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Brief interventions for cannabis use in emerging adults: A systematic review, meta-analysis, and evidence map.

Halladay J, Scherer J, MacKillop J, Woock R, Petker T, Linton V, Munn C.

Drug Alcohol Depend. 2019 Nov 1;204:107565. doi: 10.1016/j.drugalcdep.2019.107565. Epub 2019 Sep 19.


Predictors of aging out of heavy episodic drinking in emerging adults: a systematic review protocol.

Petker TD, Halladay J, Vedelago L, Ferro MA, Tucker J, Goldman MS, Murphy JG, MacKillop J.

Syst Rev. 2019 Sep 4;8(1):230. doi: 10.1186/s13643-019-1139-9.


Temporal Changes in the Cross-Sectional Associations between Cannabis Use, Suicidal Ideation, and Depression in a Nationally Representative Sample of Canadian Adults in 2012 Compared to 2002.

Halladay JE, Munn C, Boyle M, Jack SM, Georgiades K.

Can J Psychiatry. 2019 Jun 9:706743719854071. doi: 10.1177/0706743719854071. [Epub ahead of print]


Assessment of health systems guidance using the Appraisal of Guidelines for Research and Evaluation - Health Systems (AGREE-HS) instrument.

Brouwers MC, Lavis JN, Spithoff K, Vukmirovic M, Florez ID, Velez M, Kibria M, Sekercioglu N, Kamler E, Halladay J, Sandhu J, Ali A, Jaffer A, Kiflen R, Pemberton J.

Health Policy. 2019 Jul;123(7):646-651. doi: 10.1016/j.healthpol.2019.05.004. Epub 2019 May 14.


Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model.

Robertson GT, Ektnitphong VA, Scherman MS, McNeil MB, Dennison D, Korkegian A, Smith AJ, Halladay J, Carter DS, Xia Y, Zhou Y, Choi W, Berry PW, Mao W, Hernandez V, Alley MRK, Parish T, Lenaerts AJ.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02071-18. doi: 10.1128/AAC.02071-18. Print 2019 Apr.


Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

Jacobs RT, Lunde CS, Freund YR, Hernandez V, Li X, Xia Y, Carter DS, Berry PW, Halladay J, Rock F, Stefanakis R, Easom E, Plattner JJ, Ford L, Johnston KL, Cook DAN, Clare R, Cassidy A, Myhill L, Tyrer H, Gamble J, Guimaraes AF, Steven A, Lenz F, Ehrens A, Frohberger SJ, Koschel M, Hoerauf A, Hübner MP, McNamara CW, Bakowski MA, Turner JD, Taylor MJ, Ward SA.

J Med Chem. 2019 Mar 14;62(5):2521-2540. doi: 10.1021/acs.jmedchem.8b01854. Epub 2019 Feb 26.


Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M.

Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun.


Race-Specific Patterns of Treatment Intensification Among Hypertensive Patients Using Home Blood Pressure Monitoring: Analysis Using Defined Daily Doses in the Heart Healthy Lenoir Study.

Cummings DM, Adams A, Halladay J, Hinderliter A, Donahue KE, Cene CW, Li Q, Miller C, Garcia B, Tillman J, Little E, DeWalt D.

Ann Pharmacother. 2019 Apr;53(4):333-340. doi: 10.1177/1060028018806001. Epub 2018 Oct 3.


Sex Differences in the Association Between Cannabis Use and Suicidal Ideation and Attempts, Depression, and Psychological Distress Among Canadians.

Halladay JE, Boyle MH, Munn C, Jack SM, Georgiades K.

Can J Psychiatry. 2019 May;64(5):345-350. doi: 10.1177/0706743718804542. Epub 2018 Sep 27. Erratum in: Can J Psychiatry. 2019 Aug;64(8):586.


Asthma dissemination around patient-centered treatments in North Carolina (ADAPT-NC): a cluster randomized control trial evaluating dissemination of an evidence-based shared decision-making intervention for asthma management.

