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Nephrotic syndrome without kidney injury revealing intravascular large B cell lymphoma.

Pothen L, Aydin S, Camboni A, Hainaut P.

BMJ Case Rep. 2019 Jun 12;12(6). pii: e229359. doi: 10.1136/bcr-2019-229359.


Pulmonary Edema: Consider an Unusual Suspect.

Jopart C, Hainaut P, Ghaye B.

J Belg Soc Radiol. 2019 May 15;103(1):33. doi: 10.5334/jbsr.1819. No abstract available.


Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculosis drugs: Two case reports and a review of the literature.

Coster A, Aerts O, Herman A, Marot L, Horst N, Kenyon C, Vlieghe E, Hainaut P, Baeck M.

Contact Dermatitis. 2019 Apr 25. doi: 10.1111/cod.13296. [Epub ahead of print]


Response to: Concern regarding classification of germlineTP53 variants as likely pathogenic.

de Andrade KC, Frone MN, Wegman-Ostrosky T, Khincha PP, Kim J, Amadou A, Santiago KM, Fortes FP, Lemonnier N, Mirabello L, Stewart DR, Hainaut P, Kowalski LP, Savage SA, Achatz MI.

Hum Mutat. 2019 Jun;40(6):832-833. doi: 10.1002/humu.23749. Epub 2019 Apr 18. No abstract available.


Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome.

Tak CR, Biltaji E, Kohlmann W, Maese L, Hainaut P, Villani A, Malkin D, Sherwin CMT, Brixner DI, Schiffman JD.

Pediatr Blood Cancer. 2019 May;66(5):e27629. doi: 10.1002/pbc.27629. Epub 2019 Feb 4.


p53, stem cell biology and childhood blastomas.

Oh L, Hafsi H, Hainaut P, Ariffin H.

Curr Opin Oncol. 2019 Mar;31(2):84-91. doi: 10.1097/CCO.0000000000000504.


Variable population prevalence estimates of germline TP53 variants: A gnomAD-based analysis.

de Andrade KC, Frone MN, Wegman-Ostrosky T, Khincha PP, Kim J, Amadou A, Santiago KM, Fortes FP, Lemonnier N, Mirabello L, Stewart DR, Hainaut P, Kowalski LP, Savage SA, Achatz MI.

Hum Mutat. 2019 Jan;40(1):97-105. doi: 10.1002/humu.23673. Epub 2018 Nov 19.


Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms.

Mazein A, Ostaszewski M, Kuperstein I, Watterson S, Le Novère N, Lefaudeux D, De Meulder B, Pellet J, Balaur I, Saqi M, Nogueira MM, He F, Parton A, Lemonnier N, Gawron P, Gebel S, Hainaut P, Ollert M, Dogrusoz U, Barillot E, Zinovyev A, Schneider R, Balling R, Auffray C.

NPJ Syst Biol Appl. 2018 Jun 2;4:21. doi: 10.1038/s41540-018-0059-y. eCollection 2018.


Correction to: Design and rationale of the non-interventional, edoxaban treatment in routiNe clinical prActice in patients with venous ThromboEmbolism in Europe (ETNA-VTE-Europe) study.

Cohen AT, Ay C, Hainaut P, Décousus H, Hoffmann U, Gaine S, Coppens M, da Silva PM, Jimenez D, Amann-Vesti B, Brüggenjürgen B, Levy P, Bastida JL, Vicaut E, Laeis P, Fronk EM, Zierhut W, Malzer T, Bramlage P, Agnelli G; ETNA-VTE-Europe investigators.

Thromb J. 2018 May 31;16:18. doi: 10.1186/s12959-018-0173-5. eCollection 2018.


Design and rationale of the non-interventional, edoxaban treatment in routiNe clinical prActice in patients with venous ThromboEmbolism in Europe (ETNA-VTE-Europe) study.

