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Items: 42

1.

Emergence of methicillin-resistant Staphylococcus aureus (MRSA) ST8 in raw milk and traditional dairy products in the Tizi Ouzou area of Algeria.

Titouche Y, Hakem A, Houali K, Meheut T, Vingadassalon N, Ruiz-Ripa L, Salmi D, Chergui A, Chenouf N, Hennekinne JA, Torres C, Auvray F.

J Dairy Sci. 2019 May 30. pii: S0022-0302(19)30466-7. doi: 10.3168/jds.2018-16208. [Epub ahead of print]

2.

Zoonotic Cryptosporidium species and subtypes in lambs and goat kids in Algeria.

Baroudi D, Hakem A, Adamu H, Amer S, Khelef D, Adjou K, Dahmani H, Chen X, Roellig D, Feng Y, Xiao L.

Parasit Vectors. 2018 Nov 6;11(1):582. doi: 10.1186/s13071-018-3172-2.

3.

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.

Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R.

J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2.

4.

First molecular investigation of Cryptosporidium spp. in young calves in Algeria.

Benhouda D, Hakem A, Sannella AR, Benhouda A, Cacciò SM.

Parasite. 2017;24:15. doi: 10.1051/parasite/2017014. Epub 2017 May 12.

5.

Molecular characterization of zoonotic pathogens Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in calves in Algeria.

Baroudi D, Khelef D, Hakem A, Abdelaziz A, Chen X, Lysen C, Roellig D, Xiao L.

Vet Parasitol Reg Stud Reports. 2017 May;8:66-69. doi: 10.1016/j.vprsr.2017.02.005. Epub 2017 Feb 12.

PMID:
31014640
6.

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.

Guturi KKN, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R.

Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638.

7.

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.

Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R.

Oncogene. 2016 Sep 15;35(37):4836-45. doi: 10.1038/onc.2016.16. Epub 2016 Feb 15.

PMID:
26876210
8.

INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.

Dzneladze I, He R, Woolley JF, Son MH, Sharobim MH, Greenberg SA, Gabra M, Langlois C, Rashid A, Hakem A, Ibrahimova N, Arruda A, Löwenberg B, Valk PJ, Minden MD, Salmena L.

Leukemia. 2015 Jul;29(7):1485-95. doi: 10.1038/leu.2015.51. Epub 2015 Mar 4.

PMID:
25736236
9.

Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.

El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A.

Oncogene. 2015 Apr 2;34(14):1780-9. doi: 10.1038/onc.2014.121. Epub 2014 May 26.

PMID:
24858046
10.

Evaluation of serum mesothelin in malignant and benign ovarian masses.

Ibrahim M, Bahaa A, Ibrahim A, El Hakem AA, Abo-El Noor A, El Tohamy U.

Arch Gynecol Obstet. 2014 Jul;290(1):107-13. doi: 10.1007/s00404-014-3147-2. Epub 2014 Jan 21.

PMID:
24445964
11.

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.

12.

Pirh2: an E3 ligase with central roles in the regulation of cell cycle, DNA damage response, and differentiation.

Halaby MJ, Hakem R, Hakem A.

Cell Cycle. 2013 Sep 1;12(17):2733-7. doi: 10.4161/cc.25785. Epub 2013 Aug 5. Review.

13.

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.

Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R.

Cell Death Differ. 2013 Jun;20(6):812-22. doi: 10.1038/cdd.2013.7. Epub 2013 Mar 1.

14.

Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.

Halaby MJ, Hakem A, Li L, El Ghamrasni S, Venkatesan S, Hande PM, Sanchez O, Hakem R.

PLoS Genet. 2013;9(1):e1003259. doi: 10.1371/journal.pgen.1003259. Epub 2013 Jan 31.

15.

Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.

Hakem A, El Ghamrasni S, Maire G, Lemmers B, Karaskova J, Jurisicova A, Sanchez O, Squire J, Hakem R.

Blood. 2012 Apr 12;119(15):3495-502. doi: 10.1182/blood-2011-07-367532. Epub 2012 Feb 16.

16.

Role of Pirh2 in mediating the regulation of p53 and c-Myc.

Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, Perez-Ordonez B, Mes-Masson AM, Penn L, Squire J, Chen X, Jurisica I, Arrowsmith C, Sanchez O, Benchimol S, Hakem R.

PLoS Genet. 2011 Nov;7(11):e1002360. doi: 10.1371/journal.pgen.1002360. Epub 2011 Nov 17.

17.

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.

Bohgaki T, Mozo J, Salmena L, Matysiak-Zablocki E, Bohgaki M, Sanchez O, Strasser A, Hakem A, Hakem R.

J Cell Biol. 2011 Oct 17;195(2):277-91. doi: 10.1083/jcb.201103053.

18.

Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis.

Jung YS, Hakem A, Hakem R, Chen X.

