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Items: 38

1.

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MP, Haldar SM, Lin CY, McKinsey TA.

Circ Res. 2019 Aug 14. doi: 10.1161/CIRCRESAHA.119.315125. [Epub ahead of print]

PMID:
31409188
2.

Epigenetic therapies in heart failure.

Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM.

J Mol Cell Cardiol. 2019 May;130:197-204. doi: 10.1016/j.yjmcc.2019.04.012. Epub 2019 Apr 13.

PMID:
30991033
3.

Drugging transcription in heart failure.

Padmanabhan A, Haldar SM.

J Physiol. 2019 Mar 30. doi: 10.1113/JP276745. [Epub ahead of print]

PMID:
30927446
4.

Unusual transcription factor protects against heart failure.

Padmanabhan A, Haldar SM.

Science. 2018 Dec 21;362(6421):1359-1360. doi: 10.1126/science.aav8956. No abstract available.

PMID:
30573617
5.

The Cardiac Myofibroblast.

Alexanian M, Haldar SM.

Circ Res. 2018 Dec 7;123(12):1258-1260. doi: 10.1161/CIRCRESAHA.118.314185. No abstract available.

PMID:
30566054
6.

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice.

Walter LM, Deguise MO, Meijboom KE, Betts CA, Ahlskog N, van Westering TLE, Hazell G, McFall E, Kordala A, Hammond SM, Abendroth F, Murray LM, Shorrock HK, Prosdocimo DA, Haldar SM, Jain MK, Gillingwater TH, Claus P, Kothary R, Wood MJA, Bowerman M.

EBioMedicine. 2018 May;31:226-242. doi: 10.1016/j.ebiom.2018.04.024. Epub 2018 May 4.

7.

BET bromodomain proteins regulate enhancer function during adipogenesis.

Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2144-2149. doi: 10.1073/pnas.1711155115. Epub 2018 Feb 14.

8.

Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform.

Padmanabhan A, Haldar SM.

Circ Heart Fail. 2018 Feb;11(2):e004793. doi: 10.1161/CIRCHEARTFAILURE.117.004793. No abstract available.

9.

Probing the Pathogenesis of Duchenne Muscular Dystrophy Using Mouse Models.

Morrison-Nozik A, Haldar SM.

Methods Mol Biol. 2018;1687:107-119. doi: 10.1007/978-1-4939-7374-3_8.

10.

BRD4 inhibition for the treatment of pathological organ fibrosis.

Stratton MS, Haldar SM, McKinsey TA.

F1000Res. 2017 Jun 28;6. pii: F1000 Faculty Rev-1015. doi: 10.12688/f1000research.11339.1. eCollection 2017. Review.

11.

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.

Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM.

Sci Transl Med. 2017 May 17;9(390). pii: eaah5084. doi: 10.1126/scitranslmed.aah5084.

12.

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.

Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA.

Cell Rep. 2016 Aug 2;16(5):1366-1378. doi: 10.1016/j.celrep.2016.06.074. Epub 2016 Jul 14.

13.

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Haldar SM, Srivastava D.

Trends Mol Med. 2016 Jul;22(7):530-533. doi: 10.1016/j.molmed.2016.05.001. Epub 2016 May 26.

PMID:
27237981
14.

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6780-9. doi: 10.1073/pnas.1512968112. Epub 2015 Nov 23.

15.

Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse.

Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK.

Ultrastruct Pathol. 2015;39(5):336-9. doi: 10.3109/01913123.2015.1042610. Epub 2015 Jun 25.

16.

Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.

Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI.

Circ Res. 2015 Jul 3;117(2):166-77. doi: 10.1161/CIRCRESAHA.117.306666. Epub 2015 Jun 1.

17.

Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning.

Duan Q, Madan ND, Wu J, Kalisz J, Doshi KY, Haldar SM, Liu L, Pierre SV.

J Mol Cell Cardiol. 2015 Mar;80:114-25. doi: 10.1016/j.yjmcc.2014.12.021. Epub 2015 Jan 7.

18.

Neuroprotection in ischemic stroke: AhR we making progress?

Padmanabhan A, Haldar SM.

