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Items: 1 to 50 of 113

1.

Shopping Detail Information and Home Freezer Sampling Confirmed the Role of Commercial, Modified-Atmosphere Packaged Meatballs as a Vehicle for Listeriosis in Finland.

Keto-Timonen R, Markkula A, Halkilahti J, Huttunen R, Räsänen S, Salmenlinna S, Heikkilä A, Puisto M, Närhinen M, Hakkinen M, Korkeala H, Jalava K.

Front Public Health. 2019 Aug 6;7:216. doi: 10.3389/fpubh.2019.00216. eCollection 2019.

2.

Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood.

Mäntyselkä A, Haapala EA, Lindi V, Häkkinen MR, Auriola S, Jääskeläinen J, Lakka TA.

Horm Res Paediatr. 2019;91(5):329-335. doi: 10.1159/000501719. Epub 2019 Aug 9.

PMID:
31401625
3.

Genomic Epidemiology and Phenotyping Reveal on-Farm Persistence and Cold Adaptation of Raw Milk Outbreak-Associated Yersinia pseudotuberculosis.

Castro H, Jaakkonen A, Hakakorpi A, Hakkinen M, Isidro J, Korkeala H, Lindström M, Hallanvuo S.

Front Microbiol. 2019 May 14;10:1049. doi: 10.3389/fmicb.2019.01049. eCollection 2019.

4.

Agreeing on global research priorities for medication safety: an international prioritisation exercise.

Sheikh A, Rudan I, Cresswell K, Dhingra-Kumar N, Tan ML, Häkkinen ML, Donaldson L; World Health Organization's Management Team on Research Priorities for Medication Safety.

J Glob Health. 2019 Jun;9(1):010422. doi: 10.7189/jogh.09.010422.

5.

Longitudinal Study of Shiga Toxin-Producing Escherichia coli and Campylobacter jejuni on Finnish Dairy Farms and in Raw Milk.

Jaakkonen A, Castro H, Hallanvuo S, Ranta J, Rossi M, Isidro J, Lindström M, Hakkinen M.

Appl Environ Microbiol. 2019 Mar 22;85(7). pii: e02910-18. doi: 10.1128/AEM.02910-18. Print 2019 Apr 1.

6.

Blood steroids are associated with prognosis and fat distribution in endometrial cancer.

Tangen IL, Fasmer KE, Konings GF, Jochems A, Delvoux B, Xanthoulea S, Stokowy T, Strand E, Berg HF, Auriola S, Trovik J, Häkkinen MR, Haldorsen IS; ENITEC. Electronic address: https://www.esgo.org, Krakstad C, Romano A.

Gynecol Oncol. 2019 Jan;152(1):46-52. doi: 10.1016/j.ygyno.2018.10.024. Epub 2018 Oct 26.

PMID:
30554934
7.

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue.

Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S.

J Pharm Biomed Anal. 2019 Feb 5;164:642-652. doi: 10.1016/j.jpba.2018.11.035. Epub 2018 Nov 16.

PMID:
30472582
8.

High buprenorphine-related mortality is persistent in Finland.

Kriikku P, Häkkinen M, Ojanperä I.

Forensic Sci Int. 2018 Oct;291:76-82. doi: 10.1016/j.forsciint.2018.08.010. Epub 2018 Aug 17.

PMID:
30170272
9.

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure.

Konings GF, Saarinen N, Delvoux B, Kooreman L, Koskimies P, Krakstad C, Fasmer KE, Haldorsen IS, Zaffagnini A, Häkkinen MR, Auriola S, Dubois L, Lieuwes N, Verhaegen F, Schyns LE, Kruitwagen RF; ENITEC Consortium, Xanthoulea S, Romano A.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2547. doi: 10.3390/ijms19092547.

10.

Altered Polyamine Profiles in Colorectal Cancer.

Venäläinen MK, Roine AN, Häkkinen MR, Vepsäläinen JJ, Kumpulainen PS, Kiviniemi MS, Lehtimäki T, Oksala NK, Rantanen TK.

Anticancer Res. 2018 Jun;38(6):3601-3607. doi: 10.21873/anticanres.12634.

PMID:
29848716
11.

New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro.

Muluneh F, Häkkinen MR, El-Dairi R, Pasanen M, Juvonen RO.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1344-1352. doi: 10.1002/rcm.8173.

PMID:
29788543
12.

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue.

Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S.

J Pharm Biomed Anal. 2018 Apr 15;152:165-172. doi: 10.1016/j.jpba.2018.01.034. Epub 2018 Jan 31.

