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Items: 1 to 50 of 426

1.

A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism.

Jones C, Bisserier M, Bueno-Beti C, Bonnet G, Neves-Zaph S, Lee SY, Milara J, Dorfmüller P, Humbert M, Leopold JA, Hadri L, Hajjar RJ, Sassi Y.

Cardiovasc Res. 2019 Sep 14. pii: cvz244. doi: 10.1093/cvr/cvz244. [Epub ahead of print]

PMID:
31529026
2.

Sarco/Endoplasmic Reticulum Ca2+-ATPase is a more effective calcium remover than Sodium-Calcium Exchanger in human embryonic stem cell-derived cardiomyocytes.

Li S, Chopra A, Keung W, Chan C, Costa KD, Kong CW, Hajjar RJ, Chen C, Li R.

Am J Physiol Heart Circ Physiol. 2019 Jul 26. doi: 10.1152/ajpheart.00540.2018. [Epub ahead of print]

PMID:
31347915
3.

Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.

Zaleta-Rivera K, Dainis A, Ribeiro AJS, Cordero P, Rubio G, Shang C, Liu J, Finsterbach T, Parikh VN, Sutton S, Seo K, Sinha N, Jain N, Huang Y, Hajjar RJ, Kay MA, Szczesna-Cordary D, Pruitt BL, Wheeler MT, Ashley EA.

Circulation. 2019 Aug 27;140(9):765-778. doi: 10.1161/CIRCULATIONAHA.118.036965. Epub 2019 Jul 18.

PMID:
31315475
4.

Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA.

Sci Rep. 2019 May 16;9(1):7502. doi: 10.1038/s41598-019-42953-w.

5.

Animal model of left atrial thrombus in congestive heart failure in rats.

Chen J, Strauss B, Liang L, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H63-H72. doi: 10.1152/ajpheart.00086.2019. Epub 2019 May 10.

PMID:
31074653
6.

CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy.

LaRocca TJ, Altman P, Jarrah AA, Gordon R, Wang E, Hadri L, Burke MW, Haddad GE, Hajjar RJ, Tarzami ST.

Int J Mol Sci. 2019 May 8;20(9). pii: E2267. doi: 10.3390/ijms20092267.

7.

Child Health Promotion in Underserved Communities: The FAMILIA Trial.

Fernandez-Jimenez R, Jaslow R, Bansilal S, Santana M, Diaz-Munoz R, Latina J, Soto AV, Vedanthan R, Al-Kazaz M, Giannarelli C, Kovacic JC, Bagiella E, Kasarskis A, Fayad ZA, Hajjar RJ, Fuster V.

J Am Coll Cardiol. 2019 Apr 30;73(16):2011-2021. doi: 10.1016/j.jacc.2019.01.057.

8.

MicroRNA-25 upregulation protects spinal cords, yet is bad for the heart: The dark side of noncoding RNAS.

Katz MG, Fargnoli AS, Hajjar RJ, Jeong D.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):e87-e88. doi: 10.1016/j.jtcvs.2019.03.054. Epub 2019 Apr 16. No abstract available.

PMID:
31003740
9.

Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics.

Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Ishikawa K, Watanabe S, Picatoste B, Flores E, Garcia-Ropero A, Sanz J, Hajjar RJ, Fuster V, Badimon JJ.

J Am Coll Cardiol. 2019 Apr 23;73(15):1931-1944. doi: 10.1016/j.jacc.2019.01.056.

PMID:
30999996
10.

Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.

Asensio-Lopez MC, Lax A, Fernandez Del Palacio MJ, Sassi Y, Hajjar RJ, Januzzi JL, Bayes-Genis A, Pascual-Figal DA.

J Mol Cell Cardiol. 2019 May;130:216-233. doi: 10.1016/j.yjmcc.2019.04.009. Epub 2019 Apr 15.

PMID:
30998979
11.

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats.

Katz MG, Fargnoli AS, Gubara SM, Bisserier M, Sassi Y, Bridges CR, Hajjar RJ, Hadri L.

J Vis Exp. 2019 Mar 8;(145). doi: 10.3791/59050.

PMID:
30907889
12.

Surgical and physiological challenges in the development of left and right heart failure in rat models.

Katz MG, Fargnoli AS, Gubara SM, Chepurko E, Bridges CR, Hajjar RJ.

Heart Fail Rev. 2019 Sep;24(5):759-777. doi: 10.1007/s10741-019-09783-4. Review.

PMID:
30903356
13.

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.

Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, Park WJ, Kho C.

Circ Res. 2019 Apr 26;124(9):e63-e80. doi: 10.1161/CIRCRESAHA.118.313865. Erratum in: Circ Res. 2019 Jun 7;124(12):e149.

PMID:
30786847
14.

Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer.

Katz MG, Fargnoli AS, Gubara SM, Fish K, Weber T, Bridges CR, Hajjar RJ, Ishikawa K.

J Cardiovasc Dev Dis. 2019 Feb 15;6(1). pii: E8. doi: 10.3390/jcdd6010008. Review.

15.

Role of the PRC2-Six1-miR-25 signaling axis in heart failure.

