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Items: 50

1.

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations.

Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M, Halls ML.

Sci Signal. 2018 Oct 9;11(551). pii: eaan1188. doi: 10.1126/scisignal.aan1188.

PMID:
30301787
2.

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists.

Fletcher MM, Halls ML, Zhao P, Clydesdale L, Christopoulos A, Sexton PM, Wootten D.

Biochem Pharmacol. 2018 Sep 7;156:406-419. doi: 10.1016/j.bcp.2018.09.003. [Epub ahead of print]

PMID:
30195733
3.

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M.

Sci Signal. 2018 Jul 17;11(539). pii: eaas9609. doi: 10.1126/scisignal.aas9609.

PMID:
30018083
4.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.

PMID:
30012612
5.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, Porter CJH, McLean P, Hicks GA, Geppetti P, Halls ML, Canals M, Bunnett NW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314. doi: 10.1073/pnas.1706656114. Epub 2017 Oct 30.

6.

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.

Halls ML, Canals M.

Trends Pharmacol Sci. 2018 Feb;39(2):148-157. doi: 10.1016/j.tips.2017.09.005. Epub 2017 Oct 17. Review.

PMID:
29054309
7.

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.

8.

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release.

Ercole F, Whittaker MR, Halls ML, Boyd BJ, Davis TP, Quinn JF.

Chem Commun (Camb). 2017 Jul 13;53(57):8030-8033. doi: 10.1039/c7cc03820h.

PMID:
28671224
9.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW.

Sci Transl Med. 2017 May 31;9(392). pii: eaal3447. doi: 10.1126/scitranslmed.aal3447.

10.

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease.

Lucato CM, Lupton CJ, Halls ML, Ellisdon AM.

J Mol Biol. 2017 May 5;429(9):1289-1304. doi: 10.1016/j.jmb.2017.03.021. Epub 2017 Mar 22. Review.

PMID:
28342736
11.

Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities.

Halls ML, Cooper DMF.

Pharmacol Ther. 2017 Apr;172:171-180. doi: 10.1016/j.pharmthera.2017.01.001. Epub 2017 Jan 26. Review.

PMID:
28132906
12.

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

Furness SGB, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D, Sexton PM.

Cell. 2016 Oct 20;167(3):739-749.e11. doi: 10.1016/j.cell.2016.09.021. Epub 2016 Oct 6.

13.

β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.

Chang A, Le CP, Walker AK, Creed SJ, Pon CK, Albold S, Carroll D, Halls ML, Lane JR, Riedel B, Ferrari D, Sloan EK.

Brain Behav Immun. 2016 Oct;57:106-115. doi: 10.1016/j.bbi.2016.06.011. Epub 2016 Jun 16.

14.

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.

Ang SY, Hutchinson DS, Patil N, Evans BA, Bathgate RAD, Halls ML, Hossain MA, Summers RJ, Kocan M.

Br J Pharmacol. 2017 May;174(10):1077-1089. doi: 10.1111/bph.13522. Epub 2016 Jul 13. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.

15.

The complexity of signalling mediated by the glucagon-like peptide-1 receptor.

Fletcher MM, Halls ML, Christopoulos A, Sexton PM, Wootten D.

Biochem Soc Trans. 2016 Apr 15;44(2):582-8. doi: 10.1042/BST20150244. Review.

PMID:
27068973
16.

Compartmentalization of GPCR signalling controls unique cellular responses.

Ellisdon AM, Halls ML.

Biochem Soc Trans. 2016 Apr 15;44(2):562-7. doi: 10.1042/BST20150236. Review.

PMID:
27068970
17.

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

Halls ML, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP, Canals M.

Sci Signal. 2016 Feb 9;9(414):ra16. doi: 10.1126/scisignal.aac9177.

PMID:
26861044
18.

Macromolecular Hydrogen Sulfide Donors Trigger Spatiotemporally Confined Changes in Cell Signaling.

Ercole F, Mansfeld FM, Kavallaris M, Whittaker MR, Quinn JF, Halls ML, Davis TP.

Biomacromolecules. 2016 Jan 11;17(1):371-83. doi: 10.1021/acs.biomac.5b01469. Epub 2015 Dec 23.

PMID:
26653086
19.

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK.

Breast Cancer Res. 2015 Nov 25;17(1):145. doi: 10.1186/s13058-015-0655-3.

20.

The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.

Pon CK, Lane JR, Sloan EK, Halls ML.

FASEB J. 2016 Mar;30(3):1144-54. doi: 10.1096/fj.15-277798. Epub 2015 Nov 17.

21.

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

Halls ML, Poole DP, Ellisdon AM, Nowell CJ, Canals M.

Methods Mol Biol. 2015;1335:131-61. doi: 10.1007/978-1-4939-2914-6_10.

PMID:
26260599
22.

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.

23.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner.

Hughes ML, Liu B, Halls ML, Wagstaff KM, Patil R, Velkov T, Jans DA, Bunnett NW, Scanlon MJ, Porter CJ.

J Biol Chem. 2015 May 29;290(22):13895-906. doi: 10.1074/jbc.M114.605998. Epub 2015 Apr 6.

25.

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

Jensen DD, Halls ML, Murphy JE, Canals M, Cattaruzza F, Poole DP, Lieu T, Koon HW, Pothoulakis C, Bunnett NW.

J Biol Chem. 2014 Jul 18;289(29):20283-94. doi: 10.1074/jbc.M114.578179. Epub 2014 Jun 4.

26.

Relaxin family peptides and their receptors.

Bathgate RA, Halls ML, van der Westhuizen ET, Callander GE, Kocan M, Summers RJ.

