse.

Ramirez L, Hamad AR.

World J Diabetes. 2013 Aug 15;4(4):88-91. doi: 10.4239/wjd.v4.i4.88.


Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model.

Shao H, Scott SG, Nakata C, Hamad AR, Chakravarti S.

PLoS One. 2013;8(1):e54765. doi: 10.1371/journal.pone.0054765. Epub 2013 Jan 24.


Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity.

Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S.

J Biol Chem. 2012 Oct 19;287(43):35860-72. doi: 10.1074/jbc.M112.380550. Epub 2012 Aug 3. Erratum in: J Biol Chem. 2014 Dec 5;289(49):33874.


The potential of Fas ligand (apoptosis-inducing molecule) as an unconventional therapeutic target in type 1 diabetes.

Hamad AR, Arcara K, Uddin S, Donner T.

Front Immunol. 2012 Jul 12;3:196. doi: 10.3389/fimmu.2012.00196. eCollection 2012.


Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.

Xiao Z, Mohamood AS, Uddin S, Gutfreund R, Nakata C, Marshall A, Kimura H, Caturegli P, Womer KL, Huang Y, Jie C, Chakravarti S, Schneck JP, Yagita H, Hamad AR.

Am J Pathol. 2011 Aug;179(2):725-32. doi: 10.1016/j.ajpath.2011.04.016. Epub 2011 Jun 15.


Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis.

Lohr K, Sardana H, Lee S, Wu F, Huso DL, Hamad AR, Chakravarti S.

Inflamm Bowel Dis. 2012 Jan;18(1):143-51. doi: 10.1002/ibd.21713. Epub 2011 Apr 11.


Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury.

Ko GJ, Jang HR, Huang Y, Womer KL, Liu M, Higbee E, Xiao Z, Yagita H, Racusen L, Hamad AR, Rabb H.

J Am Soc Nephrol. 2011 Apr;22(4):732-42. doi: 10.1681/ASN.2010010121. Epub 2011 Mar 24.


Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin.

Lee S, Bowrin K, Hamad AR, Chakravarti S.

J Biol Chem. 2009 Aug 28;284(35):23662-9. doi: 10.1074/jbc.M109.026229. Epub 2009 Jun 15.


Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.

Rhee KJ, Wu S, Wu X, Huso DL, Karim B, Franco AA, Rabizadeh S, Golub JE, Mathews LE, Shin J, Sartor RB, Golenbock D, Hamad AR, Gan CM, Housseau F, Sears CL.

Infect Immun. 2009 Apr;77(4):1708-18. doi: 10.1128/IAI.00814-08. Epub 2009 Feb 2.


Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells.

Mohamood AS, Bargatze D, Xiao Z, Jie C, Yagita H, Ruben D, Watson J, Chakravarti S, Schneck JP, Hamad AR.

PLoS One. 2008;3(10):e3465. doi: 10.1371/journal.pone.0003465. Epub 2008 Oct 21.


High-fat diet modulates non-CD1d-restricted natural killer T cells and regulatory T cells in mouse colon and exacerbates experimental colitis.

Ma X, Torbenson M, Hamad AR, Soloski MJ, Li Z.

Clin Exp Immunol. 2008 Jan;151(1):130-8. Epub 2007 Nov 7.


A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury.

Ma X, Hua J, Mohamood AR, Hamad AR, Ravi R, Li Z.

Hepatology. 2007 Nov;46(5):1519-29.


Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically.

Mohamood AS, Guler ML, Xiao Z, Zheng D, Hess A, Wang Y, Yagita H, Schneck JP, Hamad AR.

Am J Pathol. 2007 Jul;171(1):97-106.


Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells.

Mohamood AS, Trujillo CJ, Zheng D, Jie C, Murillo FM, Schneck JP, Hamad AR.

Int Immunol. 2006 Aug;18(8):1265-77. Epub 2006 Jun 12.


B220+ double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production.

Hamad AR, Mohamood AS, Trujillo CJ, Huang CT, Yuan E, Schneck JP.

J Immunol. 2003 Sep 1;171(5):2421-6.


Antigen-induced T cell death is regulated by CD4 expression.

Hamad AR, Schneck JP.

Int Rev Immunol. 2001 Oct;20(5):535-46. Review.


Brucellosis among animals and human contacts in eastern Sudan.

El-Ansary EH, Mohammed BA, Hamad AR, Karom AG.

Saudi Med J. 2001 Jul;22(7):577-9.


Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity.

Hamad AR, Srikrishnan A, Mirmonsef P, Broeren CP, June CH, Pardoll D, Schneck JP.

J Exp Med. 2001 May 21;193(10):1113-21.


Soluble, high-affinity dimers of T-cell receptors and class II major histocompatibility complexes: biochemical probes for analysis and modulation of immune responses.

Lebowitz MS, O'Herrin SM, Hamad AR, Fahmy T, Marguet D, Barnes NC, Pardoll D, Bieler JG, Schneck JP.

Cell Immunol. 1999 Mar 15;192(2):175-84.


Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor.

Hamad AR, O'Herrin SM, Lebowitz MS, Srikrishnan A, Bieler J, Schneck J, Pardoll D.

J Exp Med. 1998 Nov 2;188(9):1633-40.


Transcytosis of staphylococcal superantigen toxins.

Hamad AR, Marrack P, Kappler JW.

J Exp Med. 1997 Apr 21;185(8):1447-54.


Murine transfer factors: dose-response relationships and routes of administration.

Kirkpatrick CH, Hamad AR, Morton LC.

Cell Immunol. 1995 Sep;164(2):203-6.


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