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Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.

Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B.

J Clin Invest. 2018 Jul 2;128(7):2927-2943. doi: 10.1172/JCI120481. Epub 2018 Jun 4.


NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27Kip1 expression in malignant melanoma and other human tumors.

Antony S, Jiang G, Wu Y, Meitzler JL, Makhlouf HR, Haines DC, Butcher D, Hoon DS, Ji J, Zhang Y, Juhasz A, Lu J, Liu H, Dahan I, Konate M, Roy KK, Doroshow JH.

Mol Carcinog. 2017 Dec;56(12):2643-2662. doi: 10.1002/mc.22708. Epub 2017 Aug 30.


Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.

Yang Y, Yang HH, Hu Y, Watson PH, Liu H, Geiger TR, Anver MR, Haines DC, Martin P, Green JE, Lee MP, Hunter KW, Wakefield LM.

Oncotarget. 2017 May 9;8(19):30621-30643. doi: 10.18632/oncotarget.15695.


NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.

Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, Wu X, Antony S, Wu Y, Melillo G, Meitzler JL, Haines DC, Butcher D, Roy K, Doroshow JH.

J Biol Chem. 2017 May 12;292(19):7866-7887. doi: 10.1074/jbc.M116.768283. Epub 2017 Mar 22.


RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice.

Song Y, Sullivan T, Klarmann K, Gilbert D, O'Sullivan TN, Lu L, Wang S, Haines DC, Van Dyke T, Keller JR.

PLoS One. 2017 Feb 3;12(2):e0171510. doi: 10.1371/journal.pone.0171510. eCollection 2017.


H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.

Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ, Kawahara T, Isono Y, Makiyama K, Warner AC, Haines DC, Wei MH, Zbar B, Hagenau H, Feigenbaum L, Kondo K, Nakaigawa N, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS.

Hum Mol Genet. 2017 Jan 15;26(2):354-366. doi: 10.1093/hmg/ddw392.


Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A.

Wu Y, Meitzler JL, Antony S, Juhasz A, Lu J, Jiang G, Liu H, Hollingshead M, Haines DC, Butcher D, Panter MS, Roy K, Doroshow JH.

Oncotarget. 2016 Oct 18;7(42):68412-68433. doi: 10.18632/oncotarget.12032.


Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.

Hartford SA, Chittela R, Ding X, Vyas A, Martin B, Burkett S, Haines DC, Southon E, Tessarollo L, Sharan SK.

PLoS Genet. 2016 Aug 4;12(8):e1006236. doi: 10.1371/journal.pgen.1006236. eCollection 2016 Aug.


BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.

Thirthagiri E, Klarmann KD, Shukla AK, Southon E, Biswas K, Martin BK, North SL, Magidson V, Burkett S, Haines DC, Noer K, Matthai R, Tessarollo L, Loncarek J, Keller JR, Sharan SK.

Hum Mol Genet. 2016 May 15;25(10):1934-1945. Epub 2016 Feb 26.


Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration.

Kim S, Song JH, Kim S, Qu P, Martin BK, Sehareen WS, Haines DC, Lin PC, Sharan SK, Chang S.

Oncotarget. 2016 Mar 8;7(10):11094-112. doi: 10.18632/oncotarget.7150.


An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers.

Prueitt RL, Wallace TA, Glynn SA, Yi M, Tang W, Luo J, Dorsey TH, Stagliano KE, Gillespie JW, Hudson RS, Terunuma A, Shoe JL, Haines DC, Yfantis HG, Han M, Martin DN, Jordan SV, Borin JF, Naslund MJ, Alexander RB, Stephens RM, Loffredo CA, Lee DH, Putluri N, Sreekumar A, Hurwitz AA, Ambs S.

Cancer Res. 2016 Mar 1;76(5):1055-1065. doi: 10.1158/0008-5472.CAN-14-3630. Epub 2015 Dec 30.


C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4.

Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quiñones OA, Johnson PF.

Mol Cell Biol. 2015 Dec 14;36(5):693-713. doi: 10.1128/MCB.00911-15.


Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.

Hasumi H, Baba M, Hasumi Y, Lang M, Huang Y, Oh HF, Matsuo M, Merino MJ, Yao M, Ito Y, Furuya M, Iribe Y, Kodama T, Southon E, Tessarollo L, Nagashima K, Haines DC, Linehan WM, Schmidt LS.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1624-31. doi: 10.1073/pnas.1419502112. Epub 2015 Mar 16.


COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models.

Xu L, Stevens J, Hilton MB, Seaman S, Conrads TP, Veenstra TD, Logsdon D, Morris H, Swing DA, Patel NL, Kalen J, Haines DC, Zudaire E, St Croix B.

