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Items: 1 to 50 of 55

1.

The failing of the obesity paradox in the failing heart.

Tourki B, Halade GV.

Am J Physiol Heart Circ Physiol. 2018 Aug 3. doi: 10.1152/ajpheart.00496.2018. [Epub ahead of print] No abstract available.

PMID:
30074838
2.

Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters inflammation-resolution program in the myocardium.

Jadapalli JK, Wright GM, Kain V, Sherwani MA, Yusuf N, Halade GV.

Am J Physiol Heart Circ Physiol. 2018 Aug 3. doi: 10.1152/ajpheart.00290.2018. [Epub ahead of print]

PMID:
30074834
3.

The Mouse Heart Attack Research Tool (mHART) 1.0 Database.

DeLeon-Pennell KY, Iyer RP, Ma Y, Yabluchanskiy A, Zamilpa R, Chiao YA, Cannon P, Cates C, Flynn ER, Halade GV, de Castro Bras LE, Lindsey ML.

Am J Physiol Heart Circ Physiol. 2018 May 18. doi: 10.1152/ajpheart.00172.2018. [Epub ahead of print]

PMID:
29775405
4.

Unified nexus of macrophages and maresins in cardiac reparative mechanisms.

Jadapalli JK, Halade GV.

FASEB J. 2018 May 11:fj201800254R. doi: 10.1096/fj.201800254R. [Epub ahead of print]

PMID:
29750575
5.

Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.

Kain V, Ingle KA, Kabarowski J, Barnes S, Limdi NA, Prabhu SD, Halade GV.

J Mol Cell Cardiol. 2018 May;118:70-80. doi: 10.1016/j.yjmcc.2018.03.004. Epub 2018 Mar 8.

6.

Splenic leukocytes define the resolution of inflammation in heart failure.

Halade GV, Norris PC, Kain V, Serhan CN, Ingle KA.

Sci Signal. 2018 Mar 6;11(520). pii: eaao1818. doi: 10.1126/scisignal.aao1818.

PMID:
29511119
7.

Paradigm shift - Metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery.

Halade GV, Black LM, Verma MK.

Biotechnol Adv. 2018 Jul - Aug;36(4):935-953. doi: 10.1016/j.biotechadv.2018.02.014. Epub 2018 Feb 28. Review.

PMID:
29499340
8.

Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure.

Halade GV, Kain V, Serhan CN.

FASEB J. 2018 Jul;32(7):3717-3729. doi: 10.1096/fj.201701173RR. Epub 2018 Feb 13.

PMID:
29455574
9.

Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart.

Halade GV, Dorbane A, Ingle KA, Kain V, Schmitter JM, Rhourri-Frih B.

Anal Bioanal Chem. 2018 Mar;410(7):1965-1976. doi: 10.1007/s00216-018-0863-7. Epub 2018 Feb 6.

PMID:
29411084
10.

Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology.

Halade GV, Kain V, Ingle KA.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H255-H267. doi: 10.1152/ajpheart.00528.2017. Epub 2017 Nov 3.

PMID:
29101178
11.

Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation.

Kain V, Ingle KA, Kachman M, Baum H, Shanmugam G, Rajasekaran NS, Young ME, Halade GV.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H160-H169. doi: 10.1152/ajpheart.00297.2017. Epub 2017 Oct 6.

PMID:
28986357
12.

Obesity and Cardiometabolic Defects in Heart Failure Pathology.

Halade GV, Kain V.

Compr Physiol. 2017 Sep 12;7(4):1463-1477. doi: 10.1002/cphy.c170011. Review.

PMID:
28915332
13.

Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing.

Kain V, Liu F, Kozlovskaya V, Ingle KA, Bolisetty S, Agarwal A, Khedkar S, Prabhu SD, Kharlampieva E, Halade GV.

Sci Rep. 2017 Aug 30;7(1):9999. doi: 10.1038/s41598-017-10441-8.

14.

Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.

Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1098-H1108. doi: 10.1152/ajpheart.00101.2017. Epub 2017 Aug 19.

PMID:
28822962
15.

Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.

Kain V, Halade GV.

Front Cardiovasc Med. 2017 May 31;4:31. doi: 10.3389/fcvm.2017.00031. eCollection 2017. Review.

16.

Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing.

Halade GV, Kain V, Ingle KA, Prabhu SD.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H89-H102. doi: 10.1152/ajpheart.00040.2017. Epub 2017 Apr 14.

17.

Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction.

Halade GV, Kain V, Black LM, Prabhu SD, Ingle KA.

Aging (Albany NY). 2016 Oct 18;8(11):2611-2634. doi: 10.18632/aging.101077.

18.

Neutrophils: Friend, foe, or contextual ally in myocardial healing.

