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Items: 1 to 50 of 170

1.

The oral microbiota: dynamic communities and host interactions.

Lamont RJ, Koo H, Hajishengallis G.

Nat Rev Microbiol. 2018 Oct 9. doi: 10.1038/s41579-018-0089-x. [Epub ahead of print] Review.

PMID:
30301974
2.

Safety profile after prolonged C3 inhibition.

Reis ES, Berger N, Wang X, Koutsogiannaki S, Doot RK, Gumas JT, Foukas PG, Resuello RRG, Tuplano JV, Kukis D, Tarantal AF, Young AJ, Kajikawa T, Soulika AM, Mastellos DC, Yancopoulou D, Biglarnia AR, Huber-Lang M, Hajishengallis G, Nilsson B, Lambris JD.

Clin Immunol. 2018 Sep 20;197:96-106. doi: 10.1016/j.clim.2018.09.004. [Epub ahead of print]

PMID:
30217791
3.

Gingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis.

Bostanci N, Bao K, Li X, Maekawa T, Grossmann J, Panse C, Briones RA, Resuello RRG, Tuplano JV, Garcia CAG, Reis ES, Lambris JD, Hajishengallis G.

J Proteome Res. 2018 Sep 7;17(9):3153-3175. doi: 10.1021/acs.jproteome.8b00263. Epub 2018 Aug 29.

PMID:
30111112
4.

The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis.

Kim H, Kajikawa T, Walsh MC, Takegahara N, Jeong YH, Hajishengallis G, Choi Y.

BMB Rep. 2018 Sep;51(9):468-473.

5.

Myelopoiesis in the Context of Innate Immunity.

Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T.

J Innate Immun. 2018 Jun 6:1-8. doi: 10.1159/000489406. [Epub ahead of print] Review.

6.

Smad6 Methylation Represses NFκB Activation and Periodontal Inflammation.

Zhang T, Wu J, Ungvijanpunya N, Jackson-Weaver O, Gou Y, Feng J, Ho TV, Shen Y, Liu J, Richard S, Jin J, Hajishengallis G, Chai Y, Xu J.

J Dent Res. 2018 Jul;97(7):810-819. doi: 10.1177/0022034518755688. Epub 2018 Feb 8.

PMID:
29420098
7.

Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow.

Chen LS, Kourtzelis I, Singh RP, Grossklaus S, Wielockx B, Hajishengallis G, Chavakis T, Mitroulis I.

Thromb Haemost. 2018 Feb 7. doi: 10.1055/s-0038-1624582. [Epub ahead of print] No abstract available.

PMID:
29415284
8.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.

9.

Novel mechanisms and functions of complement.

Hajishengallis G, Reis ES, Mastellos DC, Ricklin D, Lambris JD.

Nat Immunol. 2017 Nov 16;18(12):1288-1298. doi: 10.1038/ni.3858. Review.

PMID:
29144501
10.

Metabolic nuclear receptors in periodontal host-microbe interactions and inflammation.

Hajishengallis G, Lamont RJ.

Mol Oral Microbiol. 2017 Dec;32(6):443-445. doi: 10.1111/omi.12198. Epub 2017 Oct 5. No abstract available.

PMID:
28984043
11.

Meeting report: The 12th European oral microbiology workshop (EOMW) in Stockholm, Sweden.

Belibasakis GN, Curtis MA, Hajishengallis G, Zaura E.

Virulence. 2018 Jan 1;9(1):64-69. doi: 10.1080/21505594.2017.1376147. Epub 2017 Nov 10. No abstract available.

12.

Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates.

Kajikawa T, Briones RA, Resuello RRG, Tuplano JV, Reis ES, Hajishengallis E, Garcia CAG, Yancopoulou D, Lambris JD, Hajishengallis G.

Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215. doi: 10.1016/j.omtm.2017.08.001. eCollection 2017 Sep 15.

13.

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G.

Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017.

14.

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T.

J Clin Invest. 2017 Oct 2;127(10):3624-3639. doi: 10.1172/JCI92571. Epub 2017 Aug 28.

15.

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice.

Subramanian P, Prucnal M, Gercken B, Economopoulou M, Hajishengallis G, Chavakis T.

Thromb Haemost. 2017 Oct 5;117(10):2003-2005. doi: 10.1160/TH17-03-0160. Epub 2017 Aug 10. No abstract available.

16.

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later.

Hajishengallis G, Korostoff JM.