Mol Cell Biol. 2011 Oct;31(19):3997-4006. doi: 10.1128/MCB.05808-11. Epub 2011 Jul 26.

19.

Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.

El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.

PLoS Genet. 2011 May;7(5):e1001385. doi: 10.1371/journal.pgen.1001385. Epub 2011 May 19.

20.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.

PLoS Genet. 2011 Apr;7(4):e1001381. doi: 10.1371/journal.pgen.1001381. Epub 2011 Apr 28.

21.

Dysregulation of the mevalonate pathway promotes transformation.

Clendening JW, Pandyra A, Boutros PC, El Ghamrasni S, Khosravi F, Trentin GA, Martirosyan A, Hakem A, Hakem R, Jurisica I, Penn LZ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15051-6. doi: 10.1073/pnas.0910258107. Epub 2010 Aug 9.

22.

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.

Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.

J Exp Med. 2010 May 10;207(5):983-97. doi: 10.1084/jem.20092437. Epub 2010 Apr 12.

23.

Essential role for Bclaf1 in lung development and immune system function.

McPherson JP, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak-Zablocki E, Hakem A, Azami SA, Cardoso R, Fish J, Sanchez O, Post M, Hakem R.

Cell Death Differ. 2009 Feb;16(2):331-9. doi: 10.1038/cdd.2008.167. Epub 2008 Nov 14.

24.

Functional interplay of p53 and Mus81 in DNA damage responses and cancer.

Pamidi A, Cardoso R, Hakem A, Matysiak-Zablocki E, Poonepalli A, Tamblyn L, Perez-Ordonez B, Hande MP, Sanchez O, Hakem R.

Cancer Res. 2007 Sep 15;67(18):8527-35.

25.

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.

Lemmers B, Salmena L, Bidère N, Su H, Matysiak-Zablocki E, Murakami K, Ohashi PS, Jurisicova A, Lenardo M, Hakem R, Hakem A.

J Biol Chem. 2007 Mar 9;282(10):7416-23. Epub 2007 Jan 9.

26.

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.

Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW.

Genes Dev. 2005 Sep 1;19(17):1974-9. Epub 2005 Aug 17.

27.

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.

McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R.

EMBO J. 2004 Sep 15;23(18):3677-88. Epub 2004 Sep 2.

28.

Collaboration of Brca1 and Chk2 in tumorigenesis.

McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R.

Genes Dev. 2004 May 15;18(10):1144-53. Epub 2004 May 6.

29.

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

Woo M, Hakem R, Furlonger C, Hakem A, Duncan GS, Sasaki T, Bouchard D, Lu L, Wu GE, Paige CJ, Mak TW.

Nat Immunol. 2003 Oct;4(10):1016-22. Epub 2003 Sep 14.

PMID:
12970760
30.

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, Hakem R.

Genes Dev. 2003 Apr 1;17(7):883-95. Epub 2003 Mar 21.

31.

Brca1 required for T cell lineage development but not TCR loci rearrangement.

Mak TW, Hakem A, McPherson JP, Shehabeldin A, Zablocki E, Migon E, Duncan GS, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J, Hakem R.

Nat Immunol. 2000 Jul;1(1):77-82.

PMID:
10881179
32.

In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.

Woo M, Hakem A, Elia AJ, Hakem R, Duncan GS, Patterson BJ, Mak TW.

J Immunol. 1999 Nov 1;163(9):4909-16.

33.

The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.

Hakem A, Sasaki T, Kozieradzki I, Penninger JM.

J Exp Med. 1999 Mar 15;189(6):957-68.

34.

Apaf1 is required for mitochondrial pathways of apoptosis and brain development.

Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW.

Cell. 1998 Sep 18;94(6):739-50.

35.

Differential requirement for caspase 9 in apoptotic pathways in vivo.

Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, Mak TW.

Cell. 1998 Aug 7;94(3):339-52.

36.

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW.

Genes Dev. 1998 Mar 15;12(6):806-19.

37.

The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.

Penninger JM, Sirard C, Mittrücker HW, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, Mak TW.

Immunity. 1997 Aug;7(2):243-54.

38.

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW.

Cell. 1996 Jun 28;85(7):1009-23.

39.

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.

Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger JM, Mak TW.

Cell. 1996 Feb 23;84(4):551-62.

40.

[The pacemaker: an element in identification].

Hannouz MM, Hakem AR, Oussadit A.

Acta Med Leg Soc (Liege). 1989;39(1):301-2. French. No abstract available.

PMID:
2520709
41.

[Sexual offenses: between myth and reality].

Hakem AR, Mekherbeche D, Hannouz MM.

Acta Med Leg Soc (Liege). 1989;39(1):289-94. French. No abstract available.

PMID:
2520707
42.

[Medically assisted procreation and the Moslem law].

Mekherbeche H, Hakem AR, Hannouz NM.

Acta Med Leg Soc (Liege). 1988;38(2):71-3. French. No abstract available.

PMID:
2979489

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