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Items: 1 to 50 of 70

1.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ.

Nat Immunol. 2019 Oct 21. doi: 10.1038/s41590-019-0515-x. [Epub ahead of print]

PMID:
31636464
2.

Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.

Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN.

Nat Immunol. 2019 Oct 3. doi: 10.1038/s41590-019-0528-5. [Epub ahead of print]

PMID:
31582823
3.

Defining 'T cell exhaustion'.

Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D.

Nat Rev Immunol. 2019 Sep 30. doi: 10.1038/s41577-019-0221-9. [Epub ahead of print] Review.

PMID:
31570879
4.

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.

LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, Gillis JE, Sen DR, Gaudiano EF, Al Abosy R, Freeman GJ, Haining WN, Sharpe AH.

Nat Immunol. 2019 Oct;20(10):1335-1347. doi: 10.1038/s41590-019-0480-4. Epub 2019 Sep 16.

PMID:
31527834
5.

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

Netravali IA, Cariappa A, Yates K, Haining WN, Bertocchi A, Allard-Chamard H, Rosenberg I, Pillai S.

Glycobiology. 2019 Aug 14. pii: cwz062. doi: 10.1093/glycob/cwz062. [Epub ahead of print]

PMID:
31411667
6.

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.

LaFleur MW, Nguyen TH, Coxe MA, Yates KB, Trombley JD, Weiss SA, Brown FD, Gillis JE, Coxe DJ, Doench JG, Haining WN, Sharpe AH.

Nat Commun. 2019 Apr 10;10(1):1668. doi: 10.1038/s41467-019-09656-2.

7.

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade.

Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN.

Nat Immunol. 2019 Mar;20(3):326-336. doi: 10.1038/s41590-019-0312-6. Epub 2019 Feb 18. Erratum in: Nat Immunol. 2019 Oct 3;:.

8.

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.

Nature. 2019 Jan;565(7737):43-48. doi: 10.1038/s41586-018-0768-9. Epub 2018 Dec 17.

PMID:
30559380
9.

Publisher Correction: Gene regulation: c-Maf in CD4+ T cells: it's all about context.

Haining WN, Weiss SA.

Nat Immunol. 2018 Oct;19(10):1146. doi: 10.1038/s41590-018-0204-1.

PMID:
30143753
10.

Maintenance of CD4 T cell fitness through regulation of Foxo1.

Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA.

Nat Immunol. 2018 Aug;19(8):838-848. doi: 10.1038/s41590-018-0157-4. Epub 2018 Jul 9.

11.

c-Maf in CD4+ T cells: it's all about context.

Haining WN, Weiss SA.

Nat Immunol. 2018 May;19(5):429-431. doi: 10.1038/s41590-018-0087-1. No abstract available. Erratum in: Nat Immunol. 2018 Oct;19(10):1146.

PMID:
29670237
12.

Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells.

Yates K, Bi K, Haining WN, Cantor H, Kim HJ.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2162-2167. doi: 10.1073/pnas.1720447115. Epub 2018 Feb 9.

13.

Pooled in vivo screens for cancer immunotherapy target discovery.

Lane-Reticker SK, Manguso RT, Haining WN.

Immunotherapy. 2018 Mar;10(3):167-170. doi: 10.2217/imt-2017-0164. No abstract available.

PMID:
29370725
14.

Origin and differentiation of human memory CD8 T cells after vaccination.

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R.

Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13.

15.

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.

Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK.

Cancer Discov. 2018 Feb;8(2):216-233. doi: 10.1158/2159-8290.CD-17-0915. Epub 2017 Nov 3.

16.

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection.

Wolski D, Foote PK, Chen DY, Lewis-Ximenez LL, Fauvelle C, Aneja J, Walker A, Tonnerre P, Torres-Cornejo A, Kvistad D, Imam S, Waring MT, Tully DC, Allen TM, Chung RT, Timm J, Haining WN, Kim AY, Baumert TF, Lauer GM.