Ludden T, Shade L, Reeves K, Welch M, Taylor YJ, Mohanan S, McWilliams A, Halladay J, Donahue K, Coyne-Beasley T, Dolor RJ, Bray P, Tapp H.

J Asthma. 2018 Sep 25:1-12. doi: 10.1080/02770903.2018.1514630. [Epub ahead of print]


Brief interventions for cannabis use in emerging adults: protocol for a systematic review, meta-analysis, and evidence map.

Halladay J, Petker T, Fein A, Munn C, MacKillop J.

Syst Rev. 2018 Jul 25;7(1):106. doi: 10.1186/s13643-018-0772-z.


Patient and provider perspectives on uptake of a shared decision making intervention for asthma in primary care practices.

Welch M, Ludden T, Mottus K, Bray P, Hendrickson L, Rees J, Halladay J, Tapp H.

J Asthma. 2019 May;56(5):562-572. doi: 10.1080/02770903.2018.1471703. Epub 2018 Jun 21.


Ensuring respect for persons in COMPASS: a cluster randomised pragmatic clinical trial.

Andrews JE, Moore JB, Weinberg RB, Sissine M, Gesell S, Halladay J, Rosamond W, Bushnell C, Jones S, Means P, King NMP, Omoyeni D, Duncan PW; COMPASS investigators and stakeholders.

J Med Ethics. 2018 Aug;44(8):560-566. doi: 10.1136/medethics-2017-104478. Epub 2018 May 2.


Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.

Halladay JR, Lenhart KC, Robasky K, Jones W, Homan WF, Cummings DM, Cené CW, Hinderliter AL, Miller CL, Donahue KE, Garcia BA, Keyserling TC, Ammerman AS, Patterson C, DeWalt DA, Johnston LF, Willis MS, Schisler JC.

J Pers Med. 2018 Apr 30;8(2). pii: E16. doi: 10.3390/jpm8020016.


Organizational Leadership and Adaptive Reserve in Blood Pressure Control: The Heart Health NOW Study.

Henderson KH, DeWalt DA, Halladay J, Weiner BJ, Kim JI, Fine J, Cykert S.

Ann Fam Med. 2018 Apr;16(Suppl 1):S29-S34. doi: 10.1370/afm.2210.


A Person-Centered Approach to Poststroke Care: The COMprehensive Post-Acute Stroke Services Model.

Bushnell CD, Duncan PW, Lycan SL, Condon CN, Pastva AM, Lutz BJ, Halladay JR, Cummings DM, Arnan MK, Jones SB, Sissine ME, Coleman SW, Johnson AM, Gesell SB, Mettam LH, Freburger JK, Barton-Percival B, Taylor KM, Prvu-Bettger J, Lundy-Lamm G, Rosamond WD; COMPASS Trial.

J Am Geriatr Soc. 2018 May;66(5):1025-1030. doi: 10.1111/jgs.15322. Epub 2018 Mar 23.


Optimizing research in symptomatic uterine fibroids with development of a computable phenotype for use with electronic health records.

Hoffman SR, Vines AI, Halladay JR, Pfaff E, Schiff L, Westreich D, Sundaresan A, Johnson LS, Nicholson WK.

Am J Obstet Gynecol. 2018 Jun;218(6):610.e1-610.e7. doi: 10.1016/j.ajog.2018.02.002. Epub 2018 Feb 9.


Community Advisory Boards Guiding Engaged Research Efforts within a Clinical Translational Sciences Award: Key Contextual Factors Explored.

Halladay JR, Donahue KE, Sleath B, Reuland D, Black A, Mitchell CM, Breland CE, Coyne-Beasley T, Mottus K, Watson SN, Lewis V, Wynn M, Corbie-Smith G.

Prog Community Health Partnersh. 2017;11(4):367-377. doi: 10.1353/cpr.2017.0044.


