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Items: 1 to 50 of 181


Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2017 Apr 3;127(4):1589. doi: 10.1172/JCI92172. Epub 2017 Apr 3. No abstract available.


IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death.

Rütti S, Howald C, Arous C, Dermitzakis E, Halban PA, Bouzakri K.

Mol Metab. 2015 Nov 17;5(2):122-131. doi: 10.1016/j.molmet.2015.11.003. eCollection 2016 Feb.


Erratum. Small Interfering RNA-Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045-3055.

Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

Diabetes. 2016 Mar;65(3):818. doi: 10.2337/db16-er03. No abstract available.


Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio.

Hansen JS, Rutti S, Arous C, Clemmesen JO, Secher NH, Drescher A, Gonelle-Gispert C, Halban PA, Pedersen BK, Weigert C, Bouzakri K, Plomgaard P.

J Clin Endocrinol Metab. 2016 Feb;101(2):550-60. doi: 10.1210/jc.2015-3668. Epub 2015 Dec 10.


The skeleton in the closet: actin cytoskeletal remodeling in β-cell function.

Arous C, Halban PA.

Am J Physiol Endocrinol Metab. 2015 Oct 1;309(7):E611-20. doi: 10.1152/ajpendo.00268.2015. Epub 2015 Aug 18. Review.


Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression.

Arous C, Ferreira PG, Dermitzakis ET, Halban PA.

J Biol Chem. 2015 Jun 5;290(23):14491. doi: 10.1074/jbc.A114.611111. No abstract available.


50 years forward: beta cells.

Halban PA.

Diabetologia. 2015 Aug;58(8):1688-92. doi: 10.1007/s00125-015-3601-0. Epub 2015 May 10.


Short term exposure of beta cells to low concentrations of interleukin-1β improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression.

Arous C, Ferreira PG, Dermitzakis ET, Halban PA.

J Biol Chem. 2015 Mar 6;290(10):6653-69. doi: 10.1074/jbc.M114.611111. Epub 2015 Jan 13. Erratum in: J Biol Chem. 2015 Jun 5;290(23):14491.


Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα.

Rutti S, Arous C, Schvartz D, Timper K, Sanchez JC, Dermitzakis E, Donath MY, Halban PA, Bouzakri K.

Mol Metab. 2014 Aug 11;3(7):731-41. doi: 10.1016/j.molmet.2014.07.007. eCollection 2014 Oct.


β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

Diabetes Care. 2014 Jun;37(6):1751-8. doi: 10.2337/dc14-0396. Epub 2014 May 8. Review.


β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

J Clin Endocrinol Metab. 2014 Jun;99(6):1983-92. doi: 10.1210/jc.2014-1425. Epub 2014 Apr 8.


Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells.

Rütti S, Arous C, Nica AC, Kanzaki M, Halban PA, Bouzakri K.

FEBS Lett. 2014 Jan 3;588(1):15-20. doi: 10.1016/j.febslet.2013.10.050. Epub 2013 Nov 14.


Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome.

Nica AC, Ongen H, Irminger JC, Bosco D, Berney T, Antonarakis SE, Halban PA, Dermitzakis ET.

Genome Res. 2013 Sep;23(9):1554-62. doi: 10.1101/gr.150706.112. Epub 2013 May 28.


Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model.

Jiménez-González M, Jaques F, Rodríguez S, Porciuncula A, Principe RM, Abizanda G, Iñiguez M, Escalada J, Salvador J, Prósper F, Halban PA, Barajas M.

Diabetologia. 2013 Apr;56(4):838-46. doi: 10.1007/s00125-012-2822-8. Epub 2013 Jan 29. Erratum in: Diabetologia. 2013 Apr;56(4):941.


Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion.

Arous C, Rondas D, Halban PA.

Diabetologia. 2013 Apr;56(4):792-802. doi: 10.1007/s00125-012-2800-1. Epub 2013 Jan 26.


A new paradigm for improved co-ordination and efficacy of European biomedical research: taking diabetes as a model.

Halban PA, Boulton AJ, Smith U.

Diabetologia. 2013 Mar;56(3):439-43. doi: 10.1007/s00125-012-2790-z. Epub 2012 Dec 13.


Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease.

Plomgaard P, Halban PA, Bouzakri K.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:78-84. doi: 10.1111/j.1463-1326.2012.01641.x. Review.


In vitro proliferation of adult human beta-cells.

Rutti S, Sauter NS, Bouzakri K, Prazak R, Halban PA, Donath MY.

PLoS One. 2012;7(4):e35801. doi: 10.1371/journal.pone.0035801. Epub 2012 Apr 26.


Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion.

Rondas D, Tomas A, Soto-Ribeiro M, Wehrle-Haller B, Halban PA.

J Biol Chem. 2012 Jan 20;287(4):2423-36. doi: 10.1074/jbc.M111.279885. Epub 2011 Dec 2.


Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, Halban PA, Gromada J, Drucker DJ, Gribble FM, Ehses JA, Donath MY.

Nat Med. 2011 Oct 30;17(11):1481-9. doi: 10.1038/nm.2513.


Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat.

Giroix MH, Irminger JC, Lacraz G, Noll C, Calderari S, Ehses JA, Coulaud J, Cornut M, Kassis N, Schmidlin F, Paul JL, Kergoat M, Janel N, Halban PA, Homo-Delarche F.

Diabetologia. 2011 Sep;54(9):2451-62. doi: 10.1007/s00125-011-2223-4. Epub 2011 Jul 10.


