Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117

1.

Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila.

Pandey A, Harvey BM, Lopez MF, Ito A, Haltiwanger RS, Jafar-Nejad H.

Cell Rep. 2019 Nov 12;29(7):2054-2066.e6. doi: 10.1016/j.celrep.2019.10.027.

PMID:
31722217
2.

Analyzing the Effects of O-Fucosylation on Secretion of ADAMTS Proteins Using Cell-Based Assays.

Berardinelli SJ, Haltiwanger RS.

Methods Mol Biol. 2020;2043:25-43. doi: 10.1007/978-1-4939-9698-8_3.

PMID:
31463900
3.

Emerging structural insights into glycosyltransferase-mediated synthesis of glycans.

Moremen KW, Haltiwanger RS.

Nat Chem Biol. 2019 Sep;15(9):853-864. doi: 10.1038/s41589-019-0350-2. Epub 2019 Aug 19. Review.

4.

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC.

Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27.

5.

Protein O-fucosylation: structure and function.

Holdener BC, Haltiwanger RS.

Curr Opin Struct Biol. 2019 Jun;56:78-86. doi: 10.1016/j.sbi.2018.12.005. Epub 2019 Jan 26. Review.

PMID:
30690220
6.

Altered Notch Signaling in Dowling-Degos Disease: Additional Mutations in POGLUT1 and Further Insights into Disease Pathogenesis.

Ralser DJ, Takeuchi H, Fritz G, Basmanav FB, Effern M, Sivalingam S, El-Shabrawi-Caelen L, Degirmentepe EN, Kocatürk E, Singh M, Booken N, Spierings NMK, Schnabel V, Heineke A, Knuever J, Wolf S, Wehner M, Tronnier M, Leverkus M, Tantcheva-Poór I, Wenzel J, Oji V, Has C, Hölzel M, Frank J, Haltiwanger RS, Betz RC.

J Invest Dermatol. 2019 Apr;139(4):960-964. doi: 10.1016/j.jid.2018.10.030. Epub 2018 Nov 9. No abstract available.

PMID:
30414910
7.

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.

Takeuchi H, Schneider M, Williamson DB, Ito A, Takeuchi M, Handford PA, Haltiwanger RS.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8395-E8402. doi: 10.1073/pnas.1804005115. Epub 2018 Aug 20.

8.

Regulation of Notch Function by O-Glycosylation.

Harvey BM, Haltiwanger RS.

Adv Exp Med Biol. 2018;1066:59-78. doi: 10.1007/978-3-319-89512-3_4. Review.

PMID:
30030822
9.

Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.

Takeuchi H, Wong D, Schneider M, Freeze HH, Takeuchi M, Berardinelli SJ, Ito A, Lee H, Nelson SF, Haltiwanger RS.

Glycobiology. 2018 May 1;28(5):276-283. doi: 10.1093/glycob/cwy014.

10.

Inhibition of Delta-induced Notch signaling using fucose analogs.

Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, Haltiwanger RS.

Nat Chem Biol. 2018 Jan;14(1):65-71. doi: 10.1038/nchembio.2520. Epub 2017 Nov 27.

11.

Functional characterization of zebrafish orthologs of the human Beta 3-Glucosyltransferase B3GLCT gene mutated in Peters Plus Syndrome.

Weh E, Takeuchi H, Muheisen S, Haltiwanger RS, Semina EV.

PLoS One. 2017 Sep 19;12(9):e0184903. doi: 10.1371/journal.pone.0184903. eCollection 2017.

12.

Other Classes of Eukaryotic Glycans.

Haltiwanger RS, Wells L, Freeze HH, Stanley P.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 13.
2017.

13.

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking.

Takeuchi H, Yu H, Hao H, Takeuchi M, Ito A, Li H, Haltiwanger RS.

J Biol Chem. 2017 Sep 22;292(38):15964-15973. doi: 10.1074/jbc.M117.800102. Epub 2017 Jul 20.

14.

Biological functions of fucose in mammals.

Schneider M, Al-Shareffi E, Haltiwanger RS.

Glycobiology. 2017 Jul 1;27(7):601-618. doi: 10.1093/glycob/cwx034. Review.

15.

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC.

Science. 2017 Mar 24;355(6331):1320-1324. doi: 10.1126/science.aaf9739. Epub 2017 Mar 2.

16.

Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases.

Sheikh MO, Halmo SM, Patel S, Middleton D, Takeuchi H, Schafer CM, West CM, Haltiwanger RS, Avci FY, Moremen KW, Wells L.

