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Time to onset in statistical signal detection revisited: A follow-up study in long-term onset adverse drug reactions.

Scholl JHG, van Hunsel FPAM, Hak E, van Puijenbroek EP.

Pharmacoepidemiol Drug Saf. 2019 Jun 12. doi: 10.1002/pds.4790. [Epub ahead of print]


No significant effect of type 2 diabetes-related genetic risk scores on HbA1c levels after initiating metformin or sulfonylurea derivatives.

Martono DP, Heerspink HJL, Hak E, Denig P, Wilffert B.

Diabetes Obes Metab. 2019 Jun 5. doi: 10.1111/dom.13803. [Epub ahead of print]


Pneumococcal conjugate vaccines for preventing acute otitis media in children.

Fortanier AC, Venekamp RP, Boonacker CW, Hak E, Schilder AG, Sanders EA, Damoiseaux RA.

Cochrane Database Syst Rev. 2019 May 28;5:CD001480. doi: 10.1002/14651858.CD001480.pub5. Review.


Improving antibacterial prescribing safety in the management of COPD exacerbations: systematic review of observational and clinical studies on potential drug interactions associated with frequently prescribed antibacterials among COPD patients.

Wang Y, Bahar MA, Jansen AME, Kocks JWH, Alffenaar JC, Hak E, Wilffert B, Borgsteede SD.

J Antimicrob Chemother. 2019 May 24. pii: dkz221. doi: 10.1093/jac/dkz221. [Epub ahead of print]


The temporal order of fluctuations in atopic disease symptoms and attention-deficit/hyperactivity disorder symptoms: a time-series study in ADHD patients.

van der Schans J, Cao Q, Bos EH, Rours GIJG, Hoekstra PJ, Hak E, de Vries TW.

Eur Child Adolesc Psychiatry. 2019 Apr 24. doi: 10.1007/s00787-019-01336-2. [Epub ahead of print]


Trends in polypharmacy and dispensed drugs among adults in the Netherlands as compared to the United States.

Oktora MP, Denig P, Bos JHJ, Schuiling-Veninga CCM, Hak E.

PLoS One. 2019 Mar 22;14(3):e0214240. doi: 10.1371/journal.pone.0214240. eCollection 2019.


A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications.

Alfian SD, Pradipta IS, Hak E, Denig P.

J Clin Epidemiol. 2019 Apr;108:44-53. doi: 10.1016/j.jclinepi.2018.12.003. Epub 2018 Dec 8. Review.


Effect estimate comparison between the prescription sequence symmetry analysis (PSSA) and parallel group study designs: A systematic review.

Idema DL, Wang Y, Biehl M, Horvatovich PL, Hak E.

PLoS One. 2018 Dec 6;13(12):e0208389. doi: 10.1371/journal.pone.0208389. eCollection 2018.


Continuation rates of alpha-blockers mono-therapy in adult men, prescribed by urologists or general practitioners: a pharmacy-based study.

Hordijk IMJ, Steffens MG, Hak E, Blanker MH.

World J Urol. 2018 Nov 13. doi: 10.1007/s00345-018-2557-3. [Epub ahead of print]


Predictors for treatment outcomes among patients with drug-susceptible tuberculosis in the Netherlands: a retrospective cohort study.

Pradipta IS, Van't Boveneind-Vrubleuskaya N, Akkerman OW, Alffenaar JWC, Hak E.

Clin Microbiol Infect. 2019 Jun;25(6):761.e1-761.e7. doi: 10.1016/j.cmi.2018.10.009. Epub 2018 Oct 27.


Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis.

Pradipta IS, Forsman LD, Bruchfeld J, Hak E, Alffenaar JW.

J Infect. 2018 Dec;77(6):469-478. doi: 10.1016/j.jinf.2018.10.004. Epub 2018 Oct 16. Review.


The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine.

Bahar MA, Kamp J, Borgsteede SD, Hak E, Wilffert B.

Br J Clin Pharmacol. 2018 Dec;84(12):2704-2715. doi: 10.1111/bcp.13741. Epub 2018 Sep 24. Review.


Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials.

Wang Y, Zijp TR, Bahar MA, Kocks JWH, Wilffert B, Hak E.

