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Items: 37

1.

Detailed Evaluation of Possible Ganglion Cell Loss in the Retina of Zucker Diabetic Fatty (ZDF) Rats.

Hajdú RI, Laurik LK, Szabó K, Dékány B, Almási Z, Énzsöly A, Szabó A, Radovits T, Mátyás C, Oláh A, Szél Á, Somfai GM, Dávid C, Lukáts Á.

Sci Rep. 2019 Jul 18;9(1):10463. doi: 10.1038/s41598-019-46879-1.

2.

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans.

Jüttner J, Szabo A, Gross-Scherf B, Morikawa RK, Rompani SB, Hantz P, Szikra T, Esposti F, Cowan CS, Bharioke A, Patino-Alvarez CP, Keles Ö, Kusnyerik A, Azoulay T, Hartl D, Krebs AR, Schübeler D, Hajdu RI, Lukats A, Nemeth J, Nagy ZZ, Wu KC, Wu RH, Xiang L, Fang XL, Jin ZB, Goldblum D, Hasler PW, Scholl HPN, Krol J, Roska B.

Nat Neurosci. 2019 Aug;22(8):1345-1356. doi: 10.1038/s41593-019-0431-2. Epub 2019 Jul 8.

PMID:
31285614
3.

Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats.

Szabó K, Énzsöly A, Dékány B, Szabó A, Hajdú RI, Radovits T, Mátyás C, Oláh A, Laurik LK, Somfai GM, Merkely B, Szél Á, Lukáts Á.

Sci Rep. 2017 Aug 21;7(1):8891. doi: 10.1038/s41598-017-09068-6.

4.

Study of retinal neurodegeneration and maculopathy in diabetic Meriones shawi: A particular animal model with human-like macula.

Hammoum I, Benlarbi M, Dellaa A, Szabó K, Dékány B, Csaba D, Almási Z, Hajdú RI, Azaiz R, Charfeddine R, Lukáts Á, Ben Chaouacha-Chekir R.

J Comp Neurol. 2017 Sep 1;525(13):2890-2914. doi: 10.1002/cne.24245. Epub 2017 Jun 7.

PMID:
28542922
5.

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.

Debenham JS, Madsen-Duggan C, Clements MJ, Walsh TF, Kuethe JT, Reibarkh M, Salowe SP, Sonatore LM, Hajdu R, Milligan JA, Visco DM, Zhou D, Lingham RB, Stickens D, DeMartino JA, Tong X, Wolff M, Pang J, Miller RR, Sherer EC, Hale JJ.

J Med Chem. 2016 Dec 22;59(24):11039-11049. doi: 10.1021/acs.jmedchem.6b01242. Epub 2016 Nov 30.

PMID:
28002958
6.

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y.

ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13.

7.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Park MK, London C, Xiong Y, Tata J, Bennett DJ, Cooke A, Cai J, Carswell E, Robinson J, MacLean J, Brown L, Belshaw S, Clarkson TR, Liu K, Liang GB, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Kuethe J, Rivera N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Ali A.

ACS Med Chem Lett. 2015 Apr 7;6(5):573-8. doi: 10.1021/acsmedchemlett.5b00054. eCollection 2015 May 14.

8.

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.

Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, Chang L, Bakshi RK, Dellureficio JP, Hong Q, McLaughlin M, Belyk KM, Krska SW, Makarewicz AK, Martel EJ, Leone JF, Frey L, Karanam B, Madeira M, Alvaro R, Shuman J, Salituro G, Terebetski JL, Jochnowitz N, Mistry S, McGowan E, Hajdu R, Rosenbach M, Abbadie C, Alexander JP, Shiao LL, Sullivan KM, Nargund RP, Wyvratt MJ, Lin LS, DeVita RJ.

ACS Med Chem Lett. 2014 Apr 10;5(6):717-21. doi: 10.1021/ml5001239. eCollection 2014 Jun 12.

9.

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.