Physiol Rev. 2013 Jan;93(1):405-80. doi: 10.1152/physrev.00001.2012. Review.

27.

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

Willoughby D, Halls ML, Everett KL, Ciruela A, Skroblin P, Klussmann E, Cooper DM.

J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12.

28.

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.

Shen JX, Wachten S, Halls ML, Everett KL, Cooper DM.

Biochem J. 2012 Nov 1;447(3):393-405. doi: 10.1042/BJ20120279.

29.

Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.

Sato M, Hutchinson DS, Halls ML, Furness SG, Bengtsson T, Evans BA, Summers RJ.

J Biol Chem. 2012 Jun 8;287(24):20674-88. doi: 10.1074/jbc.M111.280651. Epub 2012 Apr 25.

30.

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.

Willoughby D, Everett KL, Halls ML, Pacheco J, Skroblin P, Vaca L, Klussmann E, Cooper DM.

Sci Signal. 2012 Apr 10;5(219):ra29. doi: 10.1126/scisignal.2002299.

31.

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

Ayling LJ, Briddon SJ, Halls ML, Hammond GR, Vaca L, Pacheco J, Hill SJ, Cooper DM.

J Cell Sci. 2012 Feb 15;125(Pt 4):869-86. doi: 10.1242/jcs.091090. Epub 2012 Mar 7.

32.

Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation.

Halls ML.

Br J Pharmacol. 2012 Mar;165(6):1644-1658. doi: 10.1111/j.1476-5381.2011.01470.x. Review.

33.

Regulation by Ca2+-signaling pathways of adenylyl cyclases.

Halls ML, Cooper DM.

Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004143. doi: 10.1101/cshperspect.a004143. Review.

34.

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.

Halls ML, Cooper DM.

EMBO J. 2010 Aug 18;29(16):2772-87. doi: 10.1038/emboj.2010.168. Epub 2010 Jul 27.

35.

AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, Ciruela A, Cooper DM.

J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.

36.

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation.

Samuel CS, Mookerjee I, Halls ML, Summers RJ, Chew E, Bathgate RA, Tregear GW, Hewitson TD.

Ann N Y Acad Sci. 2009 Apr;1160:294-9. doi: 10.1111/j.1749-6632.2008.03823.x. Review.

PMID:
19416207
37.

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

Halls ML, Papaioannou M, Wade JD, Evans BA, Bathgate RA, Summers RJ.

Ann N Y Acad Sci. 2009 Apr;1160:117-20. doi: 10.1111/j.1749-6632.2008.03813.x.

PMID:
19416171
38.

Relaxin activates multiple cAMP signaling pathway profiles in different target cells.

Halls ML, Hewitson TD, Moore XL, Du XJ, Bathgate RA, Summers RJ.

Ann N Y Acad Sci. 2009 Apr;1160:108-11. doi: 10.1111/j.1749-6632.2008.03814.x.

PMID:
19416169
39.

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

Summers RJ, Bathgate RA, Wade JD, van der Westhuizen ET, Halls ML.

Ann N Y Acad Sci. 2009 Apr;1160:99-104. doi: 10.1111/j.1749-6632.2009.03828.x.

PMID:
19416167
40.

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2.

Mookerjee I, Hewitson TD, Halls ML, Summers RJ, Mathai ML, Bathgate RA, Tregear GW, Samuel CS.

FASEB J. 2009 Apr;23(4):1219-29. doi: 10.1096/fj.08-120857. Epub 2008 Dec 10.

PMID:
19073841
41.

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

Halls ML, van der Westhuizen ET, Wade JD, Evans BA, Bathgate RA, Summers RJ.

Mol Pharmacol. 2009 Feb;75(2):415-28. doi: 10.1124/mol.108.051227. Epub 2008 Nov 24.

42.

Relaxin family peptide receptors--from orphans to therapeutic targets.

van der Westhuizen ET, Halls ML, Samuel CS, Bathgate RA, Unemori EN, Sutton SW, Summers RJ.

Drug Discov Today. 2008 Aug;13(15-16):640-51. doi: 10.1016/j.drudis.2008.04.002. Epub 2008 Jun 6. Review.

PMID:
18675759
43.

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways.

Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ.

Br J Pharmacol. 2007 Mar;150(6):677-91. Epub 2007 Feb 12. Review.

44.

Relaxin receptors--new drug targets for multiple disease states.

Van Der Westhuizen ET, Summers RJ, Halls ML, Bathgate RA, Sexton PM.

Curr Drug Targets. 2007 Jan;8(1):91-104. Review.

PMID:
17266534
45.

Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes.

Halls ML, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2007 Jan;320(1):281-90. Epub 2006 Oct 25.

46.

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.

Halls ML, Bathgate RA, Summers RJ.

Mol Pharmacol. 2006 Jul;70(1):214-26. Epub 2006 Mar 28.

47.

Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes.

Halls ML, Bathgate RA, Roche PJ, Summers RJ.

Ann N Y Acad Sci. 2005 May;1041:292-5.

PMID:
15956720
48.

Signal switching after stimulation of LGR7 receptors by human relaxin 2.

Halls ML, Bathgate RA, Summers RJ.

Ann N Y Acad Sci. 2005 May;1041:288-91.

PMID:
15956719
49.

Identification of binding sites with differing affinity and potency for relaxin analogues on LGR7 and LGR8 receptors.

Halls ML, Bathgate RA, Sudo S, Kumagai J, Bond CP, Summers RJ.

Ann N Y Acad Sci. 2005 May;1041:17-21.

PMID:
15956682
50.

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RA, Summers RJ.

J Pharmacol Exp Ther. 2005 May;313(2):677-87. Epub 2005 Jan 12.

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