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Items: 40


Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.

Justin N, Zhang Y, Tarricone C, Martin SR, Chen S, Underwood E, De Marco V, Haire LF, Walker PA, Reinberg D, Wilson JR, Gamblin SJ.

Nat Commun. 2016 Apr 28;7:11316. doi: 10.1038/ncomms11316.


Recent evolution of equine influenza and the origin of canine influenza.

Collins PJ, Vachieri SG, Haire LF, Ogrodowicz RW, Martin SR, Walker PA, Xiong X, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11175-80. doi: 10.1073/pnas.1406606111. Epub 2014 Jul 14.


FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.

Pennell S, Déclais AC, Li J, Haire LF, Berg W, Saldanha JW, Taylor IA, Rouse J, Lilley DM, Smerdon SJ.

Cell Rep. 2014 Jul 10;8(1):84-93. doi: 10.1016/j.celrep.2014.06.001. Epub 2014 Jun 26.


Receptor binding by H10 influenza viruses.

Vachieri SG, Xiong X, Collins PJ, Walker PA, Martin SR, Haire LF, Zhang Y, McCauley JW, Gamblin SJ, Skehel JJ.

Nature. 2014 Jul 24;511(7510):475-7. doi: 10.1038/nature13443.


The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].


Structural basis of AMPK regulation by small molecule activators.

Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ.

Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.


Receptor binding by an H7N9 influenza virus from humans.

Xiong X, Martin SR, Haire LF, Wharton SA, Daniels RS, Bennett MS, McCauley JW, Collins PJ, Walker PA, Skehel JJ, Gamblin SJ.

Nature. 2013 Jul 25;499(7459):496-9. doi: 10.1038/nature12372.


H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

van der Vries E, Collins PJ, Vachieri SG, Xiong X, Liu J, Walker PA, Haire LF, Hay AJ, Schutten M, Osterhaus AD, Martin SR, Boucher CA, Skehel JJ, Gamblin SJ.

PLoS Pathog. 2012 Sep;8(9):e1002914. doi: 10.1371/journal.ppat.1002914. Epub 2012 Sep 20.


Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization.

Stieglitz B, Rittinger K, Haire LF.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):816-9. doi: 10.1107/S1744309112022208. Epub 2012 Jun 28.


Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.

Stieglitz B, Haire LF, Dikic I, Rittinger K.

J Biol Chem. 2012 Jun 15;287(25):20823-9. doi: 10.1074/jbc.M112.359547. Epub 2012 May 1.


The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.

Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, Smerdon SJ.

Nucleic Acids Res. 2012 May;40(9):3913-28. doi: 10.1093/nar/gkr1300. Epub 2012 Jan 10.


HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M.

Nature. 2011 Nov 6;480(7377):379-82. doi: 10.1038/nature10623.


ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, Carling D.

Cell Metab. 2011 Nov 2;14(5):707-14. doi: 10.1016/j.cmet.2011.09.009. Epub 2011 Oct 20.


A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.

Corti D, Voss J, Gamblin SJ, Codoni G, Macagno A, Jarrossay D, Vachieri SG, Pinna D, Minola A, Vanzetta F, Silacci C, Fernandez-Rodriguez BM, Agatic G, Bianchi S, Giacchetto-Sasselli I, Calder L, Sallusto F, Collins P, Haire LF, Temperton N, Langedijk JP, Skehel JJ, Lanzavecchia A.

Science. 2011 Aug 12;333(6044):850-6. doi: 10.1126/science.1205669. Epub 2011 Jul 28.


Structure of mammalian AMPK and its regulation by ADP.

Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ.

Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.


Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface.

Goldstone DC, Yap MW, Robertson LE, Haire LF, Taylor WR, Katzourakis A, Stoye JP, Taylor IA.

Cell Host Microbe. 2010 Sep 16;8(3):248-59. doi: 10.1016/j.chom.2010.08.006.


Structure of the amino-terminal domain from the cell-cycle regulator Swi6.

Taylor IA, Goldstone DC, Pala P, Haire LF, Smerdon SJ.

Proteins. 2010 Oct;78(13):2861-5. doi: 10.1002/prot.22795. No abstract available.


Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

Albesa-Jové D, Bertrand T, Carpenter EP, Swain GV, Lim J, Zhang J, Haire LF, Vasisht N, Braun V, Lange A, von Eichel-Streiber C, Svergun DI, Fairweather NF, Brown KA.

J Mol Biol. 2010 Mar 12;396(5):1260-70. doi: 10.1016/j.jmb.2010.01.012. Epub 2010 Jan 11.


Structural basis for oseltamivir resistance of influenza viruses.

Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Martin SR, Daniels RS, Gregory V, Skehel JJ, Gamblin SJ, Hay AJ.

Vaccine. 2009 Oct 23;27(45):6317-23. doi: 10.1016/j.vaccine.2009.07.017.


Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.

Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17175-80. doi: 10.1073/pnas.0906849106. Epub 2009 Sep 28.


A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.

Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ.

Cell. 2009 Oct 2;139(1):100-11. doi: 10.1016/j.cell.2009.07.043.


Structure of the capsid amino-terminal domain from the betaretrovirus, Jaagsiekte sheep retrovirus.

Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA.

J Mol Biol. 2009 Mar 6;386(4):1179-92. doi: 10.1016/j.jmb.2008.10.066. Epub 2008 Nov 5.


Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants.

Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ.

Nature. 2008 Jun 26;453(7199):1258-61. doi: 10.1038/nature06956. Epub 2008 May 14.


Structure of B-MLV capsid amino-terminal domain reveals key features of viral tropism, gag assembly and core formation.

Mortuza GB, Dodding MP, Goldstone DC, Haire LF, Stoye JP, Taylor IA.

J Mol Biol. 2008 Mar 7;376(5):1493-508. doi: 10.1016/j.jmb.2007.12.043. Epub 2007 Dec 28.


Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.

Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ.

J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1.


Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.

Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y.

Nature. 2006 Nov 16;444(7117):378-82.


The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ.

Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16.


Avian and human receptor binding by hemagglutinins of influenza A viruses.

Russell RJ, Stevens DJ, Haire LF, Gamblin SJ, Skehel JJ.

Glycoconj J. 2006 Feb;23(1-2):85-92.


High-resolution structure of a retroviral capsid hexameric amino-terminal domain.

Mortuza GB, Haire LF, Stevens A, Smerdon SJ, Stoye JP, Taylor IA.

Nature. 2004 Sep 23;431(7007):481-5. Erratum in: Nature. 2004 Oct 21;431(7011):1017.


H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes.

Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ.

Virology. 2004 Aug 1;325(2):287-96.


Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.

Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ.

Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9.


The crystal structure of the globular domain of sheep prion protein.

Haire LF, Whyte SM, Vasisht N, Gill AC, Verma C, Dodson EJ, Dodson GG, Bayley PM.

J Mol Biol. 2004 Mar 5;336(5):1175-83.


The structure and receptor binding properties of the 1918 influenza hemagglutinin.

Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ.

Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5.


The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB.

Cell. 2003 Oct 3;115(1):83-95.


Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.

Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ.

Mol Cell. 2002 May;9(5):1045-54.


Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution.

Gopal B, Haire LF, Gamblin SJ, Dodson EJ, Lane AN, Papavinasasundaram KG, Colston MJ, Dodson G.

J Mol Biol. 2001 Dec 14;314(5):1087-95.


Crystallization and preliminary X-ray diffraction studies on the N-utilizing substance A (NusA) from Mycobacterium tuberculosis.

Gopal B, Papavinasasundaram KG, Colston MJ, Dodson G, Haire LF.

Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1187-8. Epub 2001 Jul 23.


The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.

Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB.

Mol Cell. 2000 Nov;6(5):1169-82.


The crystal structure of NusB from Mycobacterium tuberculosis.

Gopal B, Haire LF, Cox RA, Jo Colston M, Major S, Brannigan JA, Smerdon SJ, Dodson G.

Nat Struct Biol. 2000 Jun;7(6):475-8.


Crystallization and preliminary X-ray diffraction studies on the N-utilizing substance-B (NusB) from Mycobacterium tuberculosis.

Gopal B, Cox RA, Colston MJ, Dodson GG, Smerdon SJ, Haire LF.

Acta Crystallogr D Biol Crystallogr. 2000 Jan;56(Pt 1):64-6.


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