PMID:
29414008
13.

Controlling of N-alkylpolyamine analogue metabolism by selective deuteration.

Ucal S, Häkkinen MR, Alanne AL, Alhonen L, Vepsäläinen J, Keinänen TA, Hyvönen MT.

Biochem J. 2018 Feb 14;475(3):663-676. doi: 10.1042/BCJ20170887.

PMID:
29301981
14.

Occurrence, Persistence, and Contamination Routes of Listeria monocytogenes Genotypes on Three Finnish Dairy Cattle Farms: a Longitudinal Study.

Castro H, Jaakkonen A, Hakkinen M, Korkeala H, Lindström M.

Appl Environ Microbiol. 2018 Jan 31;84(4). pii: e02000-17. doi: 10.1128/AEM.02000-17. Print 2018 Feb 15.

15.

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.

Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M.

Am J Pathol. 2018 Jan;188(1):216-228. doi: 10.1016/j.ajpath.2017.08.036. Epub 2017 Nov 7.

PMID:
29126837
16.

Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.

Penny GM, Cochran RB, Pihlajoki M, Kyrönlahti A, Schrade A, Häkkinen M, Toppari J, Heikinheimo M, Wilson DB.

Reproduction. 2017 Oct;154(4):455-467. doi: 10.1530/REP-17-0311. Epub 2017 Jul 14.

17.

Urinary Polyamines as Biomarkers for Ovarian Cancer.

Niemi RJ, Roine AN, Häkkinen MR, Kumpulainen PS, Keinänen TA, Vepsäläinen JJ, Lehtimäki T, Oksala NK, Mäenpää JU.

Int J Gynecol Cancer. 2017 Sep;27(7):1360-1366. doi: 10.1097/IGC.0000000000001031.

PMID:
28604456
18.

Monomorphic genotypes within a generalist lineage of Campylobacter jejuni show signs of global dispersion.

Llarena AK, Zhang J, Vehkala M, Välimäki N, Hakkinen M, Hänninen ML, Roasto M, Mäesaar M, Taboada E, Barker D, Garofolo G, Cammà C, Di Giannatale E, Corander J, Rossi M.

Microb Genom. 2016 Oct 21;2(10):e000088. doi: 10.1099/mgen.0.000088. eCollection 2016 Oct.

19.

Severe Outbreak of Sorbitol-Fermenting Escherichia coli O157 via Unpasteurized Milk and Farm Visits, Finland 2012.

Jaakkonen A, Salmenlinna S, Rimhanen-Finne R, Lundström H, Heinikainen S, Hakkinen M, Hallanvuo S.

Zoonoses Public Health. 2017 Sep;64(6):468-475. doi: 10.1111/zph.12327. Epub 2017 Jan 3.

PMID:
28045227
20.

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine.

Puris E, Pasanen M, Gynther M, Häkkinen MR, Pihlajamäki J, Keränen T, Honkakoski P, Raunio H, Petsalo A.

Anal Bioanal Chem. 2017 Jan;409(1):251-268. doi: 10.1007/s00216-016-9994-x. Epub 2016 Oct 12.

PMID:
27734142
21.

Time-scale dynamics of proteome and transcriptome of the white-rot fungus Phlebia radiata: growth on spruce wood and decay effect on lignocellulose.

Kuuskeri J, Häkkinen M, Laine P, Smolander OP, Tamene F, Miettinen S, Nousiainen P, Kemell M, Auvinen P, Lundell T.

Biotechnol Biofuels. 2016 Sep 5;9(1):192. doi: 10.1186/s13068-016-0608-9. eCollection 2016.

22.

The human placental proteome is affected by maternal smoking.

Huuskonen P, Amezaga MR, Bellingham M, Jones LH, Storvik M, Häkkinen M, Keski-Nisula L, Heinonen S, O'Shaughnessy PJ, Fowler PA, Pasanen M.

Reprod Toxicol. 2016 Aug;63:22-31. doi: 10.1016/j.reprotox.2016.05.009. Epub 2016 May 14.

23.

Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics.

Kärkkäinen O, Häkkinen MR, Auriola S, Kautiainen H, Tiihonen J, Storvik M.

Alcohol. 2016 May;52:63-70. doi: 10.1016/j.alcohol.2016.03.002. Epub 2016 Mar 24.

PMID:
27139239
24.

Prevalence of Pathogenic Yersinia enterocolitica in Finnish Slaughter Pigs.

Rahikainen Ibañez T, Laukkanen-Ninios R, Hakkinen M, Johansson T, Vilar M, Korkeala H.

