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Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening.

Zhu H, Lee OW, Shah P, Jadhav A, Xu X, Patnaik S, Shen M, Hall MD.

SLAS Discov. 2019 Sep 14:2472555219873559. doi: 10.1177/2472555219873559. [Epub ahead of print]


A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.

Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD.

Mol Pharmacol. 2019 Sep 12. pii: mol.119.115964. doi: 10.1124/mol.119.115964. [Epub ahead of print]


Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.

Lee OW, Austin S, Gamma M, Cheff DM, Lee TD, Wilson KM, Johnson J, Travers J, Braisted JC, Guha R, Klumpp-Thomas C, Shen M, Hall MD.

SLAS Discov. 2019 Sep 9:2472555219873068. doi: 10.1177/2472555219873068. [Epub ahead of print]


The Opioid Crisis and the Future of Addiction and Pain Therapeutics.

Coussens NP, Sittampalam GS, Jonson SG, Hall MD, Gorby HE, Tamiz AP, McManus OB, Felder CC, Rasmussen K.

J Pharmacol Exp Ther. 2019 Sep 3. pii: jpet.119.259408. doi: 10.1124/jpet.119.259408. [Epub ahead of print]


Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.

Clausse V, Tao D, Debnath S, Fang Y, Tagad HD, Wang Y, Sun H, LeClair CA, Mazur SJ, Lane K, Shi ZD, Vasalatiy O, Eells R, Baker LK, Henderson MJ, Webb MR, Shen M, Hall MD, Appella E, Appella DH, Coussens NP.

J Biol Chem. 2019 Sep 3. pii: jbc.RA119.010201. doi: 10.1074/jbc.RA119.010201. [Epub ahead of print]


Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.

Chi AS, Tarapore RS, Hall MD, Shonka N, Gardner S, Umemura Y, Sumrall A, Khatib Z, Mueller S, Kline C, Zaky W, Khatua S, Weathers SP, Odia Y, Niazi TN, Daghistani D, Cherrick I, Korones D, Karajannis MA, Kong XT, Minturn J, Waanders A, Arillaga-Romany I, Batchelor T, Wen PY, Merdinger K, Schalop L, Stogniew M, Allen JE, Oster W, Mehta MP.

J Neurooncol. 2019 Aug 27. doi: 10.1007/s11060-019-03271-3. [Epub ahead of print]


Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcoma.

Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott G, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM.

Cancer Res. 2019 Aug 20. pii: canres.0217.2019. doi: 10.1158/0008-5472.CAN-19-0217. [Epub ahead of print]


Dissecting the genetic architecture of a stepwise infection process.

Hall MD, Routtu J, Ebert D.

Mol Ecol. 2019 Sep;28(17):3942-3957. doi: 10.1111/mec.15166. Epub 2019 Jul 29.


Can pathogens optimize both transmission and dispersal by exploiting sexual dimorphism in their hosts?

Nørgaard LS, Phillips BL, Hall MD.

Biol Lett. 2019 Jun 28;15(6):20190180. doi: 10.1098/rsbl.2019.0180. Epub 2019 Jun 19.


Pathogen exposure disrupts an organism's ability to cope with thermal stress.

Hector TE, Sgrò CM, Hall MD.

Glob Chang Biol. 2019 May 31. doi: 10.1111/gcb.14713. [Epub ahead of print]


Host sexual dimorphism affects the outcome of within-host pathogen competition.

Gipson SAY, Jimenez L, Hall MD.

Evolution. 2019 Jul;73(7):1443-1455. doi: 10.1111/evo.13760. Epub 2019 May 28.


Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression.

Wulftange WJ, Rose MA, Garmendia-Cedillos M, da Silva D, Poprawski JE, Srinivasachar D, Sullivan T, Lim L, Bliskovsky VV, Hall MD, Pohida TJ, Robey RW, Morgan NY, Gottesman MM.

J Cell Physiol. 2019 Nov;234(11):20608-20622. doi: 10.1002/jcp.28665. Epub 2019 Apr 22.


High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.

Wang S, Hwang EE, Guha R, O'Neill AF, Melong N, Veinotte CJ, Conway Saur A, Wuerthele K, Shen M, McKnight C, Alexe G, Lemieux ME, Wang A, Hughes E, Xu X, Boxer MB, Hall MD, Kung A, Berman JN, Davis MI, Stegmaier K, Crompton BD.

Clin Cancer Res. 2019 Jul 15;25(14):4552-4566. doi: 10.1158/1078-0432.CCR-17-0375. Epub 2019 Apr 12.


First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report.

Hall MD, Odia Y, Allen JE, Tarapore R, Khatib Z, Niazi TN, Daghistani D, Schalop L, Chi AS, Oster W, Mehta MP.

