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Items: 44


From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities?

Bewersdorf JP, Ardasheva A, Podoltsev NA, Singh A, Biancon G, Halene S, Zeidan AM.

Blood Rev. 2019 Sep;37:100587. doi: 10.1016/j.blre.2019.100587. Epub 2019 Jul 4. Review.


A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.

Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.

Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x.


Role of alternative splicing in hematopoietic stem cells during development.

Gao Y, Vasic R, Halene S.

Stem Cell Investig. 2018 Aug 23;5:26. doi: 10.21037/sci.2018.08.02. eCollection 2018. No abstract available.


SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.

Liang Y, Tebaldi T, Rejeski K, Joshi P, Stefani G, Taylor A, Song Y, Vasic R, Maziarz J, Balasubramanian K, Ardasheva A, Ding A, Quattrone A, Halene S.

Leukemia. 2018 Dec;32(12):2659-2671. doi: 10.1038/s41375-018-0152-7. Epub 2018 Jun 1.


Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis.

Rahmani M, Halene S, Xu ML.

Biomed Res Int. 2018 Apr 3;2018:9413015. doi: 10.1155/2018/9413015. eCollection 2018.


Whole-exome sequencing in evaluation of patients with venous thromboembolism.

Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI.

Blood Adv. 2017 Jun 29;1(16):1224-1237. doi: 10.1182/bloodadvances.2017005249. eCollection 2017 Jul 11.


Corrigendum: Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211c. No abstract available.


Health Care Use by Older Adults With Acute Myeloid Leukemia at the End of Life.

Wang R, Zeidan AM, Halene S, Xu X, Davidoff AJ, Huntington SF, Podoltsev NA, Gross CP, Gore SD, Ma X.

J Clin Oncol. 2017 Oct 20;35(30):3417-3424. doi: 10.1200/JCO.2017.72.7149. Epub 2017 Aug 7.


Rusty neutrophils in β-thalassemia: no traction!

Gaines P, Halene S.

Blood. 2017 Jun 8;129(23):3046-3047. doi: 10.1182/blood-2017-04-776393. No abstract available.


How do messenger RNA splicing alterations drive myelodysplasia?

Joshi P, Halene S, Abdel-Wahab O.

Blood. 2017 May 4;129(18):2465-2470. doi: 10.1182/blood-2017-02-692715. Epub 2017 Mar 27. Review.


2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.

Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal2463. doi: 10.1126/scitranslmed.aal2463.


Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.

de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA.

Nat Genet. 2017 Mar;49(3):451-456. doi: 10.1038/ng.3772. Epub 2017 Jan 23.


Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors.

Yang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM.

Nucleic Acids Res. 2017 Feb 17;45(3):1281-1296. doi: 10.1093/nar/gkw1214.


Novel Developments in Leukopenia and Pancytopenia.

Onuoha C, Arshad J, Astle J, Xu M, Halene S.

Prim Care. 2016 Dec;43(4):559-573. doi: 10.1016/j.pop.2016.07.005. Review.


Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice.

Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG.

Blood. 2016 Oct 6;128(14):1829-1833. doi: 10.1182/blood-2015-10-676452. Epub 2016 Aug 19.


Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.

Malu K, Garhwal R, Pelletier MG, Gotur D, Halene S, Zwerger M, Yang ZF, Rosmarin AG, Gaines P.

J Immunol. 2016 Aug 1;197(3):910-22. doi: 10.4049/jimmunol.1402285. Epub 2016 Jun 24.


Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism.

Woodson KA, Lee Y, Gopalratnam K, Halene S.

BMJ Case Rep. 2016 Jan 14;2016. pii: bcr2015213575. doi: 10.1136/bcr-2015-213575.


SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Kim E, Ilagan JO, Liang Y, Daubner GM, Lee SC, Ramakrishnan A, Li Y, Chung YR, Micol JB, Murphy ME, Cho H, Kim MK, Zebari AS, Aumann S, Park CY, Buonamici S, Smith PG, Deeg HJ, Lobry C, Aifantis I, Modis Y, Allain FH, Halene S, Bradley RK, Abdel-Wahab O.

Cancer Cell. 2015 May 11;27(5):617-30. doi: 10.1016/j.ccell.2015.04.006.


Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis.

Sui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM.

Blood. 2015 Jul 23;126(4):520-30. doi: 10.1182/blood-2014-09-601484. Epub 2015 May 11.


Stem cell maintenance: aMPLe splicing choices.

Halene S, Krause DS.

Blood. 2015 Feb 5;125(6):891-2. doi: 10.1182/blood-2014-12-616326. No abstract available.


Oxaliplatin-related acute disseminated intravascular coagulation syndrome in a patient with metastatic colon cancer.

Malkhasyan K, Halene S, Lacy J.

Clin Colorectal Cancer. 2015 Mar;14(1):e9-e12. doi: 10.1016/j.clcc.2014.09.011. Epub 2014 Oct 2. No abstract available.


