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Items: 1 to 50 of 298

1.

Lactate jump-starts mTORC1 in cancer cells.

Benjamin D, Hall MN.

EMBO Rep. 2019 Jun;20(6). pii: e48302. doi: 10.15252/embr.201948302. Epub 2019 May 27. No abstract available.

PMID:
31133599
2.

Treatment of Primary Aldosteronism with mTORC1 Inhibitors.

Trinh B, Hepprich M, Betz MJ, Burkard T, Cavelti-Weder C, Seelig E, Meienberg F, Kratschmar DV, Beuschlein F, Reincke M, Odermatt A, Hall MN, Donath MY, Swierczynska MM.

J Clin Endocrinol Metab. 2019 May 14. pii: jc.2019-00563. doi: 10.1210/jc.2019-00563. [Epub ahead of print]

PMID:
31087053
3.

TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells.

Suda K, Kaneko A, Shimobayashi M, Nakashima A, Tatsuya M, Hall MN, Ushimaru T.

Biochem Biophys Res Commun. 2019 Apr 2;511(2):434-439. doi: 10.1016/j.bbrc.2019.02.077. Epub 2019 Feb 21.

PMID:
30797551
4.

Shared Molecular Targets Confer Resistance over Short and Long Evolutionary Timescales.

Li J, Vázquez-García I, Persson K, González A, Yue JX, Barré B, Hall MN, Long A, Warringer J, Mustonen V, Liti G.

Mol Biol Evol. 2019 Apr 1;36(4):691-708. doi: 10.1093/molbev/msz006.

PMID:
30657986
5.

Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh.

Bozack AK, Hall MN, Liu X, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV.

Am J Clin Nutr. 2019 Feb 1;109(2):380-391. doi: 10.1093/ajcn/nqy148.

PMID:
30590411
6.

Proteomic Landscape of Aldosterone-Producing Adenoma.

Swierczynska MM, Betz MJ, Colombi M, Dazert E, Jenö P, Moes S, Pfaff C, Glatz K, Reincke M, Beuschlein F, Donath MY, Hall MN.

Hypertension. 2019 Feb;73(2):469-480. doi: 10.1161/HYPERTENSIONAHA.118.11733.

PMID:
30580688
7.

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.

Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN.

Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043.

8.

mTOR signalling and cellular metabolism are mutual determinants in cancer.

Mossmann D, Park S, Hall MN.

Nat Rev Cancer. 2018 Dec;18(12):744-757. doi: 10.1038/s41568-018-0074-8. Review.

PMID:
30425336
9.

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.

Martin SK, Fitter S, El Khawanky N, Grose RH, Walkley CR, Purton LE, Ruegg MA, Hall MN, Gronthos S, Zannettino ACW.

Sci Rep. 2018 Sep 28;8(1):14501. doi: 10.1038/s41598-018-32858-5.

10.

Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains.

Kessi-Pérez EI, Salinas F, Molinet J, González A, Muñiz S, Guillamón JM, Hall MN, Larrondo LF, Martínez C.

Yeast. 2019 Jan;36(1):65-74. doi: 10.1002/yea.3351. Epub 2018 Sep 5.

PMID:
30094872
11.

CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy.

Mostofa MG, Rahman MA, Koike N, Yeasmin AM, Islam N, Waliullah TM, Hosoyamada S, Shimobayashi M, Kobayashi T, Hall MN, Ushimaru T.

J Cell Biol. 2018 Aug 6;217(8):2675-2690. doi: 10.1083/jcb.201706164. Epub 2018 Jun 29.

12.

The South African Rea Phela Health Study: A randomized controlled trial of communication retention strategies.

Rhyne JM, Mumbauer A, Rheeder P, Hall MN, Genkinger J, Medina-Marino A.

PLoS One. 2018 May 24;13(5):e0196900. doi: 10.1371/journal.pone.0196900. eCollection 2018.

13.

The protein histidine phosphatase LHPP is a tumour suppressor.

Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN.

Nature. 2018 Mar 29;555(7698):678-682. doi: 10.1038/nature26140. Epub 2018 Mar 21.

14.

Network-based integration of multi-omics data for prioritizing cancer genes.

Dimitrakopoulos C, Hindupur SK, Häfliger L, Behr J, Montazeri H, Hall MN, Beerenwinkel N.

Bioinformatics. 2018 Jul 15;34(14):2441-2448. doi: 10.1093/bioinformatics/bty148.

15.

Insulin resistance causes inflammation in adipose tissue.