Halade GV, Ma Y.

J Mol Cell Cardiol. 2016 Aug;97:44-6. doi: 10.1016/j.yjmcc.2016.04.016. Epub 2016 Apr 28. No abstract available.

PMID:
27133770
19.

Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.

Kumar RR, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM, Hoidal JR, Rajasekaran NS.

J Transl Med. 2016 Apr 5;14:86. doi: 10.1186/s12967-016-0839-3.

20.

CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling.

DeLeon-Pennell KY, Tian Y, Zhang B, Cates CA, Iyer RP, Cannon P, Shah P, Aiyetan P, Halade GV, Ma Y, Flynn E, Zhang Z, Jin YF, Zhang H, Lindsey ML.

Circ Cardiovasc Genet. 2016 Feb;9(1):14-25. doi: 10.1161/CIRCGENETICS.115.001249. Epub 2015 Nov 17.

21.

Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation.

Ingle KA, Kain V, Goel M, Prabhu SD, Young ME, Halade GV.

Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1827-36. doi: 10.1152/ajpheart.00608.2015. Epub 2015 Oct 2.

22.

Big eater macrophages dominate inflammation resolution following myocardial infarction.

Kain V, Halade GV.

J Mol Cell Cardiol. 2015 Oct;87:225-7. doi: 10.1016/j.yjmcc.2015.08.019. Epub 2015 Sep 2. No abstract available.

PMID:
26342428
23.

Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction.

Voorhees AP, DeLeon-Pennell KY, Ma Y, Halade GV, Yabluchanskiy A, Iyer RP, Flynn E, Cates CA, Lindsey ML, Han HC.

J Mol Cell Cardiol. 2015 Aug;85:229-39. doi: 10.1016/j.yjmcc.2015.06.006. Epub 2015 Jun 12.

24.

Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.

Yabluchanskiy A, Ma Y, DeLeon-Pennell KY, Altara R, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):475-83. doi: 10.1093/gerona/glv034. Epub 2015 Apr 15.

25.

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function.

Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GV.

J Mol Cell Cardiol. 2015 Jul;84:24-35. doi: 10.1016/j.yjmcc.2015.04.003. Epub 2015 Apr 11.

26.

Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet.

Souto Padron de Figueiredo A, Salmon AB, Bruno F, Jimenez F, Martinez HG, Halade GV, Ahuja SS, Clark RA, DeFronzo RA, Abboud HE, El Jamali A.

J Biol Chem. 2015 May 22;290(21):13427-39. doi: 10.1074/jbc.M114.626077. Epub 2015 Mar 30.

27.

Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction.

Lopez EF, Kabarowski JH, Ingle KA, Kain V, Barnes S, Crossman DK, Lindsey ML, Halade GV.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H269-80. doi: 10.1152/ajpheart.00604.2014. Epub 2014 Dec 5.

28.

Aging and energetics' 'Top 40' future research opportunities 2010-2013.

Allison DB, Antoine LH, Ballinger SW, Bamman MM, Biga P, Darley-Usmar VM, Fisher G, Gohlke JM, Halade GV, Hartman JL, Hunter GR, Messina JL, Nagy TR, Plaisance EP, Powell ML, Roth KA, Sandel MW, Schwartz TS, Smith DL, Sweatt JD, Tollefsbol TO, Watts SA, Yang Y, Zhang J, Austad SN.

F1000Res. 2014 Sep 12;3:219. doi: 10.12688/f1000research.5212.1. eCollection 2014. Review.

29.

Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction.

Kain V, Prabhu SD, Halade GV.

Basic Res Cardiol. 2014;109(6):444. doi: 10.1007/s00395-014-0444-7. Epub 2014 Sep 24. Review.

PMID:
25248433
30.

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function.

Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ.

PLoS Pathog. 2014 Sep 18;10(9):e1004383. doi: 10.1371/journal.ppat.1004383. eCollection 2014 Sep.

31.

Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction.

Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Le Saux CJ.

J Mol Cell Cardiol. 2014 Nov;76:84-93. doi: 10.1016/j.yjmcc.2014.07.020. Epub 2014 Aug 12.

32.

Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics.

Tian Y, Koganti T, Yao Z, Cannon P, Shah P, Pietrovito L, Modesti A, Aiyetan P, DeLeon-Pennell K, Ma Y, Halade GV, Hicks C, Zhang H, Lindsey ML.

Proteomics Clin Appl. 2014 Aug;8(7-8):595-602. doi: 10.1002/prca.201400009.

33.

Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.

de Castro Brás LE, Cates CA, DeLeon-Pennell KY, Ma Y, Iyer RP, Halade GV, Yabluchanskiy A, Fields GB, Weintraub ST, Lindsey ML.

