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Items: 9


MANF protects human pancreatic beta cells against stress-induced cell death.

Hakonen E, Chandra V, Fogarty CL, Yu NY, Ustinov J, Katayama S, Galli E, Danilova T, Lindholm P, Vartiainen A, Einarsdottir E, Krjutškov K, Kere J, Saarma M, Lindahl M, Otonkoski T.

Diabetologia. 2018 Oct;61(10):2202-2214. doi: 10.1007/s00125-018-4687-y. Epub 2018 Jul 21.


sept7b is required for the differentiation of pancreatic endocrine progenitors.

Dash SN, Hakonen E, Ustinov J, Otonkoski T, Andersson O, Lehtonen S.

Sci Rep. 2016 Apr 26;6:24992. doi: 10.1038/srep24992.


[Human stem cells in the treatment of pancreatic and hepatic diseases].

Hakonen E, Toivonen S, Jalanko H, Otonkoski T.

Duodecim. 2014;130(19):1973-80. Review. Finnish.


MANF is indispensable for the proliferation and survival of pancreatic β cells.

Lindahl M, Danilova T, Palm E, Lindholm P, Võikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M.

Cell Rep. 2014 Apr 24;7(2):366-375. doi: 10.1016/j.celrep.2014.03.023. Epub 2014 Apr 13.


EGFR signaling promotes β-cell proliferation and survivin expression during pregnancy.

Hakonen E, Ustinov J, Palgi J, Miettinen PJ, Otonkoski T.

PLoS One. 2014 Apr 2;9(4):e93651. doi: 10.1371/journal.pone.0093651. eCollection 2014.


In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.

Hakonen E, Ustinov J, Eizirik DL, Sariola H, Miettinen PJ, Otonkoski T.

Diabetologia. 2014 May;57(5):970-9. doi: 10.1007/s00125-014-3175-2. Epub 2014 Feb 4.


Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation.

Hakonen E, Ustinov J, Mathijs I, Palgi J, Bouwens L, Miettinen PJ, Otonkoski T.

Diabetologia. 2011 Jul;54(7):1735-43. doi: 10.1007/s00125-011-2153-1. Epub 2011 Apr 21.


EGF receptor in pancreatic beta-cell mass regulation.

Miettinen P, Ormio P, Hakonen E, Banerjee M, Otonkoski T.

Biochem Soc Trans. 2008 Jun;36(Pt 3):280-5. doi: 10.1042/BST0360280. Review.


Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth.

Miettinen PJ, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, Juntti-Berggren L, Berggren PO, Otonkoski T.

Diabetes. 2006 Dec;55(12):3299-308.

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