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Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection.

Robison A, Snyder DT, Christensen K, Kimmel E, Hajjar AM, Jutila MA, Hedges JF.

Innate Immun. 2019 Jun 10:1753425919855420. doi: 10.1177/1753425919855420. [Epub ahead of print]


Toll-like receptor 2 and toll-like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota.

Chang AM, Liu Q, Hajjar AM, Greer A, McLean JS, Darveau RP.

J Periodontol. 2019 May 21. doi: 10.1002/JPER.18-0719. [Epub ahead of print]


Ferreting Out the Role of Infection in Cystic Fibrosis Lung Disease.

Hoffman LR, Hajjar AM.

Am J Respir Crit Care Med. 2018 May 15;197(10):1243-1244. doi: 10.1164/rccm.201801-0053ED. No abstract available.


Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.

Hajjar AM, Ernst RK, Yi J, Yam CS, Miller SI.

PLoS One. 2017 Oct 11;12(10):e0186308. doi: 10.1371/journal.pone.0186308. eCollection 2017.


A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation.

Marshall JD, Heeke DS, Rao E, Maynard SK, Hornigold D, McCrae C, Fraser N, Tovchigrechko A, Yu L, Williams N, King S, Cooper ME, Hajjar AM, Woo JC.

PLoS One. 2016 Oct 13;11(10):e0164632. doi: 10.1371/journal.pone.0164632. eCollection 2016.


TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages.

Philip M, Chiu EY, Hajjar AM, Abkowitz JL.

J Immunol Res. 2016;2016:4039038. doi: 10.1155/2016/4039038. Epub 2016 Feb 24.


Potential for using a hermetically-sealed, positive-pressured isocage system for studies involving germ-free mice outside a flexible-film isolator.

Paik J, Pershutkina O, Meeker S, Yi JJ, Dowling S, Hsu C, Hajjar AM, Maggio-Price L, Beck DA.

Gut Microbes. 2015 Jul 4;6(4):255-65. doi: 10.1080/19490976.2015.1064576. Epub 2015 Jul 15.


Bordetella pertussis Lipid A Recognition by Toll-like Receptor 4 and MD-2 Is Dependent on Distinct Charged and Uncharged Interfaces.

Maeshima N, Evans-Atkinson T, Hajjar AM, Fernandez RC.

J Biol Chem. 2015 May 22;290(21):13440-53. doi: 10.1074/jbc.M115.653881. Epub 2015 Apr 2.


Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A.

Hittle LE, Jones JW, Hajjar AM, Ernst RK, Preston A.

J Bacteriol. 2015 Feb;197(3):572-80. doi: 10.1128/JB.02236-14. Epub 2014 Nov 24.


Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.

Loomis WP, Johnson ML, Brasfield A, Blanc MP, Yi J, Miller SI, Cookson BT, Hajjar AM.

PLoS One. 2014 Oct 28;9(10):e111763. doi: 10.1371/journal.pone.0111763. eCollection 2014. Erratum in: PLoS One. 2015;10(1):e0117648.


NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.

West TE, Myers ND, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Miao EA, Hajjar AM, Peacock SJ, Liggitt HD, Skerrett SJ.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3178. doi: 10.1371/journal.pntd.0003178. eCollection 2014 Sep.


Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.

Snyder JM, Treuting PM, Nagy L, Yam C, Yi J, Brasfield A, Nguyen LP, Hajjar AM.

PLoS One. 2014 Sep 17;9(9):e107257. doi: 10.1371/journal.pone.0107257. eCollection 2014.


Innate immune detection of flagellin positively and negatively regulates salmonella infection.

Lai MA, Quarles EK, López-Yglesias AH, Zhao X, Hajjar AM, Smith KD.

PLoS One. 2013 Aug 19;8(8):e72047. doi: 10.1371/journal.pone.0072047. eCollection 2013.


Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Hajjar AM, Ernst RK, Fortuno ES 3rd, Brasfield AS, Yam CS, Newlon LA, Kollmann TR, Miller SI, Wilson CB.

PLoS Pathog. 2012;8(10):e1002963. doi: 10.1371/journal.ppat.1002963. Epub 2012 Oct 11.


Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23.

Awoniyi M, Miller SI, Wilson CB, Hajjar AM, Smith KD.

PLoS One. 2012;7(5):e37311. doi: 10.1371/journal.pone.0037311. Epub 2012 May 18.


Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK.

Infect Immun. 2012 Mar;80(3):943-51. doi: 10.1128/IAI.06109-11. Epub 2012 Jan 3.


Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.

Corbett NP, Blimkie D, Ho KC, Cai B, Sutherland DP, Kallos A, Crabtree J, Rein-Weston A, Lavoie PM, Turvey SE, Hawkins NR, Self SG, Wilson CB, Hajjar AM, Fortuno ES 3rd, Kollmann TR.

PLoS One. 2010 Nov 30;5(11):e15041. doi: 10.1371/journal.pone.0015041.


Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains.

Marr N, Novikov A, Hajjar AM, Caroff M, Fernandez RC.

J Infect Dis. 2010 Dec 15;202(12):1897-906. doi: 10.1086/657409. Epub 2010 Nov 4.


Identification, cloning, expression, and purification of Francisella lpp3: an immunogenic lipoprotein.

Parra MC, Shaffer SA, Hajjar AM, Gallis BM, Hager A, Goodlett DR, Guina T, Miller S, Collins CM.

Microbiol Res. 2010 Sep 20;165(7):531-45. doi: 10.1016/j.micres.2009.11.004. Epub 2009 Dec 14.


