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Items: 1 to 50 of 202

1.

Epigenetic prediction of complex traits and death.

McCartney DL, Hillary RF, Stevenson AJ, Ritchie SJ, Walker RM, Zhang Q, Morris SW, Bermingham ML, Campbell A, Murray AD, Whalley HC, Gale CR, Porteous DJ, Haley CS, McRae AF, Wray NR, Visscher PM, McIntosh AM, Evans KL, Deary IJ, Marioni RE.

Genome Biol. 2018 Sep 27;19(1):136. doi: 10.1186/s13059-018-1514-1.

2.

Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.

Barbu MC, Zeng Y, Shen X, Cox SR, Clarke TK, Gibson J, Adams MJ, Johnstone M, Haley CS, Lawrie SM, Deary IJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, McIntosh AM, Whalley HC.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Jul 31. pii: S2451-9022(18)30181-2. doi: 10.1016/j.bpsc.2018.07.006. [Epub ahead of print]

PMID:
30197049
3.

Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J, Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM.

Nat Commun. 2018 Aug 30;9(1):3578. doi: 10.1038/s41467-018-05310-5. No abstract available.

4.

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J; 23andMe Research Team, Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM.

Nat Commun. 2018 Apr 16;9(1):1470. doi: 10.1038/s41467-018-03819-3.

5.

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits.

Shirali M, Knott SA, Pong-Wong R, Navarro P, Haley CS.

Sci Rep. 2018 Mar 21;8(1):4982. doi: 10.1038/s41598-018-23307-4.

6.

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

Baillie JK, Bretherick A, Haley CS, Clohisey S, Gray A, Neyton LPA, Barrett J, Stahl EA, Tenesa A, Andersson R, Brown JB, Faulkner GJ, Lizio M, Schaefer U, Daub C, Itoh M, Kondo N, Lassmann T, Kawai J; IIBDGC Consortium, Mole D, Bajic VB, Heutink P, Rehli M, Kawaji H, Sandelin A, Suzuki H, Satsangi J, Wells CA, Hacohen N, Freeman TC, Hayashizaki Y, Carninci P, Forrest ARR, Hume DA.

PLoS Comput Biol. 2018 Mar 1;14(3):e1005934. doi: 10.1371/journal.pcbi.1005934. eCollection 2018 Mar.

7.

Genomic analysis of family data reveals additional genetic effects on intelligence and personality.

Hill WD, Arslan RC, Xia C, Luciano M, Amador C, Navarro P, Hayward C, Nagy R, Porteous DJ, McIntosh AM, Deary IJ, Haley CS, Penke L.

Mol Psychiatry. 2018 Jan 10. doi: 10.1038/s41380-017-0005-1. [Epub ahead of print]

PMID:
29321673
8.

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.

Hall LS, Adams MJ, Arnau-Soler A, Clarke TK, Howard DM, Zeng Y, Davies G, Hagenaars SP, Maria Fernandez-Pujals A, Gibson J, Wigmore EM, Boutin TS, Hayward C, Scotland G; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Porteous DJ, Deary IJ, Thomson PA, Haley CS, McIntosh AM.

Transl Psychiatry. 2018 Jan 10;8(1):9. doi: 10.1038/s41398-017-0034-1.

9.

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank.

Howard DM, Hall LS, Hafferty JD, Zeng Y, Adams MJ, Clarke TK, Porteous DJ, Nagy R, Hayward C, Smith BH, Murray AD, Ryan NM, Evans KL, Haley CS, Deary IJ, Thomson PA, McIntosh AM.

Transl Psychiatry. 2017 Nov 30;7(11):1263. doi: 10.1038/s41398-017-0010-9.

10.

Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank.

Howard DM, Adams MJ, Clarke TK, Wigmore EM, Zeng Y, Hagenaars SP, Lyall DM, Thomson PA, Evans KL, Porteous DJ, Nagy R, Hayward C, Haley CS, Smith BH, Murray AD, Batty GD, Deary IJ, McIntosh AM.

Wellcome Open Res. 2017 Aug 10;2:61. doi: 10.12688/wellcomeopenres.12171.1. eCollection 2017.

11.

Regional variation in health is predominantly driven by lifestyle rather than genetics.

Amador C, Xia C, Nagy R, Campbell A, Porteous D, Smith BH, Hastie N, Vitart V, Hayward C, Navarro P, Haley CS.

Nat Commun. 2017 Oct 6;8(1):801. doi: 10.1038/s41467-017-00497-5.

12.

Antagonistic genetic correlations for milking traits within the genome of dairy cattle.

Gervais O, Pong-Wong R, Navarro P, Haley CS, Nagamine Y.

