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Items: 45


Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells.

Maiti A, Qi Q, Peng X, Yan L, Takabe K, Hait NC.

Int J Oncol. 2019 Jul;55(1):116-130. doi: 10.3892/ijo.2019.4796. Epub 2019 May 6.


ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer.

Yamada A, Nagahashi M, Aoyagi T, Huang WC, Lima S, Hait NC, Maiti A, Kida K, Terracina KP, Miyazaki H, Ishikawa T, Endo I, Waters MR, Qi Q, Yan L, Milstien S, Spiegel S, Takabe K.

Mol Cancer Res. 2018 Jun;16(6):1059-1070. doi: 10.1158/1541-7786.MCR-17-0353. Epub 2018 Mar 9.


TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S.

Autophagy. 2018;14(6):942-957. doi: 10.1080/15548627.2018.1429875. Epub 2018 Mar 11.


Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.

Cancer Res. 2018 Apr 1;78(7):1713-1725. doi: 10.1158/0008-5472.CAN-17-1423. Epub 2018 Jan 19.


The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.

Hait NC, Maiti A.

Mediators Inflamm. 2017;2017:4806541. doi: 10.1155/2017/4806541. Epub 2017 Nov 15. Review.


Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy.

Ramanathan R, Raza A, Sturgill J, Lyon D, Young J, Hait NC, Takabe K.

Mediators Inflamm. 2017;2017:5984819. doi: 10.1155/2017/5984819. Epub 2017 Sep 24.


Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer.

Katsuta E, Yan L, Nagahashi M, Raza A, Sturgill JL, Lyon DE, Rashid OM, Hait NC, Takabe K.

J Surg Res. 2017 Nov;219:202-213. doi: 10.1016/j.jss.2017.05.101. Epub 2017 Jun 29.


Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival.

Maiti A, Takabe K, Hait NC.

Cell Signal. 2017 Apr;32:85-92. doi: 10.1016/j.cellsig.2017.01.021. Epub 2017 Jan 17.


FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.


Corrigendum to "Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential".

Aoki M, Aoki H, Ramanathan R, Hait NC, Takabe K.

Mediators Inflamm. 2016;2016:2856829. Epub 2016 Oct 24.


The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases.

Nagahashi M, Yuza K, Hirose Y, Nakajima M, Ramanathan R, Hait NC, Hylemon PB, Zhou H, Takabe K, Wakai T.

J Lipid Res. 2016 Sep;57(9):1636-43. doi: 10.1194/jlr.R069286. Epub 2016 Jul 26. Review.


Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential.

Aoki M, Aoki H, Ramanathan R, Hait NC, Takabe K.

Mediators Inflamm. 2016;2016:8606878. doi: 10.1155/2016/8606878. Epub 2016 Feb 7. Review. Erratum in: Mediators Inflamm. 2016;2016:2856829.


Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.

Campos LS, Rodriguez YI, Leopoldino AM, Hait NC, Lopez Bergami P, Castro MG, Sanchez ES, Maceyka M, Spiegel S, Alvarez SE.

Mol Cell Biol. 2015 Nov 9;36(2):320-9. doi: 10.1128/MCB.00554-15. Print 2016 Jan 15.


Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.

Donoviel MS, Hait NC, Ramachandran S, Maceyka M, Takabe K, Milstien S, Oravecz T, Spiegel S.

FASEB J. 2015 Dec;29(12):5018-28. doi: 10.1096/fj.15-274936. Epub 2015 Aug 31.


The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.

Hait NC, Avni D, Yamada A, Nagahashi M, Aoyagi T, Aoki H, Dumur CI, Zelenko Z, Gallagher EJ, Leroith D, Milstien S, Takabe K, Spiegel S.

Oncogenesis. 2015 Jun 8;4:e156. doi: 10.1038/oncsis.2015.16.


Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.


The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.


Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.

Nagahashi M, Takabe K, Liu R, Peng K, Wang X, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Spiegel S, Hylemon PB, Zhou H.

Hepatology. 2015 Apr;61(4):1216-26. doi: 10.1002/hep.27592. Epub 2015 Mar 9.


Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstien S, Conrad D, Spiegel S.

FASEB J. 2014 Oct;28(10):4347-58. doi: 10.1096/fj.14-251611. Epub 2014 Jul 1.


Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S, Lichtman AH, Spiegel S.

Nat Neurosci. 2014 Jul;17(7):971-80. doi: 10.1038/nn.3728. Epub 2014 May 25.


K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T.

Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26.


Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

Nagahashi M, Hait NC, Maceyka M, Avni D, Takabe K, Milstien S, Spiegel S.

Adv Biol Regul. 2014 Jan;54:112-20. doi: 10.1016/j.jbior.2013.10.001. Epub 2013 Oct 16. Review.


Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.

Nguyen-Tran DH, Hait NC, Sperber H, Qi J, Fischer K, Ieronimakis N, Pantoja M, Hays A, Allegood J, Reyes M, Spiegel S, Ruohola-Baker H.

Dis Model Mech. 2014 Jan;7(1):41-54. doi: 10.1242/dmm.013631. Epub 2013 Sep 25.


Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent.

Liu K, Guo TL, Hait NC, Allegood J, Parikh HI, Xu W, Kellogg GE, Grant S, Spiegel S, Zhang S.

PLoS One. 2013;8(2):e56471. doi: 10.1371/journal.pone.0056471. Epub 2013 Feb 20.


Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S.

Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27.


Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

Nagahashi M, Kim EY, Yamada A, Ramachandran S, Allegood JC, Hait NC, Maceyka M, Milstien S, Takabe K, Spiegel S.

FASEB J. 2013 Mar;27(3):1001-11. doi: 10.1096/fj.12-219618. Epub 2012 Nov 24.


Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S.

FASEB J. 2011 Feb;25(2):600-12. doi: 10.1096/fj.10-167502. Epub 2010 Oct 19.


Extracellular and intracellular actions of sphingosine-1-phosphate.

Strub GM, Maceyka M, Hait NC, Milstien S, Spiegel S.

Adv Exp Med Biol. 2010;688:141-55. Review.


Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.


Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.

Oskeritzian CA, Price MM, Hait NC, Kapitonov D, Falanga YT, Morales JK, Ryan JJ, Milstien S, Spiegel S.

J Exp Med. 2010 Mar 15;207(3):465-74. doi: 10.1084/jem.20091513. Epub 2010 Mar 1.


Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Takabe K, Kim RH, Allegood JC, Mitra P, Ramachandran S, Nagahashi M, Harikumar KB, Hait NC, Milstien S, Spiegel S.

J Biol Chem. 2010 Apr 2;285(14):10477-86. doi: 10.1074/jbc.M109.064162. Epub 2010 Jan 28.


Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.

Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Erratum in: Science. 2009 Oct 16;326(5951):366.


Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S.

Cancer Res. 2009 Sep 1;69(17):6915-23. doi: 10.1158/0008-5472.CAN-09-0664.


Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.

Oskeritzian CA, Alvarez SE, Hait NC, Price MM, Milstien S, Spiegel S.

Blood. 2008 Apr 15;111(8):4193-200. doi: 10.1182/blood-2007-09-115451. Epub 2008 Jan 4.


Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.

Sankala HM, Hait NC, Paugh SW, Shida D, Lépine S, Elmore LW, Dent P, Milstien S, Spiegel S.

Cancer Res. 2007 Nov 1;67(21):10466-74.


Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.

Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S.

J Biol Chem. 2007 Apr 20;282(16):12058-65. Epub 2007 Feb 20.


Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.

Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S.

Biochim Biophys Acta. 2006 Dec;1758(12):2016-26. Epub 2006 Aug 18. Review.


Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.

Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S, Spiegel S.

FEBS Lett. 2005 Oct 10;579(24):5313-7.


SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

Maceyka M, Sankala H, Hait NC, Le Stunff H, Liu H, Toman R, Collier C, Zhang M, Satin LS, Merrill AH Jr, Milstien S, Spiegel S.

J Biol Chem. 2005 Nov 4;280(44):37118-29. Epub 2005 Aug 23.


Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.

Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S.

J Biol Chem. 2005 Aug 19;280(33):29462-9. Epub 2005 Jun 10.


Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes.

Hait NC, Fujita K, Lester RL, Dickson RC.

FEBS Lett. 2002 Dec 4;532(1-2):97-102.


L-myo-lnositol 1-Phosphate Synthase from Plant Sources (Characteristics of the Chloroplastic and Cytosolic Enzymes).

RayChaudhuri A, Hait NC, Dasgupta S, Bhaduri TJ, Deb R, Majumder AL.

Plant Physiol. 1997 Oct;115(2):727-736.


L-myo-Inositol 1-phosphate synthase from Entamoeba histolytica.

Lohia A, Hait NC, Majumder AL.

Mol Biochem Parasitol. 1999 Jan 5;98(1):67-79.


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