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Items: 1 to 50 of 65

1.

Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose.

Murayama N, McMahon H, Young CG, McCracken NW, Okamura Y, Hakusui H, Tanaka M.

Xenobiotica. 2000 May;30(5):515-21.

PMID:
10875684
2.

Pharmacokinetics and safety of ascending single doses of DZ-2640, a new oral carbapenem antibiotic, administered to healthy Japanese subjects.

Tanaka M, Kato K, Hakusui H, Murakami Y, Sato K, Ito Y, Kawamoto K.

Antimicrob Agents Chemother. 2000 Mar;44(3):578-82.

3.

Pharmacokinetics of CPT-11 in rhesus monkeys.

Inaba M, Ohnishi Y, Ishii H, Tanioka Y, Yoshida Y, Sudoh K, Hakusui H, Mizuno N, Ito K, Sugiyama Y.

Cancer Chemother Pharmacol. 1998;41(2):103-8.

PMID:
9443622
4.

Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype.

Tanaka M, Ohkubo T, Otani K, Suzuki A, Kaneko S, Sugawara K, Ryokawa Y, Hakusui H, Yamamori S, Ishizaki T.

Clin Pharmacol Ther. 1997 Dec;62(6):619-28.

PMID:
9433390
5.

Effects of proton pump inhibitors on thyroid hormone metabolism in rats: a comparison of UDP-glucuronyltransferase induction.

Masubuchi N, Hakusui H, Okazaki O.

Biochem Pharmacol. 1997 Dec 1;54(11):1225-31.

PMID:
9416973
6.
7.

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.

Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H, Sugiyama Y.

J Pharmacol Exp Ther. 1997 Apr;281(1):304-14.

PMID:
9103511
8.
9.

Pharmacokinetics and tolerance of pantoprazole, a proton pump inhibitor after single and multiple oral doses in healthy Japanese volunteers.

Tanaka M, Yamazaki H, Ryokawa Y, Hakusui H, Nakamichi N, Sekino H.

Int J Clin Pharmacol Ther. 1996 Oct;34(10):415-9.

PMID:
8897077
10.

Identification of major biliary and urinary metabolites of ecabapide in rats.

Nakaoka M, Tsumura M, Ichikawa E, Suzuki W, Hakusui H, Nakazawa T.

Xenobiotica. 1996 Sep;26(9):983-94.

PMID:
8893045
11.

Nefiracetam hydroxylation by rat liver microsomes and expressed human cytochrome P450s.

Fujimaki Y, Hakusui H, Yamazoe Y.

Xenobiotica. 1996 Aug;26(8):821-30.

PMID:
8879146
12.

Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test.

Tanaka M, Kato K, Sudo K, Hakusui H, Ohkubo T, Sugawara K, Kaneko S, Otani K, Chiba K, Ishizaki T.

J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94.

PMID:
8852048
13.

Placental transfer and milk secretion of gadodiamide injection in rats.

Okazaki O, Murayama N, Masubuchi N, Nomura H, Hakusui H.

Arzneimittelforschung. 1996 Jan;46(1):83-6.

PMID:
8821524
14.

Pharmacokinetics and stability of caldiamide sodium in rats.

Okazaki O, Kurata T, Yoshioka N, Hakusui H.

Arzneimittelforschung. 1996 Jan;46(1):79-83.

PMID:
8821523
15.
16.

Pharmacokinetics and tolerance of a new fluoroquinolone antimicrobial drug after single oral doses in healthy volunteers.

Tanaka M, Tamura K, Atarashi S, Kubo Y, Oliver SD, Bentley M, Hakusui H.

Xenobiotica. 1995 Nov;25(10):1119-25.

PMID:
8578768
17.

Biliary metabolites of semotiadil fumarate in the rat.

Nakaoka M, Katoh K, Hakusui H.

Xenobiotica. 1995 Aug;25(8):847-55.

PMID:
8779225
19.

In vitro metabolism of nefiracetam by liver microsomes from rats, dogs and monkeys.

Fujimaki Y, Sudo K, Hakusui H.

Arzneimittelforschung. 1995 Jul;45(7):748-52.

PMID:
8573215
20.

Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model.

Atsumi R, Okazaki O, Hakusui H.

Biol Pharm Bull. 1995 Jul;18(7):1024-6.

PMID:
7581244
21.

Radioimmunoassay for DS-4574, an anti-allergic agent: development, evaluation and application to human plasma samples.

Murayama N, Nakaoka M, Nomura H, Hakusui H.

J Pharm Biomed Anal. 1995 Apr;13(4-5):671-3. No abstract available.

PMID:
9696586
22.

Modulation of subcellular particles of the rat small intestine and liver by ebselen.

Mizoguchi T, Nishinaka T, Nanjo H, Yagi K, Hakusui H.

Biol Pharm Bull. 1995 Apr;18(4):491-5.

PMID:
7655415
24.

Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11.

Sasaki Y, Yoshida Y, Sudoh K, Hakusui H, Fujii H, Ohtsu T, Wakita H, Igarashi T, Itoh K.

Jpn J Cancer Res. 1995 Jan;86(1):111-6.

25.

A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38.

