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Items: 1 to 50 of 107

1.

Remodeling Collapsed DNA Replication Forks for Cancer Development.

Sotiriou SK, Halazonetis TD.

Cancer Res. 2019 Apr 1;79(7):1297-1298. doi: 10.1158/0008-5472.CAN-19-0216.

PMID:
30936075
2.

Monitoring early S-phase origin firing and replication fork movement by sequencing nascent DNA from synchronized cells.

Macheret M, Halazonetis TD.

Nat Protoc. 2019 Jan;14(1):51-67. doi: 10.1038/s41596-018-0081-y.

PMID:
30487655
3.

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.

Macheret M, Halazonetis TD.

Nature. 2018 Mar 1;555(7694):112-116. doi: 10.1038/nature25507. Epub 2018 Feb 21.

4.

The role of SMARCAL1 in replication fork stability and telomere maintenance.

Lugli N, Sotiriou SK, Halazonetis TD.

DNA Repair (Amst). 2017 Aug;56:129-134. doi: 10.1016/j.dnarep.2017.06.015. Epub 2017 Jun 10. Review.

PMID:
28623093
5.

Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue.

Lugli N, Dionellis VS, Ordóñez-Morán P, Kamileri I, Sotiriou SK, Huelsken J, Halazonetis TD.

Cell Rep. 2017 Jun 13;19(11):2185-2192. doi: 10.1016/j.celrep.2017.05.051.

6.

Increased Cell Proliferation and Gene Expression of Genes Related to Bone Remodeling, Cell Adhesion and Collagen Metabolism in the Periodontal Ligament of Unopposed Molars in Growing Rats.

Dorotheou D, Farsadaki V, Bochaton-Piallat ML, Giannopoulou C, Halazonetis TD, Kiliaridis S.

Front Physiol. 2017 Feb 10;8:75. doi: 10.3389/fphys.2017.00075. eCollection 2017.

7.

A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System.

Crefcoeur RP, Zgheib O, Halazonetis TD.

PLoS One. 2017 Jan 3;12(1):e0169126. doi: 10.1371/journal.pone.0169126. eCollection 2017.

8.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.

Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, Halazonetis TD.

Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.

9.

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

Loforese G, Malinka T, Keogh A, Baier F, Simillion C, Montani M, Halazonetis TD, Candinas D, Stroka D.

EMBO Mol Med. 2017 Jan;9(1):46-60. doi: 10.15252/emmm.201506089.

10.

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication.

Roumelioti FM, Sotiriou SK, Katsini V, Chiourea M, Halazonetis TD, Gagos S.

EMBO Rep. 2016 Dec;17(12):1731-1737. Epub 2016 Oct 19.

11.

POLD3 Is Haploinsufficient for DNA Replication in Mice.

Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, Halazonetis TD, Fernandez-Capetillo O.

Mol Cell. 2016 Sep 1;63(5):877-83. doi: 10.1016/j.molcel.2016.07.007. Epub 2016 Aug 11.

12.

R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders.

Lugli N, Kamileri I, Keogh A, Malinka T, Sarris ME, Talianidis I, Schaad O, Candinas D, Stroka D, Halazonetis TD.

EMBO Rep. 2016 May;17(5):769-79. doi: 10.15252/embr.201642169. Epub 2016 Mar 18.

13.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.

Kocyłowski MK, Rey AJ, Stewart GS, Halazonetis TD.

Cell Cycle. 2015;14(11):1748-58. doi: 10.1080/15384101.2015.1010918.

14.

DNA replication stress as a hallmark of cancer.

Macheret M, Halazonetis TD.

Annu Rev Pathol. 2015;10:425-48. doi: 10.1146/annurev-pathol-012414-040424. Review.

PMID:
25621662
15.

DNA replication stress as an Achilles' heel of cancer.

Da-Rè C, Halazonetis TD.

Oncotarget. 2015 Jan 1;6(1):1-2. No abstract available.

16.

Conservative DNA replication.

Halazonetis TD.

Nat Rev Mol Cell Biol. 2014 May;15(5):300. doi: 10.1038/nrm3784. Epub 2014 Mar 26. No abstract available.

PMID:
24667655
17.

PARP inhibitors and IR join forces to strike glioblastoma-initiating cells.

Lugli N, Kamileri I, Halazonetis TD.

Cell Death Differ. 2014 Feb;21(2):192-3. doi: 10.1038/cdd.2013.172. No abstract available.

18.

