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Items: 1 to 50 of 70

1.

Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.

Aatsinki SM, Elkhwanky MS, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Wiesner RJ, Chambers KT, Finck BN, Hakkola J.

Diabetes. 2019 May;68(5):918-931. doi: 10.2337/db18-1050. Epub 2019 Mar 4.

PMID:
30833469
2.

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Hakkola J, Bernasconi C, Coecke S, Richert L, Andersson TB, Pelkonen O.

Basic Clin Pharmacol Toxicol. 2018 Sep;123 Suppl 5:42-50. doi: 10.1111/bcpt.13004. Epub 2018 Apr 29. Review.

PMID:
29527807
3.

Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver.

Hassani-Nezhad-Gashti F, Rysä J, Kummu O, Näpänkangas J, Buler M, Karpale M, Hukkanen J, Hakkola J.

Biochem Pharmacol. 2018 Feb;148:253-264. doi: 10.1016/j.bcp.2018.01.001. Epub 2018 Jan 5.

PMID:
29309761
4.

Extranuclear Sirtuins and Metabolic Stress.

Elkhwanky MS, Hakkola J.

Antioxid Redox Signal. 2018 Mar 10;28(8):662-676. doi: 10.1089/ars.2017.7270. Epub 2017 Aug 11. Review.

PMID:
28707980
5.

Arsenic, cadmium, lead and mercury levels in blood of Finnish adults and their relation to diet, lifestyle habits and sociodemographic variables.

Abass K, Koiranen M, Mazej D, Tratnik JS, Horvat M, Hakkola J, Järvelin MR, Rautio A.

Environ Sci Pollut Res Int. 2017 Jan;24(2):1347-1362. doi: 10.1007/s11356-016-7824-5. Epub 2016 Oct 24.

6.

Who watches the watchmen? Regulation of the expression and activity of sirtuins.

Buler M, Andersson U, Hakkola J.

FASEB J. 2016 Dec;30(12):3942-3960. Epub 2016 Sep 2. Review.

PMID:
27591175
7.

The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials.

Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA.

Food Funct. 2016 Jul 13;7(7):3006-16. doi: 10.1039/c6fo00656f.

PMID:
27296047
8.

Regulation of hepatic energy metabolism by the nuclear receptor PXR.

Hakkola J, Rysä J, Hukkanen J.

Biochim Biophys Acta. 2016 Sep;1859(9):1072-1082. doi: 10.1016/j.bbagrm.2016.03.012. Epub 2016 Apr 8. Review.

PMID:
27041449
9.

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis.

Rahtu-Korpela L, Määttä J, Dimova EY, Hörkkö S, Gylling H, Walkinshaw G, Hakkola J, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):608-17. doi: 10.1161/ATVBAHA.115.307136. Epub 2016 Feb 4.

PMID:
26848160
10.

The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans.

Hukkanen J, Rysa J, Makela KA, Herzig KH, Hakkola J, Savolainen MJ.

J Physiol Pharmacol. 2015 Dec;66(6):831-9.

11.

Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6.

Hu H, Yu T, Arpiainen S, Lang MA, Hakkola J, Abu-Bakar A.

Toxicol Appl Pharmacol. 2015 Nov 15;289(1):30-9. doi: 10.1016/j.taap.2015.08.021. Epub 2015 Sep 4.

PMID:
26343999
12.

Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model.

Komulainen T, Lodge T, Hinttala R, Bolszak M, Pietilä M, Koivunen P, Hakkola J, Poulton J, Morten KJ, Uusimaa J.

Toxicology. 2015 May 4;331:47-56. doi: 10.1016/j.tox.2015.03.001. Epub 2015 Mar 5.

PMID:
25745980
13.

Reactive metabolites in early drug development: predictive in vitro tools.

Pelkonen O, Pasanen M, Tolonen A, Koskinen M, Hakkola J, Abass K, Laine J, Hakkinen M, Juvonen R, Auriola S, Storvik M, Huuskonen P, Rousu T, Rahikkala M.

Curr Med Chem. 2015;22(4):538-50. Review.

PMID:
25312212
14.

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.

Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J.

FASEB J. 2014 Jul;28(7):3225-37. doi: 10.1096/fj.13-245241. Epub 2014 Mar 31.

PMID:
24687991
15.

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.

Aatsinki SM, Buler M, Salomäki H, Koulu M, Pavek P, Hakkola J.

Br J Pharmacol. 2014 May;171(9):2351-63. doi: 10.1111/bph.12585.

16.

Pregnane X receptor (PXR)--a contributor to the diabetes epidemic?