Cohen AT, Ay C, Hainaut P, Décousus H, Hoffmann U, Gaine S, Coppens M, da Silva PM, Castro DJ, Amann-Vesti B, Brüggenjürgen B, Levy P, Bastida JL, Vicaut E, Laeis P, Fronk EM, Zierhut W, Malzer T, Bramlage P, Agnelli G; ETNA-VTE-Europe investigators.

Thromb J. 2018 May 1;16:9. doi: 10.1186/s12959-018-0163-7. eCollection 2018. Erratum in: Thromb J. 2018 May 31;16:18.


Pulmonary Tumor Microembolism: When the Pathologist Looks Further Than the Radiologist.

De Greef J, Hainaut P.

Am J Med. 2018 Aug;131(8):e323. doi: 10.1016/j.amjmed.2018.03.007. Epub 2018 Mar 27. No abstract available.


Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma.

Jilkova ZM, Kuyucu AZ, Kurma K, Ahmad Pour ST, Roth GS, Abbadessa G, Yu Y, Schwartz B, Sturm N, Marche PN, Hainaut P, Decaens T.

Oncotarget. 2018 Jan 23;9(13):11145-11158. doi: 10.18632/oncotarget.24298. eCollection 2018 Feb 16.


ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer.

McLeer-Florin A, Duruisseaux M, Pinsolle J, Dubourd S, Mondet J, Phillips Houlbracq M, Magnat N, Fauré J, Chatagnon A, de Fraipont F, Giaj Levra M, Toffart AC, Ferretti G, Hainaut P, Brambilla E, Moro-Sibilot D, Lantuejoul S.

Lung Cancer. 2018 Feb;116:15-24. doi: 10.1016/j.lungcan.2017.12.004. Epub 2017 Dec 8.


Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome.

Amadou A, Waddington Achatz MI, Hainaut P.

Curr Opin Oncol. 2018 Jan;30(1):23-29. doi: 10.1097/CCO.0000000000000423. Review. Erratum in: Curr Opin Oncol. 2019 Jan;31(1):52.


Training the Next Generation of Biobankers: A Two-Year Master's Course in the Management of Biobanks.

Gormally E, Hardy I, Caboux E, di Donato JH, Hainaut P, Hofman P.

Biopreserv Biobank. 2017 Oct;15(5):438-450. doi: 10.1089/bio.2017.0002. Epub 2017 Sep 18.


Higher-than-expected population prevalence of potentially pathogenic germline TP53 variants in individuals unselected for cancer history.

de Andrade KC, Mirabello L, Stewart DR, Karlins E, Koster R, Wang M, Gapstur SM, Gaudet MM, Freedman ND, Landi MT, Lemonnier N, Hainaut P, Savage SA, Achatz MI.

Hum Mutat. 2017 Dec;38(12):1723-1730. doi: 10.1002/humu.23320. Epub 2017 Sep 21.


Cancer Diagnostic and Predictive Biomarkers 2016.

Buonaguro FM, Pauza CD, Tornesello ML, Hainaut P, Franco R, Tommasino M.

Biomed Res Int. 2017;2017:7362721. doi: 10.1155/2017/7362721. Epub 2017 Jun 18. No abstract available.


Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.

Ariffin H, Azanan MS, Abd Ghafar SS, Oh L, Lau KH, Thirunavakarasu T, Sedan A, Ibrahim K, Chan A, Chin TF, Liew FF, Jeyamogan S, Rosli ES, Baharudin R, Yap TY, Skinner R, Lum SH, Hainaut P.

Cancer. 2017 Nov 1;123(21):4207-4214. doi: 10.1002/cncr.30857. Epub 2017 Jun 27.


Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications.

Busser B, Lupo J, Sancey L, Mouret S, Faure P, Plumas J, Chaperot L, Leccia MT, Coll JL, Hurbin A, Hainaut P, Charles J.

Biomed Res Int. 2017;2017:5986129. doi: 10.1155/2017/5986129. Epub 2017 Apr 6. Review.