Liu P, Hamill TG, Chioda M, Chobanian H, Fung S, Guo Y, Chang L, Bakshi R, Hong Q, Dellureficio J, Lin LS, Abbadie C, Alexander J, Jin H, Mandala S, Shiao LL, Li W, Sanabria S, Williams D, Zeng Z, Hajdu R, Jochnowitz N, Rosenbach M, Karanam B, Madeira M, Salituro G, Powell J, Xu L, Terebetski JL, Leone JF, Miller P, Cook J, Holahan M, Joshi A, O'Malley S, Purcell M, Posavec D, Chen TB, Riffel K, Williams M, Hargreaves R, Sullivan KA, Nargund RP, DeVita RJ.

ACS Med Chem Lett. 2013 Apr 20;4(6):509-13. doi: 10.1021/ml4000996. eCollection 2013 Jun 13.

10.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R, Gollapudi A, Keohane CA, Lingham RB, Mandala SM, DeMartino JA, Tong X, Wolff M, Steinhuebel D, Kieczykowski GR, Fleitz FJ, Chapman K, Athanasopoulos J, Adam G, Akyuz CD, Jena DK, Lusen JW, Meng J, Stein BD, Xia L, Sherer EC, Hale JJ.

J Med Chem. 2012 Apr 12;55(7):2945-59. doi: 10.1021/jm201542d. Epub 2012 Feb 27.

PMID:
22364528
11.

Modeling of Cd uptake and efflux kinetics in metal-resistant bacterium Cupriavidus metallidurans.

Hajdu R, Pinheiro JP, Galceran J, Slaveykova VI.

Environ Sci Technol. 2010 Jun 15;44(12):4597-602. doi: 10.1021/es100687h.

PMID:
20491434
12.

Effect of competing ions and complexing organic substances on the cadmium uptake by the soil bacterium Sinorhizobium meliloti.

Slaveykova VI, Dedieu K, Parthasarathy N, Hajdu R.

Environ Toxicol Chem. 2009 Apr;28(4):741-8. doi: 10.1897/08-379R.1.

PMID:
19391692
13.

SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.

Yan L, Huo P, Hale JJ, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Mandala SM.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):828-31. Epub 2006 Oct 25.

PMID:
17092714
14.

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.

Yan L, Huo P, Doherty G, Toth L, Hale JJ, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Quackenbush E, Wickham A, Mandala SM.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3679-83. Epub 2006 May 11.

PMID:
16697189
15.

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

Vachal P, Toth LM, Hale JJ, Yan L, Mills SG, Chrebet GL, Koehane CA, Hajdu R, Milligan JA, Rosenbach MJ, Mandala S.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3684-7. Epub 2006 May 6.

PMID:
16682185
16.

2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

Yan L, Budhu R, Huo P, Lynch CL, Hale JJ, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Mandala SM.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3564-8. Epub 2006 Apr 18.

PMID:
16621543
17.

2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.

Colandrea VJ, Legiec IE, Huo P, Yan L, Hale JJ, Mills SG, Bergstrom J, Card D, Chebret G, Hajdu R, Keohane CA, Milligan JA, Rosenbach MJ, Shei GJ, Mandala SM.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2905-8. Epub 2006 Mar 31.

PMID:
16580205
18.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

Li Z, Chen W, Hale JJ, Lynch CL, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Parent SA, Bergstrom J, Card D, Forrest M, Quackenbush EJ, Wickham LA, Vargas H, Evans RM, Rosen H, Mandala S.

J Med Chem. 2005 Oct 6;48(20):6169-73.

PMID:
16190743
19.

Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.

Vora KA, Nichols E, Porter G, Cui Y, Keohane CA, Hajdu R, Hale J, Neway W, Zaller D, Mandala S.

J Leukoc Biol. 2005 Aug;78(2):471-80. Epub 2005 May 13.

PMID:
15894589
20.

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.

Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, Strulovici B, Rosen H, Mandala S.

J Med Chem. 2004 Dec 30;47(27):6662-5.

PMID:
15615513
21.