The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters.

Cheong J, Halladay JS, Plise E, Sodhi JK, Salphati L.

Drug Metab Lett. 2017;11(2):111-118. doi: 10.2174/1872312811666171010101248.


Efficacy of adjuvant laser therapy in reducing postsurgical complications after the removal of impacted mandibular third molars: A systematic review update and meta-analysis.

Dawdy J, Halladay J, Carrasco-Labra A, Araya I, Yanine N, Brignardello-Petersen R.

J Am Dent Assoc. 2017 Dec;148(12):887-902.e4. doi: 10.1016/j.adaj.2017.06.043. Epub 2017 Oct 5.


Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms.

Sodhi JK, Delarosa EM, Halladay JS, Driscoll JP, Mulder T, Dansette PM, Khojasteh SC.

Int J Mol Sci. 2017 Jul 20;18(7). pii: E1553. doi: 10.3390/ijms18071553.


The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial.

Duncan PW, Bushnell CD, Rosamond WD, Jones Berkeley SB, Gesell SB, D'Agostino RB Jr, Ambrosius WT, Barton-Percival B, Bettger JP, Coleman SW, Cummings DM, Freburger JK, Halladay J, Johnson AM, Kucharska-Newton AM, Lundy-Lamm G, Lutz BJ, Mettam LH, Pastva AM, Sissine ME, Vetter B.

BMC Neurol. 2017 Jul 17;17(1):133. doi: 10.1186/s12883-017-0907-1.


Methods guiding stakeholder engagement in planning a pragmatic study on changing stroke systems of care.

Gesell SB, Klein KP, Halladay J, Bettger JP, Freburger J, Cummings DM, Lutz BJ, Coleman S, Bushnell C, Rosamond W, Duncan PW.

J Clin Transl Sci. 2017 Apr;1(2):121-128. doi: 10.1017/cts.2016.26. Epub 2017 Feb 27.


Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.

Takahashi RH, Halladay JS, Siu M, Chen Y, Hop CE, Khojasteh SC, Ma S.

Drug Metab Dispos. 2017 May;45(5):430-440. doi: 10.1124/dmd.116.074336. Epub 2017 Feb 10.


A multicomponent quality improvement intervention to improve blood pressure and reduce racial disparities in rural primary care practices.

Cené CW, Halladay JR, Gizlice Z, Donahue KE, Cummings DM, Hinderliter A, Miller C, Johnson LF, Garcia B, Tillman J, Little EP, Rachide MR, Keyserling TC, Ammerman A, Zhou H, Wu JR, DeWalt D.

J Clin Hypertens (Greenwich). 2017 Apr;19(4):351-360. doi: 10.1111/jch.12944. Epub 2016 Nov 25.


The association of health literacy and blood pressure reduction in a cohort of patients with hypertension: The heart healthy lenoir trial.

Halladay JR, Donahue KE, Cené CW, Li Q, Cummings DM, Hinderliter AL, Miller CL, Garcia BA, Little E, Rachide M, Tillman J, Ammerman AS, DeWalt D.

Patient Educ Couns. 2017 Mar;100(3):542-549. doi: 10.1016/j.pec.2016.10.015. Epub 2016 Oct 20.


Achieving Health Equity: Closing The Gaps In Health Care Disparities, Interventions, And Research.

Purnell TS, Calhoun EA, Golden SH, Halladay JR, Krok-Schoen JL, Appelhans BM, Cooper LA.

Health Aff (Millwood). 2016 Aug 1;35(8):1410-5. doi: 10.1377/hlthaff.2016.0158. Review.


A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project.

Keyserling TC, Samuel-Hodge CD, Pitts SJ, Garcia BA, Johnston LF, Gizlice Z, Miller CL, Braxton DF, Evenson KR, Smith JC, Davis GB, Quenum EL, Elliott NT, Gross MD, Donahue KE, Halladay JR, Ammerman AS.