Mutant p53 targeting by the low molecular weight compound STIMA-1.

Zache N, Lambert JMR, Rökaeus N, Shen J, Hainaut P, Bergman J, Wiman KG, Bykov VJN.

Mol Oncol. 2017 May;11(5):595. doi: 10.1002/1878-0261.12065. No abstract available.


Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy.

Shepherd FA, Lacas B, Le Teuff G, Hainaut P, Jänne PA, Pignon JP, Le Chevalier T, Seymour L, Douillard JY, Graziano S, Brambilla E, Pirker R, Filipits M, Kratzke R, Soria JC, Tsao MS; LACE-Bio Collaborative Group.

J Clin Oncol. 2017 Jun 20;35(18):2018-2027. doi: 10.1200/JCO.2016.71.2893. Epub 2017 Apr 28.


Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma.

Holmila R, Sklias A, Muller DC, Degli Esposti D, Guilloreau P, Mckay J, Sangrajrang S, Srivatanakul P, Hainaut P, Merle P, Herceg Z, Nogueira da Costa A.

PLoS One. 2017 Mar 23;12(3):e0174265. doi: 10.1371/journal.pone.0174265. eCollection 2017.


Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.

Leroy B, Ballinger ML, Baran-Marszak F, Bond GL, Braithwaite A, Concin N, Donehower LA, El-Deiry WS, Fenaux P, Gaidano G, Langerød A, Hellstrom-Lindberg E, Iggo R, Lehmann-Che J, Mai PL, Malkin D, Moll UM, Myers JN, Nichols KE, Pospisilova S, Ashton-Prolla P, Rossi D, Savage SA, Strong LC, Tonin PN, Zeillinger R, Zenz T, Fraumeni JF Jr, Taschner PE, Hainaut P, Soussi T.

Cancer Res. 2017 Mar 15;77(6):1250-1260. doi: 10.1158/0008-5472.CAN-16-2179. Review.


PD-L1 protein expression assessed by immunohistochemistry is neither prognostic nor predictive of benefit from adjuvant chemotherapy in resected non-small cell lung cancer.

Tsao MS, Le Teuff G, Shepherd FA, Landais C, Hainaut P, Filipits M, Pirker R, Le Chevalier T, Graziano S, Kratze R, Soria JC, Pignon JP, Seymour L, Brambilla E.

Ann Oncol. 2017 Apr 1;28(4):882-889. doi: 10.1093/annonc/mdx003.


More chinks in the armor of cancer: potential for new therapies.

Hainaut P, Plymoth A.

Curr Opin Oncol. 2017 Jan;29(1):33-34. No abstract available.


Somatic TP53 Mutations in the Era of Genome Sequencing.

Hainaut P, Pfeifer GP.

Cold Spring Harb Perspect Med. 2016 Nov 1;6(11). pii: a026179. doi: 10.1101/cshperspect.a026179. Review.


The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.

Levine AJ, Puzio-Kuter AM, Chan CS, Hainaut P.

Cold Spring Harb Perspect Med. 2016 Sep 1;6(9). pii: a026153. doi: 10.1101/cshperspect.a026153. Review.


Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population.

Duarte-Salles T, Misra S, Stepien M, Plymoth A, Muller D, Overvad K, Olsen A, Tjønneland A, Baglietto L, Severi G, Boutron-Ruault MC, Turzanski-Fortner R, Kaaks R, Boeing H, Aleksandrova K, Trichopoulou A, Lagiou P, Bamia C, Pala V, Palli D, Mattiello A, Tumino R, Naccarati A, Bueno-de-Mesquita HB, Peeters PH, Weiderpass E, Quirós JR, Agudo A, Sánchez-Cantalejo E, Ardanaz E, Gavrila D, Dorronsoro M, Werner M, Hemmingsson O, Ohlsson B, Sjöberg K, Wareham NJ, Khaw KT, Bradbury KE, Gunter MJ, Cross AJ, Riboli E, Jenab M, Hainaut P, Beretta L.