Neonatal innate TLR-mediated responses are distinct from those of adults.

Kollmann TR, Crabtree J, Rein-Weston A, Blimkie D, Thommai F, Wang XY, Lavoie PM, Furlong J, Fortuno ES 3rd, Hajjar AM, Hawkins NR, Self SG, Wilson CB.

J Immunol. 2009 Dec 1;183(11):7150-60. doi: 10.4049/jimmunol.0901481. Epub 2009 Nov 16.


Innate immune recognition of, and response to, Clostridium sordellii.

Aldape MJ, Bryant AE, Katahira EJ, Hajjar AM, Finegold SM, Ma Y, Stevens DL.

Anaerobe. 2010 Apr;16(2):125-30. doi: 10.1016/j.anaerobe.2009.06.004. Epub 2009 Jun 25.


Inactivation of Chibby affects function of motile airway cilia.

Voronina VA, Takemaru K, Treuting P, Love D, Grubb BR, Hajjar AM, Adams A, Li FQ, Moon RT.

J Cell Biol. 2009 Apr 20;185(2):225-33. doi: 10.1083/jcb.200809144. Epub 2009 Apr 13.


Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.

Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kajikawa O, Ruzinski JT, Rona G, Black RA, Stratton S, Jarvik GP, Hajjar AM, Nickerson DA, Rieder M, Sevransky J, Maloney JP, Moss M, Martin G, Shanholtz C, Garcia JG, Gao L, Brower R, Barnes KC, Walley KR, Russell JA, Martin TR.

Am J Respir Crit Care Med. 2008 Oct 1;178(7):710-20. doi: 10.1164/rccm.200803-462OC. Epub 2008 Jul 17.


Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia.

West TE, Pelletier MR, Majure MC, Lembo A, Hajjar AM, Skerrett SJ.

Microbes Infect. 2008 Jun;10(7):773-80. doi: 10.1016/j.micinf.2008.04.008. Epub 2008 Apr 22.


Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.

Lembo A, Pelletier M, Iyer R, Timko M, Dudda JC, West TE, Wilson CB, Hajjar AM, Skerrett SJ.

J Immunol. 2008 Jun 1;180(11):7574-81.


A Francisella mutant in lipid A carbohydrate modification elicits protective immunity.

Kanistanon D, Hajjar AM, Pelletier MR, Gallagher LA, Kalhorn T, Shaffer SA, Goodlett DR, Rohmer L, Brittnacher MJ, Skerrett SJ, Ernst RK.

PLoS Pathog. 2008 Feb 8;4(2):e24. doi: 10.1371/journal.ppat.0040024.


Induction of protective immunity to Listeria monocytogenes in neonates.

Kollmann TR, Reikie B, Blimkie D, Way SS, Hajjar AM, Arispe K, Shaulov A, Wilson CB.

J Immunol. 2007 Mar 15;178(6):3695-701.


Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.

Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjöstedt A, Edebro H, Forsman M, Byström M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK.

Infect Immun. 2006 Dec;74(12):6730-8. Epub 2006 Sep 18.


Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa.

Skerrett SJ, Wilson CB, Liggitt HD, Hajjar AM.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L312-22. Epub 2006 Aug 25.


An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.

Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ.

Am J Respir Cell Mol Biol. 2005 Nov;33(5):470-5. Epub 2005 Aug 11.


Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.

Darveau RP, Pham TT, Lemley K, Reife RA, Bainbridge BW, Coats SR, Howald WN, Way SS, Hajjar AM.

Infect Immun. 2004 Sep;72(9):5041-51.


Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin.

Skerrett SJ, Liggitt HD, Hajjar AM, Ernst RK, Miller SI, Wilson CB.

Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L143-52. Epub 2004 Mar 26.


Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.

Kollmann TR, Way SS, Harowicz HL, Hajjar AM, Wilson CB.

Blood. 2004 Jun 1;103(11):4240-2. Epub 2004 Feb 24.


Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity.

Way SS, Thompson LJ, Lopes JE, Hajjar AM, Kollmann TR, Freitag NE, Wilson CB.

Cell Microbiol. 2004 Mar;6(3):235-42.


Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4.

Ernst RK, Hajjar AM, Tsai JH, Moskowitz SM, Wilson CB, Miller SI.

J Endotoxin Res. 2003;9(6):395-400.


Human Toll-like receptor 4 recognizes host-specific LPS modifications.

Hajjar AM, Ernst RK, Tsai JH, Wilson CB, Miller SI.

Nat Immunol. 2002 Apr;3(4):354-9. Epub 2002 Mar 25.


Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.

Hajjar AM, O'Mahony DS, Ozinsky A, Underhill DM, Aderem A, Klebanoff SJ, Wilson CB.

J Immunol. 2001 Jan 1;166(1):15-9.


The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13766-71.


The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, Aderem A.

Nature. 1999 Oct 21;401(6755):811-5.


Efficient isolation of human immunodeficiency virus type 1 RNA from cervical swabs.

Hajjar AM, Lewis PF, Endeshaw Y, Ndinya-Achola J, Kreiss JK, Overbaugh J.

J Clin Microbiol. 1998 Aug;36(8):2349-52.


Rocuronium in the myasthenic patient.

Baraka A, Haroun-Bizri S, Kawas N, Hajjar AM, Kawkabani N.

Anaesthesia. 1995 Nov;50(11):1007. No abstract available.


Chronic sialodacryoadenitis virus (SDAV) infection in athymic rats.

Hajjar AM, DiGiacomo RF, Carpenter JK, Bingel SA, Moazed TC.

Lab Anim Sci. 1991 Jan;41(1):22-5.


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