Oh JG, Jang SP, Yoo J, Lee MA, Lee SH, Lim T, Jeong E, Kho C, Kook H, Hajjar RJ, Park WJ, Jeong D.

J Mol Cell Cardiol. 2019 Apr;129:58-68. doi: 10.1016/j.yjmcc.2019.01.017. Epub 2019 Feb 13.

16.

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction.

Chaanine AH, Joyce LD, Stulak JM, Maltais S, Joyce DL, Dearani JA, Klaus K, Nair KS, Hajjar RJ, Redfield MM.

Circ Heart Fail. 2019 Feb;12(2):e005131. doi: 10.1161/CIRCHEARTFAILURE.118.005131.

PMID:
30744415
17.

Lentiviral-Mediated Interleukin-10 Gene Therapy for Lung Transplantation.

Katz MG, Fargnoli AS, Bridges CR, Hajjar RJ.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):817-818. doi: 10.1016/j.jtcvs.2018.07.052. No abstract available.

PMID:
30669242
18.

Experimental models of cardiac physiology and pathology.

Oh JG, Kho C, Hajjar RJ, Ishikawa K.

Heart Fail Rev. 2019 Jul;24(4):601-615. doi: 10.1007/s10741-019-09769-2. Review.

PMID:
30666533
19.

Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.

Mougenot N, Mika D, Czibik G, Marcos E, Abid S, Houssaini A, Vallin B, Guellich A, Mehel H, Sawaki D, Vandecasteele G, Fischmeister R, Hajjar RJ, Dubois-Randé JL, Limon I, Adnot S, Derumeaux G, Lipskaia L.

Cardiovasc Res. 2019 Jan 3. doi: 10.1093/cvr/cvy306. [Epub ahead of print]

PMID:
30605506
20.

PLN Foundation.

Kranias EG, Doevendans PA, Glijnis PC, Hajjar RJ.

Circ Res. 2018 Dec 7;123(12):1276-1278. doi: 10.1161/CIRCRESAHA.118.314014. No abstract available.

PMID:
30566043
21.

Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.

Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG.

J Mol Cell Cardiol. 2019 Feb;127:20-30. doi: 10.1016/j.yjmcc.2018.11.017. Epub 2018 Nov 28.

PMID:
30502350
22.

Enhancing atrial-specific gene expression using a calsequestrin cis-regulatory module 4 with a sarcolipin promoter.

Yoo J, Kohlbrenner E, Kim O, Hajjar RJ, Jeong D.

J Gene Med. 2018 Dec;20(12):e3060. doi: 10.1002/jgm.3060. Epub 2018 Dec 4.

23.

Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction.

Motloch LJ, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG.

J Am Heart Assoc. 2018 Sep 18;7(18):e009598. doi: 10.1161/JAHA.118.009598.

24.

Of Mice and Men.

Fish KM, Mleczko J, Hajjar RJ.

Circ Res. 2018 Oct 26;123(10):1109-1111. doi: 10.1161/CIRCRESAHA.118.313990. No abstract available.

PMID:
30359187
25.

miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy.

Oh JG, Watanabe S, Lee A, Gorski PA, Lee P, Jeong D, Liang L, Liang Y, Baccarini A, Sahoo S, Brown BD, Hajjar RJ, Kho C.

Circ Res. 2018 Aug 31;123(6):673-685. doi: 10.1161/CIRCRESAHA.118.312751.

26.

Human Cardiac Gene Therapy.

Ishikawa K, Weber T, Hajjar RJ.

Circ Res. 2018 Aug 17;123(5):601-613. doi: 10.1161/CIRCRESAHA.118.311587.

27.

A role for calcium in resistin transcriptional activation in diabetic hearts.

Singh R, Moreno P, Hajjar RJ, Lebeche D.

Sci Rep. 2018 Oct 23;8(1):15633. doi: 10.1038/s41598-018-34112-4.

28.

Technique of Complete Heart Isolation with Continuous Cardiac Perfusion During Cardiopulmonary Bypass: New Opportunities for Gene Therapy.

Katz MG, Fargnoli AS, Yarnall C, Perez A, Isidro A, Hajjar RJ, Bridges CR.

J Extra Corpor Technol. 2018 Sep;50(3):193-198.

29.

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells.

Stroik DR, Yuen SL, Janicek KA, Schaaf TM, Li J, Ceholski DK, Hajjar RJ, Cornea RL, Thomas DD.

Sci Rep. 2018 Aug 22;8(1):12560. doi: 10.1038/s41598-018-29685-z.

30.

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension.

Watanabe S, Ishikawa K, Plataki M, Bikou O, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018799738. doi: 10.1177/2045894018799738. Epub 2018 Aug 21.

31.

Direct measurement of left atrial and pulmonary artery pressure in rats with pulmonary hypertension.

Katz MG, Fargnoli AS, Sassi Y, Hajjar RJ, Hadri L.

J Thorac Cardiovasc Surg. 2018 Sep;156(3):1161-1163. doi: 10.1016/j.jtcvs.2018.05.026. No abstract available.

PMID:
30119283
32.

Mitral Valve Prolapse: A Disease of Valve and Ventricle.

