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Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.

Huebecker M, Moloney EB, van der Spoel AC, Priestman DA, Isacson O, Hallett PJ, Platt FM.

Mol Neurodegener. 2020 Jan 15;15(1):6. doi: 10.1186/s13024-019-0355-z.


Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.

Huebecker M, Moloney EB, van der Spoel AC, Priestman DA, Isacson O, Hallett PJ, Platt FM.

Mol Neurodegener. 2019 Nov 8;14(1):40. doi: 10.1186/s13024-019-0339-z. Erratum in: Mol Neurodegener. 2020 Jan 15;15(1):6.


Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease.

Isacson O, Brekk OR, Hallett PJ.

Front Neurol. 2019 Oct 9;10:1053. doi: 10.3389/fneur.2019.01053. eCollection 2019. Review.


Transport, retention, and release of Escherichia coli and Rhodococcus erythropolis through dry natural soils as affected by water repellency.

Sepehrnia N, Bachmann J, Hajabbasi MA, Rezanezhad F, Lichner L, Hallett PD, Coyne M.

Sci Total Environ. 2019 Dec 1;694:133666. doi: 10.1016/j.scitotenv.2019.133666. Epub 2019 Jul 29.


Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells.

Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett PJ, Bartos M, Isacson O, Pruszak J.

Stem Cells. 2019 Oct;37(10):1293-1306. doi: 10.1002/stem.3057. Epub 2019 Aug 9.


Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.

Hallett PJ, Engelender S, Isacson O.

J Neuroinflammation. 2019 Jul 22;16(1):153. doi: 10.1186/s12974-019-1532-2. Review.


Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.

Korecka JA, Thomas R, Christensen DP, Hinrich AJ, Ferrari EJ, Levy SA, Hastings ML, Hallett PJ, Isacson O.

Hum Mol Genet. 2019 Oct 1;28(19):3232-3243. doi: 10.1093/hmg/ddz126.


Surface tension, rheology and hydrophobicity of rhizodeposits and seed mucilage influence soil water retention and hysteresis.

Naveed M, Ahmed MA, Benard P, Brown LK, George TS, Bengough AG, Roose T, Koebernick N, Hallett PD.

Plant Soil. 2019;437(1):65-81. doi: 10.1007/s11104-019-03939-9. Epub 2019 Feb 2.


Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation.

Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O.

Stem Cell Reports. 2019 Jan 8;12(1):29-41. doi: 10.1016/j.stemcr.2018.11.021. Epub 2018 Dec 27.


The effect of root exudates on rhizosphere water dynamics.

Cooper LJ, Daly KR, Hallett PD, Koebernick N, George TS, Roose T.

Proc Math Phys Eng Sci. 2018 Sep;474(2217):20180149. doi: 10.1098/rspa.2018.0149. Epub 2018 Sep 5.


Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.

Brekk OR, Moskites A, Isacson O, Hallett PJ.

Sci Rep. 2018 Oct 12;8(1):15207. doi: 10.1038/s41598-018-33474-z.


Imaging microstructure of the barley rhizosphere: particle packing and root hair influences.

Koebernick N, Daly KR, Keyes SD, Bengough AG, Brown LK, Cooper LJ, George TS, Hallett PD, Naveed M, Raffan A, Roose T.

New Phytol. 2019 Mar;221(4):1878-1889. doi: 10.1111/nph.15516. Epub 2018 Nov 20.


The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.

Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ.

Neurobiol Dis. 2018 Dec;120:1-11. doi: 10.1016/j.nbd.2018.08.013. Epub 2018 Aug 24.


Interaction between contrasting rice genotypes and soil physical conditions induced by hydraulic stresses typical of alternate wetting and drying irrigation of soil.

Fang H, Zhou H, Norton GJ, Price AH, Raffan AC, Mooney SJ, Peng X, Hallett PD.

Plant Soil. 2018;430(1):233-243. doi: 10.1007/s11104-018-3715-5. Epub 2018 Jun 29.


Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.

Hallett PJ, Huebecker M, Brekk OR, Moloney EB, Rocha EM, Priestman DA, Platt FM, Isacson O.