J Neurosurg Pediatr. 2019 Apr 5:1-7. doi: 10.3171/2019.2.PEDS18480. [Epub ahead of print]


Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.

Yang SM, Yoshioka M, Strovel JW, Urban DJ, Hu X, Hall MD, Jadhav A, Maloney DJ.

Bioorg Med Chem Lett. 2019 May 15;29(10):1220-1226. doi: 10.1016/j.bmcl.2019.03.014. Epub 2019 Mar 12.


Anywhere but here: local conditions motivate dispersal in Daphnia.

Erm P, Hall MD, Phillips BL.

PeerJ. 2019 Mar 12;7:e6599. doi: 10.7717/peerj.6599. eCollection 2019.


Transmission Trees on a Known Pathogen Phylogeny: Enumeration and Sampling.

Hall MD, Colijn C.

Mol Biol Evol. 2019 Jun 1;36(6):1333-1343. doi: 10.1093/molbev/msz058.


Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP.

Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047.


Discovery of novel inhibitors of human galactokinase by virtual screening.

Hu X, Zhang YQ, Lee OW, Liu L, Tang M, Lai K, Boxer MB, Hall MD, Shen M.

J Comput Aided Mol Des. 2019 Apr;33(4):405-417. doi: 10.1007/s10822-019-00190-3. Epub 2019 Feb 26.


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Proton Pump Inhibitor Use Is Associated with an Increased Frequency of New or Worsening Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt Creation.

Lewis DS, Lee TH, Konanur M, Ziegler C, Hall MD, Pabon-Ramos WM, Suhocki PV, Smith TP, Kim CY, Choi SS, Ronald J.

J Vasc Interv Radiol. 2019 Feb;30(2):163-169. doi: 10.1016/j.jvir.2018.10.015. Epub 2019 Jan 11.


KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.

Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q.

Mol Cancer Ther. 2019 Mar;18(3):706-717. doi: 10.1158/1535-7163.MCT-18-0395. Epub 2018 Dec 6.


Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.

Iniguez AB, Alexe G, Wang EJ, Roti G, Patel S, Chen L, Kitara S, Conway A, Robichaud AL, Stolte B, Bandopadhayay P, Goodale A, Pantel S, Lee Y, Cheff DM, Hall MD, Guha R, Davis MI, Menard M, Nasholm N, Weiss WA, Qi J, Beroukhim R, Piccioni F, Johannessen C, Stegmaier K.

Cancer Cell. 2018 Dec 10;34(6):922-938.e7. doi: 10.1016/j.ccell.2018.11.005.


Proton beam therapy for gastrointestinal cancers: past, present, and future.

Badiyan SN, Hallemeier CL, Lin SH, Hall MD, Chuong MD.

J Gastrointest Oncol. 2018 Oct;9(5):962-971. doi: 10.21037/jgo.2017.11.07. Review.


Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15.


Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.

Fu Y, Urban DJ, Nani RR, Zhang YF, Li N, Fu H, Shah H, Gorka AP, Guha R, Chen L, Hall MD, Schnermann MJ, Ho M.

Hepatology. 2019 Aug;70(2):563-576. doi: 10.1002/hep.30326. Epub 2019 Feb 19.


Real-time social selection maintains honesty of a dynamic visual signal in cooperative fish.

Bachmann JC, Cortesi F, Hall MD, Marshall NJ, Salzburger W, Gante HF.

Evol Lett. 2017 Oct 25;1(5):269-278. doi: 10.1002/evl3.24. eCollection 2017 Nov.


Discovery and lead identification of quinazoline-based BRD4 inhibitors.

Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang AQ, Xu X, Shah P, Hu X, Hall MD, Jadhav A, Maloney DJ.

Bioorg Med Chem Lett. 2018 Nov 15;28(21):3483-3488. doi: 10.1016/j.bmcl.2018.08.039. Epub 2018 Aug 31.


Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research.

Cheff DM, Hall MD.

J Med Chem. 2018 Oct 11;61(19):8944. doi: 10.1021/acs.jmedchem.8b01420. Epub 2018 Sep 27. No abstract available.


Linking sex differences to the evolution of infectious disease life-histories.

Hall MD, Mideo N.

Philos Trans R Soc Lond B Biol Sci. 2018 Oct 5;373(1757). pii: 20170431. doi: 10.1098/rstb.2017.0431.


KDM5 histone demethylases repress immune response via suppression of STING.

Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.

PLoS Biol. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. eCollection 2018 Aug.


The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.

Weidner LD, Kannan P, Mitsios N, Kang SJ, Hall MD, Theodore WH, Innis RB, Mulder J.