DIAMAP: a road map for diabetes research in Europe.

Hills S, Halban PA.

J Diabetes Sci Technol. 2011 May 1;5(3):794-7.


Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle.

Bouzakri K, Plomgaard P, Berney T, Donath MY, Pedersen BK, Halban PA.

Diabetes. 2011 Apr;60(4):1111-21. doi: 10.2337/db10-1178. Epub 2011 Mar 4. Erratum in: Diabetes. 2015 Jan;64(1):312.


Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin.

Rondas D, Tomas A, Halban PA.

Diabetes. 2011 Apr;60(4):1146-57. doi: 10.2337/db10-0946. Epub 2011 Feb 25.


Prime time for DIAMAP: a road map for diabetes research in Europe.

Halban PA.

Diabetologia. 2010 Sep;53(9):1835-7. doi: 10.1007/s00125-010-1774-0. Epub 2010 May 8. No abstract available.


Cytokine production by islets in health and diabetes: cellular origin, regulation and function.

Donath MY, Böni-Schnetzler M, Ellingsgaard H, Halban PA, Ehses JA.

Trends Endocrinol Metab. 2010 May;21(5):261-7. doi: 10.1016/j.tem.2009.12.010. Epub 2010 Jan 22. Review.


Current status of islet cell replacement and regeneration therapy.

Halban PA, German MS, Kahn SE, Weir GC.

J Clin Endocrinol Metab. 2010 Mar;95(3):1034-43. doi: 10.1210/jc.2009-1819. Epub 2010 Jan 8. Review.


Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate.

Tomas A, Yermen B, Regazzi R, Pessin JE, Halban PA.

Traffic. 2010 Jan;11(1):123-37. doi: 10.1111/j.1600-0854.2009.00996.x.


Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix.

Parnaud G, Hammar E, Ribaux P, Donath MY, Berney T, Halban PA.

Mol Endocrinol. 2009 Aug;23(8):1264-71. doi: 10.1210/me.2009-0008. Epub 2009 May 14.


Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.

Hammar E, Tomas A, Bosco D, Halban PA.

Endocrinology. 2009 May;150(5):2072-9. doi: 10.1210/en.2008-1135. Epub 2008 Dec 23.


Cell therapy for type 2 diabetes: is it desirable and can we get it?

Halban PA.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:205-11. doi: 10.1111/j.1463-1326.2008.00957.x. Review.


Interleukin-6 regulates pancreatic alpha-cell mass expansion.

Ellingsgaard H, Ehses JA, Hammar EB, Van Lommel L, Quintens R, Martens G, Kerr-Conte J, Pattou F, Berney T, Pipeleers D, Halban PA, Schuit FC, Donath MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13163-8. doi: 10.1073/pnas.0801059105. Epub 2008 Aug 21.


The right stuff: beta-cell channels, cycles, and sensors.

Halban PA.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1277-8. doi: 10.1152/ajpendo.90692.2008. Epub 2008 Aug 19. No abstract available.


Order! Order! Order in the House! DIAMAP: a road map for European diabetes research.

Halban PA, Smith U.

Diabetologia. 2008 Oct;51(10):1765-7. doi: 10.1007/s00125-008-1102-0. No abstract available.


Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

Diabetes. 2008 Nov;57(11):3045-55. doi: 10.2337/db08-0485. Epub 2008 Aug 11. Erratum in: Diabetes. 2016 Mar;65(3):818.


Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. doi: 10.1210/jc.2008-0396. Epub 2008 Jul 29.


[How to explain the rebirth of the beta cell in terms of sacrifice and delivery].

Halban PA.

Journ Annu Diabetol Hotel Dieu. 2007:171-9. French. No abstract available.


Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. doi: 10.2337/db07-1469. Epub 2008 Feb 14.


Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.

Jaques F, Jousset H, Tomas A, Prost AL, Wollheim CB, Irminger JC, Demaurex N, Halban PA.

Endocrinology. 2008 May;149(5):2494-505. doi: 10.1210/en.2007-0974. Epub 2008 Jan 24.


Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.

Tomas A, Meda P, Regazzi R, Pessin JE, Halban PA.

Traffic. 2008 May;9(5):813-32. doi: 10.1111/j.1600-0854.2008.00709.x. Epub 2008 Jan 19.


Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, Thorens B.

Diabetes. 2008 Mar;57(3):584-93. Epub 2007 Nov 19.


Proliferation of sorted human and rat beta cells.

Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA.

Diabetologia. 2008 Jan;51(1):91-100. Epub 2007 Nov 10.


Dynamin is functionally coupled to insulin granule exocytosis.

Min L, Leung YM, Tomas A, Watson RT, Gaisano HY, Halban PA, Pessin JE, Hou JC.

J Biol Chem. 2007 Nov 16;282(46):33530-6. Epub 2007 Sep 11.


Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, Irminger JC, Donath MY, Halban PA.

Endocrinology. 2007 Nov;148(11):5582-90. Epub 2007 Aug 16.


The innovative medicines initiative (IMI): a shot in the arm for European diabetes research?

Halban PA.

Diabetologia. 2007 Sep;50(9):1791-1794. doi: 10.1007/s00125-007-0740-y. Epub 2007 Jul 5. No abstract available.


Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.

Diabetes. 2007 May;56(5):1268-76. Epub 2007 Feb 15.


The Fas pathway is involved in pancreatic beta cell secretory function.

Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.


Pro-survival role of gelsolin in mouse beta-cells.

Yermen B, Tomas A, Halban PA.

Diabetes. 2007 Jan;56(1):80-7.

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