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Items: 24

1.

Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR - MAPK pathway.

Mahnashi M, Elgazwi SM, Ahmed MS, Halaweish FT.

Eur J Med Chem. 2019 Jul 1;173:294-304. doi: 10.1016/j.ejmech.2019.04.018. Epub 2019 Apr 16.

PMID:
31022583
2.

Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer.

Sikander M, Malik S, Chauhan N, Khan P, Kumari S, Kashyap VK, Khan S, Ganju A, Halaweish FT, Yallapu MM, Jaggi M, Chauhan SC.

Cancers (Basel). 2019 Mar 14;11(3). pii: E364. doi: 10.3390/cancers11030364.

3.

Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation.

Alsayari A, Kopel L, Ahmed MS, Soliman HSM, Annadurai S, Halaweish FT.

BMC Complement Altern Med. 2018 Oct 9;18(1):274. doi: 10.1186/s12906-018-2295-5.

4.

Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells.

Ismail RSM, Abou-Seri SM, Eldehna WM, Ismail NSM, Elgazwi SM, Ghabbour HA, Ahmed MS, Halaweish FT, Abou El Ella DA.

Eur J Med Chem. 2018 Jul 15;155:782-796. doi: 10.1016/j.ejmech.2018.06.024. Epub 2018 Jun 19.

PMID:
30047410
5.

Ormeloxifene Suppresses Prostate Tumor Growth and Metastatic Phenotypes via Inhibition of Oncogenic β-catenin Signaling and EMT Progression.

Hafeez BB, Ganju A, Sikander M, Kashyap VK, Hafeez ZB, Chauhan N, Malik S, Massey AE, Tripathi MK, Halaweish FT, Zafar N, Singh MM, Yallapu MM, Chauhan SC, Jaggi M.

Mol Cancer Ther. 2017 Oct;16(10):2267-2280. doi: 10.1158/1535-7163.MCT-17-0157. Epub 2017 Jun 14.

6.

Biological screening of cucurbitacin inspired estrone analogs targeting mitogen-activated protein kinase (MAPK) pathway.

Ahmed MS, El-Senduny F, Taylor J, Halaweish FT.

Chem Biol Drug Des. 2017 Sep;90(3):478-484. doi: 10.1111/cbdd.12963. Epub 2017 Apr 25.

PMID:
28171685
7.

Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents.

Alsayari A, Kopel L, Ahmed MS, Pay A, Carlson T, Halaweish FT.

Steroids. 2017 Feb;118:32-40. doi: 10.1016/j.steroids.2016.11.005. Epub 2016 Nov 20.

PMID:
27876568
8.

Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer.

Sikander M, Hafeez BB, Malik S, Alsayari A, Halaweish FT, Yallapu MM, Chauhan SC, Jaggi M.

Sci Rep. 2016 Nov 8;6:36594. doi: 10.1038/srep36594.

9.

Nanoparticle formulation of ormeloxifene for pancreatic cancer.

Khan S, Chauhan N, Yallapu MM, Ebeling MC, Balakrishna S, Ellis RT, Thompson PA, Balabathula P, Behrman SW, Zafar N, Singh MM, Halaweish FT, Jaggi M, Chauhan SC.

Biomaterials. 2015;53:731-43. doi: 10.1016/j.biomaterials.2015.02.082. Epub 2015 Mar 26.

10.

Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as B-Raf inhibitors.

Ahmed MS, Kopel LC, Halaweish FT.

ChemMedChem. 2014 Jul;9(7):1361-7. doi: 10.1002/cmdc.201300523. Epub 2014 Mar 28.

PMID:
24682977
11.

Synthesis of novel estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain.

Kopel LC, Ahmed MS, Halaweish FT.

Steroids. 2013 Nov;78(11):1119-25. doi: 10.1016/j.steroids.2013.07.005. Epub 2013 Jul 27.

PMID:
23899492
12.

Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma.

Ahmed MS, Halaweish FT.

J Enzyme Inhib Med Chem. 2014 Apr;29(2):162-7. doi: 10.3109/14756366.2012.762646. Epub 2013 Jan 31.

PMID:
23368732
13.

Isolation and characterization of a bactericidal withanolide from Physalis virginiana.

Gibson KA, Reese RN, Halaweish FT, Ren Y.

Pharmacogn Mag. 2012 Jan;8(29):22-8. doi: 10.4103/0973-1296.93307.

14.

In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.

Bartalis J, Halaweish FT.

Bioorg Med Chem. 2011 Apr 15;19(8):2757-66. doi: 10.1016/j.bmc.2011.01.037. Epub 2011 Feb 2.

PMID:
21459003
15.

Isolation and characterization of ribosome-inactivating proteins from Cucurbitaceae.

Zhang D, Halaweish FT.

Chem Biodivers. 2007 Mar;4(3):431-42.

PMID:
17372945
16.
17.

Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption.

Ballard TL, Halaweish FT, Stevermer CL, Agrawal P, Vukovich MD.

Clin Exp Pharmacol Physiol. 2006 Apr;33(4):310-4.

PMID:
16620293
18.

Interactions between Euphorbia esula toxins and bovine ruminal microbes.

Kronberg SL, Halaweish FT, Hubert MB, Weimer PJ.

J Chem Ecol. 2006 Jan;32(1):15-28. Epub 2006 Feb 26.

PMID:
16525867
19.

Relationship between cucurbitacins reversed-phase high-performance liquid chromatography hydrophobicity index and basal cytotoxicity on HepG2 cells.

Bartalis J, Halaweish FT.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25;818(2):159-66.

PMID:
15734155
20.

Polyoxypregnane glycosides from Caralluma retrospiciens.

Halaweish FT, Huntimer E, Khalil AT.

Phytochem Anal. 2004 May-Jun;15(3):189-94.

PMID:
15202604
21.

Toxic and aversive diterpenes of Euphorbia esula.

Halaweish FT, Kronberg S, Hubert MB, Rice JA.

J Chem Ecol. 2002 Aug;28(8):1599-611.

PMID:
12371812
22.

A new cucurbitacin profile forCucurbita andreana: A candidate for cucurbitacin tissue culture.

Halaweish FT, Tallamy DW.

J Chem Ecol. 1993 Jun;19(6):1135-41. doi: 10.1007/BF00987375.

PMID:
24249132
23.

Cucurbitacins fromCucurbita texana: Evidence for the role of isocucurbitacins.

Halaweish FT.

J Chem Ecol. 1993 Jan;19(1):29-37. doi: 10.1007/BF00987468.

PMID:
24248508
24.

Microbial transformation of zearalenone to a zearalenone sulfate.

el-Sharkaway SH, Selim MI, Afifi MS, Halaweish FT.

Appl Environ Microbiol. 1991 Feb;57(2):549-52.

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