J Food Prot. 2016 Apr;79(4):677-81. doi: 10.4315/0362-028X.JFP-15-389.

PMID:
27052875
25.

Tracing isolates from domestic human Campylobacter jejuni infections to chicken slaughter batches and swimming water using whole-genome multilocus sequence typing.

Kovanen S, Kivistö R, Llarena AK, Zhang J, Kärkkäinen UM, Tuuminen T, Uksila J, Hakkinen M, Rossi M, Hänninen ML.

Int J Food Microbiol. 2016 Jun 2;226:53-60. doi: 10.1016/j.ijfoodmicro.2016.03.009. Epub 2016 Mar 20.

PMID:
27041390
26.
27.

Campylobacter QMRA: A Bayesian Estimation of Prevalence and Concentration in Retail Foods Under Clustering and Heavy Censoring.

Mikkelä A, Ranta J, González M, Hakkinen M, Tuominen P.

Risk Anal. 2016 Nov;36(11):2065-2080. doi: 10.1111/risa.12572. Epub 2016 Feb 9.

PMID:
26858000
28.

Outbreak of Yersinia pseudotuberculosis O:1 infection associated with raw milk consumption, Finland, spring 2014.

Pärn T, Hallanvuo S, Salmenlinna S, Pihlajasaari A, Heikkinen S, Telkki-Nykänen H, Hakkinen M, Ollgren J, Huusko S, Rimhanen-Finne R.

Euro Surveill. 2015;20(40). doi: 10.2807/1560-7917.ES.2015.20.40.30033.

29.

A Dose-Finding Study of Dexketoprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Clinical Trial on Effects on the Analgesic Concentration of Oxycodone.

Piirainen A, Kokki H, Immonen S, Eskelinen M, Häkkinen MR, Hautajärvi H, Kokki M.

Drugs R D. 2015 Dec;15(4):319-28. doi: 10.1007/s40268-015-0107-7.

30.

Molecular and Cytogenetic Characterization of Wild Musa Species.

Čížková J, Hřibová E, Christelová P, Van den Houwe I, Häkkinen M, Roux N, Swennen R, Doležel J.

PLoS One. 2015 Aug 7;10(8):e0134096. doi: 10.1371/journal.pone.0134096. eCollection 2015.

31.

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites.

Laine JE, Häkkinen MR, Auriola S, Juvonen RO, Pasanen M.

Toxicol Rep. 2015 Jul 9;2:1024-1032. doi: 10.1016/j.toxrep.2015.07.002. eCollection 2015.

32.

The effects of extracellular pH and of the transcriptional regulator PACI on the transcriptome of Trichoderma reesei.

Häkkinen M, Sivasiddarthan D, Aro N, Saloheimo M, Pakula TM.

Microb Cell Fact. 2015 Apr 30;14:63. doi: 10.1186/s12934-015-0247-z.

33.

Predominant Campylobacter jejuni sequence types persist in Finnish chicken production.

Llarena AK, Huneau A, Hakkinen M, Hänninen ML.

PLoS One. 2015 Feb 20;10(2):e0116585. doi: 10.1371/journal.pone.0116585. eCollection 2015.

34.

GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2015 May;156(5):1860-72. doi: 10.1210/en.2014-1931. Epub 2015 Feb 10.

35.

[³H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study.

Kupila J, Kärkkäinen O, Laukkanen V, Häkkinen M, Kautiainen H, Tiihonen J, Storvik M.

Psychiatry Res. 2015 Mar 30;231(3):197-201. doi: 10.1016/j.pscychresns.2014.10.026. Epub 2014 Nov 11.

PMID:
25616726
36.

Prescription opioid abuse based on representative postmortem toxicology.

Häkkinen M, Vuori E, Ojanperä I.

Forensic Sci Int. 2014 Dec;245:121-5. doi: 10.1016/j.forsciint.2014.10.028. Epub 2014 Oct 24.

PMID:
25447184
37.

Reactive metabolites in early drug development: predictive in vitro tools.

Pelkonen O, Pasanen M, Tolonen A, Koskinen M, Hakkola J, Abass K, Laine J, Hakkinen M, Juvonen R, Auriola S, Storvik M, Huuskonen P, Rousu T, Rahikkala M.

Curr Med Chem. 2015;22(4):538-50. Review.

PMID:
25312212
38.

Genome analysis of Campylobacter jejuni strains isolated from a waterborne outbreak.

Revez J, Llarena AK, Schott T, Kuusi M, Hakkinen M, Kivistö R, Hänninen ML, Rossi M.

