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Items: 30

1.
2.

ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells.

Davie N, Haleen SJ, Upton PD, Polak JM, Yacoub MH, Morrell NW, Wharton J.

Am J Respir Crit Care Med. 2002 Feb 1;165(3):398-405.

PMID:
11818328
3.

The endothelin-A-receptor antagonist PD 180988 (CI-1034) selectively reverses the pulmonary vasoconstrictor response to hypoxia in the lamb.

Coe Y, Haleen SJ, Welch KM, Coceani F.

J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S331-3.

PMID:
11078412
4.

Butenolide endothelin antagonists with improved aqueous solubility.

Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA.

J Med Chem. 1999 Jun 17;42(12):2162-8.

PMID:
10377221
5.

PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat.

Schroeder RL, Keiser JA, Cheng XM, Haleen SJ.

J Cardiovasc Pharmacol. 1998 Dec;32(6):935-43.

PMID:
9869499
6.

Endothelin B receptors on human endothelial and smooth-muscle cells show equivalent binding pharmacology.

Flynn MA, Haleen SJ, Welch KM, Cheng XM, Reynolds EE.

J Cardiovasc Pharmacol. 1998 Jul;32(1):106-16.

PMID:
9676729
7.

Assessment of endothelin receptor subtype-mediated increases of [Ca2+]i in distinct rat cell types using fluorimetric imaging.

Dooley DJ, Geer JJ, Haleen SJ, Probert AW, Welch KM.

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S192-5.

PMID:
9595435
8.

Novel selective quinazoline inhibitors of endothelin converting enzyme-1.

Ahn K, Sisneros AM, Herman SB, Pan SM, Hupe D, Lee C, Nikam S, Cheng XM, Doherty AM, Schroeder RL, Haleen SJ, Kaw S, Emoto N, Yanagisawa M.

Biochem Biophys Res Commun. 1998 Feb 4;243(1):184-90.

PMID:
9473502
9.
10.

Cardiopulmonary indications for endothelin receptor antagonists: review of recent efficacy trials.

Haleen SJ, Cheng XM.

Expert Opin Investig Drugs. 1997 May;6(5):475-87.

PMID:
15989614
11.

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM.

J Med Chem. 1997 Mar 28;40(7):1063-74.

PMID:
9089328
12.

Structure-activity relationships of the potent combined endothelin-A/endothelin-B receptor antagonist Ac-DDip16-Leu-Asp-Ile-Ile-Trp21: development of endothelin-B receptor selective antagonists.

Cody WL, He JX, DePue PL, Waite LA, Leonard DM, Sefler AM, Kaltenbronn JS, Haleen SJ, Walker DM, Flynn MA, et al.

J Med Chem. 1995 Jul 21;38(15):2809-19.

PMID:
7636842
13.

Pharmacological characterization of PD 156707, an orally active ETA receptor antagonist.

Reynolds EE, Keiser JA, Haleen SJ, Walker DM, Olszewski B, Schroeder RL, Taylor DG, Hwang O, Welch KM, Flynn MA, et al.

J Pharmacol Exp Ther. 1995 Jun;273(3):1410-7.

PMID:
7791115
14.

Structure-activity relationships of a novel series of orally active nonpeptide ETA and ETA/B endothelin receptor-selective antagonists.

Doherty AM, Patt WC, Repine J, Edmunds JJ, Berryman KA, Reisdorph BR, Walker DM, Haleen SJ, Keiser JA, Flynn MA, et al.

J Cardiovasc Pharmacol. 1995;26 Suppl 3:S358-61.

PMID:
8587414
15.

Effects of selective endothelin antagonists on the hemodynamic response to cyclosporin A.

Davis LS, Haleen SJ, Doherty AM, Cody WL, Keiser JA.

J Am Soc Nephrol. 1994 Jan;4(7):1448-54.

16.

ETA and ETB receptors coexist on rabbit pulmonary artery vascular smooth muscle mediating contraction.

LaDouceur DM, Flynn MA, Keiser JA, Reynolds E, Haleen SJ.

Biochem Biophys Res Commun. 1993 Oct 15;196(1):209-15.

PMID:
8216294
17.

Why big endothelin-1 lacks a vasodilator response.

Haleen SJ, Davis LS, LaDouceur DM, Keiser JA.

J Cardiovasc Pharmacol. 1993;22 Suppl 8:S271-3.

PMID:
7509963
18.
19.

Design of a functional hexapeptide antagonist of endothelin.

Cody WL, Doherty AM, He JX, DePue PL, Rapundalo ST, Hingorani GA, Major TC, Panek RL, Dudley DT, Haleen SJ, et al.

J Med Chem. 1992 Aug 21;35(17):3301-3. No abstract available. Erratum in: J Med Chem 1993 Jan 22;36(2):304.

PMID:
1324321
20.
21.
22.

Subclasses of cyclic GMP-specific phosphodiesterase and their role in regulating the effects of atrial natriuretic factor.

Weishaar RE, Kobylarz-Singer DC, Keiser J, Haleen SJ, Major TC, Rapundalo S, Peterson JT, Panek R.

Hypertension. 1990 May;15(5):528-40.

PMID:
2158939
23.

Species differences in the positive inotropic response to DPI 201-106, a novel cardiotonic agent.

Haleen SJ, Steffen RP, Weishaar RE.

Can J Physiol Pharmacol. 1989 Nov;67(11):1460-3.

PMID:
2560676
24.

PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties.

Haleen SJ, Steffen RP, Sircar I, Major TC, Taylor MD, Pugsley TA, Weishaar RE.

J Pharmacol Exp Ther. 1989 Jul;250(1):22-30.

PMID:
2473188
25.

2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers.

Taylor MD, Badger EW, Steffen RP, Haleen SJ, Pugsley TA, Shih YH, Weishaar RE.

J Med Chem. 1988 Aug;31(8):1659-64.

PMID:
2840504
26.

N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.

Trivedi BK, Bristol JA, Bruns RF, Haleen SJ, Steffen RP.

J Med Chem. 1988 Jan;31(1):271-3.

PMID:
3336027
27.

Correlation of adenosine receptor affinities and cardiovascular activity.

Hamilton HW, Taylor MD, Steffen RP, Haleen SJ, Bruns RF.

Life Sci. 1987 Nov 16;41(20):2295-302.

PMID:
3683077
28.

PD 116,948, a highly selective A1 adenosine receptor antagonist.

Haleen SJ, Steffen RP, Hamilton HW.

Life Sci. 1987 Feb 9;40(6):555-61.

PMID:
3807648
29.

Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.

Hamilton HW, Ortwine DF, Worth DF, Badger EW, Bristol JA, Bruns RF, Haleen SJ, Steffen RP.

J Med Chem. 1985 Aug;28(8):1071-9.

PMID:
2991519

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