Levine RA, Jerosch-Herold M, Hajjar RJ.

J Am Coll Cardiol. 2018 Aug 21;72(8):835-837. doi: 10.1016/j.jacc.2018.07.006. No abstract available.

33.

Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias.

Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ.

J Am Coll Cardiol. 2018 Aug 14;72(7):738-750. doi: 10.1016/j.jacc.2018.05.059.

34.

FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair.

Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S.

Circulation. 2019 Jan 22;139(4):518-532. doi: 10.1161/CIRCULATIONAHA.118.033794.

PMID:
29997116
35.

Modeling Pulmonary Hypertension: A Pig Model of Postcapillary Pulmonary Hypertension.

Bikou O, Ishikawa K, Fish KM, Zarragoikoetxea I, Hajjar RJ, Aguero J.

Methods Mol Biol. 2018;1816:367-383. doi: 10.1007/978-1-4939-8597-5_29.

PMID:
29987835
36.

Chronic Pulmonary Artery Embolization Models in Large Animals.

Aguero J, Hammoudi N, Bikou O, Fish KM, Zarragoikoetxea I, Hajjar RJ, Ishikawa K.

Methods Mol Biol. 2018;1816:353-366. doi: 10.1007/978-1-4939-8597-5_28.

PMID:
29987834
37.

Swine Model of Mitral Regurgitation Induced Heart Failure.

Watanabe S, Bikou O, Hajjar RJ, Ishikawa K.

Methods Mol Biol. 2018;1816:327-335. doi: 10.1007/978-1-4939-8597-5_25.

PMID:
29987831
38.

A Pig Model of Myocardial Infarction: Catheter-Based Approaches.

Bikou O, Watanabe S, Hajjar RJ, Ishikawa K.

Methods Mol Biol. 2018;1816:281-294. doi: 10.1007/978-1-4939-8597-5_22.

PMID:
29987828
39.

The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension.

Bueno-Beti C, Hadri L, Hajjar RJ, Sassi Y.

Methods Mol Biol. 2018;1816:243-252. doi: 10.1007/978-1-4939-8597-5_19.

PMID:
29987825
40.

Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration.

Bueno-Beti C, Sassi Y, Hajjar RJ, Hadri L.

Methods Mol Biol. 2018;1816:233-241. doi: 10.1007/978-1-4939-8597-5_18.

PMID:
29987824
41.
42.

Conventional Method of Transverse Aortic Constriction in Mice.

Yoo J, Chepurko V, Hajjar RJ, Jeong D.

Methods Mol Biol. 2018;1816:183-193. doi: 10.1007/978-1-4939-8597-5_14.

PMID:
29987820
43.

Ischemic Model of Heart Failure in Rats and Mice.

Chen J, Ceholski DK, Turnbull IC, Liang L, Hajjar RJ.

Methods Mol Biol. 2018;1816:175-182. doi: 10.1007/978-1-4939-8597-5_13.

PMID:
29987819
44.

Highlighting the Field of Cardiovascular Regenerative Medicine.

Zimmermann WH, Yla-Herttuala S, Hajjar RJ.

Mol Ther. 2018 Jul 5;26(7):1595. doi: 10.1016/j.ymthe.2018.06.009. Epub 2018 Jun 19. No abstract available.

45.

Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella.

Hammoudi N, Watanabe S, Bikou O, Ceccaldi A, Fish K, Yamada KP, Miyashita S, Lebreton G, Hajjar RJ, Ishikawa K.

J Cardiovasc Transl Res. 2019 Apr;12(2):135-141. doi: 10.1007/s12265-018-9812-2. Epub 2018 May 29.

PMID:
29845440
46.

Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction.

Asensio-Lopez MDC, Lax A, Fernandez Del Palacio MJ, Sassi Y, Hajjar RJ, Pascual-Figal DA.

Transl Res. 2018 Sep;199:4-23. doi: 10.1016/j.trsl.2018.04.004. Epub 2018 Apr 23.

PMID:
29753686
47.

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.

Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, Costa KD, Hajjar RJ.

J Mol Cell Cardiol. 2018 Jun;119:147-154. doi: 10.1016/j.yjmcc.2018.05.007. Epub 2018 May 9.

48.

Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovisaries).

Gordon HP, Katz MG, Fargnoli AS, Gillespie VL, Hajjar RJ, Bridges CR.

Comp Med. 2018 Jun 1;68(3):215-220. doi: 10.30802/AALAS-CM-17-000040. Epub 2018 May 10.

49.

Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis.

Rodriguez P, Sassi Y, Troncone L, Benard L, Ishikawa K, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D.

Eur Heart J. 2019 Mar 21;40(12):967-978. doi: 10.1093/eurheartj/ehy188.

PMID:
29668883
50.

A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity.

Chamberlain K, Riyad JM, Garnett T, Kohlbrenner E, Mookerjee A, Elmastour F, Benard L, Chen J, VandenDriessche T, Chuah MK, Marian AJ, Hajjar RJ, Gurha P, Weber T.

Hum Gene Ther. 2018 Aug;29(8):927-937. doi: 10.1089/hum.2017.188. Epub 2018 May 9.

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