BMC Public Health. 2016 Aug 5;16:732. doi: 10.1186/s12889-016-3370-9.


Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC.

Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Review.


Disparities in Absolute Denial of Modern Hepatitis C Therapy by Type of Insurance.

Lo Re V 3rd, Gowda C, Urick PN, Halladay JT, Binkley A, Carbonari DM, Battista K, Peleckis C, Gilmore J, Roy JA, Doshi JA, Reese PP, Reddy KR, Kostman JR.

Clin Gastroenterol Hepatol. 2016 Jul;14(7):1035-43. doi: 10.1016/j.cgh.2016.03.040. Epub 2016 Apr 5.


The Cost to Successfully Apply for Level 3 Medical Home Recognition.

Halladay JR, Mottus K, Reiter K, Mitchell CM, Donahue KE, Gabbard WM, Gush K.

J Am Board Fam Med. 2016 Jan-Feb;29(1):69-77. doi: 10.3122/jabfm.2016.01.150211.


Lessons Learned From Implementing Health Coaching in The Heart Healthy Lenoir Hypertension Study.

Donahue KE, Tillman J, Halladay JR, Cené CW, Hinderliter A, Cummings DM, Miller C, Gizlice Z, Garcia BA, Wu JR, Quenum E, Bosworth HB, Keyserling TC, DeWalt D.

Prog Community Health Partnersh. 2016;10(4):559-567. doi: 10.1353/cpr.2016.0064.


Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi RH, Choo EF, Ma S, Wong S, Halladay J, Deng Y, Rooney I, Gates M, Hop CE, Khojasteh SC, Dresser MJ, Musib L.

Drug Metab Dispos. 2016 Jan;44(1):28-39. doi: 10.1124/dmd.115.066282. Epub 2015 Oct 8.


Practice-based Research Networks (PBRNs) in the Era of Integrated Delivery Systems.

Carey TS, Halladay JR, Donahue KE, Cykert S.

J Am Board Fam Med. 2015 Sep-Oct;28(5):658-62. doi: 10.3122/jabfm.2015.05.140353. Review.


Perceived Social Standing, Medication Nonadherence, and Systolic Blood Pressure in the Rural South.

Cummings DM, Wu JR, Cene C, Halladay J, Donahue KE, Hinderliter A, Miller C, Garcia B, Penn D, Tillman J, DeWalt D.

J Rural Health. 2016 Spring;32(2):156-63. doi: 10.1111/jrh.12138. Epub 2015 Sep 3.


Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.

Ford KA, Ryslik G, Sodhi J, Halladay J, Diaz D, Dambach D, Masuda M.

Drug Metab Rev. 2015 Aug;47(3):291-319. doi: 10.3109/03602532.2015.1047026. Epub 2015 May 29. Review.


Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.

Gazzard L, Williams K, Chen H, Axford L, Blackwood E, Burton B, Chapman K, Crackett P, Drobnick J, Ellwood C, Epler J, Flagella M, Gancia E, Gill M, Goodacre S, Halladay J, Hewitt J, Hunt H, Kintz S, Lyssikatos J, Macleod C, Major S, Médard G, Narukulla R, Ramiscal J, Schmidt S, Seward E, Wiesmann C, Wu P, Yee S, Yen I, Malek S.

J Med Chem. 2015 Jun 25;58(12):5053-74. doi: 10.1021/acs.jmedchem.5b00464. Epub 2015 Jun 4.


Associations between subjective social status and physical and mental health functioning among patients with hypertension.

Cené CW, Halladay JR, Gizlice Z, Roedersheimer K, Hinderliter A, Cummings DM, Donahue KE, Perrin AJ, DeWalt DA.

J Health Psychol. 2016 Nov;21(11):2624-2635. doi: 10.1177/1359105315581514. Epub 2016 Jul 10.


A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.