Cancer Prev Res (Phila). 2016 Sep;9(9):758-65. doi: 10.1158/1940-6207.CAPR-15-0434. Epub 2016 Jun 23.


Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil.

Palmero EI, Alemar B, Schüler-Faccini L, Hainaut P, Moreira-Filho CA, Ewald IP, Santos PK, Ribeiro PL, Oliveira CB, Calvez-Kelm FL, Tavtigian S, Cossio SL, Giugliani R, Caleffi M, Ashton-Prolla P.

Genet Mol Biol. 2016 May 24;39(2):210-22. doi: 10.1590/1678-4685-GMB-2014-0363. Erratum in: Genet Mol Biol. 2017 Mar 16;:0.


Venous thromboembolism associated with acute cytomegalovirus infection: epidemiology and predisposing conditions.

Yildiz H, Zech F, Hainaut P.

Acta Clin Belg. 2016 Aug;71(4):231-4. doi: 10.1080/17843286.2016.1177265. Epub 2016 May 3.


Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.

Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J.

Genes Dev. 2016 Apr 1;30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17.


Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis.

Ma X, Le Teuff G, Lacas B, Tsao MS, Graziano S, Pignon JP, Douillard JY, Le Chevalier T, Seymour L, Filipits M, Pirker R, Jänne PA, Shepherd FA, Brambilla E, Soria JC, Hainaut P; LACE-Bio Collaborative Group.

J Thorac Oncol. 2016 Jun;11(6):850-61. doi: 10.1016/j.jtho.2016.02.002. Epub 2016 Feb 17.


Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome.

Macedo GS, Araujo Vieira I, Brandalize AP, Giacomazzi J, Inez Palmero E, Volc S, Rodrigues Paixão-Côrtes V, Caleffi M, Silva Alves M, Achatz MI, Hainaut P, Ashton-Prolla P.

Cancer Genet. 2016 Mar;209(3):97-106. doi: 10.1016/j.cancergen.2015.12.012. Epub 2016 Jan 7.


Patterns of Benign and Malignant Lesions of the Thyroid in Two Wilayahs of Northeastern Algeria.

Guidoum M, Kherfi-Kadi H, Benharkat-Boughaba O, Djemaa-Bendjazia A, Keghouche S, Abedi-Ardekani B, Azzouz A, Kadi Y, Hainaut P, Bouslama Z.

J Cancer Epidemiol. 2015;2015:849416. doi: 10.1155/2015/849416. Epub 2015 Nov 22.


The Evolution of Tumors in Mice and Humans with Germline p53 Mutations.

Levine AJ, Chan CS, Dudgeon C, Puzio-Kuter A, Hainaut P.

Cold Spring Harb Symp Quant Biol. 2015;80:139-45. doi: 10.1101/sqb.2015.80.027631. Epub 2015 Dec 7. Review.


Ancestry of the Brazilian TP53 c.1010G>A (p.Arg337His, R337H) Founder Mutation: Clues from Haplotyping of Short Tandem Repeats on Chromosome 17p.

Paskulin DD, Giacomazzi J, Achatz MI, Costa S, Reis RM, Hainaut P, dos Santos SE, Ashton-Prolla P.

PLoS One. 2015 Nov 30;10(11):e0143262. doi: 10.1371/journal.pone.0143262. eCollection 2015.


Editorial: from cancer genotypes to phenotypes: a never-ending complexity.

Hainaut P, Plymoth A.

Curr Opin Oncol. 2016 Jan;28(1):50-1. doi: 10.1097/CCO.0000000000000256. No abstract available.


Cancer Diagnostic and Predictive Biomarkers 2015.

Buonaguro FM, Pauza CD, Tornesello ML, Hainaut P, Franco R.

Biomed Res Int. 2015;2015:235985. doi: 10.1155/2015/235985. Epub 2015 Oct 12. No abstract available.