Immunity. 2017 Oct 17;47(4):648-663.e8. doi: 10.1016/j.immuni.2017.09.006.

17.

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state.

Afik S, Yates KB, Bi K, Darko S, Godec J, Gerdemann U, Swadling L, Douek DC, Klenerman P, Barnes EJ, Sharpe AH, Haining WN, Yosef N.

Nucleic Acids Res. 2017 Sep 19;45(16):e148. doi: 10.1093/nar/gkx615.

18.

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN.

Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19.

19.

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P.

Nature. 2017 Jun 15;546(7658):426-430. doi: 10.1038/nature22797. Epub 2017 Jun 7.

20.

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

Juneja VR, McGuire KA, Manguso RT, LaFleur MW, Collins N, Haining WN, Freeman GJ, Sharpe AH.

J Exp Med. 2017 Apr 3;214(4):895-904. doi: 10.1084/jem.20160801. Epub 2017 Mar 16.

21.

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F.

Nat Immunol. 2017 Feb;18(2):184-195. doi: 10.1038/ni.3644. Epub 2016 Dec 19.

22.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.

Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3.

23.

The epigenetic landscape of T cell exhaustion.

Sen DR, Kaminski J, Barnitz RA, Kurachi M, Gerdemann U, Yates KB, Tsao HW, Godec J, LaFleur MW, Brown FD, Tonnerre P, Chung RT, Tully DC, Allen TM, Frahm N, Lauer GM, Wherry EJ, Yosef N, Haining WN.

Science. 2016 Dec 2;354(6316):1165-1169. Epub 2016 Oct 27.

24.

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.

Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ.

Science. 2016 Dec 2;354(6316):1160-1165. Epub 2016 Oct 27.

25.

Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.

Provine NM, Larocca RA, Aid M, Penaloza-MacMaster P, Badamchi-Zadeh A, Borducchi EN, Yates KB, Abbink P, Kirilova M, Ng'ang'a D, Bramson J, Haining WN, Barouch DH.

J Immunol. 2016 Sep 1;197(5):1809-22. doi: 10.4049/jimmunol.1600591. Epub 2016 Jul 22.

26.

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.

Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW.

Cell Host Microbe. 2016 May 11;19(5):713-9. doi: 10.1016/j.chom.2016.04.003. Epub 2016 Apr 20.

27.

Normalizing the environment recapitulates adult human immune traits in laboratory mice.

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.

Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.

28.

Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation.

Godec J, Tan Y, Liberzon A, Tamayo P, Bhattacharya S, Butte AJ, Mesirov JP, Haining WN.

Immunity. 2016 Jan 19;44(1):194-206. doi: 10.1016/j.immuni.2015.12.006. Epub 2016 Jan 12.

29.

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.

Pesenacker AM, Wang AY, Singh A, Gillies J, Kim Y, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK.

Diabetes. 2016 Apr;65(4):1031-9. doi: 10.2337/db15-0572. Epub 2016 Jan 19.

30.

Constellation Map: Downstream visualization and interpretation of gene set enrichment results.

Tan Y, Wu F, Tamayo P, Haining WN, Mesirov JP.

F1000Res. 2015 Jun 24;4:167. doi: 10.12688/f1000research.6644.1. eCollection 2015.

31.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN.

PLoS Pathog. 2015 Oct 20;11(10):e1005177. doi: 10.1371/journal.ppat.1005177. eCollection 2015 Oct.

32.

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.

Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H.

Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616.

33.

Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection.

Plumlee CR, Obar JJ, Colpitts SL, Jellison ER, Haining WN, Lefrancois L, Khanna KM.

Sci Rep. 2015 Jul 20;5:12264. doi: 10.1038/srep12264.

34.

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.

Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH.

Science. 2015 Jan 16;347(6219):278-82. doi: 10.1126/science.aaa2148.

