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Items: 45


The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae.

Roche-Hakansson H, Vansarla G, Marks LR, Hakansson AP.

J Biol Chem. 2019 Nov 6. pii: jbc.RA119.009930. doi: 10.1074/jbc.RA119.009930. [Epub ahead of print]


HAMLET, a protein complex from human milk has bactericidal activity and enhances the activity of antibiotics against pathogenic Streptococci.

Alamiri F, Riesbeck K, Hakansson AP.

Antimicrob Agents Chemother. 2019 Oct 7. pii: AAC.01193-19. doi: 10.1128/AAC.01193-19. [Epub ahead of print]


Growing and Characterizing Biofilms Formed by Streptococcus pneumoniae.

Chao Y, Bergenfelz C, Hakansson AP.

Methods Mol Biol. 2019;1968:147-171. doi: 10.1007/978-1-4939-9199-0_13.


A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis.

Meikle V, Mossberg AK, Mitra A, Hakansson AP, Niederweis M.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01846-18. doi: 10.1128/AAC.01846-18. Print 2019 Feb.


BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.

Rath EM, Cheng YY, Pinese M, Sarun KH, Hudson AL, Weir C, Wang YD, Håkansson AP, Howell VM, Liu GJ, Reid G, Knott RB, Duff AP, Church WB.

PLoS One. 2018 Aug 29;13(8):e0203003. doi: 10.1371/journal.pone.0203003. eCollection 2018.


Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection.

Hakansson AP, Orihuela CJ, Bogaert D.

Physiol Rev. 2018 Apr 1;98(2):781-811. doi: 10.1152/physrev.00040.2016. Review.


Streptococcus pneumoniae Modulates Staphylococcus aureus Biofilm Dispersion and the Transition from Colonization to Invasive Disease.

Reddinger RM, Luke-Marshall NR, Sauberan SL, Hakansson AP, Campagnari AA.

MBio. 2018 Jan 9;9(1). pii: e02089-17. doi: 10.1128/mBio.02089-17.


Streptococcus pneumoniae Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies.

Bergenfelz C, Hakansson AP.

Curr Otorhinolaryngol Rep. 2017;5(2):115-124. doi: 10.1007/s40136-017-0152-6. Epub 2017 May 20. Review.


Panel 6: Vaccines.

Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, Hakansson AP, Mason KM, Nokso-Koivisto J, Patel J, Pelton SI, Murphy TF.

Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S76-S87. doi: 10.1177/0194599816632178. Review.


Panel 4: Report of the Microbiology Panel.

Barenkamp SJ, Chonmaitree T, Hakansson AP, Heikkinen T, King S, Nokso-Koivisto J, Novotny LA, Patel JA, Pettigrew M, Swords WE.

Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S51-S62. doi: 10.1177/0194599816639028. Review.


Low NF-κB Activation and Necroptosis in Alveolar Macrophages: A New Virulence Property of Streptococcus pneumoniae.

Hakansson AP, Bergenfelz C.

J Infect Dis. 2017 Aug 15;216(4):402-404. doi: 10.1093/infdis/jix161. No abstract available.


In Vitro and In Vivo Biofilm Formation by Pathogenic Streptococci.

Chao Y, Bergenfelz C, Håkansson AP.

Methods Mol Biol. 2017;1535:285-299.


Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease.

Reddinger RM, Luke-Marshall NR, Hakansson AP, Campagnari AA.

MBio. 2016 Aug 9;7(4). pii: e01235-16. doi: 10.1128/mBio.01235-16.


In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector.

Li Y, Beitelshees M, Fang L, Hill A, Ahmadi MK, Chen M, Davidson BA, Knight P 3rd, Smith RJ Jr, Andreadis ST, Hakansson AP, Jones CH, Pfeifer BA.

Sci Adv. 2016 Jul 1;2(7):e1600264. doi: 10.1126/sciadv.1600264. eCollection 2016 Jul.


Directed vaccination against pneumococcal disease.

Li Y, Hill A, Beitelshees M, Shao S, Lovell JF, Davidson BA, Knight PR 3rd, Hakansson AP, Pfeifer BA, Jones CH.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6898-903. doi: 10.1073/pnas.1603007113. Epub 2016 Jun 6.


Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization.

Greene CJ, Marks LR, Hu JC, Reddinger R, Mandell L, Roche-Hakansson H, King-Lyons ND, Connell TD, Hakansson AP.

Infect Immun. 2016 May 24;84(6):1693-1703. doi: 10.1128/IAI.01478-15. Print 2016 Jun.


Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components.

Rath EM, Duff AP, Håkansson AP, Vacher CS, Liu GJ, Knott RB, Church WB.

J Pharm Pharm Sci. 2015;18(4):773-824. Review.


Absence of capsule reveals glycan-mediated binding and recognition of salivary mucin MUC7 by Streptococcus pneumoniae.

Thamadilok S, Roche-Håkansson H, Håkansson AP, Ruhl S.

Mol Oral Microbiol. 2016 Apr;31(2):175-88. doi: 10.1111/omi.12113. Epub 2015 Aug 17.


Halothane modulates the type i interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model.

MacDonald BA, Chakravarthy KV, Davidson BA, Mullan BA, Alluri R, Hakansson AP, Knight PR.

Anesthesiology. 2015 Sep;123(3):590-602. doi: 10.1097/ALN.0000000000000766.


Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease.

Chao Y, Marks LR, Pettigrew MM, Hakansson AP.

Front Cell Infect Microbiol. 2015 Jan 13;4:194. doi: 10.3389/fcimb.2014.00194. eCollection 2014. Review.


Protective effects of human milk antimicrobial peptides against bacterial infection.

Hakansson AP.

J Pediatr (Rio J). 2015 Jan-Feb;91(1):4-5. doi: 10.1016/j.jped.2014.10.001. Epub 2014 Oct 18. No abstract available.


Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation.

Jones CH, Chen M, Ravikrishnan A, Reddinger R, Zhang G, Hakansson AP, Pfeifer BA.

Biomaterials. 2015 Jan;37:333-44. doi: 10.1016/j.biomaterials.2014.10.037. Epub 2014 Oct 22.


Dynamic changes in the Streptococcus pneumoniae transcriptome during transition from biofilm formation to invasive disease upon influenza A virus infection.

Pettigrew MM, Marks LR, Kong Y, Gent JF, Roche-Hakansson H, Hakansson AP.

Infect Immun. 2014 Nov;82(11):4607-19. doi: 10.1128/IAI.02225-14. Epub 2014 Aug 18.


Hybrid biosynthetic gene therapy vector development and dual engineering capacity.

Jones CH, Ravikrishnan A, Chen M, Reddinger R, Kamal Ahmadi M, Rane S, Hakansson AP, Pfeifer BA.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12360-5. doi: 10.1073/pnas.1411355111. Epub 2014 Aug 11.


Monitoring changes in membrane polarity, membrane integrity, and intracellular ion concentrations in Streptococcus pneumoniae using fluorescent dyes.

Clementi EA, Marks LR, Roche-Håkansson H, Håkansson AP.

J Vis Exp. 2014 Feb 17;(84):e51008. doi: 10.3791/51008.


Pneumococcal adaptive responses to changing host environments.

Hakansson AP.

J Infect Dis. 2014 Jul 1;210(1):1-3. Epub 2014 Feb 6. No abstract available.


Streptococcus pyogenes biofilm growth in vitro and in vivo and its role in colonization, virulence, and genetic exchange.

Marks LR, Mashburn-Warren L, Federle MJ, Hakansson AP.

J Infect Dis. 2014 Jul 1;210(1):25-34. Epub 2014 Jan 23.


Small-angle X-ray scattering of BAMLET at pH 12: a complex of α-lactalbumin and oleic acid.

Rath EM, Duff AP, Håkansson AP, Knott RB, Church WB.

Proteins. 2014 Jul;82(7):1400-8. doi: 10.1002/prot.24508. Epub 2014 Jan 25.


Biomaterials at the interface of nano- and micro-scale vector-cellular interactions in genetic vaccine design.

Jones CH, Hakansson AP, Pfeifer BA.

J Mater Chem B. 2014;46:8053-8068. doi: 10.1039/C4TB01058B. Epub 2014 Sep 12.


