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Items: 36


An improved method for studying mouse diaphragm function.

Hakim CH, Lessa TB, Jenkins GJ, Yang NN, Ambrosio CE, Duan D.

Sci Rep. 2019 Dec 19;9(1):19453. doi: 10.1038/s41598-019-55704-8.


AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.

Nance ME, Shi R, Hakim CH, Wasala NB, Yue Y, Pan X, Zhang T, Robinson CA, Duan SX, Yao G, Yang NN, Chen SJ, Wagner KR, Gersbach CA, Duan D.

Mol Ther. 2019 Sep 4;27(9):1568-1585. doi: 10.1016/j.ymthe.2019.06.012. Epub 2019 Jul 3.


Systemic Delivery of Adeno-Associated Viral Vectors in Mice and Dogs.

Wasala LP, Hakim CH, Yue Y, Yang NN, Duan D.

Methods Mol Biol. 2019;1937:281-294. doi: 10.1007/978-1-4939-9065-8_18.


Questions Answered and Unanswered by the First CRISPR Editing Study in a Canine Model of Duchenne Muscular Dystrophy.

Wasala NB, Hakim CH, Chen SJ, Yang NN, Duan D.

Hum Gene Ther. 2019 May;30(5):535-543. doi: 10.1089/hum.2018.243. Epub 2019 Feb 26.


AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.

Hakim CH, Wasala NB, Nelson CE, Wasala LP, Yue Y, Louderman JA, Lessa TB, Dai A, Zhang K, Jenkins GJ, Nance ME, Pan X, Kodippili K, Yang NN, Chen SJ, Gersbach CA, Duan D.

JCI Insight. 2018 Dec 6;3(23). pii: 124297. doi: 10.1172/jci.insight.124297.


Nitric oxide-dependent attenuation of noradrenaline-induced vasoconstriction is impaired in the canine model of Duchenne muscular dystrophy.

Kodippili K, Hakim CH, Yang HT, Pan X, Yang NN, Laughlin MH, Terjung RL, Duan D.

J Physiol. 2018 Nov;596(21):5199-5216. doi: 10.1113/JP275672. Epub 2018 Sep 20.


Automatic characterization of stride parameters in canines with a single wearable inertial sensor.

Jenkins GJ, Hakim CH, Yang NN, Yao G, Duan D.

PLoS One. 2018 Jun 14;13(6):e0198893. doi: 10.1371/journal.pone.0198893. eCollection 2018.


A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy.

Hakim CH, Wasala NB, Pan X, Kodippili K, Yue Y, Zhang K, Yao G, Haffner B, Duan SX, Ramos J, Schneider JS, Yang NN, Chamberlain JS, Duan D.

Mol Ther Methods Clin Dev. 2017 Jul 27;6:216-230. doi: 10.1016/j.omtm.2017.06.006. eCollection 2017 Sep 15.


Dual AAV Gene Therapy for Duchenne Muscular Dystrophy with a 7-kb Mini-Dystrophin Gene in the Canine Model.

Kodippili K, Hakim CH, Pan X, Yang HT, Yue Y, Zhang Y, Shin JH, Yang NN, Duan D.

Hum Gene Ther. 2018 Mar;29(3):299-311. doi: 10.1089/hum.2017.095. Epub 2017 Aug 4.


Nanotherapy for Duchenne muscular dystrophy.

Nance ME, Hakim CH, Yang NN, Duan D.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Mar;10(2). doi: 10.1002/wnan.1472. Epub 2017 Apr 11. Review.


Non-invasive evaluation of muscle disease in the canine model of Duchenne muscular dystrophy by electrical impedance myography.

Hakim CH, Mijailovic A, Lessa TB, Coates JR, Shin C, Rutkove SB, Duan D.

PLoS One. 2017 Mar 24;12(3):e0173557. doi: 10.1371/journal.pone.0173557. eCollection 2017.


Dystrophin contains multiple independent membrane-binding domains.

Zhao J, Kodippili K, Yue Y, Hakim CH, Wasala L, Pan X, Zhang K, Yang NN, Duan D, Lai Y.

Hum Mol Genet. 2016 Sep 1;25(17):3647-3653. doi: 10.1093/hmg/ddw210. Epub 2016 Jul 4.


In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Castellanos Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA.

Science. 2016 Jan 22;351(6271):403-7. doi: 10.1126/science.aad5143. Epub 2015 Dec 31.


Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus.

Yue Y, Pan X, Hakim CH, Kodippili K, Zhang K, Shin JH, Yang HT, McDonald T, Duan D.

Hum Mol Genet. 2015 Oct 15;24(20):5880-90. doi: 10.1093/hmg/ddv310. Epub 2015 Aug 11.


AAV-8 is more efficient than AAV-9 in transducing neonatal dog heart.

Pan X, Yue Y, Zhang K, Hakim CH, Kodippili K, McDonald T, Duan D.

Hum Gene Ther Methods. 2015 Apr;26(2):54-61. doi: 10.1089/hgtb.2014.128. Epub 2015 Apr 1.


Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy.

McGreevy JW, Hakim CH, McIntosh MA, Duan D.

