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Items: 28

1.

Development of a Competition-Binding Assay to Determine Binding Affinity of Molecules to Neuromelanin via Fluorescence Spectroscopy.

Fink J, Pathak H, Smith J, Achat-Mendes C, Haining RL.

Biomolecules. 2019 May 8;9(5). pii: E175. doi: 10.3390/biom9050175.

2.

Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator.

Haining RL, Achat-Mendes C.

Neural Regen Res. 2017 Mar;12(3):372-375. doi: 10.4103/1673-5374.202928. Review.

3.

Saturation Binding of Nicotine to Synthetic Neuromelanin Demonstrated by Fluorescence Spectroscopy.

Haining RL, Jones TM, Hernandez A.

Neurochem Res. 2016 Dec;41(12):3356-3363. Epub 2016 Sep 23.

PMID:
27662849
4.

Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes.

Zhang WY, Tu YB, Haining RL, Yu AM.

Drug Metab Dispos. 2009 Jan;37(1):1-4. doi: 10.1124/dmd.108.023663. Epub 2008 Oct 6.

5.

Cytochrome P450-catalyzed pathways in human brain: metabolism meets pharmacology or old drugs with new mechanism of action?

Haining RL, Nichols-Haining M.

Pharmacol Ther. 2007 Mar;113(3):537-45. Epub 2006 Dec 20. Review.

PMID:
17270273
6.

Expression, purification, and characterization of mouse CYP2d22.

Yu AM, Haining RL.

Drug Metab Dispos. 2006 Jul;34(7):1167-74. Epub 2006 Apr 4.

PMID:
16595712
7.

The human intestinal cytochrome P450 "pie".

Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC.

Drug Metab Dispos. 2006 May;34(5):880-6. Epub 2006 Feb 7.

8.

CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin.

Bland TM, Haining RL, Tracy TS, Callery PS.

Biochem Pharmacol. 2005 Oct 1;70(7):1096-103.

PMID:
16112652
9.

Differential activation of CYP2C9 variants by dapsone.

Hummel MA, Dickmann LJ, Rettie AE, Haining RL, Tracy TS.

Biochem Pharmacol. 2004 May 15;67(10):1831-41.

PMID:
15130760
10.

The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.

Yu AM, Granvil CP, Haining RL, Krausz KW, Corchero J, Küpfer A, Idle JR, Gonzalez FJ.

J Pharmacol Exp Ther. 2003 Feb;304(2):539-46.

PMID:
12538805
11.
12.

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

Ramamoorthy Y, Yu AM, Suh N, Haining RL, Tyndale RF, Sellers EM.

Biochem Pharmacol. 2002 Jun 15;63(12):2111-9.

PMID:
12110370
13.

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.

Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmann LJ.

Drug Metab Dispos. 2002 Apr;30(4):385-90.

PMID:
11901091
14.

(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.

Suzuki H, Kneller MB, Haining RL, Trager WF, Rettie AE.

Drug Metab Dispos. 2002 Mar;30(3):235-9.

PMID:
11854139
15.
17.

Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.

Yu A, Dong H, Lang D, Haining RL.

Drug Metab Dispos. 2001 Nov;29(11):1362-5.

PMID:
11602510
18.

Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.

Kilicarslan T, Haining RL, Rettie AE, Busto U, Tyndale RF, Sellers EM.

Drug Metab Dispos. 2001 Apr;29(4 Pt 1):460-5.

PMID:
11259331
19.

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.

Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD.

Drug Metab Dispos. 2000 Dec;28(12):1397-400.

PMID:
11095574
20.

A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.

Rettie AE, Haining RL, Bajpai M, Levy RH.

Epilepsy Res. 1999 Jul;35(3):253-5.

PMID:
10413320
21.

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.

Biochemistry. 1999 Mar 16;38(11):3285-92.

PMID:
10079071
22.

Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9.

Koenigs LL, Peter RM, Hunter AP, Haining RL, Rettie AE, Friedberg T, Pritchard MP, Shou M, Rushmore TH, Trager WF.

Biochemistry. 1999 Feb 23;38(8):2312-9.

PMID:
10029524
23.

Genetic association between sensitivity to warfarin and expression of CYP2C9*3.

Steward DJ, Haining RL, Henne KR, Davis G, Rushmore TH, Trager WF, Rettie AE.

Pharmacogenetics. 1997 Oct;7(5):361-7.

PMID:
9352571
24.

Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization.

Haining RL, Hunter AP, Sadeque AJ, Philpot RM, Rettie AE.

Drug Metab Dispos. 1997 Jul;25(7):790-7.

PMID:
9224773
25.

N-oxygenation of clozapine by flavin-containing monooxygenase.

Tugnait M, Hawes EM, McKay G, Rettie AE, Haining RL, Midha KK.

Drug Metab Dispos. 1997 Apr;25(4):524-7.

PMID:
9107553
27.

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