Reversal of the DNA-binding-induced loop L1 conformational switch in an engineered human p53 protein.

Emamzadah S, Tropia L, Vincenti I, Falquet B, Halazonetis TD.

J Mol Biol. 2014 Feb 20;426(4):936-44. doi: 10.1016/j.jmb.2013.12.020. Epub 2013 Dec 27.

19.

Break-induced replication repair of damaged forks induces genomic duplications in human cells.

Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD.

Science. 2014 Jan 3;343(6166):88-91. doi: 10.1126/science.1243211. Epub 2013 Dec 5.

20.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG.

Nat Cell Biol. 2013 Aug;15(8):967-77. doi: 10.1038/ncb2795. Epub 2013 Jul 14. Erratum in: Nat Cell Biol. 2013 Oct;15(10):1260.

PMID:
23851489
21.

Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells.

Crefcoeur RP, Yin R, Ulm R, Halazonetis TD.

Nat Commun. 2013;4:1779. doi: 10.1038/ncomms2800.

PMID:
23653191
22.

A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, Almusa H, Robyr D, Guipponi M, Saarela J, Gorgoulis VG, Antonarakis SE, Halazonetis TD.

Cancer Res. 2012 Dec 1;72(23):6279-89. doi: 10.1158/0008-5472.CAN-12-3869. Erratum in: Cancer Res. 2014 Jan 15;74(2):636.

23.

A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.

Schepeler T, Lamy P, Hvidberg V, Laurberg JR, Fristrup N, Reinert T, Bartkova J, Tropia L, Bartek J, Halazonetis TD, Pan CC, Borre M, Dyrskjøt L, Orntoft TF.

Oncogene. 2013 Aug 1;32(31):3577-86. doi: 10.1038/onc.2012.381. Epub 2012 Aug 27.

PMID:
22926521
24.

The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.

Kohzaki M, Chiourea M, Versini G, Adachi N, Takeda S, Gagos S, Halazonetis TD.

Carcinogenesis. 2012 Jun;33(6):1203-10. doi: 10.1093/carcin/bgs149. Epub 2012 Apr 16.

PMID:
22508716
25.

Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.

Nishimura T, Molinard G, Petty TJ, Broger L, Gabus C, Halazonetis TD, Thore S, Paszkowski J.

PLoS Genet. 2012 Feb;8(2):e1002484. doi: 10.1371/journal.pgen.1002484. Epub 2012 Feb 9.

26.

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

Nikolaev SI, Rimoldi D, Iseli C, Valsesia A, Robyr D, Gehrig C, Harshman K, Guipponi M, Bukach O, Zoete V, Michielin O, Muehlethaler K, Speiser D, Beckmann JS, Xenarios I, Halazonetis TD, Jongeneel CV, Stevenson BJ, Antonarakis SE.

Nat Genet. 2011 Dec 25;44(2):133-9. doi: 10.1038/ng.1026.

PMID:
22197931
27.

Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element.

Emamzadah S, Tropia L, Halazonetis TD.

Mol Cancer Res. 2011 Nov;9(11):1493-9. doi: 10.1158/1541-7786.MCR-11-0351. Epub 2011 Sep 20.

28.

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress.

Dereli-Öz A, Versini G, Halazonetis TD.

Mol Oncol. 2011 Aug;5(4):308-14. doi: 10.1016/j.molonc.2011.05.002. Epub 2011 May 20. Review.

29.

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.

Petty TJ, Emamzadah S, Costantino L, Petkova I, Stavridi ES, Saven JG, Vauthey E, Halazonetis TD.

EMBO J. 2011 Jun 1;30(11):2167-76. doi: 10.1038/emboj.2011.127. Epub 2011 Apr 26.

30.

Genomic instability in induced stem cells.

Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD.

Cell Death Differ. 2011 May;18(5):745-53. doi: 10.1038/cdd.2011.9. Epub 2011 Feb 11.

31.

SAHF, to senesce or not to senesce?

Kocylowski MK, Halazonetis TD.

Cell Cycle. 2011 Mar 1;10(5):738-9. Epub 2011 Mar 1. No abstract available.

PMID:
21311234
32.

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.

Cescutti R, Negrini S, Kohzaki M, Halazonetis TD.

EMBO J. 2010 Nov 3;29(21):3723-32. doi: 10.1038/emboj.2010.238. Epub 2010 Sep 24.

33.

Oncogene-induced senescence: the bright and dark side of the response.