Periodontol 2000. 2017 Oct;75(1):116-151. doi: 10.1111/prd.12181. Review.

17.

Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function.

Olsen I, Lambris JD, Hajishengallis G.

J Oral Microbiol. 2017 Jun 30;9(1):1340085. doi: 10.1080/20002297.2017.1340085. eCollection 2017. Review.

18.

Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation.

Klotzsche-von Ameln A, Cremer S, Hoffmann J, Schuster P, Khedr S, Korovina I, Troullinaki M, Neuwirth A, Sprott D, Chatzigeorgiou A, Economopoulou M, Orlandi A, Hain A, Zeiher AM, Deussen A, Hajishengallis G, Dimmeler S, Chavakis T, Chavakis E.

Thromb Haemost. 2017 Jun 2;117(6):1150-1163. doi: 10.1160/TH16-05-0354. Epub 2017 Apr 27.

19.

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.

Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T.

Nat Immunol. 2017 Jun;18(6):654-664. doi: 10.1038/ni.3728. Epub 2017 Apr 17.

20.

Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1.

Moutsopoulos NM, Zerbe CS, Wild T, Dutzan N, Brenchley L, DiPasquale G, Uzel G, Axelrod KC, Lisco A, Notarangelo LD, Hajishengallis G, Notarangelo LD, Holland SM.

N Engl J Med. 2017 Mar 23;376(12):1141-1146. doi: 10.1056/NEJMoa1612197.

21.

From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins.

Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T.

J Leukoc Biol. 2017 Sep;102(3):677-683. doi: 10.1189/jlb.3MR0117-024R. Epub 2017 Mar 14. Review.

22.

Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans.

Kajikawa T, Meshikhes F, Maekawa T, Hajishengallis E, Hosur KB, Abe T, Moss K, Chavakis T, Hajishengallis G.

J Clin Periodontol. 2017 May;44(5):472-483. doi: 10.1111/jcpe.12707. Epub 2017 Apr 12.

23.

Expression and Regulation of Cholecystokinin Receptor in the Chicken's Immune Organs and Cells.

El-Kassas S, Odemuyiwa S, Hajishengallis G, Connell TD, Nashar TO.

J Clin Cell Immunol. 2016 Dec;7(6). pii: 471. doi: 10.4172/2155-9899.1000471. Epub 2016 Nov 25.

24.

Dendritic Cell-Mediated Mechanisms Triggered by LT-IIa-B5, a Mucosal Adjuvant Derived from a Type II Heat-Labile Enterotoxin of Escherichia coli.

Lee CH, Hajishengallis G, Connell TD.

J Microbiol Biotechnol. 2017 Apr 28;27(4):709-717. doi: 10.4014/jmb.1611.11072.

25.

Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis.

Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G.

J Dent Res. 2017 May;96(5):571-577. doi: 10.1177/0022034516687248. Epub 2017 Jan 17.

26.

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation.

Hajishengallis G, Lambris JD.

Immunol Rev. 2016 Nov;274(1):233-244. doi: 10.1111/imr.12467. Review.

27.

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.

Mastellos DC, Reis ES, Yancopoulou D, Hajishengallis G, Ricklin D, Lambris JD.

Immunobiology. 2016 Oct;221(10):1046-57. doi: 10.1016/j.imbio.2016.06.013. Epub 2016 Jun 16. Review.

28.

Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte.

Hajishengallis G, Krauss JL, Jotwani R, Lambris JD.

Mol Oral Microbiol. 2017 Apr;32(2):154-165. doi: 10.1111/omi.12161. Epub 2016 May 18.

29.

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application.

Hajishengallis G, Hajishengallis E, Kajikawa T, Wang B, Yancopoulou D, Ricklin D, Lambris JD.

Semin Immunol. 2016 Jun;28(3):285-91. doi: 10.1016/j.smim.2016.03.006. Epub 2016 Mar 24. Review.

30.

Major neutrophil functions subverted by Porphyromonas gingivalis.

Olsen I, Hajishengallis G.

J Oral Microbiol. 2016 Mar 17;8:30936. doi: 10.3402/jom.v8.30936. eCollection 2016.

31.

Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts.

Hajishengallis G, Lamont RJ.

Trends Microbiol. 2016 Jun;24(6):477-489. doi: 10.1016/j.tim.2016.02.010. Epub 2016 Mar 8. Review.

32.

Immune and regulatory functions of neutrophils in inflammatory bone loss.