PLoS One. 2017 Apr 5;12(4):e0175105. doi: 10.1371/journal.pone.0175105. eCollection 2017.

13.

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

Nagy R, Boutin TS, Marten J, Huffman JE, Kerr SM, Campbell A, Evenden L, Gibson J, Amador C, Howard DM, Navarro P, Morris A, Deary IJ, Hocking LJ, Padmanabhan S, Smith BH, Joshi P, Wilson JF, Hastie ND, Wright AF, McIntosh AM, Porteous DJ, Haley CS, Vitart V, Hayward C.

Genome Med. 2017 Mar 7;9(1):23. doi: 10.1186/s13073-017-0414-4.

14.

Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D, Scotland G, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS.

PLoS Genet. 2017 Feb 14;13(2):e1006608. doi: 10.1371/journal.pgen.1006608. eCollection 2017 Feb.

15.

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder.

Zeng Y, Navarro P, Shirali M, Howard DM, Adams MJ, Hall LS, Clarke TK, Thomson PA, Smith BH, Murray A, Padmanabhan S, Hayward C, Boutin T, MacIntyre DJ, Lewis CM, Wray NR, Mehta D, Penninx BWJH, Milaneschi Y, Baune BT, Air T, Hottenga JJ, Mbarek H, Castelao E, Pistis G, Schulze TG, Streit F, Forstner AJ, Byrne EM, Martin NG, Breen G, Müller-Myhsok B, Lucae S, Kloiber S, Domenici E; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Deary IJ, Porteous DJ, Haley CS, McIntosh AM.

Biol Psychiatry. 2017 Sep 1;82(5):312-321. doi: 10.1016/j.biopsych.2016.12.012. Epub 2016 Dec 16.

16.
17.

Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression.

Zeng Y, Navarro P, Xia C, Amador C, Fernandez-Pujals AM, Thomson PA, Campbell A, Nagy R, Clarke TK, Hafferty JD, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, MacIntyre DJ, Porteous DJ, Haley CS, McIntosh AM.

EBioMedicine. 2016 Dec;14:161-167. doi: 10.1016/j.ebiom.2016.11.003. Epub 2016 Nov 4.

18.

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis.

McIntosh AM, Hall LS, Zeng Y, Adams MJ, Gibson J, Wigmore E, Hagenaars SP, Davies G, Fernandez-Pujals AM, Campbell AI, Clarke TK, Hayward C, Haley CS, Porteous DJ, Deary IJ, Smith DJ, Nicholl BI, Hinds DA, Jones AV, Scollen S, Meng W, Smith BH, Hocking LJ.

PLoS Med. 2016 Aug 16;13(8):e1002090. doi: 10.1371/journal.pmed.1002090. eCollection 2016 Aug.

19.

Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank.

Muñoz M, Pong-Wong R, Canela-Xandri O, Rawlik K, Haley CS, Tenesa A.

Nat Genet. 2016 Sep;48(9):980-3. doi: 10.1038/ng.3618. Epub 2016 Jul 18.

20.

A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder.

Zeng Y, Navarro P, Fernandez-Pujals AM, Hall LS, Clarke TK, Thomson PA, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, MacIntyre DJ, Wray NR; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Deary IJ, Porteous DJ, Haley CS, McIntosh AM.

Biol Psychiatry. 2017 Feb 15;81(4):336-346. doi: 10.1016/j.biopsych.2016.04.017. Epub 2016 May 2.

21.

Use of high-density SNP data to identify patterns of diversity and signatures of selection in broiler chickens.

Stainton JJ, Charlesworth B, Haley CS, Kranis A, Watson K, Wiener P.

J Anim Breed Genet. 2017 Apr;134(2):87-97. doi: 10.1111/jbg.12228. Epub 2016 Jun 28.

22.

Gene expression comparison of resistant and susceptible Atlantic salmon fry challenged with Infectious Pancreatic Necrosis virus reveals a marked contrast in immune response.

Robledo D, Taggart JB, Ireland JH, McAndrew BJ, Starkey WG, Haley CS, Hamilton A, Guy DR, Mota-Velasco JC, Gheyas AA, Tinch AE, Verner-Jeffreys DW, Paley RK, Rimmer GS, Tew IJ, Bishop SC, Bron JE, Houston RD.

BMC Genomics. 2016 Apr 11;17:279. doi: 10.1186/s12864-016-2600-y.

23.

The heritability and patterns of DNA methylation in normal human colorectum.

Rowlatt A, Hernández-Suárez G, Sanabria-Salas MC, Serrano-López M, Rawlik K, Hernandez-Illan E, Alenda C, Castillejo A, Soto JL, Haley CS, Tenesa A.