Glycobiology. 2017 Mar 1;27(3):206-212. doi: 10.1093/glycob/cww114.

17.

Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.

Hubmacher D, Schneider M, Berardinelli SJ, Takeuchi H, Willard B, Reinhardt DP, Haltiwanger RS, Apte SS.

Sci Rep. 2017 Feb 8;7:41871. doi: 10.1038/srep41871.

18.

Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.

Kakuda S, Haltiwanger RS.

Dev Cell. 2017 Jan 23;40(2):193-201. doi: 10.1016/j.devcel.2016.12.013. Epub 2017 Jan 12.

19.

A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss.

Servián-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-Gómez E, Rivas E, Nieto-González JL, Rivero MC, Cabrera-Serrano M, Gómez-Sánchez L, Martínez-López JA, Estrada B, Márquez C, Morgado Y, Suárez-Calvet X, Pita G, Bigot A, Gallardo E, Fernández-Chacón R, Hirano M, Haltiwanger RS, Jafar-Nejad H, Paradas C.

EMBO Mol Med. 2016 Nov 2;8(11):1289-1309. doi: 10.15252/emmm.201505815. Print 2016 Nov.

20.

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

Dubail J, Vasudevan D, Wang LW, Earp SE, Jenkins MW, Haltiwanger RS, Apte SS.

Sci Rep. 2016 Sep 30;6:33974. doi: 10.1038/srep33974.

21.

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.

Yu H, Takeuchi H, Takeuchi M, Liu Q, Kantharia J, Haltiwanger RS, Li H.

Nat Chem Biol. 2016 Sep;12(9):735-40. doi: 10.1038/nchembio.2135. Epub 2016 Jul 18.

22.

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.

Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RPT, Apte SS, Haltiwanger RS, Holdener BC.

Dev Biol. 2016 Aug 1;416(1):111-122. doi: 10.1016/j.ydbio.2016.05.038. Epub 2016 Jun 10.

23.

Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.

Harvey BM, Rana NA, Moss H, Leonardi J, Jafar-Nejad H, Haltiwanger RS.

J Biol Chem. 2016 Jul 29;291(31):16348-60. doi: 10.1074/jbc.M116.732537. Epub 2016 Jun 6.

24.

Why we love glycobiology.

Baum LG, Haltiwanger RS.

Glycobiology. 2016 Jun;26(6):543. doi: 10.1093/glycob/cww034. No abstract available.

PMID:
27122386
25.

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.

Valero-González J, Leonhard-Melief C, Lira-Navarrete E, Jiménez-Osés G, Hernández-Ruiz C, Pallarés MC, Yruela I, Vasudevan D, Lostao A, Corzana F, Takeuchi H, Haltiwanger RS, Hurtado-Guerrero R.

Nat Chem Biol. 2016 Apr;12(4):240-6. doi: 10.1038/nchembio.2019. Epub 2016 Feb 8.

26.

Editorial overview: Carbohydrate-protein interactions and glycosylation: Glycan synthesis and recognition: finding the perfect partner in a sugar-coated life.

Feizi TE, Haltiwanger RS.

Curr Opin Struct Biol. 2015 Oct;34:vii-ix. doi: 10.1016/j.sbi.2015.10.005. Epub 2015 Nov 21.

PMID:
26613983
27.

A Quarter Century of Glycobiology.

Hart GW, Schnaar RL, Haltiwanger RS.

Glycobiology. 2015 Dec;25(12):1321-2. doi: 10.1093/glycob/cwv090. No abstract available.

28.

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2.

Ramkumar N, Harvey BM, Lee JD, Alcorn HL, Silva-Gagliardi NF, McGlade CJ, Bestor TH, Wijnholds J, Haltiwanger RS, Anderson KV.

PLoS Genet. 2015 Oct 23;11(10):e1005551. doi: 10.1371/journal.pgen.1005551. eCollection 2015 Oct.

29.

Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.

Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H.

Nat Chem Biol. 2015 Nov;11(11):847-54. doi: 10.1038/nchembio.1927. Epub 2015 Sep 28.

30.

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi).

Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H.

Hepatology. 2016 Feb;63(2):550-65. doi: 10.1002/hep.28024. Epub 2015 Oct 20.

31.

Peters plus syndrome mutations disrupt a noncanonical ER quality-control mechanism.

Vasudevan D, Takeuchi H, Johar SS, Majerus E, Haltiwanger RS.

Curr Biol. 2015 Feb 2;25(3):286-295. doi: 10.1016/j.cub.2014.11.049. Epub 2014 Dec 24.

