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PBP2a in β-Lactam-Resistant Laboratory Mutants and Clinical Isolates: Disruption Versus Reduced Penicillin Affinity.

van der Linden M, Rutschmann J, Maurer P, Hakenbeck R.

Microb Drug Resist. 2018 Jul/Aug;24(6):718-731. doi: 10.1089/mdr.2017.0302. Epub 2017 Dec 1.


Diversity of Mosaic pbp2x Families in Penicillin-Resistant Streptococcus pneumoniae from Iran and Romania.

Mousavi SF, Pana M, Feizabadi M, Jalali P, Ghita M, Denapaite D, Hakenbeck R.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01535-17. doi: 10.1128/AAC.01535-17. Print 2017 Dec.


Long Persistence of a Streptococcus pneumoniae 23F Clone in a Cystic Fibrosis Patient.

Rieger M, Mauch H, Hakenbeck R.

mSphere. 2017 Jun 7;2(3). pii: e00201-17. doi: 10.1128/mSphere.00201-17. eCollection 2017 May-Jun.


New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary.

Schweizer I, Blättner S, Maurer P, Peters K, Vollmer D, Vollmer W, Hakenbeck R, Denapaite D.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00414-17. doi: 10.1128/AAC.00414-17. Print 2017 Jul.


Insight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci.

van der Linden M, Otten J, Bergmann C, Latorre C, Liñares J, Hakenbeck R.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02646-16. doi: 10.1128/AAC.02646-16. Print 2017 May.


Promoter Identification and Transcription Analysis of Penicillin-Binding Protein Genes in Streptococcus pneumoniae R6.

Peters K, Pipo J, Schweizer I, Hakenbeck R, Denapaite D.

Microb Drug Resist. 2016 Sep;22(6):487-98. doi: 10.1089/mdr.2016.0084. Epub 2016 Jul 13.


Highly Variable Streptococcus oralis Strains Are Common among Viridans Streptococci Isolated from Primates.

Denapaite D, Rieger M, Köndgen S, Brückner R, Ochigava I, Kappeler P, Mätz-Rensing K, Leendertz F, Hakenbeck R.

mSphere. 2016 Mar 9;1(2). pii: e00041-15. doi: 10.1128/mSphere.00041-15. eCollection 2016 Mar-Apr.


Corrigendum: Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae.

Gisch N, Schwudke D, Thomsen S, Heß N, Hakenbeck R, Denapaite D.

Sci Rep. 2016 Apr 22;6:24424. doi: 10.1038/srep24424. No abstract available.


Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant.

Todorova K, Maurer P, Rieger M, Becker T, Bui NK, Gray J, Vollmer W, Hakenbeck R.

Mol Microbiol. 2015 Sep;97(5):866-80. doi: 10.1111/mmi.13070. Epub 2015 Jun 19.


Joachim-Volker Höltje (1941-2014).

Hakenbeck R, de Pedro M, Romeis T, Vollmer W.

Mol Microbiol. 2015 Feb;95(4):573-5. doi: 10.1111/mmi.12881. No abstract available.


Discovery of β-lactam-resistant variants in diverse pneumococcal populations.

Hakenbeck R.

Genome Med. 2014 Sep 25;6(9):72. doi: 10.1186/s13073-014-0072-8. eCollection 2014.


Mechanism of β-lactam action in Streptococcus pneumoniae: the piperacillin paradox.

Philippe J, Gallet B, Morlot C, Denapaite D, Hakenbeck R, Chen Y, Vernet T, Zapun A.

Antimicrob Agents Chemother. 2015 Jan;59(1):609-21. doi: 10.1128/AAC.04283-14. Epub 2014 Nov 10.


Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.

Schweizer I, Peters K, Stahlmann C, Hakenbeck R, Denapaite D.

Microb Drug Resist. 2014 Jun;20(3):250-7. doi: 10.1089/mdr.2014.0082. Epub 2014 May 19.


A low-affinity penicillin-binding protein 2x variant is required for heteroresistance in Streptococcus pneumoniae.

Engel H, Mika M, Denapaite D, Hakenbeck R, Mühlemann K, Heller M, Hathaway LJ, Hilty M.

Antimicrob Agents Chemother. 2014 Jul;58(7):3934-41. doi: 10.1128/AAC.02547-14. Epub 2014 Apr 28.


Streptococcus pneumoniae PBP2x mid-cell localization requires the C-terminal PASTA domains and is essential for cell shape maintenance.

Peters K, Schweizer I, Beilharz K, Stahlmann C, Veening JW, Hakenbeck R, Denapaite D.

Mol Microbiol. 2014 May;92(4):733-55. doi: 10.1111/mmi.12588. Epub 2014 Apr 17.


