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Items: 35


Extramedullary lesions to the pericardium and right atrium in refractory multiple myeloma.

Fukae T, Hakuno D.

Blood. 2019 Oct 31;134(18):1562. doi: 10.1182/blood.2019002696. No abstract available.


Combinations of Cardiac and Non-cardiac Predictors for Prognoses in Patients with Acute Heart Failure.

Hakuno D, Fukae T, Takahashi M, Takiguchi S, Li HC, Nishizawa K, Nozaki H, Sueyoshi K.

Eur Heart J Qual Care Clin Outcomes. 2019 Oct 29. pii: qcz059. doi: 10.1093/ehjqcco/qcz059. [Epub ahead of print]


Armored Heart Because of Tuberculous Constrictive Pericarditis.

Uchi T, Hakuno D, Fukae T, Takahashi M, Takiguchi S, Li HC, Nishizawa K, Nozaki H, Sueyoshi K.

Circ Cardiovasc Imaging. 2019 Mar;12(3):e008726. doi: 10.1161/CIRCIMAGING.118.008726. No abstract available.


Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction.

Hakuno D, Kimura M, Ito S, Satoh J, Nakashima Y, Horie T, Kuwabara Y, Nishiga M, Ide Y, Baba O, Nishi H, Nakao T, Nishino T, Nakazeki F, Koyama S, Hanada R, Randolph RR, Endo J, Kimura T, Ono K.

Sci Rep. 2018 Nov 13;8(1):16749. doi: 10.1038/s41598-018-35194-w.


MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways.

Baba O, Horie T, Nakao T, Hakuno D, Nakashima Y, Nishi H, Kuwabara Y, Nishiga M, Nishino T, Ide Y, Nakazeki F, Koyama S, Kimura M, Hanada R, Kawahara M, Kimura T, Ono K.

Mol Cell Biol. 2018 Jun 28;38(14). pii: e00604-17. doi: 10.1128/MCB.00604-17. Print 2018 Jul 15.


Dynamic changes of serum microRNA-122-5p through therapeutic courses indicates amelioration of acute liver injury accompanied by acute cardiac decompensation.

Koyama S, Kuragaichi T, Sato Y, Kuwabara Y, Usami S, Horie T, Baba O, Hakuno D, Nakashima Y, Nishino T, Nishiga M, Nakao T, Arai H, Kimura T, Ono K.

ESC Heart Fail. 2017 May;4(2):112-121. doi: 10.1002/ehf2.12123. Epub 2016 Dec 1.


Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.

Izuhara M, Kuwabara Y, Saito N, Yamamoto E, Hakuno D, Nakashima Y, Horie T, Baba O, Nishiga M, Nakao T, Nishino T, Nakazeki F, Ide Y, Kimura M, Kimura T, Ono K.

PLoS One. 2017 Mar 2;12(3):e0172798. doi: 10.1371/journal.pone.0172798. eCollection 2017.


MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.

Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K.

Circ Res. 2017 Mar 3;120(5):835-847. doi: 10.1161/CIRCRESAHA.116.309528. Epub 2016 Dec 5.


Elevation of Derivatives of Reactive Oxygen Metabolites Elevated in Young "Disaster Responders" in Hypertension due to Great East Japan Earthquake.

Shiraishi Y, Kujiraoka T, Hakuno D, Masaki N, Tokuno S, Adachi T.

Int Heart J. 2016;57(1):61-6. doi: 10.1536/ihj.15-303. Epub 2016 Jan 8.


Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.

Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.

PLoS One. 2015 Nov 12;10(11):e0142904. doi: 10.1371/journal.pone.0142904. eCollection 2015.


Right Ventricular Wall Dissection With Ventricular Septal Rupture Following Myocardial Infarction Visualized on 3-Dimensional Transthoracic Echocardiography.

Hakuno D, Isobe S, Masaki N, Adachi T.

Circ J. 2015;79(9):2072-4. doi: 10.1253/circj.CJ-14-1246. Epub 2015 Jun 2. No abstract available.


Plasma amino acid profiling identifies specific amino acid associations with cardiovascular function in patients with systolic heart failure.

Hakuno D, Hamba Y, Toya T, Adachi T.

PLoS One. 2015 Feb 6;10(2):e0117325. doi: 10.1371/journal.pone.0117325. eCollection 2015.


Right coronary artery-left ventricle fistula with giant coronary artery aneurysm.

Isobe S, Hakuno D, Isoda S, Hayashi K, Adachi T.

Eur Heart J Cardiovasc Imaging. 2015 Feb;16(2):231. doi: 10.1093/ehjci/jeu205. Epub 2014 Oct 21. No abstract available.


Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice.

Toya T, Hakuno D, Shiraishi Y, Kujiraoka T, Adachi T.

Physiol Rep. 2014 Sep 28;2(9). pii: e12130. doi: 10.14814/phy2.12130. Print 2014 Sep 1.


Association between brachial-ankle pulse wave velocity and the ratio of l-arginine to asymmetric dimethylarginine in patients undergoing coronary angiography.

Masaki N, Hakuno D, Toya T, Shiraishi Y, Kujiraoka T, Namba T, Yada H, Kimura K, Miyazaki K, Adachi T.

J Cardiol. 2015 Apr;65(4):311-7. doi: 10.1016/j.jjcc.2014.06.005. Epub 2014 Jul 16.


Spontaneous hemostasis of coronary artery aneurysm rupture.