Sasaki Y, Hakusui H, Mizuno S, Morita M, Miya T, Eguchi K, Shinkai T, Tamura T, Ohe Y, Saijo N.

Jpn J Cancer Res. 1995 Jan;86(1):101-10.

26.

Pharmacokinetics and tolerance of DU-6859a, a new fluoroquinolone, after single and multiple oral doses in healthy volunteers.

Nakashima M, Uematsu T, Kosuge K, Umemura K, Hakusui H, Tanaka M.

Antimicrob Agents Chemother. 1995 Jan;39(1):170-4. Erratum in: Antimicrob Agents Chemother 1995 Apr;39(4):1015.

27.

Radioimmunoassay for DS-4574, an antiallergic agent: development, evaluation, and application to human plasma samples.

Murayama N, Nakaoka M, Nomura H, Hakusui H.

J Pharm Sci. 1994 Nov;83(11):1574-7.

PMID:
7891277
29.

Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase.

Satoh T, Hosokawa M, Atsumi R, Suzuki W, Hakusui H, Nagai E.

Biol Pharm Bull. 1994 May;17(5):662-4.

PMID:
7920428
30.

Toxicokinetics: its significance and practical problems.

Kato R, Case DE, Hakusui H, Noda K, Sagami F, Horii I, Mayahara H, Cayen MN, Marriott TB, Igarashi T.

J Toxicol Sci. 1993 Nov;18(4):211-38. Review. No abstract available.

PMID:
8295226
31.

Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.

Tanaka M, Kurata T, Fujisawa C, Ohshima Y, Aoki H, Okazaki O, Hakusui H.

Antimicrob Agents Chemother. 1993 Oct;37(10):2173-8.

32.

Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats.

Kawato Y, Sekiguchi M, Akahane K, Tsutomi Y, Hirota Y, Kuga H, Suzuki W, Hakusui H, Sato K.

J Pharm Pharmacol. 1993 May;45(5):444-8.

PMID:
8099964
33.
34.

Phase I study of DQ-2556, a new parenteral 3-quaternary ammonium cephalosporin antibiotic.

Nakashima M, Uematsu T, Kanamaru M, Mizuno A, Matsubayashi K, Okazaki O, Hashimoto S, Hakusui H, Osada Y.

J Clin Pharmacol. 1993 Jan;33(1):57-62.

PMID:
8429115
35.

Effects of antacids, ferrous sulfate, and ranitidine on absorption of DR-3355 in humans.

Shiba K, Sakai O, Shimada J, Okazaki O, Aoki H, Hakusui H.

Antimicrob Agents Chemother. 1992 Oct;36(10):2270-4.

36.

Single- and multiple-dose pharmacokinetics of nefiracetam, a new nootropic agent, in healthy volunteers.

Fujimaki Y, Sudo K, Hakusui H, Tachizawa H, Murasaki M.

J Pharm Pharmacol. 1992 Sep;44(9):750-4.

PMID:
1360528
37.

Species-related stereoselective disposition of ofloxacin in the rat, dog and monkey.

Okazaki O, Kurata T, Hakusui H, Tachizawa H.

Xenobiotica. 1992 Apr;22(4):439-50.

PMID:
1523865
38.

Simultaneous determination of nefiracetam and its metabolites by high-performance liquid chromatography.

Fujimaki Y, Sudo K, Hakusui H.

J Chromatogr. 1992 Mar 27;575(2):261-8.

PMID:
1629302
39.

Simple isocratic high-performance liquid chromatographic method for measurement of iodixanol in human plasma.

Nomura H, Teshima E, Hakusui H.

J Chromatogr. 1991 Dec 6;572(1-2):333-8.

PMID:
1818070
40.

Enantioselective disposition of ofloxacin in humans.

Okazaki O, Kojima C, Hakusui H, Nakashima M.

Antimicrob Agents Chemother. 1991 Oct;35(10):2106-9.

41.
42.

Stereoselective metabolism of carvedilol in the rat. Use of enantiomerically radiolabeled pseudoracemates.

Fujimaki M, Shintani S, Hakusui H.

Drug Metab Dispos. 1991 Jul-Aug;19(4):749-53.

PMID:
1680650
43.

Stereoselective glucuronidation of ofloxacin in rat liver microsomes.

Okazaki O, Kurata T, Hakusui H, Tachizawa H.

Drug Metab Dispos. 1991 Mar-Apr;19(2):376-80.

PMID:
1676640
44.
45.

Pharmacokinetics of midaglizole, a new hypoglycaemic agent, in healthy subjects.

Nomura H, Yamada F, Hakusui H.

Biopharm Drug Dispos. 1990 Nov;11(8):701-13.

PMID:
2271746
46.

Identification of two major biliary metabolites of carvedilol in rats.

Fujimaki M, Hakusui H.

Xenobiotica. 1990 Oct;20(10):1025-34.

PMID:
2082592
48.
49.
50.

Disposition and effect of the new thromboxane synthetase inhibitor 6-(1-imidazolylmethyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid in man.

Tanaka M, Ono K, Hakusui H, Takegoshi T, Shiozawa T, Nii S, Shibata H.

Arzneimittelforschung. 1990 Jun;40(6):712-5.

PMID:
2397009

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