Altered lipid composition in Streptococcus pneumoniae cpoA mutants.

Meiers M, Volz C, Eisel J, Maurer P, Henrich B, Hakenbeck R.

BMC Microbiol. 2014 Jan 20;14:12. doi: 10.1186/1471-2180-14-12.


Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974.

Wyres KL, van Tonder A, Lambertsen LM, Hakenbeck R, Parkhill J, Bentley SD, Brueggemann AB.

BMC Genomics. 2013 Jul 24;14:500. doi: 10.1186/1471-2164-14-500.


The capsule of Streptococcus pneumoniae contributes to virulence in the insect model Manduca sexta.

Roth A, Reichmann P, Hakenbeck R.

J Mol Microbiol Biotechnol. 2012;22(5):326-34. doi: 10.1159/000345327. Epub 2012 Dec 5.


Pneumococcal capsular switching: a historical perspective.

Wyres KL, Lambertsen LM, Croucher NJ, McGee L, von Gottberg A, Liñares J, Jacobs MR, Kristinsson KG, Beall BW, Klugman KP, Parkhill J, Hakenbeck R, Bentley SD, Brueggemann AB.

J Infect Dis. 2013 Feb 1;207(3):439-49. doi: 10.1093/infdis/jis703. Epub 2012 Nov 21. Erratum in: J Infect Dis. 2013 Oct 1;208(7):1187.


The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success.

Wyres KL, Lambertsen LM, Croucher NJ, McGee L, von Gottberg A, Liñares J, Jacobs MR, Kristinsson KG, Beall BW, Klugman KP, Parkhill J, Hakenbeck R, Bentley SD, Brueggemann AB.

Genome Biol. 2012 Nov 16;13(11):R103. doi: 10.1186/gb-2012-13-11-r103.


Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events.

Sauerbier J, Maurer P, Rieger M, Hakenbeck R.

Mol Microbiol. 2012 Nov;86(3):692-706. doi: 10.1111/mmi.12009. Epub 2012 Sep 12.


Mutations in Streptococcus pneumoniae penicillin-binding protein 2x: importance of the C-terminal penicillin-binding protein and serine/threonine kinase-associated domains for beta-lactam binding.

Maurer P, Todorova K, Sauerbier J, Hakenbeck R.

Microb Drug Resist. 2012 Jun;18(3):314-21. doi: 10.1089/mdr.2012.0022. Epub 2012 Mar 28.


Biosynthesis of teichoic acids in Streptococcus pneumoniae and closely related species: lessons from genomes.

Denapaite D, Brückner R, Hakenbeck R, Vollmer W.

Microb Drug Resist. 2012 Jun;18(3):344-58. doi: 10.1089/mdr.2012.0026. Epub 2012 Mar 20.


Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae.

Hakenbeck R, Brückner R, Denapaite D, Maurer P.

Future Microbiol. 2012 Mar;7(3):395-410. doi: 10.2217/fmb.12.2. Review.


Cell surface proteins in S. pneumoniae, S. mitis and S. oralis.

Madhour A, Maurer P, Hakenbeck R.

Iran J Microbiol. 2011 Jun;3(2):58-67.


A new variant of the capsule 3 cluster occurs in Streptococcus pneumoniae from deceased wild chimpanzees.

Denapaite D, Hakenbeck R.

PLoS One. 2011;6(9):e25119. doi: 10.1371/journal.pone.0025119. Epub 2011 Sep 28.


Effect of new alleles of the histidine kinase gene ciaH on the activity of the response regulator CiaR in Streptococcus pneumoniae R6.

Müller M, Marx P, Hakenbeck R, Brückner R.

Microbiology. 2011 Nov;157(Pt 11):3104-12. doi: 10.1099/mic.0.053157-0. Epub 2011 Sep 8.


Genome of Streptococcus oralis strain Uo5.

Reichmann P, Nuhn M, Denapaite D, Brückner R, Henrich B, Maurer P, Rieger M, Klages S, Reinhard R, Hakenbeck R.

J Bacteriol. 2011 Jun;193(11):2888-9. doi: 10.1128/JB.00321-11. Epub 2011 Apr 1.


Activity of the two-component regulatory system CiaRH in Streptococcus pneumoniae R6.

Halfmann A, Schnorpfeil A, Müller M, Marx P, Günzler U, Hakenbeck R, Brückner R.

J Mol Microbiol Biotechnol. 2011 Apr;20(2):96-104. doi: 10.1159/000324893. Epub 2011 Mar 22.


Identification of genes for small non-coding RNAs that belong to the regulon of the two-component regulatory system CiaRH in Streptococcus.

Marx P, Nuhn M, Kovács M, Hakenbeck R, Brückner R.