Gorgoulis VG, Halazonetis TD.

Curr Opin Cell Biol. 2010 Dec;22(6):816-27. doi: 10.1016/j.ceb.2010.07.013. Epub 2010 Sep 16. Review.

PMID:
20807678
34.

Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.

Petty TJ, Nishimura T, Emamzadah S, Gabus C, Paszkowski J, Halazonetis TD, Thore S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):916-8. doi: 10.1107/S1744309110021068. Epub 2010 Jul 29.

35.

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.

Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis TD, Takeda S.

J Cell Biol. 2010 Jun 28;189(7):1117-27. doi: 10.1083/jcb.200912012.

36.

Genomic instability--an evolving hallmark of cancer.

Negrini S, Gorgoulis VG, Halazonetis TD.

Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8. doi: 10.1038/nrm2858. Review.

PMID:
20177397
37.

Emerging common themes in regulation of PIKKs and PI3Ks.

Lempiäinen H, Halazonetis TD.

EMBO J. 2009 Oct 21;28(20):3067-73. doi: 10.1038/emboj.2009.281. Epub 2009 Sep 24. Review.

38.

Cyclic olefin homopolymer-based microfluidics for protein crystallization and in situ X-ray diffraction.

Emamzadah S, Petty TJ, De Almeida V, Nishimura T, Joly J, Ferrer JL, Halazonetis TD.

Acta Crystallogr D Biol Crystallogr. 2009 Sep;65(Pt 9):913-20. doi: 10.1107/S0907444909021489. Epub 2009 Aug 6.

39.

Microcollimator for micrometer-wide stripe irradiation of cells using 20-30 keV X rays.

Pataky K, Villanueva G, Liani A, Zgheib O, Jenkins N, Halazonetis DJ, Halazonetis TD, Brugger J.

Radiat Res. 2009 Aug;172(2):252-9. doi: 10.1667/RR1483.1.

PMID:
19630530
40.

Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas.

Liontos M, Niforou K, Velimezi G, Vougas K, Evangelou K, Apostolopoulou K, Vrtel R, Damalas A, Kontovazenitis P, Kotsinas A, Zoumpourlis V, Tsangaris GT, Kittas C, Ginsberg D, Halazonetis TD, Bartek J, Gorgoulis VG.

Am J Pathol. 2009 Jul;175(1):376-91. doi: 10.2353/ajpath.2009.081160. Epub 2009 Jun 18.

41.

An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks.

Zgheib O, Pataky K, Brugger J, Halazonetis TD.

Mol Cell Biol. 2009 Feb;29(4):1050-8. doi: 10.1128/MCB.01011-08. Epub 2008 Dec 8.

42.

An oncogene-induced DNA damage model for cancer development.

Halazonetis TD, Gorgoulis VG, Bartek J.

Science. 2008 Mar 7;319(5868):1352-5. doi: 10.1126/science.1140735. Review.

PMID:
18323444
43.

Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.

Tuttle RL, Bothos J, Summers MK, Luca FC, Halazonetis TD.

Mol Cancer Res. 2007 Dec;5(12):1304-11. doi: 10.1158/1541-7786.MCR-07-0388.

44.

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG.

Cancer Res. 2007 Nov 15;67(22):10899-909.

45.
46.

DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter.

Halazonetis TD, Bartek J.

Mol Cell. 2006 Dec 28;24(6):809-10. Review.

47.

Evaluation of claspin as a proliferation marker in human cancer and normal tissues.

Tsimaratou K, Kletsas D, Kastrinakis NG, Tsantoulis PK, Evangelou K, Sideridou M, Liontos M, Poulias I, Venere M, Salmas M, Kittas C, Halazonetis TD, Gorgoulis VG.

J Pathol. 2007 Feb;211(3):331-9.

PMID:
17152083
48.

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG.

Nature. 2006 Nov 30;444(7119):633-7.

PMID:
17136093
49.

Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.

Lukas J, Bohr VA, Halazonetis TD.

DNA Repair (Amst). 2006 May 10;5(5):591-601. Epub 2006 Feb 28.

PMID:
16504601
50.

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.

Livingstone M, Ruan H, Weiner J, Clauser KR, Strack P, Jin S, Williams A, Greulich H, Gardner J, Venere M, Mochan TA, DiTullio RA Jr, Moravcevic K, Gorgoulis VG, Burkhardt A, Halazonetis TD.

Cancer Res. 2005 Sep 1;65(17):7533-40.

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