J Antimicrob Chemother. 2018 Dec 1;73(12):3231-3243. doi: 10.1093/jac/dky326.


Concordance assessment of self-reported medication use in the Netherlands three-generation Lifelines Cohort study with the pharmacy database The PharmLines initiative.

Sediq R, van der Schans J, Dotinga A, Alingh RA, Wilffert B, Bos JH, Schuiling-Veninga CC, Hak E.

Clin Epidemiol. 2018 Aug 16;10:981-989. doi: 10.2147/CLEP.S163037. eCollection 2018.


Long-term incidence and risk factors of cardiovascular events in Asian populations: systematic review and meta-analysis of population-based cohort studies.

Irawati S, Wasir R, Floriaan Schmidt A, Islam A, Feenstra T, Buskens E, Wilffert B, Hak E.

Curr Med Res Opin. 2019 Feb;35(2):291-299. doi: 10.1080/03007995.2018.1491149. Epub 2018 Jul 30.


Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study.

Zakiyah N, Ter Heijne LF, Bos JH, Hak E, Postma MJ, Schuiling-Veninga CCM.

BMC Pregnancy Childbirth. 2018 May 29;18(1):187. doi: 10.1186/s12884-018-1825-y.



van der Schans J, Hak E, Hoekstra PJ, de Vries TW.

Chest. 2018 May;153(5):1280-1281. doi: 10.1016/j.chest.2018.02.009. No abstract available.


The potential economic value of influenza vaccination for healthcare workers in The Netherlands.

Meijboom MJ, Riphagen-Dalhuisen J, Hak E.

Influenza Other Respir Viruses. 2018 Jul;12(4):457-464. doi: 10.1111/irv.12558. Epub 2018 May 24.


Discontinuation and dose adjustment of metoprolol after metoprolol-paroxetine/fluoxetine co-prescription in Dutch elderly.

Bahar MA, Wang Y, Bos JHJ, Wilffert B, Hak E.

Pharmacoepidemiol Drug Saf. 2018 Jun;27(6):621-629. doi: 10.1002/pds.4422. Epub 2018 Mar 24.


Impact and cost-effectiveness of different vaccination strategies to reduce the burden of pneumococcal disease among elderly in the Netherlands.

Thorrington D, van Rossum L, Knol M, de Melker H, Rümke H, Hak E, van Hoek AJ.

PLoS One. 2018 Feb 9;13(2):e0192640. doi: 10.1371/journal.pone.0192640. eCollection 2018.


Risks versus benefits of medication use during pregnancy: what do women perceive?

Mulder B, Bijlsma MJ, Schuiling-Veninga CC, Morssink LP, van Puijenbroek E, Aarnoudse JG, Hak E, de Vries TW.

Patient Prefer Adherence. 2017 Dec 20;12:1-8. doi: 10.2147/PPA.S146091. eCollection 2018.


Pharmacy-based predictors of non-persistence with and non-adherence to statin treatment among patients on oral diabetes medication in the Netherlands.

Alfian SD, Worawutputtapong P, Schuiling-Veninga CCM, van der Schans J, Bos JHJ, Hak E, Denig P.

Curr Med Res Opin. 2018 Jun;34(6):1013-1019. doi: 10.1080/03007995.2017.1417242. Epub 2018 Jan 15.


A prediction model-based algorithm for computer-assisted database screening of adverse drug reactions in the Netherlands.

Scholl JHG, van Hunsel FPAM, Hak E, van Puijenbroek EP.

Pharmacoepidemiol Drug Saf. 2018 Feb;27(2):199-205. doi: 10.1002/pds.4364. Epub 2017 Dec 21.


[Upward trend in the use of psychostimulants by adults].

van der Koog L, van der Schans J, Tjioe MA, Bos JHJ, Bijker BJ, Hak E, Schuiling-Veninga CCM.

Ned Tijdschr Geneeskd. 2017;161:D1660. Dutch.


Association between in-hospital guideline adherence and postdischarge major adverse outcomes of patients with acute coronary syndrome in Vietnam: a prospective cohort study.