Hum Mol Genet. 2016 Jun 15;25(12):2600-2611. Epub 2016 Mar 2.

24.

Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D; Generation Scotland, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS.

PLoS Genet. 2016 Feb 2;12(2):e1005804. doi: 10.1371/journal.pgen.1005804. eCollection 2016 Feb. Erratum in: PLoS Genet. 2017 Feb 14;13(2):e1006608.

25.

Genetic loci inherited from hens lacking maternal behaviour both inhibit and paradoxically promote this behaviour.

Basheer A, Haley CS, Law A, Windsor D, Morrice D, Talbot R, Wilson PW, Sharp PJ, Dunn IC.

Genet Sel Evol. 2015 Dec 30;47:100. doi: 10.1186/s12711-015-0180-y.

26.

Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations.

Shirali M, Pong-Wong R, Navarro P, Knott S, Hayward C, Vitart V, Rudan I, Campbell H, Hastie ND, Wright AF, Haley CS.

Heredity (Edinb). 2016 Mar;116(3):333-8. doi: 10.1038/hdy.2015.107. Epub 2015 Dec 23.

27.

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS).

Fernandez-Pujals AM, Adams MJ, Thomson P, McKechanie AG, Blackwood DH, Smith BH, Dominiczak AF, Morris AD, Matthews K, Campbell A, Linksted P, Haley CS, Deary IJ, Porteous DJ, MacIntyre DJ, McIntosh AM.

PLoS One. 2015 Nov 16;10(11):e0142197. doi: 10.1371/journal.pone.0142197. eCollection 2015.

28.

Efficiency of genomic prediction for boar taint reduction in Danish Landrace pigs.

Lukić B, Pong-Wong R, Rowe SJ, de Koning DJ, Velander I, Haley CS, Archibald AL, Woolliams JA.

Anim Genet. 2015 Dec;46(6):607-16. doi: 10.1111/age.12369. Epub 2015 Oct 9.

29.

Recent genomic heritage in Scotland.

Amador C, Huffman J, Trochet H, Campbell A, Porteous D; Generation Scotland, Wilson JF, Hastie N, Vitart V, Hayward C, Navarro P, Haley CS.

BMC Genomics. 2015 Jun 6;16:437. doi: 10.1186/s12864-015-1605-2.

30.

Application of high-dimensional feature selection: evaluation for genomic prediction in man.

Bermingham ML, Pong-Wong R, Spiliopoulou A, Hayward C, Rudan I, Campbell H, Wright AF, Wilson JF, Agakov F, Navarro P, Haley CS.

Sci Rep. 2015 May 19;5:10312. doi: 10.1038/srep10312.

31.

Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models.

Spiliopoulou A, Nagy R, Bermingham ML, Huffman JE, Hayward C, Vitart V, Rudan I, Campbell H, Wright AF, Wilson JF, Pong-Wong R, Agakov F, Navarro P, Haley CS.

Hum Mol Genet. 2015 Jul 15;24(14):4167-82. doi: 10.1093/hmg/ddv145. Epub 2015 Apr 26.

32.

Detecting signatures of selection in nine distinct lines of broiler chickens.

Stainton JJ, Haley CS, Charlesworth B, Kranis A, Watson K, Wiener P.

Anim Genet. 2015 Feb;46(1):37-49. doi: 10.1111/age.12252. Epub 2014 Dec 16.

PMID:
25515710
33.

Detecting epistasis in human complex traits.

Wei WH, Hemani G, Haley CS.

Nat Rev Genet. 2014 Nov;15(11):722-33. doi: 10.1038/nrg3747. Epub 2014 Sep 9. Review.

PMID:
25200660
34.

Analysis of the genetics of boar taint reveals both single SNPs and regional effects.

Rowe SJ, Karacaören B, de Koning DJ, Lukic B, Hastings-Clark N, Velander I, Haley CS, Archibald AL.

BMC Genomics. 2014 Jun 3;15:424. doi: 10.1186/1471-2164-15-424.

35.

Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid.

Wei WH, Guo Y, Kindt AS, Merriman TR, Semple CA, Wang K, Haley CS.

Hum Mol Genet. 2014 Oct 1;23(19):5061-8. doi: 10.1093/hmg/ddu227. Epub 2014 May 12.

36.

A genome-wide linkage analysis for reproductive traits in F2 Large White × Meishan cross gilts.

Hernandez SC, Finlayson HA, Ashworth CJ, Haley CS, Archibald AL.

Anim Genet. 2014 Apr;45(2):191-7. doi: 10.1111/age.12123. Epub 2014 Jan 23.

37.

The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits.

