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The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.

Bernstock JD, Ye DG, Estevez D, Chagoya G, Wang YC, Gessler F, Hallenbeck JM, Yang W.

Curr Issues Mol Biol. 2019 Aug 18;35:127-144. doi: 10.21775/cimb.035.127. [Epub ahead of print]


Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.

Nadareishvili Z, Kelley D, Luby M, Simpkins AN, Leigh R, Lynch JK, Hsia AW, Benson RT, Johnson KR, Hallenbeck JM, Latour LL.

Ann Clin Transl Neurol. 2019 Mar 13;6(4):817-820. doi: 10.1002/acn3.757. eCollection 2019 Apr.


SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

Bernstock JD, Peruzzotti-Jametti L, Leonardi T, Vicario N, Ye D, Lee YJ, Maric D, Johnson KR, Mou Y, Van Den Bosch A, Winterbone M, Friedman GK, Franklin RJM, Hallenbeck JM, Pluchino S.

EBioMedicine. 2019 Apr;42:214-224. doi: 10.1016/j.ebiom.2019.03.035. Epub 2019 Mar 21.


A combined banding method that allows the reliable identification of chromosomes as well as differentiation of AT- and GC-rich heterochromatin.

Lemskaya NA, Kulemzina AI, Beklemisheva VR, Biltueva LS, Proskuryakova AA, Hallenbeck JM, Perelman PL, Graphodatsky AS.

Chromosome Res. 2018 Dec;26(4):307-315. doi: 10.1007/s10577-018-9589-9. Epub 2018 Nov 15.


Drugging SUMOylation for neuroprotection and oncotherapy.

Bernstock JD, Ye DG, Lee YJ, Gessler F, Friedman GK, Zheng W, Hallenbeck JM.

Neural Regen Res. 2018 Mar;13(3):415-416. doi: 10.4103/1673-5374.228718. No abstract available.


Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S.

Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. doi: 10.1016/j.stem.2018.01.020. Epub 2018 Feb 22.


Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.

Karhausen J, Bernstock JD, Johnson KR, Sheng H, Ma Q, Shen Y, Yang W, Hallenbeck JM, Paschen W.

Lab Invest. 2018 Jun;98(6):799-813. doi: 10.1038/s41374-018-0035-6. Epub 2018 Feb 22.


Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels.

Lee YJ, Bernstock JD, Klimanis D, Hallenbeck JM.

Front Mol Neurosci. 2018 Jan 30;11:22. doi: 10.3389/fnmol.2018.00022. eCollection 2018.


Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological-Pathological Correlation.

Bernstock JD, Ye DG, Griffin A, Lee YJ, Lynch J, Latour LL, Friedman GK, Maric D, Hallenbeck JM.

Front Neurol. 2018 Jan 12;8:738. doi: 10.3389/fneur.2017.00738. eCollection 2017.


SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Bernstock JD, Yang W, Ye DG, Shen Y, Pluchino S, Lee YJ, Hallenbeck JM, Paschen W.

J Cereb Blood Flow Metab. 2018 Jan;38(1):5-16. doi: 10.1177/0271678X17742260. Epub 2017 Nov 17. Review.


Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W.

FASEB J. 2018 Mar;32(3):1677-1691. doi: 10.1096/fj.201700711R. Epub 2018 Jan 3.


Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM.

Sci Rep. 2017 Aug 7;7(1):7425. doi: 10.1038/s41598-017-07631-9.


Development of a systems-based in situ multiplex biomarker screening approach for the assessment of immunopathology and neural tissue plasticity in male rats after traumatic brain injury.

Bogoslovsky T, Bernstock JD, Bull G, Gouty S, Cox BM, Hallenbeck JM, Maric D.

J Neurosci Res. 2018 Apr;96(4):487-500. doi: 10.1002/jnr.24054. Epub 2017 May 2.


Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.

Bernstock JD, Peruzzotti-Jametti L, Ye D, Gessler FA, Maric D, Vicario N, Lee YJ, Pluchino S, Hallenbeck JM.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2314-2319. doi: 10.1177/0271678X17700432. Epub 2017 Mar 17. Review.


Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose.

Lee YJ, Bernstock JD, Nagaraja N, Ko B, Hallenbeck JM.

J Neurochem. 2016 Jul;138(1):101-16. doi: 10.1111/jnc.13643. Epub 2016 Jun 6.


A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.

Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM.

J Cereb Blood Flow Metab. 2016 Feb;36(2):426-41. doi: 10.1177/0271678X15609939. Epub 2015 Oct 23.


Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats.

Zhao J, Mou Y, Bernstock JD, Klimanis D, Wang S, Spatz M, Maric D, Johnson K, Klinman DM, Li X, Li X, Hallenbeck JM.