Hukkanen J, Hakkola J, Rysä J.

Drug Metabol Drug Interact. 2014;29(1):3-15. doi: 10.1515/dmdi-2013-0036. Review.

PMID:
24166671
17.

Pregnane X receptor agonists impair postprandial glucose tolerance.

Rysä J, Buler M, Savolainen MJ, Ruskoaho H, Hakkola J, Hukkanen J.

Clin Pharmacol Ther. 2013 Jun;93(6):556-63. doi: 10.1038/clpt.2013.48. Epub 2013 Mar 5.

PMID:
23588309
18.

Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

Buler M, Aatsinki SM, Izzi V, Hakkola J.

PLoS One. 2012;7(11):e49863. doi: 10.1371/journal.pone.0049863. Epub 2012 Nov 16.

20.

Preservation, induction or incorporation of metabolism into the in vitro cellular system - views to current opportunities and limitations.

Pelkonen O, Turpeinen M, Hakkola J, Abass K, Pasanen M, Raunio H, Vähäkangas K.

Toxicol In Vitro. 2013 Aug;27(5):1578-83. doi: 10.1016/j.tiv.2012.06.002. Epub 2012 Jun 19.

PMID:
22728233
21.

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

Abu-Bakar A, Hakkola J, Juvonen R, Rahnasto-Rilla M, Raunio H, Lang MA.

Curr Drug Metab. 2013 Jan;14(1):137-50. Review.

PMID:
22497566
22.

Characterization of human cytochrome P450 induction by pesticides.

Abass K, Lämsä V, Reponen P, Küblbeck J, Honkakoski P, Mattila S, Pelkonen O, Hakkola J.

Toxicology. 2012 Mar 29;294(1):17-26. doi: 10.1016/j.tox.2012.01.010. Epub 2012 Jan 28.

PMID:
22310298
23.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

24.

Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function.

Buler M, Aatsinki SM, Skoumal R, Hakkola J.

Biochem Pharmacol. 2011 Dec 15;82(12):2008-15. doi: 10.1016/j.bcp.2011.09.006. Epub 2011 Sep 16.

PMID:
21933665
25.

Metabolism of ophthalmic timolol: new aspects of an old drug.

Volotinen M, Hakkola J, Pelkonen O, Vapaatalo H, Mäenpää J.

Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303. doi: 10.1111/j.1742-7843.2011.00694.x. Review.

26.

Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis.

Anttila S, Raunio H, Hakkola J.

Am J Respir Cell Mol Biol. 2011 May;44(5):583-90. doi: 10.1165/rcmb.2010-0189RT. Epub 2010 Nov 19. Review.

PMID:
21097654
27.

Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.

Lämsä V, Levonen AL, Leinonen H, Ylä-Herttuala S, Yamamoto M, Hakkola J.

Chem Res Toxicol. 2010 May 17;23(5):977-85. doi: 10.1021/tx100084c.

PMID:
20402460
28.

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes.

Volotinen M, Korjamo T, Tolonen A, Turpeinen M, Pelkonen O, Hakkola J, Mäenpää J.

Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):302-9. doi: 10.1111/j.1742-7843.2009.00487.x. Epub 2009 Nov 11.

29.

Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.

Volotinen M, Mäenpää J, Kankuri E, Oksala O, Pelkonen O, Nakajima M, Yokoi T, Hakkola J.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3099-105. doi: 10.1167/iovs.08-2790. Epub 2009 Mar 25.

PMID:
19324859
30.

Cytochromes P450, induction and cholesterol--what are the connections?

Pelkonen O, Hakkola J.

Eur J Clin Pharmacol. 2008 Sep;64(9):837-9. doi: 10.1007/s00228-008-0522-6. Epub 2008 Jul 17. No abstract available.

PMID:
18633603
31.

Inhibition and induction of human cytochrome P450 enzymes: current status.

Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H.

Arch Toxicol. 2008 Oct;82(10):667-715. doi: 10.1007/s00204-008-0332-8. Epub 2008 Jul 11. Review.

PMID:
18618097
32.

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

Arpiainen S, Järvenpää SM, Manninen A, Viitala P, Lang MA, Pelkonen O, Hakkola J.

Toxicol Appl Pharmacol. 2008 Oct 1;232(1):135-41. doi: 10.1016/j.taap.2008.06.001. Epub 2008 Jun 17.

PMID:
18602936
33.

Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta.

Rahi M, Heikkinen T, Hakkola J, Hakala K, Wallerman O, Wadelius M, Wadelius C, Laine K.