Neurobiol Aging. 2018 Jul;67:189-200. doi: 10.1016/j.neurobiolaging.2018.02.028. Epub 2018 Mar 29.


Plant exudates may stabilize or weaken soil depending on species, origin and time.

Naveed M, Brown LK, Raffan AC, George TS, Bengough AG, Roose T, Sinclair I, Koebernick N, Cooper L, Hackett CA, Hallett PD.

Eur J Soil Sci. 2017 Nov;68(6):806-816. doi: 10.1111/ejss.12487. Epub 2017 Oct 27.


Fluid flow in porous media using image-based modelling to parametrize Richards' equation.

Cooper LJ, Daly KR, Hallett PD, Naveed M, Koebernick N, Bengough AG, George TS, Roose T.

Proc Math Phys Eng Sci. 2017 Nov;473(2207):20170178. doi: 10.1098/rspa.2017.0178. Epub 2017 Nov 22.


High-resolution synchrotron imaging shows that root hairs influence rhizosphere soil structure formation.

Koebernick N, Daly KR, Keyes SD, George TS, Brown LK, Raffan A, Cooper LJ, Naveed M, Bengough AG, Sinclair I, Hallett PD, Roose T.

New Phytol. 2017 Oct;216(1):124-135. doi: 10.1111/nph.14705. Epub 2017 Jul 31.


Seq-ing Markers of Midbrain Dopamine Neurons.

Osborn T, Hallett PJ.

Cell Stem Cell. 2017 Jan 5;20(1):11-12. doi: 10.1016/j.stem.2016.12.014.


Mapping and expression of genes associated with raspberry fruit ripening and softening.

Simpson CG, Cullen DW, Hackett CA, Smith K, Hallett PD, McNicol J, Woodhead M, Graham J.

Theor Appl Genet. 2017 Mar;130(3):557-572. doi: 10.1007/s00122-016-2835-7. Epub 2016 Dec 9.


Evaluation of spot and passive sampling for monitoring, flux estimation and risk assessment of pesticides within the constraints of a typical regulatory monitoring scheme.

Zhang Z, Troldborg M, Yates K, Osprey M, Kerr C, Hallett PD, Baggaley N, Rhind SM, Dawson JJC, Hough RL.

Sci Total Environ. 2016 Nov 1;569-570:1369-1379. doi: 10.1016/j.scitotenv.2016.06.219. Epub 2016 Jul 15.


NIR-NIR fluorescence: A new genre of fingermark visualisation techniques.

King RS, Hallett PM, Foster D.

Forensic Sci Int. 2016 May;262:e28-33. doi: 10.1016/j.forsciint.2016.03.037. Epub 2016 Mar 24.


Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.

Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson O.

Mol Neurobiol. 2016 Oct;53(8):5161-77. doi: 10.1007/s12035-015-9435-4. Epub 2015 Sep 23.


Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.

Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O.

Neurobiol Dis. 2015 Oct;82:495-503. doi: 10.1016/j.nbd.2015.09.009. Epub 2015 Sep 25.


Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.

Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O.

Antioxid Redox Signal. 2015 Aug 20;23(6):550-64. doi: 10.1089/ars.2015.6307. Epub 2015 Jul 29.


Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O.

Ann Clin Transl Neurol. 2015 Apr;2(4):433-8. doi: 10.1002/acn3.177. Epub 2015 Feb 6.


Improving intercropping: a synthesis of research in agronomy, plant physiology and ecology.

Brooker RW, Bennett AE, Cong WF, Daniell TJ, George TS, Hallett PD, Hawes C, Iannetta PP, Jones HG, Karley AJ, Li L, McKenzie BM, Pakeman RJ, Paterson E, Schöb C, Shen J, Squire G, Watson CA, Zhang C, Zhang F, Zhang J, White PJ.

New Phytol. 2015 Apr;206(1):107-117. Epub 2014 Nov 3. Review.


A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O.

PLoS One. 2015 Mar 27;10(3):e0121072. doi: 10.1371/journal.pone.0121072. eCollection 2015.


Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O.

Cell Stem Cell. 2015 Mar 5;16(3):269-74. doi: 10.1016/j.stem.2015.01.018. Epub 2015 Feb 26.


Seeing into the infrared: a novel IR fluorescent fingerprint powder.