Biofilm formation enhances fomite survival of Streptococcus pneumoniae and Streptococcus pyogenes.

Marks LR, Reddinger RM, Hakansson AP.

Infect Immun. 2014 Mar;82(3):1141-6. doi: 10.1128/IAI.01310-13. Epub 2013 Dec 26.


A complex of equine lysozyme and oleic acid with bactericidal activity against Streptococcus pneumoniae.

Clementi EA, Wilhelm KR, Schleucher J, Morozova-Roche LA, Hakansson AP.

PLoS One. 2013 Nov 18;8(11):e80649. doi: 10.1371/journal.pone.0080649. eCollection 2013.


Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease.

Marks LR, Davidson BA, Knight PR, Hakansson AP.

MBio. 2013 Jul 23;4(4). pii: e00438-13. doi: 10.1128/mBio.00438-13.


Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET.

Marks LR, Clementi EA, Hakansson AP.

PLoS One. 2013 May 1;8(5):e63158. doi: 10.1371/journal.pone.0063158. Print 2013.


High levels of genetic recombination during nasopharyngeal carriage and biofilm formation in Streptococcus pneumoniae.

Marks LR, Reddinger RM, Hakansson AP.

MBio. 2012 Sep 25;3(5). pii: e00200-12. doi: 10.1128/mBio.00200-12. Print 2012.


The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents.

Marks LR, Clementi EA, Hakansson AP.

PLoS One. 2012;7(8):e43514. doi: 10.1371/journal.pone.0043514. Epub 2012 Aug 15.


A novel initiation mechanism of death in Streptococcus pneumoniae induced by the human milk protein-lipid complex HAMLET and activated during physiological death.

Clementi EA, Marks LR, Duffey ME, Hakansson AP.

J Biol Chem. 2012 Aug 3;287(32):27168-82. doi: 10.1074/jbc.M112.371070. Epub 2012 Jun 14.


Pneumococcal interactions with epithelial cells are crucial for optimal biofilm formation and colonization in vitro and in vivo.

Marks LR, Parameswaran GI, Hakansson AP.

Infect Immun. 2012 Aug;80(8):2744-60. doi: 10.1128/IAI.00488-12. Epub 2012 May 29.


Oleic acid is a key cytotoxic component of HAMLET-like complexes.

Permyakov SE, Knyazeva EL, Khasanova LM, Fadeev RS, Zhadan AP, Roche-Hakansson H, Håkansson AP, Akatov VS, Permyakov EA.

Biol Chem. 2012 Jan;393(1-2):85-92. doi: 10.1515/BC-2011-230.


Role of dihydrolipoamide dehydrogenase in regulation of raffinose transport in Streptococcus pneumoniae.

Tyx RE, Roche-Hakansson H, Hakansson AP.

J Bacteriol. 2011 Jul;193(14):3512-24. doi: 10.1128/JB.01410-10. Epub 2011 May 20.


A novel method for preparation of HAMLET-like protein complexes.

Permyakov SE, Knyazeva EL, Leonteva MV, Fadeev RS, Chekanov AV, Zhadan AP, Håkansson AP, Akatov VS, Permyakov EA.

Biochimie. 2011 Sep;93(9):1495-501. doi: 10.1016/j.biochi.2011.05.002. Epub 2011 May 11.


Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.

Hakansson AP, Roche-Hakansson H, Mossberg AK, Svanborg C.

PLoS One. 2011 Mar 10;6(3):e17717. doi: 10.1371/journal.pone.0017717.


Streptolysin O inhibits clathrin-dependent internalization of group A Streptococcus.

Logsdon LK, Håkansson AP, Cortés G, Wessels MR.

MBio. 2011 Feb 15;2(1):e00332-10. doi: 10.1128/mBio.00332-10. Print 2011.


Enzymatic characterization of dihydrolipoamide dehydrogenase from Streptococcus pneumoniae harboring its own substrate.

Håkansson AP, Smith AW.

J Biol Chem. 2007 Oct 5;282(40):29521-30. Epub 2007 Aug 9.


Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae.

Daniels CC, Briles TC, Mirza S, Håkansson AP, Briles DE.

Microb Pathog. 2006 May;40(5):228-33. Epub 2006 Mar 15.


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