BMC Genomics. 2010 Nov 24;11:661. doi: 10.1186/1471-2164-11-661.


Williopsis saturnus yeast killer toxin does not kill Streptococcus pneumoniae.

Ochigava I, Collier PJ, Walker GM, Hakenbeck R.

Antonie Van Leeuwenhoek. 2011 Mar;99(3):559-66. doi: 10.1007/s10482-010-9524-3. Epub 2010 Oct 22.


The genome of Streptococcus mitis B6--what is a commensal?

Denapaite D, Brückner R, Nuhn M, Reichmann P, Henrich B, Maurer P, Schähle Y, Selbmann P, Zimmermann W, Wambutt R, Hakenbeck R.

PLoS One. 2010 Feb 25;5(2):e9426. doi: 10.1371/journal.pone.0009426.


The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics.

Eldholm V, Gutt B, Johnsborg O, Brückner R, Maurer P, Hakenbeck R, Mascher T, Håvarstein LS.

J Bacteriol. 2010 Apr;192(7):1761-73. doi: 10.1128/JB.01489-09. Epub 2010 Jan 29.


Versatility of choline metabolism and choline-binding proteins in Streptococcus pneumoniae and commensal streptococci.

Hakenbeck R, Madhour A, Denapaite D, Brückner R.

FEMS Microbiol Rev. 2009 May;33(3):572-86. Review.


An ABC transporter of Streptococcus pneumoniae involved in susceptibility to vancoresmycin and bacitracin.

Becker P, Hakenbeck R, Henrich B.

Antimicrob Agents Chemother. 2009 May;53(5):2034-41. doi: 10.1128/AAC.01485-08. Epub 2009 Mar 9.


An important site in PBP2x of penicillin-resistant clinical isolates of Streptococcus pneumoniae: mutational analysis of Thr338.

Zerfass I, Hakenbeck R, Denapaite D.

Antimicrob Agents Chemother. 2009 Mar;53(3):1107-15. doi: 10.1128/AAC.01107-08. Epub 2008 Dec 15.


Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence.

Kharat AS, Denapaite D, Gehre F, Brückner R, Vollmer W, Hakenbeck R, Tomasz A.

J Bacteriol. 2008 Sep;190(17):5907-14. doi: 10.1128/JB.00628-08. Epub 2008 Jul 11.


Penicillin-binding protein 2x of Streptococcus pneumoniae: three new mutational pathways for remodelling an essential enzyme into a resistance determinant.

Maurer P, Koch B, Zerfass I, Krauss J, van der Linden M, Frère JM, Contreras-Martel C, Hakenbeck R.

J Mol Biol. 2008 Mar 7;376(5):1403-16. doi: 10.1016/j.jmb.2007.12.058. Epub 2008 Jan 4.


Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20.

Izdebski R, Rutschmann J, Fiett J, Sadowy E, Gniadkowski M, Hryniewicz W, Hakenbeck R.

Antimicrob Agents Chemother. 2008 Mar;52(3):1021-7. Epub 2007 Dec 26.


Diversity of bacteriocins and activity spectrum in Streptococcus pneumoniae.

Lux T, Nuhn M, Hakenbeck R, Reichmann P.

J Bacteriol. 2007 Nov;189(21):7741-51. Epub 2007 Aug 17.


New Streptococcus pneumoniae clones in deceased wild chimpanzees.

Chi F, Leider M, Leendertz F, Bergmann C, Boesch C, Schenk S, Pauli G, Ellerbrok H, Hakenbeck R.

J Bacteriol. 2007 Aug;189(16):6085-8. Epub 2007 Jun 22.


Crossing the barrier: evolution and spread of a major class of mosaic pbp2x in Streptococcus pneumoniae, S. mitis and S. oralis.

Chi F, Nolte O, Bergmann C, Ip M, Hakenbeck R.

Int J Med Microbiol. 2007 Nov;297(7-8):503-12. Epub 2007 Apr 24.


A new integrative reporter plasmid for Streptococcus pneumoniae.

Halfmann A, Hakenbeck R, Brückner R.

FEMS Microbiol Lett. 2007 Mar;268(2):217-24.


The two-component regulatory system TCS08 is involved in cellobiose metabolism of Streptococcus pneumoniae R6.

McKessar SJ, Hakenbeck R.

J Bacteriol. 2007 Feb;189(4):1342-50. Epub 2006 Oct 6.


Mosaic genes and mosaic chromosomes-genomic variation in Streptococcus pneumoniae.

Brückner R, Nuhn M, Reichmann P, Weber B, Hakenbeck R.

Int J Med Microbiol. 2004 Sep;294(2-3):157-68. Review.


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