Uemoto Y, Pong-Wong R, Navarro P, Vitart V, Hayward C, Wilson JF, Rudan I, Campbell H, Hastie ND, Wright AF, Haley CS.

Front Genet. 2013 Nov 19;4:232. doi: 10.3389/fgene.2013.00232. eCollection 2013.

38.

Properties of local interactions and their potential value in complementing genome-wide association studies.

Wei W, Gyenesei A, Semple CA, Haley CS.

PLoS One. 2013 Aug 5;8(8):e71203. doi: 10.1371/journal.pone.0071203. Print 2013.

39.

Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies.

Joshi PK, Prendergast J, Fraser RM, Huffman JE, Vitart V, Hayward C, McQuillan R, Glodzik D, Polašek O, Hastie ND, Rudan I, Campbell H, Wright AF, Haley CS, Wilson JF, Navarro P.

PLoS One. 2013 Jul 16;8(7):e68604. doi: 10.1371/journal.pone.0068604. Print 2013.

40.

Secreted phosphoprotein 1 expression in endometrium and placental tissues of hyperprolific large white and meishan gilts.

Hernandez SC, Hogg CO, Billon Y, Sanchez MP, Bidanel JP, Haley CS, Archibald AL, Ashworth CJ.

Biol Reprod. 2013 May 16;88(5):120. doi: 10.1095/biolreprod.112.104679. Print 2013 May.

PMID:
23575146
41.

The genomic signature of trait-associated variants.

Kindt AS, Navarro P, Semple CA, Haley CS.

BMC Genomics. 2013 Feb 18;14:108. doi: 10.1186/1471-2164-14-108.

42.

The heritability of human disease: estimation, uses and abuses.

Tenesa A, Haley CS.

Nat Rev Genet. 2013 Feb;14(2):139-49. doi: 10.1038/nrg3377. Review.

PMID:
23329114
43.

Development of a genetic tool for product regulation in the diverse British pig breed market.

Wilkinson S, Archibald AL, Haley CS, Megens HJ, Crooijmans RP, Groenen MA, Wiener P, Ogden R.

BMC Genomics. 2012 Nov 15;13:580. doi: 10.1186/1471-2164-13-580.

44.

Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping.

Nagamine Y, Pong-Wong R, Navarro P, Vitart V, Hayward C, Rudan I, Campbell H, Wilson J, Wild S, Hicks AA, Pramstaller PP, Hastie N, Wright AF, Haley CS.

PLoS One. 2012;7(10):e46501. doi: 10.1371/journal.pone.0046501. Epub 2012 Oct 15.

45.

Uncovering networks from genome-wide association studies via circular genomic permutation.

Cabrera CP, Navarro P, Huffman JE, Wright AF, Hayward C, Campbell H, Wilson JF, Rudan I, Hastie ND, Vitart V, Haley CS.

G3 (Bethesda). 2012 Sep;2(9):1067-75. doi: 10.1534/g3.112.002618. Epub 2012 Sep 1.

46.

BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies.

Gyenesei A, Moody J, Laiho A, Semple CA, Haley CS, Wei WH.

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W628-32. doi: 10.1093/nar/gks550. Epub 2012 Jun 11.

47.

High-throughput analysis of epistasis in genome-wide association studies with BiForce.

Gyenesei A, Moody J, Semple CA, Haley CS, Wei WH.

Bioinformatics. 2012 Aug 1;28(15):1957-64. doi: 10.1093/bioinformatics/bts304. Epub 2012 May 21. Erratum in: Bioinformatics. 2013 Oct 15;29(20):2667-8.

48.

Characterization of the genetic diversity, structure and admixture of British chicken breeds.

Wilkinson S, Wiener P, Teverson D, Haley CS, Hocking PM.

Anim Genet. 2012 Oct;43(5):552-63. doi: 10.1111/j.1365-2052.2011.02296.x. Epub 2011 Dec 7.

PMID:
22497565
49.

Investigation of the genetic architecture of a bone carcass weight QTL on BTA6.

Gutiérrez-Gil B, Wiener P, Williams JL, Haley CS.

Anim Genet. 2012 Dec;43(6):654-61. doi: 10.1111/j.1365-2052.2012.02322.x. Epub 2012 Feb 27.

PMID:
22497262
50.

Complex traits analysis of chicken growth using targeted genetical genomics.

Cabrera CP, Dunn IC, Fell M, Wilson PW, Burt DW, Waddington D, Talbot R, Hocking PM, Law A, Knott S, Haley CS, de Koning DJ.

Anim Genet. 2012 Apr;43(2):163-71. doi: 10.1111/j.1365-2052.2011.02223.x. Epub 2011 Jul 7.

PMID:
22404352

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