Dis Model Mech. 2015 Mar;8(3):195-213. doi: 10.1242/dmm.018424. Review.


Early loss of ambulation is not a representative clinical feature in Duchenne muscular dystrophy dogs: remarks on the article of Barthélémy et al.

Duan D, Hakim CH, Ambrosio CE, Smith BF, Sweeney HL.

Dis Model Mech. 2015 Mar;8(3):193-4. doi: 10.1242/dmm.019216. No abstract available.


The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice.

Wasala NB, Zhang K, Wasala LP, Hakim CH, Duan D.

PLoS Curr. 2015 Feb 10;7. pii: doi: 10.1371/


Night Activity Reduction is a Signature Physiological Biomarker for Duchenne Muscular Dystrophy Dogs.

Hakim CH, Peters AA, Feng F, Yao G, Duan D.

J Neuromuscul Dis. 2015;2(4):397-407.


Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1, -6, and -9 in neonatal dogs.

Hakim CH, Yue Y, Shin JH, Williams RR, Zhang K, Smith BF, Duan D.

Mol Ther Methods Clin Dev. 2014 Mar 5;1:14002.


RNAi-mediated Gene Silencing of Mutant Myotilin Improves Myopathy in LGMD1A Mice.

Liu J, Wallace LM, Garwick-Coppens SE, Sloboda DD, Davis CS, Hakim CH, Hauser MA, Brooks SV, Mendell JR, Harper SQ.

Mol Ther Nucleic Acids. 2014 Apr 29;3:e160. doi: 10.1038/mtna.2014.13.


Alpha 7 integrin preserves the function of the extensor digitorum longus muscle in dystrophin-null mice.

Hakim CH, Burkin DJ, Duan D.

J Appl Physiol (1985). 2013 Nov 1;115(9):1388-92. doi: 10.1152/japplphysiol.00602.2013. Epub 2013 Aug 29.


Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy.

Zhang Y, Yue Y, Li L, Hakim CH, Zhang K, Thomas GD, Duan D.

Hum Mol Genet. 2013 Sep 15;22(18):3720-9. doi: 10.1093/hmg/ddt224. Epub 2013 May 15.


Quantitative phenotyping of Duchenne muscular dystrophy dogs by comprehensive gait analysis and overnight activity monitoring.

Shin JH, Greer B, Hakim CH, Zhou Z, Chung YC, Duan Y, He Z, Duan D.

PLoS One. 2013;8(3):e59875. doi: 10.1371/journal.pone.0059875. Epub 2013 Mar 27.


Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy.

Shin JH, Pan X, Hakim CH, Yang HT, Yue Y, Zhang K, Terjung RL, Duan D.

Mol Ther. 2013 Apr;21(4):750-7. doi: 10.1038/mt.2012.283. Epub 2013 Jan 15.


Truncated dystrophins reduce muscle stiffness in the extensor digitorum longus muscle of mdx mice.

Hakim CH, Duan D.

J Appl Physiol (1985). 2013 Feb 15;114(4):482-9. doi: 10.1152/japplphysiol.00866.2012. Epub 2012 Dec 6.


Dystrophin deficiency compromises force production of the extensor carpi ulnaris muscle in the canine model of Duchenne muscular dystrophy.

Yang HT, Shin JH, Hakim CH, Pan X, Terjung RL, Duan D.

PLoS One. 2012;7(9):e44438. doi: 10.1371/journal.pone.0044438. Epub 2012 Sep 4.


Gender differences in contractile and passive properties of mdx extensor digitorum longus muscle.

Hakim CH, Duan D.

Muscle Nerve. 2012 Feb;45(2):250-6. doi: 10.1002/mus.22275.


Temperature effects on morphological integrity and Ca²⁺ signaling in freshly isolated murine feed artery endothelial cell tubes.

Socha MJ, Hakim CH, Jackson WF, Segal SS.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H773-83. doi: 10.1152/ajpheart.00214.2011. Epub 2011 Jun 24.


The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice.

Hakim CH, Grange RW, Duan D.

J Appl Physiol (1985). 2011 Jun;110(6):1656-63. doi: 10.1152/japplphysiol.01425.2010. Epub 2011 Mar 17.


Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction.

Shin JH, Hakim CH, Zhang K, Duan D.

Muscle Nerve. 2011 Feb;43(2):283-6. doi: 10.1002/mus.21873. Epub 2010 Dec 9.


Monitoring murine skeletal muscle function for muscle gene therapy.

Hakim CH, Li D, Duan D.

Methods Mol Biol. 2011;709:75-89. doi: 10.1007/978-1-61737-982-6_5.


Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null mice.

Li D, Yue Y, Lai Y, Hakim CH, Duan D.

J Pathol. 2011 Jan;223(1):88-98. doi: 10.1002/path.2799. Epub 2010 Oct 28.


Connexin isoform expression in smooth muscle cells and endothelial cells of hamster cheek pouch arterioles and retractor feed arteries.

Hakim CH, Jackson WF, Segal SS.

Microcirculation. 2008 Aug;15(6):503-14. doi: 10.1080/10739680801982808. Erratum in: Microcirculation. 2008 Oct;15(7):689.

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