Hum Exp Toxicol. 2008 Jan;27(1):65-71. doi: 10.1177/0960327108088971.

PMID:
18480151
34.

Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers.

Huuskonen P, Storvik M, Reinisalo M, Honkakoski P, Rysä J, Hakkola J, Pasanen M.

Clin Pharmacol Ther. 2008 Apr;83(4):542-50. Epub 2007 Oct 27.

PMID:
17928820
35.

Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells.

Biggs JS, Wan J, Cutler NS, Hakkola J, Uusimäki P, Raunio H, Yost GS.

Mol Pharmacol. 2007 Sep;72(3):514-25. Epub 2007 Jun 4.

PMID:
17548528
36.

Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.

Arpiainen S, Lämsä V, Pelkonen O, Yim SH, Gonzalez FJ, Hakkola J.

J Mol Biol. 2007 Jun 8;369(3):640-52. Epub 2007 Apr 1.

PMID:
17466327
37.

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.

Abu-Bakar A, Lämsä V, Arpiainen S, Moore MR, Lang MA, Hakkola J.

Drug Metab Dispos. 2007 May;35(5):787-94. Epub 2007 Feb 15.

PMID:
17303623
38.

Placental transfer of quetiapine in relation to P-glycoprotein activity.

Rahi M, Heikkinen T, Härtter S, Hakkola J, Hakala K, Wallerman O, Wadelius M, Wadelius C, Laine K.

J Psychopharmacol. 2007 Sep;21(7):751-6. Epub 2007 Jan 26.

PMID:
17259208
39.

Characterization of androgen-regulated expression of CYP3A5 in human prostate.

Moilanen AM, Hakkola J, Vaarala MH, Kauppila S, Hirvikoski P, Vuoristo JT, Edwards RJ, Paavonen TK.

Carcinogenesis. 2007 May;28(5):916-21. Epub 2006 Nov 20.

PMID:
17116727
40.

Functional role of P-glycoprotein in the human blood-placental barrier.

Mölsä M, Heikkinen T, Hakkola J, Hakala K, Wallerman O, Wadelius M, Wadelius C, Laine K.

Clin Pharmacol Ther. 2005 Aug;78(2):123-31.

PMID:
16084847
41.

Regulation of CYP3A genes in the human respiratory tract.

Raunio H, Hakkola J, Pelkonen O.

Chem Biol Interact. 2005 Jan 15;151(2):53-62. Review.

PMID:
15698577
42.

Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway.

Arpiainen S, Raffalli-Mathieu F, Lang MA, Pelkonen O, Hakkola J.

Mol Pharmacol. 2005 Apr;67(4):1325-33. Epub 2005 Jan 18.

PMID:
15657367
43.

Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I.

Ulvila J, Arpiainen S, Pelkonen O, Aida K, Sueyoshi T, Negishi M, Hakkola J.

Biochem J. 2004 Aug 1;381(Pt 3):887-94.

44.

Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.

Anttila S, Hakkola J, Tuominen P, Elovaara E, Husgafvel-Pursiainen K, Karjalainen A, Hirvonen A, Nurminen T.

Cancer Res. 2003 Dec 15;63(24):8623-8.

45.

Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells.

Hakkola J, Hu Y, Ingelman-Sundberg M.

J Pharmacol Exp Ther. 2003 Mar;304(3):1048-54.

PMID:
12604681
46.

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

Hukkanen J, Väisänen T, Lassila A, Piipari R, Anttila S, Pelkonen O, Raunio H, Hakkola J.

J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.

PMID:
12538830
47.

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung.

Hukkanen J, Pelkonen O, Hakkola J, Raunio H.

Crit Rev Toxicol. 2002 Sep;32(5):391-411. Review.

PMID:
12389869
48.

The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV.

Parkkila S, Kivelä AJ, Kaunisto K, Parkkila AK, Hakkola J, Rajaniemi H, Waheed A, Sly WS.

BMC Gastroenterol. 2002 May 21;2:13.

49.

In vitro screening of cytochrome P450 induction potential.

Pelkonen O, Hukkanen J, Honkakoski P, Hakkola J, Viitala P, Raunio H.

Ernst Schering Res Found Workshop. 2002;(37):105-37. Review. No abstract available.

PMID:
11975192
50.

Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers.

Hakkola J, Raunio H, Purkunen R, Saarikoski S, Vähäkangas K, Pelkonen O, Edwards RJ, Boobis AR, Pasanen M.

Biol Neonate. 2001;80(3):193-201.

PMID:
11585982

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