Sodhi JK, Wong S, Kirkpatrick DS, Liu L, Khojasteh SC, Hop CE, Barr JT, Jones JP, Halladay JS.

Drug Metab Dispos. 2015 Jun;43(6):908-15. doi: 10.1124/dmd.114.061804. Epub 2015 Apr 6.


Patient perspectives on tobacco use treatment in primary care.

Halladay JR, Vu M, Ripley-Moffitt C, Gupta SK, O'Meara C, Goldstein AO.

Prev Chronic Dis. 2015 Feb 5;12:E14. doi: 10.5888/pcd12.140408.


Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.

Gazzard L, Appleton B, Chapman K, Chen H, Clark K, Drobnick J, Goodacre S, Halladay J, Lyssikatos J, Schmidt S, Sideris S, Wiesmann C, Williams K, Wu P, Yen I, Malek S.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5704-5709. doi: 10.1016/j.bmcl.2014.10.063. Epub 2014 Oct 27.


Comparing traditional and participatory dissemination of a shared decision making intervention (ADAPT-NC): a cluster randomized trial.

Tapp H, McWilliams A, Ludden T, Kuhn L, Taylor Y, Alkhazraji T, Halladay J, Derkowski D, Mohanan S, Dulin M.

Implement Sci. 2014 Oct 29;9:158. doi: 10.1186/s13012-014-0158-0.


A method to determine the impact of patient-centered care interventions in primary care.

Daaleman TP, Shea CM, Halladay J, Reed D.

Patient Educ Couns. 2014 Dec;97(3):327-31. doi: 10.1016/j.pec.2014.09.009. Epub 2014 Sep 22.


Costs and benefits of transforming primary care practices: a qualitative study of North Carolina's Improving Performance in Practice.

Reiter KL, Halladay JR, Mitchell CM, Ward K, Lee SY, Steiner B, Donahue KE.

J Healthc Manag. 2014 Mar-Apr;59(2):95-108.


Patient and practice perspectives on strategies for controlling blood pressure, North Carolina, 2010-2012.

Donahue KE, Vu MB, Halladay JR, Miller C, Garcia BA, Cummings DM, Cene CW, Hinderliter A, Little E, Rachide M, DeWalt D.

Prev Chronic Dis. 2014 Apr 24;11:E69; quiz E69. doi: 10.5888/pcd11.130157.


1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.

Sodhi JK, Ford KA, Mukadam S, Wong S, Hop CE, Khojasteh SC, Halladay JS.

Drug Metab Dispos. 2014 May;42(5):813-7. doi: 10.1124/dmd.113.055913. Epub 2014 Feb 18.


More extensive implementation of the chronic care model is associated with better lipid control in diabetes.

Halladay JR, DeWalt DA, Wise A, Qaqish B, Reiter K, Lee SY, Lefebvre A, Ward K, Mitchell CM, Donahue KE.

J Am Board Fam Med. 2014 Jan-Feb;27(1):34-41. doi: 10.3122/jabfm.2014.01.130070.


Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J, Flagella M, Fuji R, Gill A, Halladay J, Harris SF, Heffron TP, Kleinheinz T, Lee DW, Le Pichon CE, Liu X, Lyssikatos JP, Medhurst AD, Moffat JG, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Wong S, Zhang S, Zhang X, Zhu H, Sweeney ZK.

J Med Chem. 2014 Feb 13;57(3):921-36. doi: 10.1021/jm401654j. Epub 2014 Jan 15.


On the maintenance of hepatocyte intracellular pH 7.0 in the in-vitro metabolic stability assay.

Berezhkovskiy LM, Wong S, Halladay JS.

J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):683-9. doi: 10.1007/s10928-013-9339-8. Epub 2013 Nov 1.


Engaging a network of primary care practices in an effort to better assist patients in quitting tobacco use.

Halladay J, Gianforcaro R.

N C Med J. 2013 Sep-Oct;74(5):402-3. No abstract available.

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