Epilepsia. 2018 Aug;59(8):1507-1517. doi: 10.1111/epi.14505. Epub 2018 Jul 21.


High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

Coussens NP, Kales SC, Henderson MJ, Lee OW, Horiuchi KY, Wang Y, Chen Q, Kuznetsova E, Wu J, Chakka S, Cheff DM, Cheng KC, Shinn P, Brimacombe KR, Shen M, Simeonov A, Lal-Nag M, Ma H, Jadhav A, Hall MD.

J Biol Chem. 2018 Aug 31;293(35):13750-13765. doi: 10.1074/jbc.RA118.004274. Epub 2018 Jun 26.


A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.

Martinez NJ, Asawa RR, Cyr MG, Zakharov A, Urban DJ, Roth JS, Wallgren E, Klumpp-Thomas C, Coussens NP, Rai G, Yang SM, Hall MD, Marugan JJ, Simeonov A, Henderson MJ.

Sci Rep. 2018 Jun 21;8(1):9472. doi: 10.1038/s41598-018-27834-y.


Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24. Review.


Risk of Radiation Vasculopathy and Stroke in Pediatric Patients Treated With Proton Therapy for Brain and Skull Base Tumors.

Hall MD, Bradley JA, Rotondo RL, Hanel R, Shah C, Morris CG, Aldana PR, Indelicato DJ.

Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):854-859. doi: 10.1016/j.ijrobp.2018.03.027. Epub 2018 Mar 29.


Revisiting the role of ABC transporters in multidrug-resistant cancer.

Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE, Gottesman MM.

Nat Rev Cancer. 2018 Jul;18(7):452-464. doi: 10.1038/s41568-018-0005-8. Review.


Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.


Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.


Better living through chemistry: Addressing emerging antibiotic resistance.

Coussens NP, Molinaro AL, Culbertson KJ, Peryea T, Zahoránszky-Köhalmi G, Hall MD, Daines DA.

Exp Biol Med (Maywood). 2018 Mar;243(6):538-553. doi: 10.1177/1535370218755659. Epub 2018 Feb 6. Review.


Genetic constraints on adaptation: a theoretical primer for the genomics era.

Connallon T, Hall MD.

Ann N Y Acad Sci. 2018 Jun;1422(1):65-87. doi: 10.1111/nyas.13536. Epub 2018 Jan 24. Review.


Interactions between host sex and age of exposure modify the virulence-transmission trade-off.

Gipson SAY, Hall MD.

J Evol Biol. 2018 Mar;31(3):428-437. doi: 10.1111/jeb.13237. Epub 2018 Jan 22.


Cisplatin is retained in the cochlea indefinitely following chemotherapy.

Breglio AM, Rusheen AE, Shide ED, Fernandez KA, Spielbauer KK, McLachlin KM, Hall MD, Amable L, Cunningham LL.

Nat Commun. 2017 Nov 21;8(1):1654. doi: 10.1038/s41467-017-01837-1.


Albumin-bilirubin grade versus MELD score for predicting survival after transjugular intrahepatic portosystemic shunt (TIPS) creation.

Ronald J, Wang Q, Choi SS, Suhocki PV, Hall MD, Smith TP, Kim CY.

Diagn Interv Imaging. 2018 Mar;99(3):163-168. doi: 10.1016/j.diii.2017.10.008. Epub 2017 Nov 16.


Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ.

J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9.


Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.

Urban DJ, Martinez NJ, Davis MI, Brimacombe KR, Cheff DM, Lee TD, Henderson MJ, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall MD.

Sci Rep. 2017 Oct 6;7(1):12758. doi: 10.1038/s41598-017-12630-x.


Erratum: The impact of host sex on the outcome of co-infection.

Thompson O, Gipson SAY, Hall MD.

Sci Rep. 2017 Sep 28;7(1):12374. doi: 10.1038/s41598-017-12310-w.


Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.

Coussens NP, Braisted JC, Peryea T, Sittampalam GS, Simeonov A, Hall MD.

Pharmacol Rev. 2017 Oct;69(4):479-496. doi: 10.1124/pr.117.013755. Review.


The Evolutionary Consequences of Stepwise Infection Processes.

Hall MD, Bento G, Ebert D.

Trends Ecol Evol. 2017 Aug;32(8):612-623. doi: 10.1016/j.tree.2017.05.009. Epub 2017 Jun 22.


The impact of host sex on the outcome of co-infection.

Thompson O, Gipson SAY, Hall MD.

Sci Rep. 2017 Apr 19;7(1):910. doi: 10.1038/s41598-017-00835-z. Erratum in: Sci Rep. 2017 Sep 28;7(1):12374.

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