Nguyen T, Le KK, Cao HTK, Tran DTT, Ho LM, Thai TND, Pham HTK, Pham PT, Nguyen TH, Hak E, Pham TT, Taxis K.

BMJ Open. 2017 Oct 5;7(10):e017008. doi: 10.1136/bmjopen-2017-017008.


Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.

Daud ANA, Bergman JEH, Kerstjens-Frederikse WS, van der Vlies P, Hak E, Berger RMF, Groen H, Wilffert B.

Pharmacogenomics. 2017 Jul;18(10):987-1001. doi: 10.2217/pgs-2017-0036. Epub 2017 Jun 22.


Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.

van der Schans J, Aikman B, de Vries TW, Hoekstra PJ, Hak E.

Chest. 2017 Jun;151(6):1406-1407. doi: 10.1016/j.chest.2017.03.052. No abstract available.


[Effectiveness of influenza vaccine in the Netherlands: predominant circulating virus type and vaccine match are important conditions].

van Doorn E, Darvishian M, Dijkstra F, Bijlsma MJ, Donker GA, de Lange MMA, Cadenau LM, Hak E, Meijer A.

Ned Tijdschr Geneeskd. 2017;161:D1648. Dutch.


Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction: a systematic review on CYP2C9, CYP2C19 and CYP2D6.

Bahar MA, Setiawan D, Hak E, Wilffert B.

Pharmacogenomics. 2017 May;18(7):701-739. doi: 10.2217/pgs-2017-0194. Epub 2017 May 8. Review.


Influenza vaccine effectiveness estimates in the Dutch population from 2003 to 2014: The test-negative design case-control study with different control groups.

van Doorn E, Darvishian M, Dijkstra F, Donker GA, Overduin P, Meijer A, Hak E.

Vaccine. 2017 May 15;35(21):2831-2839. doi: 10.1016/j.vaccine.2017.04.012. Epub 2017 Apr 12.


Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research.

Daud ANA, Bergsma EL, Bergman JEH, De Walle HEK, Kerstjens-Frederikse WS, Bijker BJ, Hak E, Wilffert B.

BMC Pregnancy Childbirth. 2017 Apr 14;17(1):120. doi: 10.1186/s12884-017-1290-z.


Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial.

van Doorn E, Pleguezuelos O, Liu H, Fernandez A, Bannister R, Stoloff G, Oftung F, Norley S, Huckriede A, Frijlink HW, Hak E.

BMC Infect Dis. 2017 Apr 4;17(1):241. doi: 10.1186/s12879-017-2341-9.


Methylphenidate use and school performance among primary school children: a descriptive study.

van der Schans J, Çiçek R, Vardar S, Bos JH, de Vries TW, Hoekstra PJ, Hak E.

BMC Psychiatry. 2017 Mar 29;17(1):116. doi: 10.1186/s12888-017-1279-1.


The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly.

Bahar MA, Hak E, Bos JHJ, Borgsteede SD, Wilffert B.

Pharmacoepidemiol Drug Saf. 2017 Jul;26(7):752-765. doi: 10.1002/pds.4200. Epub 2017 Mar 26.


Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine: Phase IIb study protocol.

van Doorn E, Liu H, Ben-Yedidia T, Hassin S, Visontai I, Norley S, Frijlink HW, Hak E.

Medicine (Baltimore). 2017 Mar;96(11):e6339. doi: 10.1097/MD.0000000000006339.


Maternal use of drug substrates of placental transporters and the effect of transporter-mediated drug interactions on the risk of congenital anomalies.

Daud AN, Bergman JE, Oktora MP, Kerstjens-Frederikse WS, Groen H, Bos JH, Hak E, Wilffert B.

PLoS One. 2017 Mar 13;12(3):e0173530. doi: 10.1371/journal.pone.0173530. eCollection 2017.


Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies.

Darvishian M, van den Heuvel ER, Bissielo A, Castilla J, Cohen C, Englund H, Gefenaite G, Huang WT, la Bastide-van Gemert S, Martinez-Baz I, McAnerney JM, Ntshoe GM, Suzuki M, Turner N, Hak E.

Lancet Respir Med. 2017 Mar;5(3):200-211. doi: 10.1016/S2213-2600(17)30043-7. Epub 2017 Feb 9.


Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses.

Schans JV, Çiçek R, de Vries TW, Hak E, Hoekstra PJ.

Neurosci Biobehav Rev. 2017 Mar;74(Pt A):139-148. doi: 10.1016/j.neubiorev.2017.01.011. Epub 2017 Jan 20. Review.


Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children.

Tran YH, Groen H, Bergman JE, Hak E, Wilffert B.

Pharmacoepidemiol Drug Saf. 2017 Mar;26(3):265-273. doi: 10.1002/pds.4161. Epub 2017 Jan 18.


Influenza Vaccine Effectiveness in the Netherlands from 2003/2004 through 2013/2014: The Importance of Circulating Influenza Virus Types and Subtypes.

Darvishian M, Dijkstra F, van Doorn E, Bijlsma MJ, Donker GA, de Lange MM, Cadenau LM, Hak E, Meijer A.

PLoS One. 2017 Jan 9;12(1):e0169528. doi: 10.1371/journal.pone.0169528. eCollection 2017.


Is Heterogeneity in the Effects of Statins on Infection Outcomes across Clinical Studies Due to Bias?

Pouwels KB, Hak E.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):7002-7003. doi: 10.1128/AAC.01839-16. Print 2016 Nov. No abstract available.


Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project.

Liu H, Frijlink HW, Huckriede A, van Doorn E, Schmidt E, Leroy O, Rimmelzwaan G, McCullough K, Whelan M, Hak E.

Vaccine. 2016 Nov 21;34(48):5845-5854. doi: 10.1016/j.vaccine.2016.10.040. Epub 2016 Oct 25. Review.


Poor guideline adherence in the initiation of antidepressant treatment in children and adolescents in the Netherlands: choice of antidepressant and dose.

de Vries YA, de Jonge P, Kalverdijk L, Bos JH, Schuiling-Veninga CC, Hak E.

Eur Child Adolesc Psychiatry. 2016 Nov;25(11):1161-1170. Epub 2016 Mar 17.


An explorative study of school performance and antipsychotic medication.

van der Schans J, Vardar S, Çiçek R, Bos HJ, Hoekstra PJ, de Vries TW, Hak E.

BMC Psychiatry. 2016 Sep 21;16(1):332.


[Antidepressant guidelines poorly adhered to in young people].

de Vries YA, de Jonge P, Kalverdijk L, Bos HJ, Schuiling-Veninga CC, Hak E.

Ned Tijdschr Geneeskd. 2016;160:D627. Dutch.


Predictors of HbA1c levels in patients initiating metformin.

Martono DP, Hak E, Lambers Heerspink H, Wilffert B, Denig P.

Curr Med Res Opin. 2016 Dec;32(12):2021-2028. Epub 2016 Sep 20.


Association between statins and infections among patients with diabetes: a cohort and prescription sequence symmetry analysis.

Pouwels KB, Widyakusuma NN, Bos JH, Hak E.

Pharmacoepidemiol Drug Saf. 2016 Oct;25(10):1124-1130. doi: 10.1002/pds.4052. Epub 2016 Jun 30.


Association between medication prescription for atopic diseases and attention-deficit/hyperactivity disorder.

van der Schans J, Pleiter JC, de Vries TW, Schuiling-Veninga CC, Bos JH, Hoekstra PJ, Hak E.

Ann Allergy Asthma Immunol. 2016 Aug;117(2):186-91. doi: 10.1016/j.anai.2016.05.025. Epub 2016 Jun 14.


Antibiotic use during pregnancy and asthma in preschool children: the influence of confounding.

Mulder B, Pouwels KB, Schuiling-Veninga CC, Bos HJ, de Vries TW, Jick SS, Hak E.

Clin Exp Allergy. 2016 Sep;46(9):1214-26. doi: 10.1111/cea.12756. Epub 2016 Jun 13.


Meta-Analysis on Randomized Controlled Trials of Vaccines with QS-21 or ISCOMATRIX Adjuvant: Safety and Tolerability.

Bigaeva E, Doorn Ev, Liu H, Hak E.

PLoS One. 2016 May 5;11(5):e0154757. doi: 10.1371/journal.pone.0154757. eCollection 2016.

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