Dietary Carbohydrate, Glycemic Index, Glycemic Load, and Breast Cancer Risk Among Mexican Women.

Amadou A, Degoul J, Hainaut P, Chajes V, Biessy C, Torres Mejia G, Huybrechts I, Moreno Macia H, Ortega C, Angeles-Llerenas A, Romieu I.

Epidemiology. 2015 Nov;26(6):917-24. doi: 10.1097/EDE.0000000000000374.


Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali.

Traoré F, Gormally E, Villar S, Friesen MD, Groopman JD, Vernet G, Diallo S, Hainaut P, Maiga MY.

BMC Infect Dis. 2015 Apr 11;15:180. doi: 10.1186/s12879-015-0916-x.


(18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome.

Nogueira ST, Lima EN, Nóbrega AF, Torres Ido C, Cavicchioli M, Hainaut P, Achatz MI.

Front Oncol. 2015 Feb 19;5:38. doi: 10.3389/fonc.2015.00038. eCollection 2015.


Breast cancer in Latin America: global burden, patterns, and risk factors.

Amadou A, Torres-Mejía G, Hainaut P, Romieu I.

Salud Publica Mex. 2014 Sep-Oct;56(5):547-54.


Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients.

Balter V, Nogueira da Costa A, Bondanese VP, Jaouen K, Lamboux A, Sangrajrang S, Vincent N, Fourel F, Télouk P, Gigou M, Lécuyer C, Srivatanakul P, Bréchot C, Albarède F, Hainaut P.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):982-5. doi: 10.1073/pnas.1415151112. Epub 2015 Jan 12.


Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia.

Suarez M I, Uribe D, Jaramillo CM, Osorio G, Perez JC, Lopez R, Hoyos S, Hainaut P, Pineau P, Navas MC.

Ann Hepatol. 2015 Jan-Feb;14(1):64-74.


p53 in metabolism, aging and cancer.

Hainaut P.

Ann Dermatol Venereol. 2014 Dec;141(12 Suppl):S200-1. doi: 10.1016/j.annder.2014.10.004. Epub 2014 Oct 29. Review. No abstract available.


Changes in the pattern of breast cancer burden among African American women: evidence based on 29 states and District of Columbia during 1998 to 2010.

Sighoko D, Fackenthal JD, Hainaut P.

Ann Epidemiol. 2015 Jan;25(1):15-25.e10. doi: 10.1016/j.annepidem.2014.09.006. Epub 2014 Sep 22.


Statin-induced rhabdomyolysis mimicking polymyositis on (18)F-FDG PET imaging.

Yildiz H, Roelants V, Hainaut P.

Acta Clin Belg. 2015 Apr;70(2):151-2. doi: 10.1179/2295333714Y.0000000085. Epub 2014 Nov 24. No abstract available.


Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome.

Ariffin H, Chan AS, Oh L, Abd-Ghafar S, Ong GB, Mohamed M, Razali H, Juraida E, Teo SH, Karsa M, Shamsani J, Hainaut P.

Clin Genet. 2015 Nov;88(5):450-5. doi: 10.1111/cge.12525. Epub 2014 Nov 13.


Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome.

Ariffin H, Hainaut P, Puzio-Kuter A, Choong SS, Chan AS, Tolkunov D, Rajagopal G, Kang W, Lim LL, Krishnan S, Chen KS, Achatz MI, Karsa M, Shamsani J, Levine AJ, Chan CS.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15497-501. doi: 10.1073/pnas.1417322111. Epub 2014 Oct 13.


Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts.

Perriaud L, Marcel V, Sagne C, Favaudon V, Guédin A, De Rache A, Guetta C, Hamon F, Teulade-Fichou MP, Hainaut P, Mergny JL, Hall J.

Carcinogenesis. 2014 Dec;35(12):2706-15. doi: 10.1093/carcin/bgu206. Epub 2014 Sep 30.

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