Shimobayashi M, Albert V, Woelnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jenö P, Beglinger C, Peterli R, Hall MN.

J Clin Invest. 2018 Apr 2;128(4):1538-1550. doi: 10.1172/JCI96139. Epub 2018 Mar 12.

16.

Seasonality of dipteran-mediated methylmercury flux from ponds.

Chumchal MM, Drenner RW, Hall MN, Polk DK, Williams EB, Ortega-Rodriguez CL, Kennedy JH.

Environ Toxicol Chem. 2018 Jul;37(7):1846-1851. doi: 10.1002/etc.4134. Epub 2018 Apr 11.

PMID:
29528144
17.

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.

Bantug GR, Fischer M, Grählert J, Balmer ML, Unterstab G, Develioglu L, Steiner R, Zhang L, Costa ASH, Gubser PM, Burgener AV, Sauder U, Löliger J, Belle R, Dimeloe S, Lötscher J, Jauch A, Recher M, Hönger G, Hall MN, Romero P, Frezza C, Hess C.

Immunity. 2018 Mar 20;48(3):542-555.e6. doi: 10.1016/j.immuni.2018.02.012. Epub 2018 Mar 6.

18.

Architecture of the human mTORC2 core complex.

Stuttfeld E, Aylett CH, Imseng S, Boehringer D, Scaiola A, Sauer E, Hall MN, Maier T, Ban N.

Elife. 2018 Feb 9;7. pii: e33101. doi: 10.7554/eLife.33101.

19.

Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study.

Niedzwiecki MM, Liu X, Zhu H, Hall MN, Slavkovich V, Ilievski V, Levy D, Siddique AB, Kibriya MG, Parvez F, Islam T, Ahmed A, Navas-Acien A, Graziano JH, Finnell RH, Ahsan H, Gamble MV.

Environ Int. 2018 Apr;113:133-142. doi: 10.1016/j.envint.2018.01.015. Epub 2018 Feb 6.

20.

Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency.

Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB.

PLoS One. 2018 Jan 5;13(1):e0190963. doi: 10.1371/journal.pone.0190963. eCollection 2018.

21.

mTORC2 Promotes Tumorigenesis via Lipid Synthesis.

Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P, Heim MH, Riezman I, Riezman H, Hall MN.

Cancer Cell. 2017 Dec 11;32(6):807-823.e12. doi: 10.1016/j.ccell.2017.11.011.

22.

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.

Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P.

Elife. 2017 Dec 5;6. pii: e32497. doi: 10.7554/eLife.32497.

23.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

24.

NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.

25.

An Amazing Turn of Events.

Hall MN.

Cell. 2017 Sep 21;171(1):18-22. doi: 10.1016/j.cell.2017.08.021. Epub 2017 Sep 6.

26.

mTOR Signaling Confers Resistance to Targeted Cancer Drugs.

Guri Y, Hall MN.

Trends Cancer. 2016 Nov;2(11):688-697. doi: 10.1016/j.trecan.2016.10.006. Epub 2016 Nov 4. Review.

PMID:
28741507
27.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.

28.

mTORC1 Controls Synthesis of Its Activator GTP.

Benjamin D, Hall MN.

Cell Rep. 2017 Jun 27;19(13):2643-2644. doi: 10.1016/j.celrep.2017.06.032. Review.

29.

Transplantation of Skeletal Muscle Stem Cells.

Hall MN, Hall JK, Cadwallader AB, Pawlikowski BT, Doles JD, Elston TL, Olwin BB.

Methods Mol Biol. 2017;1556:237-244. doi: 10.1007/978-1-4939-6771-1_12.

PMID:
28247353
30.

Nutrient sensing and TOR signaling in yeast and mammals.

González A, Hall MN.

EMBO J. 2017 Feb 15;36(4):397-408. doi: 10.15252/embj.201696010. Epub 2017 Jan 17. Review.

31.

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.

Fitter S, Matthews MP, Martin SK, Xie J, Ooi SS, Walkley CR, Codrington JD, Ruegg MA, Hall MN, Proud CG, Gronthos S, Zannettino ACW.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00668-16. doi: 10.1128/MCB.00668-16. Print 2017 Apr 1.

32.

Syrosingopine sensitizes cancer cells to killing by metformin.

Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN.

Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec.

33.

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA.

Nat Commun. 2016 Oct 27;7:13226. doi: 10.1038/ncomms13226.

34.

Continuity: A Central Principle of Primary Care.

Hall MN.

J Grad Med Educ. 2016 Oct;8(4):615-616. No abstract available.