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, Hajdu R, Rosenbach M, Keohane CA, Mandala S, Spiegel S, Proia RL.

J Biol Chem. 2004 Dec 10;279(50):52487-92. Epub 2004 Sep 30.

22.

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.

Yan L, Hale JJ, Lynch CL, Budhu R, Gentry A, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Chrebet G, Bergstrom J, Card D, Rosen H, Mandala SM.

Bioorg Med Chem Lett. 2004 Oct 4;14(19):4861-6.

PMID:
15341940
23.

Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.

Hale JJ, Yan L, Neway WE, Hajdu R, Bergstrom JD, Milligan JA, Shei GJ, Chrebet GL, Thornton RA, Card D, Rosenbach M, HughRosen, Mandala S.

Bioorg Med Chem. 2004 Sep 15;12(18):4803-7.

PMID:
15336258
24.

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

Hale JJ, Doherty G, Toth L, Mills SG, Hajdu R, Keohane CA, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Forrest M, Sun SY, West S, Xie H, Nomura N, Rosen H, Mandala S.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3501-5.

PMID:
15177461
25.

The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.

Hale JJ, Doherty G, Toth L, Li Z, Mills SG, Hajdu R, Ann Keohane C, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Rosen H, Mandala S.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3495-9.

PMID:
15177460
26.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

Hale JJ, Neway W, Mills SG, Hajdu R, Ann Keohane C, Rosenbach M, Milligan J, Shei GJ, Chrebet G, Bergstrom J, Card D, Koo GC, Koprak SL, Jackson JJ, Rosen H, Mandala S.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3351-5.

PMID:
15149705
27.

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J, Mills S, Nomura N, Rosen H, Rosenbach M, Shei GJ, Singer II, Tian M, West S, White V, Xie J, Proia RL, Mandala S.

J Pharmacol Exp Ther. 2004 May;309(2):758-68. Epub 2004 Jan 27.

PMID:
14747617
28.

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H.

Science. 2002 Apr 12;296(5566):346-9. Epub 2002 Mar 28.

29.

Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.

Rosen H, Hajdu R, Silver L, Kropp H, Dorso K, Kohler J, Sundelof JG, Huber J, Hammond GG, Jackson JJ, Gill CJ, Thompson R, Pelak BA, Epstein-Toney JH, Lankas G, Wilkening RR, Wildonger KJ, Blizzard TA, DiNinno FP, Ratcliffe RW, Heck JV, Kozarich JW, Hammond ML.

Science. 1999 Jan 29;283(5402):703-6.

30.

Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).

Hajdu R, Thompson R, Sundelof JG, Pelak BA, Bouffard FA, Dropinski JF, Kropp H.

Antimicrob Agents Chemother. 1997 Nov;41(11):2339-44.

31.

Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.

Sundelof JG, Hajdu R, Gill CJ, Thompson R, Rosen H, Kropp H.

Antimicrob Agents Chemother. 1997 Aug;41(8):1743-8.

32.

Pharmacokinetics of L-671,329 in rhesus monkeys and DBA/2 mice.

Sundelof JG, Hajdu R, Cleare WJ, Onishi J, Kropp H.

Antimicrob Agents Chemother. 1992 Mar;36(3):607-10.

33.

A new class of potent, slowly reversible dehydropeptidase inhibitors.

Parsons WH, Hajdu R, Schoen WR, Combs PL, Sundelof J, Patchett AA.

Biochem Int. 1991 Apr;23(6):1107-15.

PMID:
1953807
34.
35.

Imipenem cross-reactivity with penicillin in humans.

Saxon A, Adelman DC, Patel A, Hajdu R, Calandra GB.

J Allergy Clin Immunol. 1988 Aug;82(2):213-7.

PMID:
2457043
36.

Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine.

Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ.

Drug Metab Dispos. 1986 Nov-Dec;14(6):668-73.

PMID:
2877824
37.

Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase.

Kropp H, Sundelof JG, Hajdu R, Kahan FM.

Antimicrob Agents Chemother. 1982 Jul;22(1):62-70.

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