Hajishengallis G, Moutsopoulos NM, Hajishengallis E, Chavakis T.

Semin Immunol. 2016 Apr;28(2):146-58. doi: 10.1016/j.smim.2016.02.002. Epub 2016 Feb 28. Review.

33.

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3.

Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G.

J Clin Periodontol. 2016 Mar;43(3):238-49. doi: 10.1111/jcpe.12507. Epub 2016 Mar 3.

34.

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation.

Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T.

Thromb Haemost. 2016 Apr;115(4):781-8. doi: 10.1160/TH15-05-0429. Epub 2015 Dec 17.

35.
36.

Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.

Subramanian P, Mitroulis I, Hajishengallis G, Chavakis T.

Curr Opin Hematol. 2016 Jan;23(1):36-43. doi: 10.1097/MOH.0000000000000198. Review.

37.

DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

Shin J, Maekawa T, Abe T, Hajishengallis E, Hosur K, Pyaram K, Mitroulis I, Chavakis T, Hajishengallis G.

Sci Transl Med. 2015 Sep 30;7(307):307ra155. doi: 10.1126/scitranslmed.aac5380.

38.

Role of bacteria in leukocyte adhesion deficiency-associated periodontitis.

Hajishengallis G, Moutsopoulos NM.

Microb Pathog. 2016 May;94:21-6. doi: 10.1016/j.micpath.2015.09.003. Epub 2015 Sep 14. Review.

39.

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway.

Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G.

Nat Commun. 2015 Sep 16;6:8272. doi: 10.1038/ncomms9272.

40.

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention.

Mastellos DC, Ricklin D, Hajishengallis E, Hajishengallis G, Lambris JD.

Mol Oral Microbiol. 2016 Feb;31(1):3-17. doi: 10.1111/omi.12129. Epub 2015 Oct 7. Review.

41.

Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches.

Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD.

Adv Exp Med Biol. 2015;865:57-74. doi: 10.1007/978-3-319-18603-0_4. Review.

42.

Basic biology and role of interleukin-17 in immunity and inflammation.

Zenobia C, Hajishengallis G.

Periodontol 2000. 2015 Oct;69(1):142-59. doi: 10.1111/prd.12083. Review.

43.

Sex dimorphism in periodontitis in animal models.

Duan X, Gleason RC, Li F, Hosur KB, Duan X, Huang D, Wang H, Hajishengallis G, Liang S.

J Periodontal Res. 2016 Apr;51(2):196-202. doi: 10.1111/jre.12298. Epub 2015 Jul 22.

44.

The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis.

Abe T, AlSarhan M, Benakanakere MR, Maekawa T, Kinane DF, Cancro MP, Korostoff JM, Hajishengallis G.

J Immunol. 2015 Aug 15;195(4):1427-35. doi: 10.4049/jimmunol.1500496. Epub 2015 Jul 6.

45.

Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis.

Kim PD, Xia-Juan X, Crump KE, Abe T, Hajishengallis G, Sahingur SE.

Infect Immun. 2015 Jul;83(7):2992-3002. doi: 10.1128/IAI.00424-15. Epub 2015 May 11.

46.

Inborn errors in immunity: unique natural models to dissect oral immunity.

Moutsopoulos NM, Lionakis MS, Hajishengallis G.

J Dent Res. 2015 Jun;94(6):753-8. doi: 10.1177/0022034515583533. Epub 2015 Apr 21. Review.

47.

Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits.

El-Kassas S, Faraj R, Martin K, Hajishengallis G, Connell TD, Nashar T.

Cell Immunol. 2015 Jun;295(2):150-62. doi: 10.1016/j.cellimm.2015.02.014. Epub 2015 Mar 5.

48.

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.

Mastellos DC, Yancopoulou D, Kokkinos P, Huber-Lang M, Hajishengallis G, Biglarnia AR, Lupu F, Nilsson B, Risitano AM, Ricklin D, Lambris JD.

Eur J Clin Invest. 2015 Apr;45(4):423-40. doi: 10.1111/eci.12419. Epub 2015 Mar 9. Review.

49.

Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis.

Zenobia C, Hajishengallis G.

Virulence. 2015;6(3):236-43. doi: 10.1080/21505594.2014.999567. Review.

50.

The enduring importance of animal models in understanding periodontal disease.

Hajishengallis G, Lamont RJ, Graves DT.

Virulence. 2015;6(3):229-35. doi: 10.4161/21505594.2014.990806. Review.

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