35.

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.

Godec J, Cowley GS, Barnitz RA, Alkan O, Root DE, Sharpe AH, Haining WN.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):512-7. doi: 10.1073/pnas.1413291112. Epub 2014 Dec 29. Erratum in: Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4968. Alkan, Ozan [added].

36.

Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, Wherry EJ.

Immunity. 2014 May 15;40(5):801-13. doi: 10.1016/j.immuni.2014.04.010.

37.

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.

Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, Yates K, Godec J, Klatt MG, Regev A, Wherry EJ, Haining WN.

Nat Immunol. 2014 Apr;15(4):373-83. doi: 10.1038/ni.2834. Epub 2014 Mar 2.

38.

Strength in numbers: comparing vaccine signatures the modular way.

Haining WN.

Nat Immunol. 2014 Feb;15(2):139-41. doi: 10.1038/ni.2807. No abstract available.

PMID:
24448573
39.

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.

Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Zhang W, Liao X, Hodi FS, O'Connell K, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, Alyea EP 3rd, Kim HT, Wu CJ.

Blood. 2014 Feb 27;123(9):1412-21. doi: 10.1182/blood-2013-08-523001. Epub 2013 Dec 19.

40.

Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response.

Tan Y, Tamayo P, Nakaya H, Pulendran B, Mesirov JP, Haining WN.

Eur J Immunol. 2014 Jan;44(1):285-95. doi: 10.1002/eji.201343657. Epub 2013 Nov 29.

41.

Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions.

Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH.

Immunity. 2013 Sep 19;39(3):496-507. doi: 10.1016/j.immuni.2013.08.034.

42.

Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis.

Barnitz RA, Imam S, Yates K, Haining WN.

Methods Mol Biol. 2013;979:161-73. doi: 10.1007/978-1-62703-290-2_13.

PMID:
23397395
43.

Viewing transplantation immunology through today's lens: new models, new imaging, and new insights.

Huang AY, Haining WN, Barkauskas DS, Myers JT, Petrosiute A, Garrett AP, Singh K, Cooke KR, Kean LS.

Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S44-51. doi: 10.1016/j.bbmt.2012.10.020. Epub 2012 Oct 22. Review. No abstract available.

44.

Thinking inside the box: how T cell inhibitory receptors signal.

Haining WN.

Nat Med. 2012 Sep;18(9):1338-9. doi: 10.1038/nm.2921. No abstract available.

PMID:
22961161
45.

CD28 costimulation regulates genome-wide effects on alternative splicing.

Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH.

PLoS One. 2012;7(6):e40032. doi: 10.1371/journal.pone.0040032. Epub 2012 Jun 29.

46.

Identifying gnostic predictors of the vaccine response.

Haining WN, Pulendran B.

Curr Opin Immunol. 2012 Jun;24(3):332-6. doi: 10.1016/j.coi.2012.03.010. Epub 2012 May 26. Review.

47.

Travels in time: assessing the functional complexity of T cells.

Haining WN.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1359-60. doi: 10.1073/pnas.1119856109. Epub 2012 Jan 20. No abstract available.

48.

The numerology of T cell functional diversity.

Haining WN.

Immunity. 2012 Jan 27;36(1):10-2. doi: 10.1016/j.immuni.2012.01.006.

49.

Deconvolving heterogeneity in the CD8+ T-cell response to HIV.

Haining WN, Barnitz RA.

Curr Opin HIV AIDS. 2012 Jan;7(1):38-43. doi: 10.1097/COH.0b013e32834dde1c. Review.

50.

Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.

West EE, Youngblood B, Tan WG, Jin HT, Araki K, Alexe G, Konieczny BT, Calpe S, Freeman GJ, Terhorst C, Haining WN, Ahmed R.

Immunity. 2011 Aug 26;35(2):285-98. doi: 10.1016/j.immuni.2011.05.017.

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