35.

Sex-Specific Associations between One-Carbon Metabolism Indices and Posttranslational Histone Modifications in Arsenic-Exposed Bangladeshi Adults.

Howe CG, Liu X, Hall MN, Ilievski V, Caudill MA, Malysheva O, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV.

Cancer Epidemiol Biomarkers Prev. 2017 Feb;26(2):261-269. doi: 10.1158/1055-9965.EPI-16-0202. Epub 2016 Oct 20.

36.

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.

Driscoll DR, Karim SA, Sano M, Gay DM, Jacob W, Yu J, Mizukami Y, Gopinathan A, Jodrell DI, Evans TR, Bardeesy N, Hall MN, Quattrochi BJ, Klimstra DS, Barry ST, Sansom OJ, Lewis BC, Morton JP.

Cancer Res. 2016 Dec 1;76(23):6911-6923. Epub 2016 Oct 6.

37.

TOR and paradigm change: cell growth is controlled.

Hall MN.

Mol Biol Cell. 2016 Sep 15;27(18):2804-6. doi: 10.1091/mbc.E15-05-0311. Review.

38.

Supplementation with Folic Acid, but Not Creatine, Increases Plasma Betaine, Decreases Plasma Dimethylglycine, and Prevents a Decrease in Plasma Choline in Arsenic-Exposed Bangladeshi Adults.

Hall MN, Howe CG, Liu X, Caudill MA, Malysheva O, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV.

J Nutr. 2016 May;146(5):1062-7. doi: 10.3945/jn.115.227132. Epub 2016 Apr 6.

39.

eIF4A moonlights as an off switch for TORC1.

Swierczynska MM, Hall MN.

EMBO J. 2016 May 17;35(10):1013-4. doi: 10.15252/embj.201694326. Epub 2016 Apr 4. No abstract available.

40.

mTORC2 critically regulates renal potassium handling.

Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB.

J Clin Invest. 2016 May 2;126(5):1773-82. doi: 10.1172/JCI80304. Epub 2016 Apr 4.

41.

Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.

Drägert K, Bhattacharya I, Hall MN, Humar R, Battegay E, Haas E.

Biochem Biophys Res Commun. 2016 Apr 22;473(1):317-322. doi: 10.1016/j.bbrc.2016.03.102. Epub 2016 Mar 22.

PMID:
27016480
42.

Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and Women.

Howe CG, Liu X, Hall MN, Slavkovich V, Ilievski V, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV.

Environ Health Perspect. 2016 Aug;124(8):1234-40. doi: 10.1289/ehp.1510412. Epub 2016 Mar 11.

43.

New Psychiatry Residency Program at Carolinas HealthCare System.

Hall MN, Osborne KH.

N C Med J. 2016 Mar-Apr;77(2):126-7. doi: 10.18043/ncm.77.2.126. No abstract available.

44.

Power Is Not a Dirty Word.

Hall MN.

Fam Med. 2016 Mar;48(3):236-7. No abstract available.

45.

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P.

Cell Rep. 2016 Feb 9;14(5):1206-1217. doi: 10.1016/j.celrep.2015.12.095. Epub 2016 Jan 21.

46.

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.

Dazert E, Colombi M, Boldanova T, Moes S, Adametz D, Quagliata L, Roth V, Terracciano L, Heim MH, Jenoe P, Hall MN.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1381-6. doi: 10.1073/pnas.1523434113. Epub 2016 Jan 19.

47.

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.

Albert V, Svensson K, Shimobayashi M, Colombi M, Muñoz S, Jimenez V, Handschin C, Bosch F, Hall MN.

EMBO Mol Med. 2016 Mar 1;8(3):232-46. doi: 10.15252/emmm.201505610.

48.

Architecture of human mTOR complex 1.

Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T.

Science. 2016 Jan 1;351(6268):48-52. doi: 10.1126/science.aaa3870. Epub 2015 Dec 17.

49.

Multiple amino acid sensing inputs to mTORC1.

Shimobayashi M, Hall MN.

Cell Res. 2016 Jan;26(1):7-20. doi: 10.1038/cr.2015.146. Epub 2015 Dec 11. Review.

50.

Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult.

Aimi F, Georgiopoulou S, Kalus I, Lehner F, Hegglin A, Limani P, Gomes de Lima V, Rüegg MA, Hall MN, Lindenblatt N, Haas E, Battegay EJ, Humar R.

Sci Rep. 2015 Dec 4;5:17705. doi: 10.1038/srep17705.

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