Sci Transl Med. 2014 Jun 25;6(242):242ra84. doi: 10.1126/scitranslmed.3008455.


Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.

Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J, Marston Linehan W.

Hum Mol Genet. 2014 Nov 1;23(21):5706-19. doi: 10.1093/hmg/ddu286. Epub 2014 Jun 6.


Longitudinal imaging of cancer cell metastases in two preclinical models: a correlation of noninvasive imaging to histopathology.

Adiseshaiah PP, Patel NL, Ileva LV, Kalen JD, Haines DC, McNeil SE.

Int J Mol Imaging. 2014;2014:102702. doi: 10.1155/2014/102702. Epub 2014 Mar 3.


Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues.

Song Y, Gilbert D, O'Sullivan TN, Yang C, Pan W, Fathalizadeh A, Lu L, Haines DC, Martin PL, Van Dyke T.

PLoS One. 2013 Dec 2;8(12):e80459. doi: 10.1371/journal.pone.0080459. eCollection 2013.


Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.

Postnikov YV, Furusawa T, Haines DC, Factor VM, Bustin M.

Mol Cancer Res. 2014 Jan;12(1):82-90. doi: 10.1158/1541-7786.MCR-13-0392. Epub 2013 Dec 2.


Magnetic resonance imaging (MRI)-guided transurethral ultrasound therapy of the prostate: a preclinical study with radiological and pathological correlation using customised MRI-based moulds.

Partanen A, Yerram NK, Trivedi H, Dreher MR, Oila J, Hoang AN, Volkin D, Nix J, Turkbey B, Bernardo M, Haines DC, Benjamin CJ, Linehan WM, Choyke P, Wood BJ, Ehnholm GJ, Venkatesan AM, Pinto PA.

BJU Int. 2013 Aug;112(4):508-16. doi: 10.1111/bju.12126. Epub 2013 Jun 7.


Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B.

Cell Rep. 2013 May 30;3(5):1457-64. doi: 10.1016/j.celrep.2013.04.019. Epub 2013 May 16.


Aluminum-substituted heme domain of P450BM-3 (BMP): introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450.

Davydov DR, Ponomarev GV, Bobrovnikova-Marjon E, Haines DC, Peterson JA.

Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):41-51. doi: 10.1002/bab.1085.


Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines.

Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, Meitzler JL, Hollingshead M, Haines DC, Butcher D, Roy K, Doroshow JH.

J Immunol. 2013 Feb 15;190(4):1859-72. doi: 10.4049/jimmunol.1201725. Epub 2013 Jan 7.


The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy.

Kinjo T, Tomaru K, Haines DC, Klinman DM.

Respir Res. 2012 Jun 18;13:47. doi: 10.1186/1465-9921-13-47.


Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling.

De Matteis F, Ballou DP, Coon MJ, Estabrook RW, Haines DC.

Biochem Pharmacol. 2012 Aug 1;84(3):374-82. doi: 10.1016/j.bcp.2012.04.016. Epub 2012 Apr 28.


TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.

Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, Tschantz WR, Zhang XM, Saha S, Fleming T, St Croix B.

Cancer Cell. 2012 Feb 14;21(2):212-26. doi: 10.1016/j.ccr.2012.01.004.


Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.

Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK.

Nat Med. 2011 Sep 25;17(10):1275-82. doi: 10.1038/nm.2459. Erratum in: Nat Med. 2011 Nov;17(11):1521. Nat Med. 2011 Oct;17(10):2 p following 1282.


A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation.

Haines DC, Hegde A, Chen B, Zhao W, Bondlela M, Humphreys JM, Mullin DA, Tomchick DR, Machius M, Peterson JA.

Biochemistry. 2011 Oct 4;50(39):8333-41. doi: 10.1021/bi201099j. Epub 2011 Sep 6.


Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD(50) yields insight into the efficacy of prophylactics.

Marziaz ML, Frazier K, Guidry PB, Ruiz RA, Petrikovics I, Haines DC.

J Appl Toxicol. 2013 Jan;33(1):50-5. doi: 10.1002/jat.1709. Epub 2011 Jul 13.


GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64. doi: 10.1073/pnas.1017192108. Epub 2011 Mar 18.


Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin.

Horke S, Witte I, Altenhöfer S, Wilgenbus P, Goldeck M, Förstermann U, Xiao J, Kramer GL, Haines DC, Chowdhary PK, Haley RW, Teiber JF.

Biochem J. 2010 Jan 27;426(1):73-83. doi: 10.1042/BJ20091414.


Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.

Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7. doi: 10.1073/pnas.0908853106. Epub 2009 Oct 22.


Host-derived tumor endothelial marker 8 promotes the growth of melanoma.

Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, Haines DC, Tessarollo L, St Croix B.

Cancer Res. 2009 Aug 1;69(15):6021-6. doi: 10.1158/0008-5472.CAN-09-1086. Epub 2009 Jul 21.


Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer.

Colbert LH, Westerlind KC, Perkins SN, Haines DC, Berrigan D, Donehower LA, Fuchs-Young R, Hursting SD.

Med Sci Sports Exerc. 2009 Aug;41(8):1597-605. doi: 10.1249/MSS.0b013e31819f1f05.


Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice.

Hursting SD, Perkins SN, Lavigne JA, Beltran L, Haines DC, Hill HL, Alvord WG, Barrett JC, DiGiovanni J.

Mol Carcinog. 2009 Aug;48(8):671-7. doi: 10.1002/mc.20548.


Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.

Kuznetsov SG, Haines DC, Martin BK, Sharan SK.

Cancer Res. 2009 Feb 1;69(3):863-72. doi: 10.1158/0008-5472.CAN-08-3057. Epub 2009 Jan 20.


Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

Philip S, Swaminathan S, Kuznetsov SG, Kanugula S, Biswas K, Chang S, Loktionova NA, Haines DC, Kaldis P, Pegg AE, Sharan SK.

Cancer Res. 2008 Dec 1;68(23):9973-81. doi: 10.1158/0008-5472.CAN-08-1179.


A single mutation in P450BM-3 enhances acyl homoserine lactone: acyl homoserine substrate binding selectivity nearly 250-fold.

Chowdhary PK, Stewart L, Lopez C, Haines DC.

J Biotechnol. 2008 Jul 31;135(4):374-6. doi: 10.1016/j.jbiotec.2008.05.005. Epub 2008 May 20.


Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone.

Teiber JF, Horke S, Haines DC, Chowdhary PK, Xiao J, Kramer GL, Haley RW, Draganov DI.

Infect Immun. 2008 Jun;76(6):2512-9. doi: 10.1128/IAI.01606-07. Epub 2008 Mar 17.


Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.

Haines DC, Chen B, Tomchick DR, Bondlela M, Hegde A, Machius M, Peterson JA.

Biochemistry. 2008 Mar 25;47(12):3662-70. doi: 10.1021/bi7023964. Epub 2008 Feb 26.


Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.

Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS.

J Natl Cancer Inst. 2008 Jan 16;100(2):140-54. doi: 10.1093/jnci/djm288. Epub 2008 Jan 8.


Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines.

Chowdhary PK, Keshavan N, Nguyen HQ, Peterson JA, González JE, Haines DC.

Biochemistry. 2007 Dec 18;46(50):14429-37. Epub 2007 Nov 20.


Interactions of substrates at the surface of P450s can greatly enhance substrate potency.

Hegde A, Haines DC, Bondlela M, Chen B, Schaffer N, Tomchick DR, Machius M, Nguyen H, Chowdhary PK, Stewart L, Lopez C, Peterson JA.

Biochemistry. 2007 Dec 11;46(49):14010-7. Epub 2007 Nov 16.


Cloning, expression and characterization of a fast self-sufficient P450: CYP102A5 from Bacillus cereus.

Chowdhary PK, Alemseghed M, Haines DC.

Arch Biochem Biophys. 2007 Dec 1;468(1):32-43. Epub 2007 Sep 19.


Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3.

Kitazume T, Haines DC, Estabrook RW, Chen B, Peterson JA.

Biochemistry. 2007 Oct 23;46(42):11892-901. Epub 2007 Sep 29.


Itch genetically interacts with Notch1 in a mouse autoimmune disease model.

Matesic LE, Haines DC, Copeland NG, Jenkins NA.

Hum Mol Genet. 2006 Dec 15;15(24):3485-97. Epub 2006 Nov 9.


L-Canavanine made by Medicago sativa interferes with quorum sensing in Sinorhizobium meliloti.

Keshavan ND, Chowdhary PK, Haines DC, González JE.

J Bacteriol. 2005 Dec;187(24):8427-36.


Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.

Birger Y, Catez F, Furusawa T, Lim JH, Prymakowska-Bosak M, West KL, Postnikov YV, Haines DC, Bustin M.

Cancer Res. 2005 Aug 1;65(15):6711-8.


Modulation of zinc- and cobalt-binding affinities through changes in the stability of the zinc ribbon protein L36.

Kou W, Kolla HS, Ortiz-Acevedo A, Haines DC, Junker M, Dieckmann GR.

J Biol Inorg Chem. 2005 Mar;10(2):167-80. Epub 2005 Mar 4.


Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium.

Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T.

Cancer Res. 2004 Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725.

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