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Items: 18


GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment.

Halaby MJ, Hezaveh K, Lamorte S, Ciudad MT, Kloetgen A, MacLeod BL, Guo M, Chakravarthy A, Medina TDS, Ugel S, Tsirigos A, Bronte V, Munn DH, Pugh TJ, De Carvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL.

Sci Immunol. 2019 Dec 13;4(42). pii: eaax8189. doi: 10.1126/sciimmunol.aax8189.


Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.

Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL.

Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14.


Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.

Duhlin A, Chen Y, Wermeling F, Sedimbi SK, Lindh E, Shinde R, Halaby MJ, Kaiser Y, Winqvist O, McGaha TL, Karlsson MC.

J Immunol. 2016 Oct 1;197(7):2618-26. doi: 10.4049/jimmunol.1401129. Epub 2016 Aug 24.


Deregulation of Internal Ribosome Entry Site-Mediated p53 Translation in Cancer Cells with Defective p53 Response to DNA Damage.

Halaby MJ, Harris BR, Miskimins WK, Cleary MP, Yang DQ.

Mol Cell Biol. 2015 Dec;35(23):4006-17. doi: 10.1128/MCB.00365-15. Epub 2015 Sep 21.


Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage.

Halaby MJ, Li Y, Harris BR, Jiang S, Miskimins WK, Cleary MP, Yang DQ.

Biomed Res Int. 2015;2015:708158. doi: 10.1155/2015/708158. Epub 2015 Jul 26.


Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.

El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A.

Oncogene. 2015 Apr 2;34(14):1780-9. doi: 10.1038/onc.2014.121. Epub 2014 May 26.


Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation.

Halaby MJ, Hakem R, Hakem A.

Cell Cycle. 2013 Sep 1;12(17):2733-7. doi: 10.4161/cc.25785. Epub 2013 Aug 5. Review.


Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt.

Halaby MJ, Kastein BK, Yang DQ.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):708-13. doi: 10.1016/j.bbrc.2013.05.047. Epub 2013 May 20.


The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.

Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R.

Cell Death Differ. 2013 Jun;20(6):812-22. doi: 10.1038/cdd.2013.7. Epub 2013 Mar 1.


Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.

Halaby MJ, Hakem A, Li L, El Ghamrasni S, Venkatesan S, Hande PM, Sanchez O, Hakem R.

PLoS Genet. 2013;9(1):e1003259. doi: 10.1371/journal.pgen.1003259. Epub 2013 Jan 31.


Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.

El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.

PLoS Genet. 2011 May;7(5):e1001385. doi: 10.1371/journal.pgen.1001385. Epub 2011 May 19.


Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration.

Yang DQ, Halaby MJ, Li Y, Hibma JC, Burn P.

Drug Discov Today. 2011 Apr;16(7-8):332-8. doi: 10.1016/j.drudis.2011.02.001. Epub 2011 Feb 15. Review.


Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.

Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.

J Exp Med. 2010 May 10;207(5):983-97. doi: 10.1084/jem.20092437. Epub 2010 Apr 12.


ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells.

Halaby MJ, Hibma JC, He J, Yang DQ.

Cell Signal. 2008 Aug;20(8):1555-63. doi: 10.1016/j.cellsig.2008.04.011. Epub 2008 Apr 26.


A novel phenotypic marker for ATM-deficient 129S6/SvEvTac-ATMtm1Awb/J mice.

Hibma JC, Neufeld DA, Halaby MJ, Yang DQ.

Anat Rec (Hoboken). 2007 Mar;290(3):243-50.


p53 translational control: a new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics.

Halaby MJ, Yang DQ.

Gene. 2007 Jun 15;395(1-2):1-7. Epub 2007 Feb 16. Review.


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