Circulation. 2014 Dec 2;130(23):2002-4. doi: 10.1161/CIRCULATIONAHA.114.013533. Epub 2014 Oct 30. No abstract available.

PMID:
25359167
19.

Epigenetic mechanisms in heart failure pathogenesis.

Di Salvo TG, Haldar SM.

Circ Heart Fail. 2014 Sep;7(5):850-863. doi: 10.1161/CIRCHEARTFAILURE.114.001193. Review. No abstract available.

20.

BET-ting on chromatin-based therapeutics for heart failure.

Haldar SM, McKinsey TA.

J Mol Cell Cardiol. 2014 Sep;74:98-102. doi: 10.1016/j.yjmcc.2014.05.002. Epub 2014 May 14. Review.

21.

Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.

Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM.

J Biol Chem. 2014 Feb 28;289(9):5914-24. doi: 10.1074/jbc.M113.531384. Epub 2014 Jan 8.

22.

BET bromodomains mediate transcriptional pause release in heart failure.

Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM.

Cell. 2013 Aug 1;154(3):569-82. doi: 10.1016/j.cell.2013.07.013.

23.

The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry.

Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN.

Mol Cell Biol. 2013 Jun;33(11):2104-15. doi: 10.1128/MCB.01474-12. Epub 2013 Mar 18.

24.

S-nitrosylation: integrator of cardiovascular performance and oxygen delivery.

Haldar SM, Stamler JS.

J Clin Invest. 2013 Jan;123(1):101-10. doi: 10.1172/JCI62854. Epub 2013 Jan 2. Review.

25.

String mitochondria in mouse soleus muscle.

Fujioka H, Tandler B, Haldar SM, Jain MK, Hoppel CL.

Microsc Res Tech. 2013 Mar;76(3):237-41. doi: 10.1002/jemt.22158. Epub 2012 Nov 23.

PMID:
23174930
26.

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44. doi: 10.1073/pnas.1121060109. Epub 2012 Apr 9.

27.

Klf15 orchestrates circadian nitrogen homeostasis.

Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK.

Cell Metab. 2012 Mar 7;15(3):311-23. doi: 10.1016/j.cmet.2012.01.020.

28.

Circadian rhythms govern cardiac repolarization and arrhythmogenesis.

Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK.

Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852.

29.

S-Nitrosylation at the interface of autophagy and disease.

Haldar SM, Stamler JS.

Mol Cell. 2011 Jul 8;43(1):1-3. doi: 10.1016/j.molcel.2011.06.014.

30.

The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.

Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK.

Immunity. 2011 May 27;34(5):715-28. doi: 10.1016/j.immuni.2011.04.014. Epub 2011 May 12. Erratum in: Immunity. 2011 Jul 22;35(1):146.

31.

Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.

Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA Jr, Jain MK, Gerber AN.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):642-9. doi: 10.1165/rcmb.2010-0369OC. Epub 2011 Jan 21.

32.

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy.

Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK.

J Mol Cell Cardiol. 2010 Aug;49(2):334-8. doi: 10.1016/j.yjmcc.2010.04.008. Epub 2010 Apr 28.

33.

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.

Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK.

Sci Transl Med. 2010 Apr 7;2(26):26ra26. doi: 10.1126/scitranslmed.3000502.

34.

Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium.

Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK.

J Biol Chem. 2009 Jul 31;284(31):20522-30. doi: 10.1074/jbc.M109.025346. Epub 2009 Jun 1.

35.

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, Jain MK.

J Mol Cell Cardiol. 2008 Aug;45(2):193-7. doi: 10.1016/j.yjmcc.2008.05.005. Epub 2008 May 20.

36.

Kruppel-like Factors (KLFs) in muscle biology.

Haldar SM, Ibrahim OA, Jain MK.

J Mol Cell Cardiol. 2007 Jul;43(1):1-10. Epub 2007 Apr 19. Review.

37.

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.

Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Liao R, Jain MK.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7074-9. Epub 2007 Apr 16. Erratum in: Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13851. Pinto, Yigal [corrected to Pinto, Yigal M].

38.

Infective endocarditis: diagnosis and management.

Haldar SM, O'Gara PT.

Nat Clin Pract Cardiovasc Med. 2006 Jun;3(6):310-7. Review.

PMID:
16729009

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