Antioxid Redox Signal. 2014 Nov 10;21(14):1974-85. doi: 10.1089/ars.2013.5411. Epub 2014 Feb 19.

34.

Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice.

Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin YF, Lindsey ML.

Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1830-42. doi: 10.1152/ajpheart.00224.2013. Epub 2013 Oct 18.

35.

Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle.

Zamilpa R, Zhang J, Chiao YA, de Castro Brás LE, Halade GV, Ma Y, Hacker SO, Lindsey ML.

Methods Mol Biol. 2013;1037:313-24. doi: 10.1007/978-1-62703-505-7_18.

36.

Concentrated fish oil (Lovaza(R)) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice.

Halade GV, Williams PJ, Veigas JM, Barnes JL, Fernandes G.

Exp Biol Med (Maywood). 2013 Jun;238(6):610-22. doi: 10.1177/1535370213489485.

37.

Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction.

Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV.

Cardiovasc Pathol. 2013 Nov-Dec;22(6):481-7. doi: 10.1016/j.carpath.2013.06.002. Epub 2013 Jul 27.

38.

Texas 3-step decellularization protocol: looking at the cardiac extracellular matrix.

de Castro Brás LE, Ramirez TA, DeLeon-Pennell KY, Chiao YA, Ma Y, Dai Q, Halade GV, Hakala K, Weintraub ST, Lindsey ML.

J Proteomics. 2013 Jun 28;86:43-52. doi: 10.1016/j.jprot.2013.05.004. Epub 2013 May 14.

39.

Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.

Halade GV, Jin YF, Lindsey ML.

Pharmacol Ther. 2013 Jul;139(1):32-40. doi: 10.1016/j.pharmthera.2013.03.009. Epub 2013 Apr 3. Review.

40.

Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation.

Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, Lindsey ML.

Circ Res. 2013 Feb 15;112(4):675-88. doi: 10.1161/CIRCRESAHA.111.300502. Epub 2012 Dec 20.

41.

Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction.

Wang Y, Yang T, Ma Y, Halade GV, Zhang J, Lindsey ML, Jin YF.

BMC Genomics. 2012;13 Suppl 6:S21. doi: 10.1186/1471-2164-13-S6-S21. Epub 2012 Oct 26.

42.

Extracellular matrix and fibroblast communication following myocardial infarction.

Ma Y, Halade GV, Lindsey ML.

J Cardiovasc Transl Res. 2012 Dec;5(6):848-57. doi: 10.1007/s12265-012-9398-z. Epub 2012 Aug 28. Review.

43.

Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction.

Zamilpa R, Ibarra J, de Castro Brás LE, Ramirez TA, Nguyen N, Halade GV, Zhang J, Dai Q, Dayah T, Chiao YA, Lowell W, Ahuja SS, D'Armiento J, Jin YF, Lindsey ML.

J Mol Cell Cardiol. 2012 Nov;53(5):599-608. doi: 10.1016/j.yjmcc.2012.07.017. Epub 2012 Aug 3.

44.

DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity.

Ma Y, Lindsey ML, Halade GV.

Expert Opin Drug Discov. 2012 Aug;7(8):711-21. doi: 10.1517/17460441.2012.694862. Epub 2012 Jun 24. Review.

45.

Roles of saturated vs. polyunsaturated fat in heart failure survival: not all fats are created equal.

Halade GV, Jin YF, Lindsey ML.

Cardiovasc Res. 2012 Jan 1;93(1):4-5. doi: 10.1093/cvr/cvr298. Epub 2011 Nov 8. No abstract available.

46.

t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity.

Rahman MM, Halade GV, Williams PJ, Fernandes G.

J Cell Physiol. 2011 Sep;226(9):2406-14. doi: 10.1002/jcp.22578.

47.

Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice.

Halade GV, Williams PJ, Lindsey ML, Fernandes G.

Pharmacol Res. 2011 Apr;63(4):300-7. doi: 10.1016/j.phrs.2010.12.012. Epub 2010 Dec 28.

48.

Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice.

Halade GV, El Jamali A, Williams PJ, Fajardo RJ, Fernandes G.

Exp Gerontol. 2011 Jan;46(1):43-52. doi: 10.1016/j.exger.2010.09.014. Epub 2010 Oct 12.

49.

The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet.

Rahman M, Halade GV, Bhattacharya A, Fernandes G.

Oxid Med Cell Longev. 2009 Nov-Dec;2(5):307-16. doi: 10.4161/oxim.2.5.9579.

50.

Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice.

Halade GV, Rahman MM, Williams PJ, Fernandes G.

J Nutr Biochem. 2011 May;22(5):459-69. doi: 10.1016/j.jnutbio.2010.03.015. Epub 2010 Jul 24.

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