Kimura T, Hakuno D, Isoda S, Adachi T.

Circ J. 2014;78(10):2519-20. Epub 2014 Jun 27. No abstract available.


Images in clinical medicine. Endocardial calcification in Behçet's disease.

Nishida T, Hakuno D.

N Engl J Med. 2013 Nov 21;369(21):e28. doi: 10.1056/NEJMicm1305579. No abstract available.


Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction.

Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.

J Am Heart Assoc. 2013 Aug 16;2(4):e000361. doi: 10.1161/JAHA.113.000361.


Transient right-sided Serratia endocarditis after a percutaneous transhepatic procedure.

Hakuno D, Toya T, Adachi T.

J Echocardiogr. 2013 Mar;11(1):36-7. doi: 10.1007/s12574-012-0155-8. Epub 2012 Nov 2. No abstract available.


Platypnea-orthodeoxia syndrome due to PFO and aortic dilation.

Shiraishi Y, Hakuno D, Isoda K, Miyazaki K, Adachi T.

JACC Cardiovasc Imaging. 2012 May;5(5):570-1. doi: 10.1016/j.jcmg.2012.01.015. No abstract available.


Deficiency of CuZn superoxide dismutase promotes inflammation and alters medial structure following vascular injury.

Ishigami N, Isoda K, Adachi T, Niida T, Kujiraoka T, Hakuno D, Kondo H, Kusuhara M, Ohsuzu F.

J Atheroscler Thromb. 2011;18(11):1009-17. Epub 2011 Sep 24.


Role of angiogenetic factors in cardiac valve homeostasis and disease.

Hakuno D, Kimura N, Yoshioka M, Fukuda K.

J Cardiovasc Transl Res. 2011 Dec;4(6):727-40. doi: 10.1007/s12265-011-9317-8. Epub 2011 Aug 25. Review.


Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.

Hakuno D, Kimura N, Yoshioka M, Mukai M, Kimura T, Okada Y, Yozu R, Shukunami C, Hiraki Y, Kudo A, Ogawa S, Fukuda K.

J Clin Invest. 2010 Jul;120(7):2292-306. doi: 10.1172/JCI40973. Epub 2010 Jun 14. Erratum in: J Clin Invest. 2011 Jan 4;121(1):454.


Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.

Kimura N, Shukunami C, Hakuno D, Yoshioka M, Miura S, Docheva D, Kimura T, Okada Y, Matsumura G, Shin'oka T, Yozu R, Kobayashi J, Ishibashi-Ueda H, Hiraki Y, Fukuda K.

Circulation. 2008 Oct 21;118(17):1737-47. doi: 10.1161/CIRCULATIONAHA.108.780031. Epub 2008 Oct 6.


Molecular mechanisms underlying the onset of degenerative aortic valve disease.

Hakuno D, Kimura N, Yoshioka M, Fukuda K.

J Mol Med (Berl). 2009 Jan;87(1):17-24. doi: 10.1007/s00109-008-0400-9. Epub 2008 Sep 3. Review.


Common marmoset embryonic stem cell can differentiate into cardiomyocytes.

Chen H, Hattori F, Murata M, Li W, Yuasa S, Onizuka T, Shimoji K, Ohno Y, Sasaki E, Kimura K, Hakuno D, Sano M, Makino S, Ogawa S, Fukuda K.

Biochem Biophys Res Commun. 2008 May 9;369(3):801-6. doi: 10.1016/j.bbrc.2008.02.141. Epub 2008 Mar 10.


IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system.

Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT.

J Clin Invest. 2007 Jun;117(6):1538-49. Epub 2007 May 10.


[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function].

Hakuno D, Fukuda K.

Clin Calcium. 2007 Mar;17(3):361-72. Review. Japanese.


Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved.

Tomita Y, Makino S, Hakuno D, Hattan N, Kimura K, Miyoshi S, Murata M, Ieda M, Fukuda K.

Med Biol Eng Comput. 2007 Feb;45(2):209-20. Epub 2007 Jan 30. Review.


Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells.

Hakuno D, Takahashi T, Lammerding J, Lee RT.

J Biol Chem. 2005 Nov 25;280(47):39534-44. Epub 2005 Sep 11.


Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells.

Davis ME, Motion JP, Narmoneva DA, Takahashi T, Hakuno D, Kamm RD, Zhang S, Lee RT.

Circulation. 2005 Feb 1;111(4):442-50.


Role of EGF Receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes.

Kodama H, Fukuda K, Takahashi T, Sano M, Kato T, Tahara S, Hakuno D, Sato T, Manabe T, Konishi F, Ogawa S.

J Mol Cell Cardiol. 2002 Feb;34(2):139-50.


Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors.

Hakuno D, Fukuda K, Makino S, Konishi F, Tomita Y, Manabe T, Suzuki Y, Umezawa A, Ogawa S.

Circulation. 2002 Jan 22;105(3):380-6.


Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.

Kato T, Sano M, Miyoshi S, Sato T, Hakuno D, Ishida H, Kinoshita-Nakazawa H, Fukuda K, Ogawa S.

Circ Res. 2000 Nov 10;87(10):937-45.


Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation.

Sano M, Fukuda K, Kodama H, Takahashi T, Kato T, Hakuno D, Sato T, Manabe T, Tahara S, Ogawa S.

Biochem Biophys Res Commun. 2000 Mar 24;269(3):798-802.


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