BMC Genomics. 2014 Sep 8;15:768. doi: 10.1186/1471-2164-15-768.

39.

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.

Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen MR, Awosanya M, Suvitie P, Kujari H, Aittokallio T, Handelsman DJ, Auriola S, Perheentupa A, Poutanen M.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2188-97. doi: 10.1210/jc.2014-1913. Epub 2014 Aug 19.

PMID:
25137424
40.

Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model.

Knuuttila M, Yatkin E, Kallio J, Savolainen S, Laajala TD, Aittokallio T, Oksala R, Häkkinen M, Keski-Rahkonen P, Auriola S, Poutanen M, Mäkelä S.

Am J Pathol. 2014 Aug;184(8):2163-73. doi: 10.1016/j.ajpath.2014.04.010. Epub 2014 Jun 17.

PMID:
24949550
41.

Profiles of pregabalin and gabapentin abuse by postmortem toxicology.

Häkkinen M, Vuori E, Kalso E, Gergov M, Ojanperä I.

Forensic Sci Int. 2014 Aug;241:1-6. doi: 10.1016/j.forsciint.2014.04.028. Epub 2014 May 5.

PMID:
24835028
42.

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.

Landreh L, Spinnler K, Schubert K, Häkkinen MR, Auriola S, Poutanen M, Söder O, Svechnikov K, Mayerhofer A.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1227-35. doi: 10.1210/jc.2013-4199. Epub 2014 Mar 31.

PMID:
24684461
43.

Detection of prostate cancer by an electronic nose: a proof of principle study.

Roine A, Veskimäe E, Tuokko A, Kumpulainen P, Koskimäki J, Keinänen TA, Häkkinen MR, Vepsäläinen J, Paavonen T, Lekkala J, Lehtimäki T, Tammela TL, Oksala NK.

J Urol. 2014 Jul;192(1):230-4. doi: 10.1016/j.juro.2014.01.113. Epub 2014 Feb 25.

PMID:
24582536
44.

Nanocrystal-based per-oral itraconazole delivery: superior in vitro dissolution enhancement versus Sporanox® is not realized in in vivo drug absorption.

Sarnes A, Kovalainen M, Häkkinen MR, Laaksonen T, Laru J, Kiesvaara J, Ilkka J, Oksala O, Rönkkö S, Järvinen K, Hirvonen J, Peltonen L.

J Control Release. 2014 Apr 28;180:109-16. doi: 10.1016/j.jconrel.2014.02.016. Epub 2014 Feb 22.

PMID:
24566254
45.

Chloropicrin-induced toxic responses in human lung epithelial cells.

Pesonen M, Häkkinen M, Rilla K, Juvonen R, Kuitunen T, Pasanen M, Vähäkangas K.

Toxicol Lett. 2014 Apr 21;226(2):236-44. doi: 10.1016/j.toxlet.2014.02.006. Epub 2014 Feb 15.

PMID:
24548678
46.

Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production.

Häkkinen M, Valkonen MJ, Westerholm-Parvinen A, Aro N, Arvas M, Vitikainen M, Penttilä M, Saloheimo M, Pakula TM.

Biotechnol Biofuels. 2014 Jan 28;7(1):14. doi: 10.1186/1754-6834-7-14.

47.

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.

Häkkinen MR, Roine A, Auriola S, Tuokko A, Veskimäe E, Keinänen TA, Lehtimäki T, Oksala N, Vepsäläinen J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 15;941:81-9. doi: 10.1016/j.jchromb.2013.10.009. Epub 2013 Oct 15.

PMID:
24185098
48.

Cloning and characterization of a novel acidic cutinase from Sirococcus conigenus.

Nyyssölä A, Pihlajaniemi V, Häkkinen M, Kontkanen H, Saloheimo M, Nakari-Setälä T.

Appl Microbiol Biotechnol. 2014 Apr;98(8):3639-50.

PMID:
24121867
49.

AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study.

Kärkkäinen O, Kupila J, Häkkinen M, Laukkanen V, Tupala E, Kautiainen H, Tiihonen J, Storvik M.

Psychiatry Res. 2013 Dec 30;214(3):429-34. doi: 10.1016/j.pscychresns.2013.09.012. Epub 2013 Oct 8.

PMID:
24119876
50.

Parenteral buprenorphine-naloxone abuse is a major cause of fatal buprenorphine-related poisoning.

Häkkinen M, Heikman P, Ojanperä I.

Forensic Sci Int. 2013 Oct 10;232(1-3):11-5. doi: 10.1016/j.forsciint.2013.06.017. Epub 2013 Jul 19.

PMID:
24053859

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