King RS, Hallett PM, Foster D.

Forensic Sci Int. 2015 Apr;249:e21-6. doi: 10.1016/j.forsciint.2015.01.020. Epub 2015 Feb 2.


Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

Hallett PJ, Cooper O, Sadi D, Robertson H, Mendez I, Isacson O.

Cell Rep. 2014 Jun 26;7(6):1755-61. doi: 10.1016/j.celrep.2014.05.027. Epub 2014 Jun 6.


ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.

McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O.

Exp Neurol. 2014 Nov;261:217-29. doi: 10.1016/j.expneurol.2014.05.024. Epub 2014 Jun 4.


Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson O.

Neurosci Lett. 2014 Jul 25;576:73-8. doi: 10.1016/j.neulet.2014.05.044. Epub 2014 May 29.


Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ.

Hum Mol Genet. 2014 Sep 1;23(17):4510-27. doi: 10.1093/hmg/ddu166. Epub 2014 Apr 12.


Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK.

Neurobiol Dis. 2014 Apr;64:79-87. doi: 10.1016/j.nbd.2013.12.011. Epub 2013 Dec 31.


Root hairs improve root penetration, root-soil contact, and phosphorus acquisition in soils of different strength.

Haling RE, Brown LK, Bengough AG, Young IM, Hallett PD, White PJ, George TS.

J Exp Bot. 2013 Sep;64(12):3711-21. doi: 10.1093/jxb/ert200. Epub 2013 Jul 16.


Matching roots to their environment.

White PJ, George TS, Gregory PJ, Bengough AG, Hallett PD, McKenzie BM.

Ann Bot. 2013 Jul;112(2):207-22. doi: 10.1093/aob/mct123.


Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.

Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O.

Stem Cells. 2013 Aug;31(8):1548-62. doi: 10.1002/stem.1415.


The rheological properties of the seed coat mucilage of Capsella bursa-pastoris L. Medik. (shepherd's purse).

Deng W, Iannetta PP, Hallett PD, Toorop PE, Squire GR, Jeng DS.

Biorheology. 2013;50(1-2):57-67. doi: 10.3233/BIR-130627.


Soil strength and macropore volume limit root elongation rates in many UK agricultural soils.

Valentine TA, Hallett PD, Binnie K, Young MW, Squire GR, Hawes C, Bengough AG.

Ann Bot. 2012 Jul;110(2):259-70. doi: 10.1093/aob/mcs118. Epub 2012 Jun 8.


α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.

Hallett PJ, McLean JR, Kartunen A, Langston JW, Isacson O.

Neurobiol Dis. 2012 Aug;47(2):258-67. doi: 10.1016/j.nbd.2012.04.009. Epub 2012 Apr 19.


Using stem cells and iPS cells to discover new treatments for Parkinson's disease.

Cooper O, Hallett P, Isacson O.

Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S14-6. doi: 10.1016/S1353-8020(11)70007-4. Review.


Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.

Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O.

Stem Cells. 2011 Jul;29(7):1052-63. doi: 10.1002/stem.662.


The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.

Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O.

J Neurosci. 2010 Dec 1;30(48):16091-101. doi: 10.1523/JNEUROSCI.2400-10.2010.


Root elongation, water stress, and mechanical impedance: a review of limiting stresses and beneficial root tip traits.

Bengough AG, McKenzie BM, Hallett PD, Valentine TA.

J Exp Bot. 2011 Jan;62(1):59-68. doi: 10.1093/jxb/erq350. Review.


Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23.


Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.

Chung CY, Koprich JB, Hallett PJ, Isacson O.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22474-9. doi: 10.1073/pnas.0912193106. Epub 2009 Dec 10.


Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate.

Silverdale MA, Kobylecki C, Hallett PJ, Li Q, Dunah AW, Ravenscroft P, Bezard E, Brotchie JM.

Synapse. 2010 Feb;64(2):177-80. doi: 10.1002/syn.20739. No abstract available.


No evidence for disease-like processes in fetal transplants.

Hallett PJ, Cooper O, Isacson O.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):E104; author reply E105. doi: 10.1073/pnas.0908169106. Epub 2009 Sep 2. No abstract available.

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