The regulatory role of serum response factor pathway in neutrophil inflammatory response.

Taylor A, Halene S.

Curr Opin Hematol. 2015 Jan;22(1):67-73. doi: 10.1097/MOH.0000000000000099. Review.


Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2014 Apr;32(4):364-72. doi: 10.1038/nbt.2858. Epub 2014 Mar 16. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.


SRF is required for neutrophil migration in response to inflammation.

Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S.

Blood. 2014 May 8;123(19):3027-36. doi: 10.1182/blood-2013-06-507582. Epub 2014 Feb 26.


Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia.

Kim Y, Schulz VP, Satake N, Gruber TA, Teixeira AM, Halene S, Gallagher PG, Krause DS.

Leukemia. 2014 Apr;28(4):945-8. doi: 10.1038/leu.2013.314. Epub 2013 Oct 25. No abstract available.


Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.

Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16636-41. doi: 10.1073/pnas.1213196109. Epub 2012 Sep 24.


Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

Khanna-Gupta A, Abayasekara N, Levine M, Sun H, Virgilio M, Nia N, Halene S, Sportoletti P, Jeong JY, Pandolfi PP, Berliner N.

J Biol Chem. 2012 Sep 21;287(39):32728-37. Epub 2012 Jul 31.


MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.

Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE Jr, Krause DS.

Blood. 2012 Sep 13;120(11):2317-29. doi: 10.1182/blood-2012-04-420828. Epub 2012 Jul 17.


Gaucher disease gene GBA functions in immune regulation.

Liu J, Halene S, Yang M, Iqbal J, Yang R, Mehal WZ, Chuang WL, Jain D, Yuen T, Sun L, Zaidi M, Mistry PK.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10018-23. doi: 10.1073/pnas.1200941109. Epub 2012 Jun 4.


Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.

Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS.

Dev Cell. 2012 Mar 13;22(3):573-84. doi: 10.1016/j.devcel.2011.12.019. Epub 2012 Mar 1.


Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia.

Bajaj R, Xu F, Xiang B, Wilcox K, Diadamo AJ, Kumar R, Pietraszkiewicz A, Halene S, Li P.

Mol Cytogenet. 2011 Jan 20;4:3. doi: 10.1186/1755-8166-4-3.


Pattern of hypomethylating agents use among elderly patients with myelodysplastic syndromes.

Wang R, Gross CP, Maggiore RJ, Halene S, Soulos PR, Raza A, Galili N, Ma X.

Leuk Res. 2011 Jul;35(7):904-8. doi: 10.1016/j.leukres.2010.10.007. Epub 2010 Nov 9.


Serum response factor is an essential transcription factor in megakaryocytic maturation.

Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS.

Blood. 2010 Sep 16;116(11):1942-50. doi: 10.1182/blood-2010-01-261743. Epub 2010 Jun 4.


Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.

Zhang Y, Tang W, Jones MC, Xu W, Halene S, Wu D.

J Biol Chem. 2010 Aug 6;285(32):24805-14. doi: 10.1074/jbc.M110.142885. Epub 2010 Jun 4.


C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.

Halene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause D, Berliner N.

Exp Hematol. 2010 Feb;38(2):90-103. doi: 10.1016/j.exphem.2009.11.004. Epub 2009 Dec 5.


Neighborhood socioeconomic status influences the survival of elderly patients with myelodysplastic syndromes in the United States.

Wang R, Gross CP, Halene S, Ma X.

Cancer Causes Control. 2009 Oct;20(8):1369-76. doi: 10.1007/s10552-009-9362-7. Epub 2009 May 20.


Comorbidities and survival in a large cohort of patients with newly diagnosed myelodysplastic syndromes.

Wang R, Gross CP, Halene S, Ma X.

Leuk Res. 2009 Dec;33(12):1594-8. doi: 10.1016/j.leukres.2009.02.005. Epub 2009 Mar 25.


Sustained remission from angioimmunoblastic T-cell lymphoma induced by alemtuzumab.

Halene S, Zieske A, Berliner N.

Nat Clin Pract Oncol. 2006 Mar;3(3):165-8; quiz 169.


Effects of the negative control region on expression from retroviral LTR.

Wang L, Haas D, Halene S, Kohn DB.

Mol Ther. 2003 Apr;7(4):438-40. No abstract available.


Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest.

Halene S, Kohn DB.

Hum Gene Ther. 2000 Jun 10;11(9):1259-67. Review.


Immune response to green fluorescent protein: implications for gene therapy.

Stripecke R, Carmen Villacres M, Skelton D, Satake N, Halene S, Kohn D.

Gene Ther. 1999 Jul;6(7):1305-12.


Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells.

Robbins PB, Skelton DC, Yu XJ, Halene S, Leonard EH, Kohn DB.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10182-7.


Ruptured aortic pseudo-aneurysm: a rare presentation as aortocaval fistula.

Pagni S, Halene S, Kwass W, Khachane V.

J Cardiovasc Surg (Torino). 1997 Apr;38(2):165-8.


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