32.

The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila.

Haltom AR, Lee TV, Harvey BM, Leonardi J, Chen YJ, Hong Y, Haltiwanger RS, Jafar-Nejad H.

PLoS Genet. 2014 Nov 20;10(11):e1004795. doi: 10.1371/journal.pgen.1004795. eCollection 2014 Nov.

33.

Novel roles for O-linked glycans in protein folding.

Vasudevan D, Haltiwanger RS.

Glycoconj J. 2014 Oct;31(6-7):417-26. doi: 10.1007/s10719-014-9556-4.

34.

Analyzing the posttranslational modification status of Notch using mass spectrometry.

Kakuda S, Haltiwanger RS.

Methods Mol Biol. 2014;1187:209-21. doi: 10.1007/978-1-4939-1139-4_16.

PMID:
25053492
35.

Significance of glycosylation in Notch signaling.

Takeuchi H, Haltiwanger RS.

Biochem Biophys Res Commun. 2014 Oct 17;453(2):235-42. doi: 10.1016/j.bbrc.2014.05.115. Epub 2014 Jun 6. Review.

36.

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.

Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5. doi: 10.1073/pnas.1319683111. Epub 2014 May 6.

37.

O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function.

Müller J, Rana NA, Serth K, Kakuda S, Haltiwanger RS, Gossler A.

PLoS One. 2014 Feb 12;9(2):e88571. doi: 10.1371/journal.pone.0088571. eCollection 2014.

38.

Enzymatic analysis of the protein O-glycosyltransferase, Rumi, acting toward epidermal growth factor-like (EGF) repeats.

Takeuchi H, Haltiwanger RS.

Methods Mol Biol. 2013;1022:119-28. doi: 10.1007/978-1-62703-465-4_10.

PMID:
23765658
39.

Negative regulation of notch signaling by xylose.

Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H.

PLoS Genet. 2013 Jun;9(6):e1003547. doi: 10.1371/journal.pgen.1003547. Epub 2013 Jun 6.

40.

A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.

Yamamoto S, Charng WL, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ.

Science. 2012 Nov 30;338(6111):1229-32. doi: 10.1126/science.1228745.

41.

6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.

Al-Shareffi E, Chaubard JL, Leonhard-Melief C, Wang SK, Wong CH, Haltiwanger RS.

Glycobiology. 2013 Feb;23(2):188-98. doi: 10.1093/glycob/cws140. Epub 2012 Oct 8.

42.

Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats.

Takeuchi H, Kantharia J, Sethi MK, Bakker H, Haltiwanger RS.

J Biol Chem. 2012 Oct 5;287(41):33934-44. doi: 10.1074/jbc.M112.401315. Epub 2012 Aug 7.

43.

Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.

Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H.

J Biol Chem. 2012 Jan 20;287(4):2739-48. doi: 10.1074/jbc.M111.302406. Epub 2011 Nov 23.

44.

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.

Takeuchi H, Fernández-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RS.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16600-5. doi: 10.1073/pnas.1109696108. Epub 2011 Sep 26.

45.

Glycobiology: the study of the sweet life.

Haltiwanger RS, Feizi T.

Curr Opin Struct Biol. 2011 Oct;21(5):573-5. doi: 10.1016/j.sbi.2011.08.010. Epub 2011 Sep 22. No abstract available.

PMID:
21945039
46.

Fringe benefits: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors.

Rana NA, Haltiwanger RS.

Curr Opin Struct Biol. 2011 Oct;21(5):583-9. doi: 10.1016/j.sbi.2011.08.008. Epub 2011 Sep 15. Review.

47.

O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.

Rana NA, Nita-Lazar A, Takeuchi H, Kakuda S, Luther KB, Haltiwanger RS.

J Biol Chem. 2011 Sep 9;286(36):31623-37. doi: 10.1074/jbc.M111.268243. Epub 2011 Jul 8.

48.

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.

Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H.

Development. 2011 May;138(10):1925-34. doi: 10.1242/dev.060020. Epub 2011 Apr 13.

49.

O-fucosylation of thrombospondin type 1 repeats.

Leonhard-Melief C, Haltiwanger RS.

Methods Enzymol. 2010;480:401-16. doi: 10.1016/S0076-6879(10)80018-7. Review.

PMID:
20816219
50.

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC.

Dev Biol. 2010 Oct 1;346(1):25-38. doi: 10.1016/j.ydbio.2010.07.008. Epub 2010 Jul 14.

Supplemental Content

Loading ...
Support Center