PLoS One. 2015 Oct 16;10(10):e0140772. doi: 10.1371/journal.pone.0140772. eCollection 2015.


Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning.

Miyake S, Wakita H, Bernstock JD, Castri P, Ruetzler C, Miyake J, Lee YJ, Hallenbeck JM.

J Neurochem. 2015 Dec;135(5):943-57. doi: 10.1111/jnc.13368. Epub 2015 Oct 22.


Global SUMOylation is a molecular mechanism underlying hypothermia-induced ischemic tolerance.

Lee YJ, Mou Y, Klimanis D, Bernstock JD, Hallenbeck JM.

Front Cell Neurosci. 2014 Dec 4;8:416. doi: 10.3389/fncel.2014.00416. eCollection 2014.


Anti-lymphoproliferative activity of alpha-2-macroglobulin in the plasma of hibernating 13-lined ground squirrels and woodchucks.

Sieckmann DG, Jaffe H, Golech S, Cai D, Hallenbeck JM, McCarron RM.

Vet Immunol Immunopathol. 2014 Sep 15;161(1-2):1-11. doi: 10.1016/j.vetimm.2014.05.006. Epub 2014 May 20.


Biological networks in ischemic tolerance - rethinking the approach to clinical conditioning.

Anrather J, Hallenbeck JM.

Transl Stroke Res. 2013 Feb;4(1):114-29. doi: 10.1007/s12975-012-0244-z. Review.


SUMO and ischemic tolerance.

Lee YJ, Hallenbeck JM.

Neuromolecular Med. 2013 Dec;15(4):771-81. doi: 10.1007/s12017-013-8239-9. Epub 2013 Jun 18. Review.


A method for hypothermia-induction and maintenance allows precise body and brain temperature control in mice.

Mou Y, Wilgenburg BJ, Lee YJ, Hallenbeck JM.

J Neurosci Methods. 2013 Feb 15;213(1):1-5. doi: 10.1016/j.jneumeth.2012.11.006. Epub 2012 Nov 19.


Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

Lee YJ, Johnson KR, Hallenbeck JM.

PLoS One. 2012;7(10):e47787. doi: 10.1371/journal.pone.0047787. Epub 2012 Oct 18.


Immunologic privilege in the central nervous system and the blood-brain barrier.

Muldoon LL, Alvarez JI, Begley DJ, Boado RJ, Del Zoppo GJ, Doolittle ND, Engelhardt B, Hallenbeck JM, Lonser RR, Ohlfest JR, Prat A, Scarpa M, Smeyne RJ, Drewes LR, Neuwelt EA.

J Cereb Blood Flow Metab. 2013 Jan;33(1):13-21. doi: 10.1038/jcbfm.2012.153. Epub 2012 Oct 17. Review.


Tracks of a non-main path traveler: 2011 Thomas Willis Lecture.

Hallenbeck JM.

Stroke. 2012 Feb;43(2):585-90. doi: 10.1161/STROKEAHA.111.643668. Epub 2012 Jan 12.


Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage.

Lee YJ, Mou Y, Maric D, Klimanis D, Auh S, Hallenbeck JM.

PLoS One. 2011;6(10):e25852. doi: 10.1371/journal.pone.0025852. Epub 2011 Oct 7.


Intranasal delivery of E-selectin reduces atherosclerosis in ApoE-/- mice.

Li X, Johnson KR, Bryant M, Elkahloun AG, Amar M, Remaley AT, De Silva R, Hallenbeck JM, Quandt JA.

PLoS One. 2011;6(6):e20620. doi: 10.1371/journal.pone.0020620. Epub 2011 Jun 20.


Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia.

Famakin BM, Mou Y, Ruetzler CA, Bembry J, Maric D, Hallenbeck JM.

Brain Res. 2011 May 4;1388:148-56. doi: 10.1016/j.brainres.2011.02.074. Epub 2011 Mar 1.


Regulation of Akt during torpor in the hibernating ground squirrel, Ictidomys tridecemlineatus.

McMullen DC, Hallenbeck JM.

J Comp Physiol B. 2010 Aug;180(6):927-34. doi: 10.1007/s00360-010-0468-8. Epub 2010 Mar 30.


Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke.

Batra A, Latour LL, Ruetzler CA, Hallenbeck JM, Spatz M, Warach S, Henning EC.

J Cereb Blood Flow Metab. 2010 Jun;30(6):1188-99. doi: 10.1038/jcbfm.2010.1. Epub 2010 Mar 3.


Introduction of a new journal.

Hallenbeck JM.

Transl Stroke Res. 2010 Mar;1(1):1. doi: 10.1007/s12975-010-0013-9. No abstract available.


Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9.

Barr TL, Latour LL, Lee KY, Schaewe TJ, Luby M, Chang GS, El-Zammar Z, Alam S, Hallenbeck JM, Kidwell CS, Warach S.

Stroke. 2010 Mar;41(3):e123-8. doi: 10.1161/STROKEAHA.109.570515. Epub 2009 Dec 24.


Feridex preloading permits tracking of CNS-resident macrophages after transient middle cerebral artery occlusion.

Henning EC, Ruetzler CA, Gaudinski MR, Hu TC, Latour LL, Hallenbeck JM, Warach S.

J Cereb Blood Flow Metab. 2009 Jul;29(7):1229-39. doi: 10.1038/jcbfm.2009.48. Epub 2009 May 6.


SUMOylation participates in induction of ischemic tolerance.

Lee YJ, Castri P, Bembry J, Maric D, Auh S, Hallenbeck JM.

J Neurochem. 2009 Apr;109(1):257-67. doi: 10.1111/j.1471-4159.2009.05957.x. Epub 2009 Feb 5.


Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats.

Ishibashi S, Maric D, Mou Y, Ohtani R, Ruetzler C, Hallenbeck JM.

J Cereb Blood Flow Metab. 2009 Mar;29(3):606-20. doi: 10.1038/jcbfm.2008.153. Epub 2008 Dec 24.


Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma.

Henning EC, Latour LL, Hallenbeck JM, Warach S.

Stroke. 2008 Dec;39(12):3405-10. doi: 10.1161/STROKEAHA.108.520304. Epub 2008 Aug 28.


Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case-control study.

Nadareishvili Z, Michaud K, Hallenbeck JM, Wolfe F.

Arthritis Rheum. 2008 Aug 15;59(8):1090-6. doi: 10.1002/art.23935.


Spatial and temporal activation of brain regions in hibernation: c-fos expression during the hibernation bout in thirteen-lined ground squirrel.

Bratincsák A, McMullen D, Miyake S, Tóth ZE, Hallenbeck JM, Palkovits M.

J Comp Neurol. 2007 Dec 1;505(4):443-58.


Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model.

Wakita H, Ruetzler C, Illoh KO, Chen Y, Takanohashi A, Spatz M, Hallenbeck JM.

J Cereb Blood Flow Metab. 2008 Feb;28(2):341-53. Epub 2007 Jul 18.


Neuroprotection by endogenous and exogenous PACAP following stroke.

Chen Y, Samal B, Hamelink CR, Xiang CC, Chen Y, Chen M, Vaudry D, Brownstein MJ, Hallenbeck JM, Eiden LE.

Regul Pept. 2006 Nov 15;137(1-2):4-19. Epub 2006 Oct 4.


Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells.

Lee YJ, Miyake S, Wakita H, McMullen DC, Azuma Y, Auh S, Hallenbeck JM.

J Cereb Blood Flow Metab. 2007 May;27(5):950-62. Epub 2006 Sep 6.


Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.

Hillion JA, Li Y, Maric D, Takanohashi A, Klimanis D, Barker JL, Hallenbeck JM.

J Cereb Blood Flow Metab. 2006 Oct;26(10):1323-31. Epub 2006 Mar 1.


Immunology of ischemic vascular disease: plaque to attack.

Hallenbeck JM, Hansson GK, Becker KJ.

Trends Immunol. 2005 Oct;26(10):550-6. Review.


Antibiotics for vascular diseases: a meta-analysis of randomized controlled trials.

Illoh KO, Illoh OC, Feseha HB, Hallenbeck JM.

Atherosclerosis. 2005 Apr;179(2):403-12. Epub 2004 Dec 18.


Development of an ischemic tolerance model in a PC12 cell line.

Hillion JA, Takahashi K, Maric D, Ruetzler C, Barker JL, Hallenbeck JM.

J Cereb Blood Flow Metab. 2005 Feb;25(2):154-162. doi: 10.1038/sj.jcbfm.9600003.


Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death.

Nadareishvili ZG, Li H, Wright V, Maric D, Warach S, Hallenbeck JM, Dambrosia J, Barker JL, Baird AE.

Neurology. 2004 Oct 26;63(8):1446-51.


Determining the fetal inflammatory response in an experimental model of intrauterine inflammation in rats.

Bell MJ, Hallenbeck JM, Gallo V.

Pediatr Res. 2004 Oct;56(4):541-6. Epub 2004 Aug 4.


Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning.

Takahashi K, Ginis I, Nishioka R, Klimanis D, Barone FC, White RF, Chen Y, Hallenbeck JM.

J Cereb Blood Flow Metab. 2004 Jun;24(6):623-7.


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